DNA-directed RNA polymerase III subunit RPC6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase Rpc34 subunit, putative

Species:

Leishmania mexicana

UniProt:

E9ALU1_LEIMU

TriTrypDb:

LmxM.08_29.1320

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	11
GO:0005666	RNA polymerase III complex	4	11
GO:0030880	RNA polymerase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Expansion

Sequence features

E9ALU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALU1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	11
GO:0006383	transcription by RNA polymerase III	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.403
CLV_C14_Caspase3-7	400	404	PF00656	0.439
CLV_NRD_NRD_1	167	169	PF00675	0.308
CLV_NRD_NRD_1	177	179	PF00675	0.301
CLV_NRD_NRD_1	316	318	PF00675	0.433
CLV_NRD_NRD_1	57	59	PF00675	0.325
CLV_PCSK_FUR_1	131	135	PF00082	0.306
CLV_PCSK_FUR_1	55	59	PF00082	0.430
CLV_PCSK_KEX2_1	133	135	PF00082	0.369
CLV_PCSK_KEX2_1	167	169	PF00082	0.306
CLV_PCSK_KEX2_1	177	179	PF00082	0.306
CLV_PCSK_KEX2_1	186	188	PF00082	0.306
CLV_PCSK_KEX2_1	316	318	PF00082	0.433
CLV_PCSK_KEX2_1	57	59	PF00082	0.325
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.369
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.430
CLV_PCSK_PC7_1	53	59	PF00082	0.430
CLV_PCSK_SKI1_1	126	130	PF00082	0.313
CLV_PCSK_SKI1_1	168	172	PF00082	0.433
CLV_PCSK_SKI1_1	309	313	PF00082	0.340
CLV_Separin_Metazoa	383	387	PF03568	0.266
DEG_MDM2_SWIB_1	162	170	PF02201	0.430
DEG_SPOP_SBC_1	2	6	PF00917	0.545
DEG_SPOP_SBC_1	244	248	PF00917	0.372
DEG_SPOP_SBC_1	352	356	PF00917	0.280
DOC_CKS1_1	294	299	PF01111	0.433
DOC_CYCLIN_RxL_1	29	39	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.350
DOC_MAPK_gen_1	334	343	PF00069	0.349
DOC_MAPK_HePTP_8	54	70	PF00069	0.350
DOC_MAPK_MEF2A_6	336	345	PF00069	0.356
DOC_PP1_RVXF_1	176	183	PF00149	0.430
DOC_PP2B_LxvP_1	343	346	PF13499	0.183
DOC_USP7_MATH_1	191	195	PF00917	0.412
DOC_USP7_MATH_1	244	248	PF00917	0.315
DOC_USP7_MATH_1	254	258	PF00917	0.332
DOC_USP7_MATH_1	3	7	PF00917	0.480
DOC_USP7_MATH_1	351	355	PF00917	0.439
DOC_USP7_MATH_1	87	91	PF00917	0.312
DOC_USP7_UBL2_3	119	123	PF12436	0.430
DOC_WW_Pin1_4	293	298	PF00397	0.415
LIG_14-3-3_CanoR_1	103	113	PF00244	0.354
LIG_14-3-3_CanoR_1	134	139	PF00244	0.430
LIG_14-3-3_CanoR_1	16	25	PF00244	0.185
LIG_14-3-3_CanoR_1	172	180	PF00244	0.346
LIG_14-3-3_CanoR_1	309	314	PF00244	0.325
LIG_14-3-3_CanoR_1	386	391	PF00244	0.423
LIG_Actin_WH2_2	41	59	PF00022	0.306
LIG_BRCT_BRCA1_1	256	260	PF00533	0.366
LIG_Clathr_ClatBox_1	138	142	PF01394	0.306
LIG_deltaCOP1_diTrp_1	164	173	PF00928	0.430
LIG_FHA_1	169	175	PF00498	0.413
LIG_FHA_1	274	280	PF00498	0.311
LIG_FHA_1	289	295	PF00498	0.275
LIG_FHA_1	379	385	PF00498	0.442
LIG_FHA_1	94	100	PF00498	0.407
LIG_FHA_2	17	23	PF00498	0.355
LIG_FHA_2	228	234	PF00498	0.430
LIG_FHA_2	288	294	PF00498	0.366
LIG_FHA_2	323	329	PF00498	0.412
LIG_GBD_Chelix_1	70	78	PF00786	0.430
LIG_LIR_Gen_1	181	189	PF02991	0.433
LIG_LIR_Gen_1	256	265	PF02991	0.429
LIG_LIR_Gen_1	406	416	PF02991	0.430
LIG_LIR_Gen_1	64	74	PF02991	0.330
LIG_LIR_Nem_3	181	185	PF02991	0.436
LIG_LIR_Nem_3	256	261	PF02991	0.429
LIG_LIR_Nem_3	64	70	PF02991	0.330
LIG_Pex14_2	162	166	PF04695	0.433
LIG_SH2_CRK	258	262	PF00017	0.433
LIG_SH2_PTP2	67	70	PF00017	0.306
LIG_SH2_STAP1	258	262	PF00017	0.366
LIG_SH2_STAT5	136	139	PF00017	0.308
LIG_SH2_STAT5	153	156	PF00017	0.353
LIG_SH2_STAT5	442	445	PF00017	0.306
LIG_SH2_STAT5	67	70	PF00017	0.306
