Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALT7_LEIMU

TriTrypDb:

LmxM.08_29.1350

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ALT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.512
CLV_NRD_NRD_1	302	304	PF00675	0.650
CLV_NRD_NRD_1	314	316	PF00675	0.471
CLV_NRD_NRD_1	409	411	PF00675	0.624
CLV_NRD_NRD_1	677	679	PF00675	0.696
CLV_NRD_NRD_1	811	813	PF00675	0.728
CLV_NRD_NRD_1	857	859	PF00675	0.646
CLV_PCSK_KEX2_1	408	410	PF00082	0.616
CLV_PCSK_KEX2_1	811	813	PF00082	0.728
CLV_PCSK_KEX2_1	822	824	PF00082	0.620
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.733
CLV_PCSK_SKI1_1	317	321	PF00082	0.607
CLV_PCSK_SKI1_1	346	350	PF00082	0.432
CLV_PCSK_SKI1_1	410	414	PF00082	0.623
DEG_APCC_DBOX_1	331	339	PF00400	0.425
DEG_SCF_FBW7_1	180	186	PF00400	0.693
DEG_SCF_FBW7_1	530	535	PF00400	0.631
DEG_SCF_FBW7_1	873	880	PF00400	0.694
DEG_SPOP_SBC_1	30	34	PF00917	0.555
DEG_SPOP_SBC_1	56	60	PF00917	0.659
DEG_SPOP_SBC_1	562	566	PF00917	0.648
DOC_CDC14_PxL_1	197	205	PF14671	0.577
DOC_CKS1_1	169	174	PF01111	0.654
DOC_CKS1_1	180	185	PF01111	0.576
DOC_CKS1_1	212	217	PF01111	0.646
DOC_CKS1_1	595	600	PF01111	0.506
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.631
DOC_MAPK_gen_1	315	323	PF00069	0.610
DOC_MAPK_gen_1	47	56	PF00069	0.670
DOC_MAPK_gen_1	858	865	PF00069	0.642
DOC_MAPK_MEF2A_6	137	144	PF00069	0.674
DOC_MAPK_MEF2A_6	315	323	PF00069	0.610
DOC_MAPK_MEF2A_6	47	56	PF00069	0.537
DOC_MAPK_NFAT4_5	316	324	PF00069	0.606
DOC_PP1_RVXF_1	362	369	PF00149	0.632
DOC_PP4_FxxP_1	169	172	PF00568	0.649
DOC_SPAK_OSR1_1	827	831	PF12202	0.548
DOC_USP7_MATH_1	341	345	PF00917	0.512
DOC_USP7_MATH_1	389	393	PF00917	0.636
DOC_USP7_MATH_1	403	407	PF00917	0.451
DOC_USP7_MATH_1	440	444	PF00917	0.557
DOC_USP7_MATH_1	466	470	PF00917	0.568
DOC_USP7_MATH_1	532	536	PF00917	0.670
DOC_USP7_MATH_1	562	566	PF00917	0.745
DOC_USP7_MATH_1	57	61	PF00917	0.659
DOC_USP7_MATH_1	620	624	PF00917	0.681
DOC_USP7_MATH_1	716	720	PF00917	0.679
DOC_USP7_MATH_1	806	810	PF00917	0.677
DOC_USP7_MATH_1	842	846	PF00917	0.621
DOC_USP7_MATH_1	849	853	PF00917	0.555
DOC_USP7_MATH_2	215	221	PF00917	0.579
DOC_USP7_UBL2_3	316	320	PF12436	0.626
DOC_WW_Pin1_4	120	125	PF00397	0.635
DOC_WW_Pin1_4	168	173	PF00397	0.650
DOC_WW_Pin1_4	176	181	PF00397	0.612
DOC_WW_Pin1_4	186	191	PF00397	0.524
DOC_WW_Pin1_4	208	213	PF00397	0.670
