Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALT8_LEIMU

TriTrypDb:

LmxM.08_29.1340

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ALT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.652
CLV_C14_Caspase3-7	358	362	PF00656	0.587
CLV_C14_Caspase3-7	542	546	PF00656	0.652
CLV_NRD_NRD_1	154	156	PF00675	0.569
CLV_NRD_NRD_1	157	159	PF00675	0.479
CLV_NRD_NRD_1	259	261	PF00675	0.720
CLV_NRD_NRD_1	69	71	PF00675	0.346
CLV_NRD_NRD_1	81	83	PF00675	0.258
CLV_PCSK_KEX2_1	142	144	PF00082	0.554
CLV_PCSK_KEX2_1	154	156	PF00082	0.404
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.554
CLV_PCSK_SKI1_1	158	162	PF00082	0.492
CLV_PCSK_SKI1_1	175	179	PF00082	0.240
CLV_PCSK_SKI1_1	82	86	PF00082	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DEG_SPOP_SBC_1	347	351	PF00917	0.585
DEG_SPOP_SBC_1	482	486	PF00917	0.521
DEG_SPOP_SBC_1	535	539	PF00917	0.514
DOC_CKS1_1	25	30	PF01111	0.702
DOC_CKS1_1	300	305	PF01111	0.714
DOC_CKS1_1	469	474	PF01111	0.667
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	562	568	PF00134	0.661
DOC_MAPK_gen_1	154	162	PF00069	0.608
DOC_MAPK_gen_1	59	69	PF00069	0.518
DOC_PP1_RVXF_1	210	217	PF00149	0.610
DOC_PP2B_LxvP_1	296	299	PF13499	0.628
DOC_PP2B_LxvP_1	308	311	PF13499	0.539
DOC_PP2B_LxvP_1	562	565	PF13499	0.653
DOC_PP4_FxxP_1	25	28	PF00568	0.609
DOC_PP4_FxxP_1	588	591	PF00568	0.501
DOC_USP7_MATH_1	237	241	PF00917	0.615
DOC_USP7_MATH_1	385	389	PF00917	0.567
DOC_USP7_MATH_1	413	417	PF00917	0.632
DOC_USP7_MATH_1	465	469	PF00917	0.647
DOC_USP7_MATH_1	6	10	PF00917	0.592
DOC_USP7_MATH_1	606	610	PF00917	0.668
DOC_WW_Pin1_4	145	150	PF00397	0.598
DOC_WW_Pin1_4	24	29	PF00397	0.528
DOC_WW_Pin1_4	291	296	PF00397	0.735
DOC_WW_Pin1_4	299	304	PF00397	0.596
DOC_WW_Pin1_4	306	311	PF00397	0.561
DOC_WW_Pin1_4	318	323	PF00397	0.549
DOC_WW_Pin1_4	350	355	PF00397	0.766
DOC_WW_Pin1_4	369	374	PF00397	0.519
DOC_WW_Pin1_4	459	464	PF00397	0.781
DOC_WW_Pin1_4	468	473	PF00397	0.635
DOC_WW_Pin1_4	504	509	PF00397	0.770
DOC_WW_Pin1_4	525	530	PF00397	0.717
DOC_WW_Pin1_4	543	548	PF00397	0.686
DOC_WW_Pin1_4	9	14	PF00397	0.721
LIG_14-3-3_CanoR_1	206	214	PF00244	0.539
LIG_14-3-3_CanoR_1	408	413	PF00244	0.563
LIG_14-3-3_CanoR_1	584	589	PF00244	0.691
LIG_Actin_WH2_2	162	177	PF00022	0.546
LIG_APCC_ABBA_1	187	192	PF00400	0.632
LIG_APCC_ABBA_1	216	221	PF00400	0.605
LIG_BIR_III_4	361	365	PF00653	0.560
LIG_BRCT_BRCA1_1	32	36	PF00533	0.625
LIG_BRCT_BRCA1_1	320	324	PF00533	0.624
LIG_BRCT_BRCA1_1	413	417	PF00533	0.667
LIG_BRCT_BRCA1_1	450	454	PF00533	0.613
LIG_BRCT_BRCA1_1	499	503	PF00533	0.650
LIG_FHA_1	106	112	PF00498	0.632
LIG_FHA_1	295	301	PF00498	0.672
LIG_FHA_1	351	357	PF00498	0.685
