Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALT3_LEIMU

TriTrypDb:

LmxM.08_29.1390

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ALT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.512
CLV_NRD_NRD_1	197	199	PF00675	0.440
CLV_NRD_NRD_1	246	248	PF00675	0.670
CLV_NRD_NRD_1	324	326	PF00675	0.668
CLV_NRD_NRD_1	443	445	PF00675	0.705
CLV_NRD_NRD_1	491	493	PF00675	0.650
CLV_NRD_NRD_1	582	584	PF00675	0.652
CLV_NRD_NRD_1	659	661	PF00675	0.688
CLV_PCSK_FUR_1	244	248	PF00082	0.667
CLV_PCSK_KEX2_1	246	248	PF00082	0.670
CLV_PCSK_KEX2_1	324	326	PF00082	0.668
CLV_PCSK_KEX2_1	443	445	PF00082	0.705
CLV_PCSK_KEX2_1	491	493	PF00082	0.650
CLV_PCSK_KEX2_1	582	584	PF00082	0.734
CLV_PCSK_KEX2_1	659	661	PF00082	0.688
CLV_PCSK_SKI1_1	129	133	PF00082	0.346
CLV_PCSK_SKI1_1	151	155	PF00082	0.346
CLV_PCSK_SKI1_1	157	161	PF00082	0.414
CLV_PCSK_SKI1_1	198	202	PF00082	0.487
CLV_PCSK_SKI1_1	246	250	PF00082	0.673
CLV_PCSK_SKI1_1	99	103	PF00082	0.405
DEG_SCF_FBW7_1	422	428	PF00400	0.614
DEG_SPOP_SBC_1	164	168	PF00917	0.403
DEG_SPOP_SBC_1	514	518	PF00917	0.638
DEG_SPOP_SBC_1	620	624	PF00917	0.657
DOC_CKS1_1	422	427	PF01111	0.675
DOC_CKS1_1	464	469	PF01111	0.672
DOC_CKS1_1	570	575	PF01111	0.666
DOC_CYCLIN_yCln2_LP_2	524	530	PF00134	0.493
DOC_MAPK_DCC_7	491	501	PF00069	0.698
DOC_MAPK_gen_1	155	164	PF00069	0.602
DOC_MAPK_MEF2A_6	492	501	PF00069	0.563
DOC_PP2B_LxvP_1	162	165	PF13499	0.357
DOC_PP4_FxxP_1	437	440	PF00568	0.659
DOC_PP4_FxxP_1	77	80	PF00568	0.335
DOC_PP4_MxPP_1	397	400	PF00568	0.555
DOC_USP7_MATH_1	124	128	PF00917	0.512
DOC_USP7_MATH_1	165	169	PF00917	0.398
DOC_USP7_MATH_1	2	6	PF00917	0.474
DOC_USP7_MATH_1	24	28	PF00917	0.679
DOC_USP7_MATH_1	262	266	PF00917	0.730
DOC_USP7_MATH_1	301	305	PF00917	0.522
DOC_USP7_MATH_1	351	355	PF00917	0.637
DOC_USP7_MATH_1	425	429	PF00917	0.592
DOC_USP7_MATH_1	442	446	PF00917	0.542
DOC_USP7_MATH_1	503	507	PF00917	0.708
DOC_USP7_MATH_1	535	539	PF00917	0.539
DOC_USP7_MATH_1	620	624	PF00917	0.688
DOC_USP7_MATH_1	751	755	PF00917	0.530
DOC_USP7_MATH_1	771	775	PF00917	0.600
DOC_USP7_MATH_1	94	98	PF00917	0.526
DOC_WW_Pin1_4	167	172	PF00397	0.558
DOC_WW_Pin1_4	20	25	PF00397	0.677
DOC_WW_Pin1_4	238	243	PF00397	0.670
DOC_WW_Pin1_4	297	302	PF00397	0.522
DOC_WW_Pin1_4	359	364	PF00397	0.680
DOC_WW_Pin1_4	412	417	PF00397	0.677
DOC_WW_Pin1_4	421	426	PF00397	0.724
DOC_WW_Pin1_4	451	456	PF00397	0.764
DOC_WW_Pin1_4	463	468	PF00397	0.614
DOC_WW_Pin1_4	475	480	PF00397	0.558
DOC_WW_Pin1_4	531	536	PF00397	0.616
DOC_WW_Pin1_4	539	544	PF00397	0.776
DOC_WW_Pin1_4	549	554	PF00397	0.614
DOC_WW_Pin1_4	569	574	PF00397	0.636
DOC_WW_Pin1_4	724	729	PF00397	0.628
DOC_WW_Pin1_4	743	748	PF00397	0.558
DOC_WW_Pin1_4	772	777	PF00397	0.669
LIG_14-3-3_CanoR_1	163	173	PF00244	0.570
LIG_14-3-3_CanoR_1	215	224	PF00244	0.402