DOC_WW_Pin1_4	34	39	PF00397	0.714
DOC_WW_Pin1_4	352	357	PF00397	0.632
DOC_WW_Pin1_4	433	438	PF00397	0.728
DOC_WW_Pin1_4	442	447	PF00397	0.597
DOC_WW_Pin1_4	479	484	PF00397	0.704
DOC_WW_Pin1_4	48	53	PF00397	0.571
DOC_WW_Pin1_4	523	528	PF00397	0.641
DOC_WW_Pin1_4	538	543	PF00397	0.625
DOC_WW_Pin1_4	558	563	PF00397	0.794
DOC_WW_Pin1_4	59	64	PF00397	0.600
DOC_WW_Pin1_4	594	599	PF00397	0.502
DOC_WW_Pin1_4	644	649	PF00397	0.574
DOC_WW_Pin1_4	683	688	PF00397	0.772
DOC_WW_Pin1_4	701	706	PF00397	0.660
DOC_WW_Pin1_4	712	717	PF00397	0.611
DOC_WW_Pin1_4	723	728	PF00397	0.652
DOC_WW_Pin1_4	774	779	PF00397	0.576
DOC_WW_Pin1_4	785	790	PF00397	0.681
DOC_WW_Pin1_4	796	801	PF00397	0.670
DOC_WW_Pin1_4	830	835	PF00397	0.657
DOC_WW_Pin1_4	850	855	PF00397	0.526
DOC_WW_Pin1_4	873	878	PF00397	0.687
DOC_WW_Pin1_4	898	903	PF00397	0.707
LIG_14-3-3_CanoR_1	107	114	PF00244	0.654
LIG_14-3-3_CanoR_1	346	351	PF00244	0.632
LIG_14-3-3_CanoR_1	516	522	PF00244	0.671
LIG_14-3-3_CanoR_1	577	583	PF00244	0.622
LIG_14-3-3_CanoR_1	762	771	PF00244	0.591
LIG_AP2alpha_2	242	244	PF02296	0.546
LIG_APCC_ABBA_1	241	246	PF00400	0.503
LIG_APCC_ABBA_1	348	353	PF00400	0.632
LIG_APCC_ABBA_1	368	373	PF00400	0.400
LIG_BRCT_BRCA1_1	443	447	PF00533	0.638
LIG_BRCT_BRCA1_1	580	584	PF00533	0.616
LIG_BRCT_BRCA1_1	620	624	PF00533	0.777
LIG_BRCT_BRCA1_1	705	709	PF00533	0.715
LIG_BRCT_BRCA1_1	779	783	PF00533	0.712
LIG_FHA_1	219	225	PF00498	0.398
LIG_FHA_1	262	268	PF00498	0.632
LIG_FHA_1	284	290	PF00498	0.532
LIG_FHA_1	352	358	PF00498	0.632
LIG_FHA_1	416	422	PF00498	0.592
LIG_FHA_1	423	429	PF00498	0.562
LIG_FHA_1	657	663	PF00498	0.528
LIG_FHA_1	785	791	PF00498	0.836
LIG_FHA_1	877	883	PF00498	0.697
LIG_FHA_2	212	218	PF00498	0.716
LIG_FHA_2	237	243	PF00498	0.512
LIG_FHA_2	329	335	PF00498	0.503
LIG_FHA_2	658	664	PF00498	0.640
LIG_GSK3_LRP6_1	877	883	PF00069	0.649
LIG_IBAR_NPY_1	912	914	PF08397	0.804
LIG_LIR_Apic_2	484	489	PF02991	0.643
LIG_LIR_Apic_2	494	500	PF02991	0.605
LIG_LIR_Gen_1	621	631	PF02991	0.627
LIG_LIR_Nem_3	198	203	PF02991	0.623
LIG_LIR_Nem_3	239	244	PF02991	0.541
LIG_LIR_Nem_3	264	269	PF02991	0.546
LIG_LIR_Nem_3	336	342	PF02991	0.632
LIG_LIR_Nem_3	621	627	PF02991	0.630
LIG_LIR_Nem_3	77	82	PF02991	0.498
LIG_LYPXL_yS_3	200	203	PF13949	0.619
LIG_PDZ_Class_2	918	923	PF00595	0.667
LIG_PTB_Apo_2	908	915	PF02174	0.695
LIG_PTB_Phospho_1	908	914	PF10480	0.699