LIG_FHA_1	364	370	PF00498	0.502
LIG_FHA_1	430	436	PF00498	0.679
LIG_FHA_1	484	490	PF00498	0.713
LIG_FHA_2	113	119	PF00498	0.546
LIG_FHA_2	356	362	PF00498	0.597
LIG_FHA_2	496	502	PF00498	0.519
LIG_FHA_2	75	81	PF00498	0.546
LIG_LIR_Apic_2	130	135	PF02991	0.546
LIG_LIR_Apic_2	587	591	PF02991	0.502
LIG_LIR_Apic_2	600	606	PF02991	0.495
LIG_LIR_Gen_1	366	375	PF02991	0.592
LIG_LIR_Gen_1	50	58	PF02991	0.599
LIG_LIR_Gen_1	93	100	PF02991	0.546
LIG_LIR_Nem_3	108	113	PF02991	0.632
LIG_LIR_Nem_3	179	184	PF02991	0.615
LIG_LIR_Nem_3	366	371	PF02991	0.647
LIG_LIR_Nem_3	50	54	PF02991	0.633
LIG_LIR_Nem_3	618	624	PF02991	0.627
LIG_LIR_Nem_3	86	91	PF02991	0.585
LIG_MYND_1	331	335	PF01753	0.572
LIG_PTB_Apo_2	210	217	PF02174	0.489
LIG_SH2_CRK	132	136	PF00017	0.546
LIG_SH2_CRK	430	434	PF00017	0.686
LIG_SH2_CRK	88	92	PF00017	0.546
LIG_SH2_NCK_1	418	422	PF00017	0.684
LIG_SH2_NCK_1	51	55	PF00017	0.652
LIG_SH2_PTP2	368	371	PF00017	0.654
LIG_SH2_PTP2	393	396	PF00017	0.566
LIG_SH2_SRC	368	371	PF00017	0.654
LIG_SH2_SRC	393	396	PF00017	0.615
LIG_SH2_STAP1	418	422	PF00017	0.684
LIG_SH2_STAP1	51	55	PF00017	0.652
LIG_SH2_STAT5	2	5	PF00017	0.654
LIG_SH2_STAT5	368	371	PF00017	0.661
LIG_SH2_STAT5	393	396	PF00017	0.648
LIG_SH3_3	328	334	PF00018	0.742
LIG_SH3_3	342	348	PF00018	0.652
LIG_SH3_3	407	413	PF00018	0.672
LIG_SH3_3	430	436	PF00018	0.579
LIG_SH3_3	443	449	PF00018	0.562
LIG_SH3_3	450	456	PF00018	0.653
LIG_SH3_3	529	535	PF00018	0.604
LIG_SH3_3	55	61	PF00018	0.679
LIG_SH3_3	8	14	PF00018	0.701
LIG_SUMO_SIM_par_1	165	170	PF11976	0.546
LIG_TYR_ITSM	364	371	PF00017	0.639
LIG_UBA3_1	477	481	PF00899	0.525
LIG_WRC_WIRS_1	91	96	PF05994	0.546
LIG_WW_1	48	51	PF00397	0.652
LIG_WW_3	558	562	PF00397	0.518
MOD_CDK_SPxK_1	24	30	PF00069	0.657
MOD_CK1_1	105	111	PF00069	0.546
MOD_CK1_1	267	273	PF00069	0.510
MOD_CK1_1	294	300	PF00069	0.733
MOD_CK1_1	309	315	PF00069	0.528
MOD_CK1_1	318	324	PF00069	0.628
MOD_CK1_1	346	352	PF00069	0.751
MOD_CK1_1	39	45	PF00069	0.586
MOD_CK1_1	411	417	PF00069	0.611
MOD_CK1_1	468	474	PF00069	0.611
MOD_CK1_1	74	80	PF00069	0.546
MOD_CK1_1	9	15	PF00069	0.658
MOD_CK2_1	112	118	PF00069	0.544
MOD_GlcNHglycan	19	22	PF01048	0.681
MOD_GlcNHglycan	304	307	PF01048	0.650
MOD_GlcNHglycan	335	338	PF01048	0.706
MOD_GlcNHglycan	345	348	PF01048	0.624
MOD_GlcNHglycan	387	390	PF01048	0.669
MOD_GlcNHglycan	44	47	PF01048	0.682
MOD_GlcNHglycan	541	544	PF01048	0.708
MOD_GlcNHglycan	577	580	PF01048	0.702
MOD_GlcNHglycan	73	76	PF01048	0.346
MOD_GSK3_1	176	183	PF00069	0.546
MOD_GSK3_1	202	209	PF00069	0.583
MOD_GSK3_1	228	235	PF00069	0.317
MOD_GSK3_1	281	288	PF00069	0.598
MOD_GSK3_1	294	301	PF00069	0.616
MOD_GSK3_1	30	37	PF00069	0.664
