Protein KRI1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALT4_LEIMU

TriTrypDb:

LmxM.08_29.1380

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ALT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0022613	ribonucleoprotein complex biogenesis	4	7
GO:0042274	ribosomal small subunit biogenesis	5	7
GO:0044085	cellular component biogenesis	3	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.612
CLV_C14_Caspase3-7	20	24	PF00656	0.562
CLV_NRD_NRD_1	256	258	PF00675	0.528
CLV_NRD_NRD_1	263	265	PF00675	0.596
CLV_NRD_NRD_1	406	408	PF00675	0.508
CLV_NRD_NRD_1	41	43	PF00675	0.583
CLV_NRD_NRD_1	491	493	PF00675	0.640
CLV_NRD_NRD_1	497	499	PF00675	0.670
CLV_NRD_NRD_1	601	603	PF00675	0.667
CLV_NRD_NRD_1	613	615	PF00675	0.386
CLV_NRD_NRD_1	624	626	PF00675	0.504
CLV_NRD_NRD_1	644	646	PF00675	0.612
CLV_NRD_NRD_1	653	655	PF00675	0.515
CLV_NRD_NRD_1	7	9	PF00675	0.363
CLV_NRD_NRD_1	77	79	PF00675	0.502
CLV_PCSK_FUR_1	261	265	PF00082	0.710
CLV_PCSK_FUR_1	622	626	PF00082	0.625
CLV_PCSK_FUR_1	74	78	PF00082	0.495
CLV_PCSK_KEX2_1	255	257	PF00082	0.524
CLV_PCSK_KEX2_1	261	263	PF00082	0.592
CLV_PCSK_KEX2_1	406	408	PF00082	0.519
CLV_PCSK_KEX2_1	41	43	PF00082	0.583
CLV_PCSK_KEX2_1	491	493	PF00082	0.646
CLV_PCSK_KEX2_1	497	499	PF00082	0.614
CLV_PCSK_KEX2_1	601	603	PF00082	0.667
CLV_PCSK_KEX2_1	613	615	PF00082	0.386
CLV_PCSK_KEX2_1	624	626	PF00082	0.504
CLV_PCSK_KEX2_1	644	646	PF00082	0.494
CLV_PCSK_KEX2_1	653	655	PF00082	0.515
CLV_PCSK_KEX2_1	74	76	PF00082	0.413
CLV_PCSK_KEX2_1	77	79	PF00082	0.504
CLV_PCSK_PC7_1	257	263	PF00082	0.561
CLV_PCSK_SKI1_1	10	14	PF00082	0.473
CLV_PCSK_SKI1_1	241	245	PF00082	0.503
CLV_PCSK_SKI1_1	299	303	PF00082	0.474
CLV_PCSK_SKI1_1	332	336	PF00082	0.610
CLV_PCSK_SKI1_1	412	416	PF00082	0.381
CLV_PCSK_SKI1_1	497	501	PF00082	0.801
CLV_PCSK_SKI1_1	625	629	PF00082	0.496
CLV_PCSK_SKI1_1	645	649	PF00082	0.489
CLV_Separin_Metazoa	303	307	PF03568	0.450
DEG_SPOP_SBC_1	545	549	PF00917	0.656
DOC_CYCLIN_RxL_1	204	215	PF00134	0.600
DOC_MAPK_gen_1	406	413	PF00069	0.550
DOC_MAPK_gen_1	564	572	PF00069	0.699
DOC_PP1_RVXF_1	205	212	PF00149	0.504
DOC_PP1_RVXF_1	652	659	PF00149	0.535
DOC_USP7_MATH_1	156	160	PF00917	0.650
DOC_USP7_MATH_1	373	377	PF00917	0.568
DOC_USP7_MATH_1	430	434	PF00917	0.659
DOC_USP7_MATH_1	490	494	PF00917	0.615
DOC_USP7_MATH_1	544	548	PF00917	0.732
DOC_USP7_UBL2_3	128	132	PF12436	0.523
DOC_USP7_UBL2_3	248	252	PF12436	0.444
DOC_USP7_UBL2_3	5	9	PF12436	0.487
DOC_USP7_UBL2_3	564	568	PF12436	0.680
DOC_USP7_UBL2_3	603	607	PF12436	0.508
DOC_USP7_UBL2_3	628	632	PF12436	0.493
DOC_WW_Pin1_4	583	588	PF00397	0.544
LIG_14-3-3_CanoR_1	299	308	PF00244	0.479