LIG_Rb_LxCxE_1	861	880	PF01857	0.652
LIG_Rb_pABgroove_1	235	243	PF01858	0.546
LIG_SH2_CRK	592	596	PF00017	0.549
LIG_SH2_CRK	910	914	PF00017	0.693
LIG_SH2_GRB2like	909	912	PF00017	0.711
LIG_SH2_NCK_1	497	501	PF00017	0.701
LIG_SH2_NCK_1	910	914	PF00017	0.693
LIG_SH2_PTP2	486	489	PF00017	0.484
LIG_SH2_SRC	86	89	PF00017	0.484
LIG_SH2_STAP1	269	273	PF00017	0.572
LIG_SH2_STAT3	109	112	PF00017	0.683
LIG_SH2_STAT5	109	112	PF00017	0.683
LIG_SH2_STAT5	371	374	PF00017	0.632
LIG_SH2_STAT5	486	489	PF00017	0.484
LIG_SH2_STAT5	626	629	PF00017	0.627
LIG_SH2_STAT5	86	89	PF00017	0.617
LIG_SH3_1	434	440	PF00018	0.677
LIG_SH3_2	695	700	PF14604	0.632
LIG_SH3_3	177	183	PF00018	0.687
LIG_SH3_3	209	215	PF00018	0.677
LIG_SH3_3	434	440	PF00018	0.638
LIG_SH3_3	51	57	PF00018	0.567
LIG_SH3_3	564	570	PF00018	0.662
LIG_SH3_3	63	69	PF00018	0.607
LIG_SH3_3	645	651	PF00018	0.645
LIG_SH3_3	692	698	PF00018	0.596
LIG_SH3_3	832	838	PF00018	0.623
LIG_SH3_3	875	881	PF00018	0.645
LIG_SUMO_SIM_par_1	420	425	PF11976	0.480
LIG_SUMO_SIM_par_1	861	866	PF11976	0.700
LIG_SUMO_SIM_par_1	879	886	PF11976	0.527
MOD_CDC14_SPxK_1	541	544	PF00782	0.699
MOD_CDK_SPxK_1	538	544	PF00069	0.709
MOD_CDK_SPxK_1	594	600	PF00069	0.503
MOD_CDK_SPxxK_3	796	803	PF00069	0.715
MOD_CK1_1	179	185	PF00069	0.684
MOD_CK1_1	186	192	PF00069	0.697
MOD_CK1_1	205	211	PF00069	0.587
MOD_CK1_1	34	40	PF00069	0.735
MOD_CK1_1	41	47	PF00069	0.711
MOD_CK1_1	482	488	PF00069	0.748
MOD_CK1_1	506	512	PF00069	0.692
MOD_CK1_1	561	567	PF00069	0.711
MOD_CK1_1	59	65	PF00069	0.752
MOD_CK1_1	629	635	PF00069	0.569
MOD_CK1_1	671	677	PF00069	0.607
MOD_CK1_1	703	709	PF00069	0.715
MOD_CK1_1	726	732	PF00069	0.732
MOD_CK1_1	764	770	PF00069	0.705
MOD_CK1_1	785	791	PF00069	0.618
MOD_CK1_1	833	839	PF00069	0.679
MOD_CK1_1	852	858	PF00069	0.497
MOD_CK1_1	861	867	PF00069	0.584
MOD_CK1_1	880	886	PF00069	0.561
MOD_CK1_1	898	904	PF00069	0.521
MOD_CK1_1	915	921	PF00069	0.533
MOD_CK2_1	193	199	PF00069	0.688
MOD_CK2_1	211	217	PF00069	0.736
MOD_CK2_1	330	336	PF00069	0.425
MOD_CK2_1	863	869	PF00069	0.704
MOD_GlcNHglycan	153	156	PF01048	0.611
MOD_GlcNHglycan	173	176	PF01048	0.651
MOD_GlcNHglycan	185	188	PF01048	0.591
MOD_GlcNHglycan	207	210	PF01048	0.573
MOD_GlcNHglycan	43	46	PF01048	0.706
MOD_GlcNHglycan	492	496	PF01048	0.587
MOD_GlcNHglycan	521	524	PF01048	0.775
MOD_GlcNHglycan	567	570	PF01048	0.553