LIG_SH3_3	291	297	PF00018	0.333
LIG_SH3_3	343	349	PF00018	0.249
LIG_SH3_3	393	399	PF00018	0.360
LIG_SH3_3	411	417	PF00018	0.325
LIG_SH3_3	431	437	PF00018	0.150
LIG_SH3_3	99	105	PF00018	0.350
LIG_SUMO_SIM_anti_2	76	83	PF11976	0.430
LIG_SUMO_SIM_par_1	275	280	PF11976	0.313
LIG_TRAF2_1	290	293	PF00917	0.414
LIG_TYR_ITIM	25	30	PF00017	0.430
LIG_WRC_WIRS_1	179	184	PF05994	0.436
MOD_CK1_1	194	200	PF00069	0.296
MOD_CK1_1	216	222	PF00069	0.437
MOD_CK1_1	245	251	PF00069	0.369
MOD_CK1_1	253	259	PF00069	0.243
MOD_CK1_1	355	361	PF00069	0.429
MOD_CK1_1	378	384	PF00069	0.448
MOD_CK1_1	397	403	PF00069	0.178
MOD_CK1_1	5	11	PF00069	0.493
MOD_CK1_1	88	94	PF00069	0.292
MOD_CK2_1	16	22	PF00069	0.265
MOD_CK2_1	287	293	PF00069	0.414
MOD_CK2_1	322	328	PF00069	0.376
MOD_CK2_1	36	42	PF00069	0.487
MOD_CK2_1	377	383	PF00069	0.457
MOD_CK2_1	386	392	PF00069	0.391
MOD_GlcNHglycan	193	196	PF01048	0.343
MOD_GlcNHglycan	202	205	PF01048	0.311
MOD_GlcNHglycan	215	218	PF01048	0.429
MOD_GlcNHglycan	233	236	PF01048	0.351
MOD_GlcNHglycan	248	251	PF01048	0.292
MOD_GlcNHglycan	252	255	PF01048	0.264
MOD_GlcNHglycan	349	352	PF01048	0.484
MOD_GlcNHglycan	355	358	PF01048	0.435
MOD_GlcNHglycan	365	368	PF01048	0.214
MOD_GlcNHglycan	38	41	PF01048	0.409
MOD_GlcNHglycan	87	90	PF01048	0.306
MOD_GSK3_1	1	8	PF00069	0.610
MOD_GSK3_1	141	148	PF00069	0.306
MOD_GSK3_1	168	175	PF00069	0.461
MOD_GSK3_1	209	216	PF00069	0.429
MOD_GSK3_1	227	234	PF00069	0.313
MOD_GSK3_1	242	249	PF00069	0.283
MOD_GSK3_1	250	257	PF00069	0.309
MOD_GSK3_1	269	276	PF00069	0.285
MOD_GSK3_1	347	354	PF00069	0.424
MOD_GSK3_1	394	401	PF00069	0.441
MOD_GSK3_1	438	445	PF00069	0.183
MOD_GSK3_1	93	100	PF00069	0.430
MOD_N-GLC_1	76	81	PF02516	0.423
MOD_NEK2_1	173	178	PF00069	0.407
MOD_NEK2_1	231	236	PF00069	0.423
MOD_NEK2_1	273	278	PF00069	0.306
MOD_NEK2_1	36	41	PF00069	0.330
MOD_NEK2_1	377	382	PF00069	0.433
MOD_NEK2_1	385	390	PF00069	0.319
MOD_NEK2_2	427	432	PF00069	0.450
MOD_PIKK_1	217	223	PF00454	0.433
MOD_PIKK_1	394	400	PF00454	0.371
MOD_PIKK_1	61	67	PF00454	0.433
MOD_PIKK_1	93	99	PF00454	0.430
MOD_PKA_2	15	21	PF00069	0.414
MOD_PKA_2	385	391	PF00069	0.464
MOD_PKA_2	85	91	PF00069	0.314
MOD_PKB_1	319	327	PF00069	0.424
MOD_Plk_1	168	174	PF00069	0.433
MOD_Plk_1	76	82	PF00069	0.426
MOD_Plk_1	93	99	PF00069	0.264
MOD_Plk_4	134	140	PF00069	0.377
MOD_Plk_4	273	279	PF00069	0.276
MOD_Plk_4	303	309	PF00069	0.433
MOD_Plk_4	386	392	PF00069	0.430
MOD_Plk_4	438	444	PF00069	0.455
MOD_Plk_4	76	82	PF00069	0.353
MOD_ProDKin_1	293	299	PF00069	0.415
MOD_SUMO_for_1	105	108	PF00179	0.306
MOD_SUMO_for_1	30	33	PF00179	0.430
TRG_DiLeu_BaEn_1	76	81	PF01217	0.306
TRG_DiLeu_BaEn_2	168	174	PF01217	0.430
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.430
TRG_ENDOCYTIC_2	136	139	PF00928	0.306
TRG_ENDOCYTIC_2	258	261	PF00928	0.433
TRG_ENDOCYTIC_2	27	30	PF00928	0.430
TRG_ENDOCYTIC_2	67	70	PF00928	0.306
TRG_ER_diArg_1	166	168	PF00400	0.306
TRG_ER_diArg_1	177	179	PF00400	0.306
TRG_ER_diArg_1	316	319	PF00400	0.432
TRG_ER_diArg_1	332	335	PF00400	0.413
TRG_ER_diArg_1	53	56	PF00400	0.336
TRG_NES_CRM1_1	269	280	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC6	Leptomonas seymouri	66%	100%
A0A1X0NZS8	Trypanosomatidae	38%	100%
A0A3Q8IBH1	Leishmania donovani	93%	100%
A0A3R7NQJ5	Trypanosoma rangeli	39%	100%
A4HHE3	Leishmania braziliensis	87%	100%
A4I4I9	Leishmania infantum	93%	100%
C9ZL77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ADZ0	Leishmania major	93%	100%
V5B1R1	Trypanosoma cruzi	39%	100%