Aurora kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aurora kinase

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ALU0_LEIMU

TriTrypDb:

LmxM.08_29.1330

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALU0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0046777	protein autophosphorylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0106310	protein serine kinase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	1
GO:0010857	calcium-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.389
CLV_NRD_NRD_1	263	265	PF00675	0.505
CLV_NRD_NRD_1	40	42	PF00675	0.587
CLV_NRD_NRD_1	456	458	PF00675	0.505
CLV_PCSK_KEX2_1	263	265	PF00082	0.505
CLV_PCSK_KEX2_1	40	42	PF00082	0.587
CLV_PCSK_KEX2_1	456	458	PF00082	0.505
CLV_PCSK_KEX2_1	85	87	PF00082	0.687
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.687
CLV_PCSK_PC7_1	36	42	PF00082	0.529
CLV_PCSK_SKI1_1	386	390	PF00082	0.400
DEG_SPOP_SBC_1	183	187	PF00917	0.517
DOC_CKS1_1	329	334	PF01111	0.505
DOC_CYCLIN_RxL_1	34	47	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.505
DOC_MAPK_gen_1	315	325	PF00069	0.505
DOC_MAPK_gen_1	386	395	PF00069	0.505
DOC_PP1_RVXF_1	295	301	PF00149	0.505
DOC_PP2B_LxvP_1	174	177	PF13499	0.493
DOC_PP4_FxxP_1	329	332	PF00568	0.344
DOC_USP7_MATH_1	157	161	PF00917	0.731
DOC_USP7_MATH_1	227	231	PF00917	0.727
DOC_USP7_MATH_1	4	8	PF00917	0.763
DOC_USP7_MATH_1	435	439	PF00917	0.231
DOC_USP7_MATH_1	54	58	PF00917	0.762
DOC_USP7_MATH_1	89	93	PF00917	0.636
DOC_WW_Pin1_4	129	134	PF00397	0.693
DOC_WW_Pin1_4	19	24	PF00397	0.650
DOC_WW_Pin1_4	190	195	PF00397	0.808
DOC_WW_Pin1_4	197	202	PF00397	0.727
DOC_WW_Pin1_4	240	245	PF00397	0.776
DOC_WW_Pin1_4	328	333	PF00397	0.505
DOC_WW_Pin1_4	464	469	PF00397	0.505
DOC_WW_Pin1_4	493	498	PF00397	0.427
LIG_14-3-3_CanoR_1	218	224	PF00244	0.793
LIG_14-3-3_CanoR_1	324	329	PF00244	0.505
LIG_14-3-3_CanoR_1	436	440	PF00244	0.214
LIG_14-3-3_CanoR_1	456	460	PF00244	0.466
LIG_14-3-3_CanoR_1	570	580	PF00244	0.265
LIG_14-3-3_CanoR_1	59	68	PF00244	0.480
LIG_Actin_WH2_2	245	260	PF00022	0.484
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BIR_III_4	396	400	PF00653	0.505
LIG_CtBP_PxDLS_1	515	519	PF00389	0.505
LIG_FHA_1	109	115	PF00498	0.541
LIG_FHA_1	15	21	PF00498	0.643
LIG_FHA_1	184	190	PF00498	0.634
LIG_FHA_1	366	372	PF00498	0.505
LIG_FHA_1	447	453	PF00498	0.373
LIG_FHA_1	536	542	PF00498	0.330
LIG_FHA_2	425	431	PF00498	0.505
LIG_FHA_2	441	447	PF00498	0.241
LIG_FHA_2	542	548	PF00498	0.408
LIG_LIR_Apic_2	327	332	PF02991	0.344
LIG_LIR_Apic_2	405	411	PF02991	0.408
LIG_LIR_Apic_2	462	468	PF02991	0.491
LIG_LIR_Gen_1	132	141	PF02991	0.471
LIG_LIR_Gen_1	270	279	PF02991	0.505
LIG_LIR_Nem_3	132	137	PF02991	0.765
LIG_LIR_Nem_3	270	276	PF02991	0.349
LIG_NRP_CendR_1	584	586	PF00754	0.514
LIG_SH2_CRK	273	277	PF00017	0.505
LIG_SH2_NCK_1	273	277	PF00017	0.505