MOD_GlcNHglycan	614	617	PF01048	0.581
MOD_GlcNHglycan	620	623	PF01048	0.517
MOD_GlcNHglycan	652	655	PF01048	0.699
MOD_GlcNHglycan	670	673	PF01048	0.518
MOD_GlcNHglycan	691	694	PF01048	0.700
MOD_GlcNHglycan	710	713	PF01048	0.579
MOD_GlcNHglycan	76	79	PF01048	0.670
MOD_GlcNHglycan	767	770	PF01048	0.703
MOD_GlcNHglycan	784	787	PF01048	0.548
MOD_GlcNHglycan	830	833	PF01048	0.723
MOD_GlcNHglycan	840	843	PF01048	0.594
MOD_GlcNHglycan	844	847	PF01048	0.554
MOD_GlcNHglycan	869	873	PF01048	0.643
MOD_GlcNHglycan	88	91	PF01048	0.601
MOD_GlcNHglycan	887	890	PF01048	0.576
MOD_GlcNHglycan	903	906	PF01048	0.540
MOD_GSK3_1	178	185	PF00069	0.740
MOD_GSK3_1	186	193	PF00069	0.624
MOD_GSK3_1	204	211	PF00069	0.775
MOD_GSK3_1	213	220	PF00069	0.543
MOD_GSK3_1	29	36	PF00069	0.723
MOD_GSK3_1	37	44	PF00069	0.716
MOD_GSK3_1	478	485	PF00069	0.607
MOD_GSK3_1	506	513	PF00069	0.746
MOD_GSK3_1	519	526	PF00069	0.601
MOD_GSK3_1	528	535	PF00069	0.593
MOD_GSK3_1	55	62	PF00069	0.742
MOD_GSK3_1	558	565	PF00069	0.741
MOD_GSK3_1	625	632	PF00069	0.732
MOD_GSK3_1	640	647	PF00069	0.629
MOD_GSK3_1	657	664	PF00069	0.530
MOD_GSK3_1	670	677	PF00069	0.662
MOD_GSK3_1	703	710	PF00069	0.666
MOD_GSK3_1	712	719	PF00069	0.639
MOD_GSK3_1	722	729	PF00069	0.580
MOD_GSK3_1	757	764	PF00069	0.737
MOD_GSK3_1	765	772	PF00069	0.698
MOD_GSK3_1	773	780	PF00069	0.574
MOD_GSK3_1	784	791	PF00069	0.529
MOD_GSK3_1	838	845	PF00069	0.627
MOD_GSK3_1	868	875	PF00069	0.635
MOD_GSK3_1	876	883	PF00069	0.595
MOD_GSK3_1	896	903	PF00069	0.556
MOD_GSK3_1	912	919	PF00069	0.557
MOD_N-GLC_1	193	198	PF02516	0.687
MOD_N-GLC_1	664	669	PF02516	0.690
MOD_N-GLC_1	683	688	PF02516	0.517
MOD_N-GLC_1	774	779	PF02516	0.649
MOD_N-GLC_1	828	833	PF02516	0.726
MOD_N-GLC_2	782	784	PF02516	0.542
MOD_NEK2_1	11	16	PF00069	0.530
MOD_NEK2_1	203	208	PF00069	0.669
MOD_NEK2_1	328	333	PF00069	0.537
MOD_NEK2_1	402	407	PF00069	0.546
MOD_NEK2_1	422	427	PF00069	0.460
MOD_NEK2_1	43	48	PF00069	0.810
MOD_NEK2_1	473	478	PF00069	0.681
MOD_NEK2_1	491	496	PF00069	0.700
MOD_NEK2_1	517	522	PF00069	0.717
MOD_NEK2_1	572	577	PF00069	0.569
MOD_NEK2_1	625	630	PF00069	0.792
MOD_NEK2_1	670	675	PF00069	0.707
MOD_NEK2_1	707	712	PF00069	0.712
MOD_NEK2_1	763	768	PF00069	0.647
MOD_NEK2_1	828	833	PF00069	0.678
MOD_NEK2_1	863	868	PF00069	0.701
MOD_NEK2_2	236	241	PF00069	0.512
MOD_NEK2_2	341	346	PF00069	0.512