LIG_14-3-3_CanoR_1	491	499	PF00244	0.748
LIG_14-3-3_CanoR_1	625	635	PF00244	0.493
LIG_14-3-3_CanoR_1	653	657	PF00244	0.540
LIG_BIR_III_4	23	27	PF00653	0.687
LIG_BIR_III_4	377	381	PF00653	0.690
LIG_BIR_III_4	96	100	PF00653	0.563
LIG_Clathr_ClatBox_1	456	460	PF01394	0.737
LIG_deltaCOP1_diTrp_1	117	127	PF00928	0.634
LIG_FHA_1	11	17	PF00498	0.469
LIG_FHA_1	153	159	PF00498	0.543
LIG_FHA_1	382	388	PF00498	0.563
LIG_FHA_1	400	406	PF00498	0.479
LIG_FHA_1	494	500	PF00498	0.606
LIG_FHA_1	530	536	PF00498	0.714
LIG_FHA_1	567	573	PF00498	0.590
LIG_FHA_2	242	248	PF00498	0.486
LIG_FHA_2	333	339	PF00498	0.651
LIG_FHA_2	446	452	PF00498	0.698
LIG_FHA_2	510	516	PF00498	0.768
LIG_FHA_2	583	589	PF00498	0.516
LIG_FHA_2	604	610	PF00498	0.500
LIG_FHA_2	632	638	PF00498	0.606
LIG_LIR_Apic_2	478	484	PF02991	0.570
LIG_LIR_Gen_1	298	308	PF02991	0.501
LIG_LIR_Nem_3	111	116	PF02991	0.496
LIG_LIR_Nem_3	13	17	PF02991	0.451
LIG_LIR_Nem_3	226	232	PF02991	0.632
LIG_LIR_Nem_3	237	243	PF02991	0.518
LIG_LIR_Nem_3	634	638	PF02991	0.507
LIG_Pex14_2	394	398	PF04695	0.500
LIG_REV1ctd_RIR_1	37	46	PF16727	0.394
LIG_RPA_C_Fungi	252	264	PF08784	0.649
LIG_SH2_CRK	14	18	PF00017	0.457
LIG_SH2_CRK	481	485	PF00017	0.592
LIG_SH2_GRB2like	480	483	PF00017	0.579
LIG_SH2_GRB2like	90	93	PF00017	0.498
LIG_SH2_NCK_1	481	485	PF00017	0.592
LIG_SH2_NCK_1	62	66	PF00017	0.483
LIG_SH2_SRC	90	93	PF00017	0.673
LIG_SH2_STAP1	62	66	PF00017	0.483
LIG_SH2_STAT3	480	483	PF00017	0.598
LIG_SH2_STAT5	105	108	PF00017	0.595
LIG_SH2_STAT5	318	321	PF00017	0.572
LIG_SH2_STAT5	333	336	PF00017	0.485
LIG_SH2_STAT5	366	369	PF00017	0.509
LIG_SH3_3	130	136	PF00018	0.733
LIG_SH3_3	262	268	PF00018	0.480
LIG_SH3_3	426	432	PF00018	0.532
LIG_SH3_3	435	441	PF00018	0.586
LIG_SH3_3	569	575	PF00018	0.733
LIG_SH3_4	6	13	PF00018	0.485
LIG_SUMO_SIM_anti_2	451	460	PF11976	0.731
LIG_TRAF2_1	183	186	PF00917	0.654
LIG_TRAF2_1	336	339	PF00917	0.493
LIG_TRAF2_1	449	452	PF00917	0.636
LIG_TRAF2_1	606	609	PF00917	0.509
LIG_TRFH_1	14	18	PF08558	0.457
LIG_TYR_ITIM	12	17	PF00017	0.452
LIG_UBA3_1	360	365	PF00899	0.526
LIG_UBA3_1	456	464	PF00899	0.601
MOD_CDK_SPxK_1	583	589	PF00069	0.516
MOD_CK1_1	475	481	PF00069	0.542
MOD_CK1_1	493	499	PF00069	0.520
MOD_CK1_1	548	554	PF00069	0.702
MOD_CK1_1	557	563	PF00069	0.672
MOD_CK1_1	646	652	PF00069	0.506
MOD_CK2_1	241	247	PF00069	0.496
MOD_CK2_1	32	38	PF00069	0.458
MOD_CK2_1	332	338	PF00069	0.642
MOD_CK2_1	445	451	PF00069	0.636
MOD_CK2_1	504	510	PF00069	0.700
MOD_CK2_1	582	588	PF00069	0.681
MOD_CK2_1	603	609	PF00069	0.508
MOD_CK2_1	631	637	PF00069	0.607
MOD_GlcNHglycan	150	153	PF01048	0.646
