Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9ALT9_LEIMU

TriTrypDb:

LmxM.08_29.1335

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ALT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.423
CLV_NRD_NRD_1	54	56	PF00675	0.715
CLV_NRD_NRD_1	64	66	PF00675	0.794
CLV_PCSK_KEX2_1	224	226	PF00082	0.414
CLV_PCSK_KEX2_1	64	66	PF00082	0.717
CLV_PCSK_KEX2_1	70	72	PF00082	0.659
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.717
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.659
CLV_PCSK_SKI1_1	66	70	PF00082	0.735
CLV_PCSK_SKI1_1	94	98	PF00082	0.614
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.411
DOC_MAPK_DCC_7	141	149	PF00069	0.407
DOC_MAPK_FxFP_2	103	106	PF00069	0.381
DOC_MAPK_FxFP_2	40	43	PF00069	0.419
DOC_MAPK_MEF2A_6	163	172	PF00069	0.431
DOC_PP2B_LxvP_1	208	211	PF13499	0.672
DOC_PP2B_LxvP_1	72	75	PF13499	0.423
DOC_PP4_FxxP_1	103	106	PF00568	0.381
DOC_PP4_FxxP_1	161	164	PF00568	0.434
DOC_PP4_FxxP_1	186	189	PF00568	0.287
DOC_PP4_FxxP_1	35	38	PF00568	0.497
DOC_PP4_FxxP_1	40	43	PF00568	0.412
DOC_USP7_MATH_1	198	202	PF00917	0.583
DOC_USP7_MATH_1	86	90	PF00917	0.404
DOC_USP7_UBL2_3	66	70	PF12436	0.453
DOC_WW_Pin1_4	117	122	PF00397	0.436
DOC_WW_Pin1_4	134	139	PF00397	0.393
DOC_WW_Pin1_4	206	211	PF00397	0.722
DOC_WW_Pin1_4	33	38	PF00397	0.455
DOC_WW_Pin1_4	43	48	PF00397	0.451
DOC_WW_Pin1_4	5	10	PF00397	0.596
DOC_WW_Pin1_4	82	87	PF00397	0.412
LIG_14-3-3_CanoR_1	20	26	PF00244	0.287
LIG_14-3-3_CanoR_1	94	103	PF00244	0.548
LIG_Actin_WH2_2	7	22	PF00022	0.583
LIG_BRCT_BRCA1_1	170	174	PF00533	0.352
LIG_BRCT_BRCA1_1	175	179	PF00533	0.298
LIG_BRCT_BRCA1_1	31	35	PF00533	0.243
LIG_BRCT_BRCA1_1	98	102	PF00533	0.392
LIG_FHA_1	14	20	PF00498	0.618
LIG_FHA_1	67	73	PF00498	0.449
LIG_LIR_Apic_2	101	106	PF02991	0.384
LIG_LIR_Apic_2	158	164	PF02991	0.435
LIG_LIR_Apic_2	32	38	PF02991	0.495
LIG_LIR_Gen_1	171	182	PF02991	0.267
LIG_LIR_Gen_1	97	108	PF02991	0.386
LIG_LIR_Nem_3	131	136	PF02991	0.446
LIG_LIR_Nem_3	150	154	PF02991	0.377
LIG_LIR_Nem_3	155	159	PF02991	0.422
LIG_LIR_Nem_3	171	177	PF02991	0.232
LIG_LIR_Nem_3	181	186	PF02991	0.326
LIG_LIR_Nem_3	36	42	PF02991	0.415
LIG_LIR_Nem_3	97	103	PF02991	0.389
LIG_LYPXL_yS_3	133	136	PF13949	0.451
LIG_LYPXL_yS_3	159	162	PF13949	0.404
LIG_MLH1_MIPbox_1	175	179	PF16413	0.287
LIG_MYND_1	134	138	PF01753	0.447
LIG_Pex14_2	103	107	PF04695	0.382
LIG_Pex14_2	161	165	PF04695	0.434
LIG_Pex14_2	179	183	PF04695	0.208
LIG_Pex14_2	35	39	PF04695	0.459
LIG_SH2_STAT5	178	181	PF00017	0.287
LIG_SH3_1	71	77	PF00018	0.421
LIG_SH3_3	120	126	PF00018	0.434
LIG_SH3_3	154	160	PF00018	0.546
LIG_SH3_3	207	213	PF00018	0.608
LIG_SH3_3	3	9	PF00018	0.602
LIG_SH3_3	71	77	PF00018	0.421
LIG_SH3_4	66	73	PF00018	0.450
LIG_SUMO_SIM_par_1	113	120	PF11976	0.434
LIG_TRAF2_1	57	60	PF00917	0.442
LIG_TRFH_1	102	106	PF08558	0.385
LIG_WRC_WIRS_1	174	179	PF05994	0.287
LIG_WRC_WIRS_1	30	35	PF05994	0.287
MOD_CDK_SPxxK_3	134	141	PF00069	0.445
MOD_CK1_1	125	131	PF00069	0.417
MOD_CK1_1	137	143	PF00069	0.427
MOD_CK1_1	155	161	PF00069	0.483
MOD_CK1_1	173	179	PF00069	0.258
MOD_CK1_1	24	30	PF00069	0.342
MOD_CK1_1	8	14	PF00069	0.612
MOD_CK1_1	84	90	PF00069	0.460
MOD_GlcNHglycan	21	24	PF01048	0.357
MOD_GlcNHglycan	220	223	PF01048	0.485
MOD_GSK3_1	166	173	PF00069	0.413
MOD_GSK3_1	29	36	PF00069	0.280
MOD_GSK3_1	38	45	PF00069	0.403
MOD_GSK3_1	4	11	PF00069	0.624
MOD_GSK3_1	81	88	PF00069	0.499
MOD_GSK3_1	94	101	PF00069	0.517
MOD_NEK2_1	10	15	PF00069	0.604
MOD_NEK2_1	168	173	PF00069	0.262
MOD_NEK2_1	19	24	PF00069	0.212
MOD_NEK2_1	29	34	PF00069	0.221
MOD_NEK2_1	49	54	PF00069	0.392
MOD_NEK2_1	81	86	PF00069	0.571
MOD_NEK2_1	96	101	PF00069	0.410
MOD_NEK2_2	178	183	PF00069	0.243
MOD_PKA_2	19	25	PF00069	0.506
MOD_PKB_1	92	100	PF00069	0.396
MOD_Plk_4	173	179	PF00069	0.291
MOD_Plk_4	24	30	PF00069	0.287
MOD_ProDKin_1	117	123	PF00069	0.436
MOD_ProDKin_1	134	140	PF00069	0.392
MOD_ProDKin_1	206	212	PF00069	0.721
MOD_ProDKin_1	33	39	PF00069	0.457
MOD_ProDKin_1	43	49	PF00069	0.452
MOD_ProDKin_1	5	11	PF00069	0.594
MOD_ProDKin_1	82	88	PF00069	0.411
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.446
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.378
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.243
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.617
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.407
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.436
TRG_ENDOCYTIC_2	133	136	PF00928	0.451
TRG_ENDOCYTIC_2	159	162	PF00928	0.413
TRG_ER_diArg_1	224	226	PF00400	0.613
TRG_ER_diArg_1	92	95	PF00400	0.399
TRG_NLS_MonoCore_2	62	67	PF00514	0.453
TRG_NLS_MonoExtC_3	62	67	PF00514	0.566
TRG_NLS_MonoExtN_4	213	220	PF00514	0.606
TRG_NLS_MonoExtN_4	63	68	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFD4	Leishmania donovani	58%	69%