MOD_PIKK_1	107	113	PF00454	0.633
MOD_PIKK_1	403	409	PF00454	0.572
MOD_PIKK_1	466	472	PF00454	0.700
MOD_PIKK_1	511	517	PF00454	0.613
MOD_PIKK_1	57	63	PF00454	0.652
MOD_PIKK_1	671	677	PF00454	0.654
MOD_PKA_1	858	864	PF00069	0.641
MOD_PKA_2	267	273	PF00069	0.632
MOD_PKA_2	629	635	PF00069	0.496
MOD_PKA_2	761	767	PF00069	0.587
MOD_PKB_1	120	128	PF00069	0.646
MOD_Plk_1	193	199	PF00069	0.683
MOD_Plk_1	664	670	PF00069	0.572
MOD_Plk_4	236	242	PF00069	0.568
MOD_Plk_4	482	488	PF00069	0.533
MOD_Plk_4	5	11	PF00069	0.621
MOD_Plk_4	620	626	PF00069	0.743
MOD_Plk_4	703	709	PF00069	0.546
MOD_Plk_4	858	864	PF00069	0.595
MOD_Plk_4	93	99	PF00069	0.766
MOD_ProDKin_1	120	126	PF00069	0.637
MOD_ProDKin_1	168	174	PF00069	0.652
MOD_ProDKin_1	176	182	PF00069	0.614
MOD_ProDKin_1	186	192	PF00069	0.524
MOD_ProDKin_1	208	214	PF00069	0.666
MOD_ProDKin_1	34	40	PF00069	0.718
MOD_ProDKin_1	352	358	PF00069	0.632
MOD_ProDKin_1	433	439	PF00069	0.728
MOD_ProDKin_1	442	448	PF00069	0.598
MOD_ProDKin_1	479	485	PF00069	0.702
MOD_ProDKin_1	48	54	PF00069	0.574
MOD_ProDKin_1	523	529	PF00069	0.663
MOD_ProDKin_1	538	544	PF00069	0.626
MOD_ProDKin_1	558	564	PF00069	0.793
MOD_ProDKin_1	59	65	PF00069	0.600
MOD_ProDKin_1	594	600	PF00069	0.503
MOD_ProDKin_1	644	650	PF00069	0.574
MOD_ProDKin_1	683	689	PF00069	0.776
MOD_ProDKin_1	701	707	PF00069	0.663
MOD_ProDKin_1	712	718	PF00069	0.612
MOD_ProDKin_1	723	729	PF00069	0.652
MOD_ProDKin_1	774	780	PF00069	0.576
MOD_ProDKin_1	785	791	PF00069	0.682
MOD_ProDKin_1	796	802	PF00069	0.672
MOD_ProDKin_1	830	836	PF00069	0.656
MOD_ProDKin_1	850	856	PF00069	0.527
MOD_ProDKin_1	873	879	PF00069	0.692
MOD_ProDKin_1	898	904	PF00069	0.706
MOD_SUMO_rev_2	628	637	PF00179	0.634
TRG_AP2beta_CARGO_1	336	346	PF09066	0.425
TRG_DiLeu_BaEn_1	199	204	PF01217	0.639
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.632
TRG_ENDOCYTIC_2	200	203	PF00928	0.619
TRG_ENDOCYTIC_2	592	595	PF00928	0.546
TRG_ER_diArg_1	119	122	PF00400	0.653
TRG_ER_diArg_1	408	410	PF00400	0.616
TRG_ER_diArg_1	810	812	PF00400	0.732
TRG_ER_diArg_1	906	909	PF00400	0.715
TRG_NES_CRM1_1	360	374	PF08389	0.632
TRG_NLS_Bipartite_1	303	319	PF00514	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2K7	Leishmania donovani	85%	100%
A4HHU3	Leishmania braziliensis	68%	99%
A4I4J5	Leishmania infantum	85%	100%
E9ADZ4	Leishmania major	84%	100%