LIG_SH2_STAP1	326	330	PF00017	0.505
LIG_SH2_STAP1	367	371	PF00017	0.440
LIG_SH2_STAT3	509	512	PF00017	0.427
LIG_SH2_STAT5	136	139	PF00017	0.476
LIG_SH2_STAT5	328	331	PF00017	0.505
LIG_SH2_STAT5	341	344	PF00017	0.290
LIG_SH2_STAT5	367	370	PF00017	0.505
LIG_SH2_STAT5	465	468	PF00017	0.505
LIG_SH2_STAT5	500	503	PF00017	0.505
LIG_SH3_2	415	420	PF14604	0.330
LIG_SH3_3	195	201	PF00018	0.640
LIG_SH3_3	242	248	PF00018	0.683
LIG_SH3_3	409	415	PF00018	0.505
LIG_Sin3_3	110	117	PF02671	0.490
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.427
LIG_SUMO_SIM_par_1	274	280	PF11976	0.505
LIG_SUMO_SIM_par_1	546	552	PF11976	0.501
LIG_TRAF2_1	448	451	PF00917	0.214
LIG_TRAF2_1	472	475	PF00917	0.214
LIG_UBA3_1	286	291	PF00899	0.262
LIG_UBA3_1	558	565	PF00899	0.505
LIG_WW_1	497	500	PF00397	0.505
MOD_CDC14_SPxK_1	22	25	PF00782	0.808
MOD_CDK_SPxK_1	19	25	PF00069	0.808
MOD_CDK_SPxxK_3	190	197	PF00069	0.516
MOD_CDK_SPxxK_3	244	251	PF00069	0.549
MOD_CK1_1	123	129	PF00069	0.680
MOD_CK1_1	15	21	PF00069	0.783
MOD_CK1_1	159	165	PF00069	0.711
MOD_CK1_1	175	181	PF00069	0.602
MOD_CK1_1	193	199	PF00069	0.497
MOD_CK1_1	209	215	PF00069	0.522
MOD_CK1_1	228	234	PF00069	0.801
MOD_CK1_1	240	246	PF00069	0.565
MOD_CK1_1	274	280	PF00069	0.505
MOD_CK1_1	343	349	PF00069	0.505
MOD_CK1_1	365	371	PF00069	0.505
MOD_CK1_1	477	483	PF00069	0.491
MOD_CK1_1	528	534	PF00069	0.432
MOD_CK1_1	97	103	PF00069	0.560
MOD_CK2_1	440	446	PF00069	0.441
MOD_CK2_1	469	475	PF00069	0.214
MOD_CK2_1	541	547	PF00069	0.500
MOD_Cter_Amidation	454	457	PF01082	0.505
MOD_DYRK1A_RPxSP_1	197	201	PF00069	0.507
MOD_GlcNHglycan	106	109	PF01048	0.639
MOD_GlcNHglycan	159	162	PF01048	0.765
MOD_GlcNHglycan	165	168	PF01048	0.698
MOD_GlcNHglycan	17	20	PF01048	0.610
MOD_GlcNHglycan	177	180	PF01048	0.582
MOD_GlcNHglycan	203	206	PF01048	0.693
MOD_GlcNHglycan	211	214	PF01048	0.759
MOD_GlcNHglycan	225	228	PF01048	0.670
MOD_GlcNHglycan	238	242	PF01048	0.580
MOD_GlcNHglycan	283	286	PF01048	0.505
MOD_GlcNHglycan	342	345	PF01048	0.505
MOD_GlcNHglycan	471	474	PF01048	0.505
MOD_GlcNHglycan	475	479	PF01048	0.439
MOD_GlcNHglycan	525	528	PF01048	0.350
MOD_GlcNHglycan	532	535	PF01048	0.341
MOD_GlcNHglycan	551	554	PF01048	0.505
MOD_GlcNHglycan	72	75	PF01048	0.531
MOD_GlcNHglycan	80	85	PF01048	0.623
MOD_GlcNHglycan	97	100	PF01048	0.626
MOD_GSK3_1	100	107	PF00069	0.719
MOD_GSK3_1	120	127	PF00069	0.471
MOD_GSK3_1	15	22	PF00069	0.633
MOD_GSK3_1	159	166	PF00069	0.784
MOD_GSK3_1	178	185	PF00069	0.578
MOD_GSK3_1	189	196	PF00069	0.560
MOD_GSK3_1	197	204	PF00069	0.740
MOD_GSK3_1	219	226	PF00069	0.589
MOD_GSK3_1	240	247	PF00069	0.589
MOD_GSK3_1	277	284	PF00069	0.505
MOD_GSK3_1	324	331	PF00069	0.505
MOD_GSK3_1	441	448	PF00069	0.310
MOD_GSK3_1	455	462	PF00069	0.482
MOD_GSK3_1	477	484	PF00069	0.463
MOD_GSK3_1	500	507	PF00069	0.491
MOD_GSK3_1	521	528	PF00069	0.220