MOD_GSK3_1	302	309	PF00069	0.586
MOD_GSK3_1	311	318	PF00069	0.530
MOD_GSK3_1	329	336	PF00069	0.719
MOD_GSK3_1	337	344	PF00069	0.727
MOD_GSK3_1	346	353	PF00069	0.610
MOD_GSK3_1	38	45	PF00069	0.644
MOD_GSK3_1	464	471	PF00069	0.728
MOD_GSK3_1	493	500	PF00069	0.548
MOD_GSK3_1	535	542	PF00069	0.606
MOD_N-GLC_1	185	190	PF02516	0.346
MOD_N-GLC_1	267	272	PF02516	0.565
MOD_N-GLC_1	39	44	PF02516	0.659
MOD_N-GLC_1	504	509	PF02516	0.694
MOD_N-GLC_2	234	236	PF02516	0.507
MOD_N-GLC_2	623	625	PF02516	0.499
MOD_NEK2_1	167	172	PF00069	0.554
MOD_NEK2_1	232	237	PF00069	0.510
MOD_NEK2_1	264	269	PF00069	0.600
MOD_NEK2_1	281	286	PF00069	0.522
MOD_NEK2_1	315	320	PF00069	0.786
MOD_NEK2_1	32	37	PF00069	0.667
MOD_NEK2_1	343	348	PF00069	0.722
MOD_NEK2_1	355	360	PF00069	0.653
MOD_NEK2_1	520	525	PF00069	0.617
MOD_NEK2_2	228	233	PF00069	0.316
MOD_NEK2_2	413	418	PF00069	0.490
MOD_OFUCOSY	236	241	PF10250	0.498
MOD_PIKK_1	206	212	PF00454	0.558
MOD_PIKK_1	408	414	PF00454	0.623
MOD_PIKK_1	465	471	PF00454	0.597
MOD_PIKK_1	520	526	PF00454	0.528
MOD_PIKK_1	6	12	PF00454	0.473
MOD_PIKK_1	60	66	PF00454	0.520
MOD_PK_1	134	140	PF00069	0.610
MOD_PK_1	180	186	PF00069	0.546
MOD_PK_1	30	36	PF00069	0.627
MOD_PKA_2	111	117	PF00069	0.632
MOD_Plk_1	185	191	PF00069	0.554
MOD_Plk_1	30	36	PF00069	0.796
MOD_Plk_1	39	45	PF00069	0.632
MOD_Plk_4	276	282	PF00069	0.448
MOD_Plk_4	413	419	PF00069	0.533
MOD_Plk_4	536	542	PF00069	0.710
MOD_Plk_4	564	570	PF00069	0.634
MOD_Plk_4	584	590	PF00069	0.520
MOD_Plk_4	597	603	PF00069	0.633
MOD_Plk_4	87	93	PF00069	0.602
MOD_ProDKin_1	145	151	PF00069	0.598
MOD_ProDKin_1	24	30	PF00069	0.532
MOD_ProDKin_1	291	297	PF00069	0.734
MOD_ProDKin_1	299	305	PF00069	0.599
MOD_ProDKin_1	306	312	PF00069	0.564
MOD_ProDKin_1	318	324	PF00069	0.551
MOD_ProDKin_1	350	356	PF00069	0.764
MOD_ProDKin_1	369	375	PF00069	0.514
MOD_ProDKin_1	459	465	PF00069	0.776
MOD_ProDKin_1	468	474	PF00069	0.684
MOD_ProDKin_1	504	510	PF00069	0.773
MOD_ProDKin_1	525	531	PF00069	0.715
MOD_ProDKin_1	543	549	PF00069	0.690
MOD_ProDKin_1	9	15	PF00069	0.723
MOD_SUMO_for_1	141	144	PF00179	0.533
MOD_SUMO_rev_2	52	61	PF00179	0.625
TRG_ENDOCYTIC_2	368	371	PF00928	0.661
TRG_ENDOCYTIC_2	393	396	PF00928	0.566
TRG_ENDOCYTIC_2	430	433	PF00928	0.685
TRG_ENDOCYTIC_2	51	54	PF00928	0.678
TRG_ENDOCYTIC_2	586	589	PF00928	0.520
TRG_ENDOCYTIC_2	88	91	PF00928	0.546
TRG_NLS_Bipartite_1	142	159	PF00514	0.634
TRG_NLS_MonoExtC_3	154	159	PF00514	0.482
TRG_NLS_MonoExtN_4	154	159	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF58	Leishmania donovani	90%	100%
A4HHE7	Leishmania braziliensis	71%	100%
A4I4J0	Leishmania infantum	90%	100%
E9ADZ3	Leishmania major	89%	100%