MOD_GlcNHglycan	212	215	PF01048	0.707
MOD_GlcNHglycan	44	47	PF01048	0.697
MOD_GlcNHglycan	474	477	PF01048	0.525
MOD_GlcNHglycan	492	495	PF01048	0.690
MOD_GlcNHglycan	506	509	PF01048	0.557
MOD_GlcNHglycan	525	528	PF01048	0.587
MOD_GlcNHglycan	540	543	PF01048	0.664
MOD_GlcNHglycan	548	551	PF01048	0.666
MOD_GlcNHglycan	561	564	PF01048	0.560
MOD_GlcNHglycan	628	631	PF01048	0.500
MOD_GlcNHglycan	645	648	PF01048	0.495
MOD_GSK3_1	148	155	PF00069	0.575
MOD_GSK3_1	282	289	PF00069	0.543
MOD_GSK3_1	418	425	PF00069	0.488
MOD_GSK3_1	472	479	PF00069	0.525
MOD_GSK3_1	523	530	PF00069	0.640
MOD_GSK3_1	544	551	PF00069	0.617
MOD_GSK3_1	554	561	PF00069	0.633
MOD_N-GLC_1	518	523	PF02516	0.621
MOD_NEK2_1	157	162	PF00069	0.678
MOD_NEK2_1	276	281	PF00069	0.716
MOD_NEK2_1	340	345	PF00069	0.669
MOD_NEK2_1	631	636	PF00069	0.607
MOD_NEK2_1	643	648	PF00069	0.613
MOD_NEK2_2	596	601	PF00069	0.436
MOD_NEK2_2	652	657	PF00069	0.517
MOD_PIKK_1	290	296	PF00454	0.628
MOD_PIKK_1	646	652	PF00454	0.606
MOD_PKA_1	256	262	PF00069	0.550
MOD_PKA_1	564	570	PF00069	0.585
MOD_PKA_2	256	262	PF00069	0.550
MOD_PKA_2	415	421	PF00069	0.383
MOD_PKA_2	490	496	PF00069	0.624
MOD_PKA_2	643	649	PF00069	0.611
MOD_PKA_2	652	658	PF00069	0.524
MOD_PKB_1	410	418	PF00069	0.380
MOD_Plk_2-3	223	229	PF00069	0.517
MOD_Plk_2-3	316	322	PF00069	0.566
MOD_Plk_2-3	637	643	PF00069	0.606
MOD_Plk_4	382	388	PF00069	0.583
MOD_Plk_4	476	482	PF00069	0.553
MOD_Plk_4	530	536	PF00069	0.749
MOD_ProDKin_1	583	589	PF00069	0.544
MOD_SUMO_rev_2	124	133	PF00179	0.752
MOD_SUMO_rev_2	185	193	PF00179	0.602
MOD_SUMO_rev_2	245	250	PF00179	0.453
MOD_SUMO_rev_2	454	463	PF00179	0.610
MOD_SUMO_rev_2	604	612	PF00179	0.507
TRG_DiLeu_BaEn_1	238	243	PF01217	0.504
TRG_DiLeu_BaEn_1	452	457	PF01217	0.742
TRG_DiLeu_BaEn_3	452	458	PF01217	0.612
TRG_DiLeu_LyEn_5	238	243	PF01217	0.504
TRG_ENDOCYTIC_2	14	17	PF00928	0.446
TRG_ENDOCYTIC_2	635	638	PF00928	0.487
TRG_ER_diArg_1	255	257	PF00400	0.524
TRG_ER_diArg_1	261	264	PF00400	0.602
TRG_ER_diArg_1	40	42	PF00400	0.558
TRG_ER_diArg_1	405	407	PF00400	0.527
TRG_ER_diArg_1	410	413	PF00400	0.489
TRG_ER_diArg_1	490	492	PF00400	0.742
TRG_ER_diArg_1	497	499	PF00400	0.663
TRG_ER_diArg_1	600	602	PF00400	0.668
TRG_ER_diArg_1	612	614	PF00400	0.385
TRG_ER_diArg_1	643	645	PF00400	0.621
TRG_ER_diArg_1	74	77	PF00400	0.498
TRG_NLS_MonoCore_2	4	9	PF00514	0.486
TRG_NLS_MonoExtC_3	4	9	PF00514	0.366
TRG_NLS_MonoExtN_4	2	9	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D0	Leptomonas seymouri	58%	93%
A0A3Q8IHA2	Leishmania donovani	84%	100%
A4HHE8	Leishmania braziliensis	67%	94%
A4I4J8	Leishmania infantum	84%	100%
E9ADZ7	Leishmania major	86%	100%