MOD_GSK3_1	90	97	PF00069	0.609
MOD_LATS_1	180	186	PF00433	0.725
MOD_N-GLC_1	516	521	PF02516	0.505
MOD_N-GLC_2	540	542	PF02516	0.330
MOD_NEK2_1	12	17	PF00069	0.752
MOD_NEK2_1	120	125	PF00069	0.747
MOD_NEK2_1	137	142	PF00069	0.523
MOD_NEK2_1	203	208	PF00069	0.805
MOD_NEK2_1	313	318	PF00069	0.505
MOD_NEK2_1	406	411	PF00069	0.359
MOD_NEK2_1	521	526	PF00069	0.280
MOD_NEK2_1	530	535	PF00069	0.321
MOD_NEK2_1	70	75	PF00069	0.493
MOD_NEK2_1	95	100	PF00069	0.510
MOD_NEK2_2	435	440	PF00069	0.214
MOD_NEK2_2	54	59	PF00069	0.552
MOD_OFUCOSY	60	65	PF10250	0.476
MOD_PIKK_1	501	507	PF00454	0.427
MOD_PIKK_1	59	65	PF00454	0.770
MOD_PK_1	172	178	PF00069	0.495
MOD_PKA_2	214	220	PF00069	0.538
MOD_PKA_2	281	287	PF00069	0.505
MOD_PKA_2	357	363	PF00069	0.505
MOD_PKA_2	365	371	PF00069	0.373
MOD_PKA_2	435	441	PF00069	0.214
MOD_PKA_2	455	461	PF00069	0.466
MOD_Plk_1	293	299	PF00069	0.505
MOD_Plk_1	54	60	PF00069	0.521
MOD_Plk_2-3	446	452	PF00069	0.214
MOD_Plk_4	206	212	PF00069	0.799
MOD_Plk_4	271	277	PF00069	0.359
MOD_Plk_4	324	330	PF00069	0.344
MOD_Plk_4	343	349	PF00069	0.344
MOD_Plk_4	554	560	PF00069	0.382
MOD_ProDKin_1	129	135	PF00069	0.693
MOD_ProDKin_1	19	25	PF00069	0.652
MOD_ProDKin_1	190	196	PF00069	0.806
MOD_ProDKin_1	197	203	PF00069	0.729
MOD_ProDKin_1	240	246	PF00069	0.772
MOD_ProDKin_1	328	334	PF00069	0.505
MOD_ProDKin_1	464	470	PF00069	0.505
MOD_ProDKin_1	493	499	PF00069	0.427
MOD_SUMO_for_1	388	391	PF00179	0.505
TRG_DiLeu_BaEn_1	333	338	PF01217	0.214
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.789
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.462
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.783
TRG_ENDOCYTIC_2	273	276	PF00928	0.505
TRG_ENDOCYTIC_2	326	329	PF00928	0.430
TRG_ER_diArg_1	262	264	PF00400	0.505
TRG_ER_diArg_1	295	298	PF00400	0.505
TRG_ER_diArg_1	39	41	PF00400	0.790
TRG_ER_diArg_1	42	45	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	301	306	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J842	Bodo saltans	23%	100%
A0A1X0P0R3	Trypanosomatidae	26%	97%
A0A3Q8INQ4	Leishmania donovani	27%	100%
A0A3S5H5G0	Leishmania donovani	27%	100%
A0A3S7X2F1	Leishmania donovani	86%	100%
A4H459	Leishmania braziliensis	27%	100%
A4HA97	Leishmania braziliensis	24%	100%
A4HED7	Leishmania braziliensis	29%	100%
A4HHE4	Leishmania braziliensis	72%	100%
A4HSE2	Leishmania infantum	27%	100%
A4HW76	Leishmania infantum	22%	73%
A4I1T4	Leishmania infantum	27%	100%
A5GFW1	Sus scrofa	31%	100%
E9ADZ1	Leishmania major	84%	100%
E9AHI7	Leishmania infantum	86%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
P25341	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	81%
P83099	Drosophila melanogaster	25%	87%
Q4Q9K2	Leishmania major	27%	100%
Q4QAV8	Leishmania major	28%	100%
Q4QJJ0	Leishmania major	27%	100%
Q8LPD9	Chlamydomonas reinhardtii	26%	78%
V5B639	Trypanosoma cruzi	27%	84%