LIG_14-3-3_CanoR_1	372	376	PF00244	0.646
LIG_14-3-3_CanoR_1	443	447	PF00244	0.649
LIG_14-3-3_CanoR_1	765	771	PF00244	0.627
LIG_APCC_ABBA_1	227	232	PF00400	0.518
LIG_BIR_III_2	235	239	PF00653	0.631
LIG_FHA_1	140	146	PF00498	0.546
LIG_FHA_1	33	39	PF00498	0.665
LIG_FHA_1	454	460	PF00498	0.538
LIG_FHA_1	488	494	PF00498	0.656
LIG_FHA_1	502	508	PF00498	0.569
LIG_FHA_1	570	576	PF00498	0.751
LIG_FHA_1	767	773	PF00498	0.626
LIG_FHA_2	107	113	PF00498	0.546
LIG_FHA_2	208	214	PF00498	0.507
LIG_FHA_2	255	261	PF00498	0.688
LIG_FHA_2	267	273	PF00498	0.549
LIG_FHA_2	280	286	PF00498	0.412
LIG_FHA_2	298	304	PF00498	0.344
LIG_FHA_2	604	610	PF00498	0.513
LIG_FHA_2	623	629	PF00498	0.501
LIG_FHA_2	685	691	PF00498	0.479
LIG_IBAR_NPY_1	760	762	PF08397	0.636
LIG_LIR_Apic_2	435	440	PF02991	0.589
LIG_LIR_Apic_2	604	610	PF02991	0.634
LIG_LIR_Gen_1	117	126	PF02991	0.546
LIG_LIR_Gen_1	141	150	PF02991	0.614
LIG_LIR_Gen_1	349	360	PF02991	0.499
LIG_LIR_Gen_1	72	80	PF02991	0.517
LIG_LIR_Nem_3	117	122	PF02991	0.532
LIG_LIR_Nem_3	141	147	PF02991	0.614
LIG_LIR_Nem_3	219	224	PF02991	0.497
LIG_LIR_Nem_3	349	355	PF02991	0.497
LIG_LIR_Nem_3	600	605	PF02991	0.688
LIG_LIR_Nem_3	72	76	PF02991	0.520
LIG_LIR_Nem_3	727	732	PF02991	0.553
LIG_LYPXL_SIV_4	694	702	PF13949	0.621
LIG_Pex14_2	217	221	PF04695	0.494
LIG_Pex14_2	73	77	PF04695	0.328
LIG_PTB_Apo_2	42	49	PF02174	0.558
LIG_PTB_Apo_2	756	763	PF02174	0.669
LIG_PTB_Phospho_1	756	762	PF10480	0.670
LIG_REV1ctd_RIR_1	157	164	PF16727	0.492
LIG_SH2_CRK	352	356	PF00017	0.508
LIG_SH2_CRK	370	374	PF00017	0.652
LIG_SH2_CRK	389	393	PF00017	0.586
LIG_SH2_NCK_1	234	238	PF00017	0.614
LIG_SH2_NCK_1	352	356	PF00017	0.641
LIG_SH2_NCK_1	389	393	PF00017	0.647
LIG_SH2_NCK_1	695	699	PF00017	0.622
LIG_SH2_STAP1	352	356	PF00017	0.669
LIG_SH2_STAP1	670	674	PF00017	0.578
LIG_SH2_STAP1	762	766	PF00017	0.660
LIG_SH2_STAT3	395	398	PF00017	0.564
LIG_SH2_STAT3	418	421	PF00017	0.693
LIG_SH2_STAT3	689	692	PF00017	0.527
LIG_SH2_STAT5	395	398	PF00017	0.555
LIG_SH2_STAT5	409	412	PF00017	0.624
LIG_SH2_STAT5	562	565	PF00017	0.647
LIG_SH2_STAT5	574	577	PF00017	0.657
LIG_SH2_STAT5	605	608	PF00017	0.508
LIG_SH3_1	419	425	PF00018	0.733
LIG_SH3_1	491	497	PF00018	0.643
LIG_SH3_1	607	613	PF00018	0.568
LIG_SH3_3	168	174	PF00018	0.541
LIG_SH3_3	370	376	PF00018	0.588
LIG_SH3_3	396	402	PF00018	0.607
LIG_SH3_3	419	425	PF00018	0.823
LIG_SH3_3	461	467	PF00018	0.666
LIG_SH3_3	490	496	PF00018	0.611
LIG_SH3_3	508	514	PF00018	0.627
LIG_SH3_3	541	547	PF00018	0.716
LIG_SH3_3	607	613	PF00018	0.593
LIG_SH3_3	671	677	PF00018	0.568
LIG_SH3_3	722	728	PF00018	0.679
LIG_SUMO_SIM_par_1	768	775	PF11976	0.625
LIG_TRAF2_1	268	271	PF00917	0.500
LIG_TYR_ITIM	368	373	PF00017	0.649
LIG_WRC_WIRS_1	280	285	PF05994	0.471
LIG_WRC_WIRS_1	536	541	PF05994	0.602
MOD_CDC14_SPxK_1	241	244	PF00782	0.595
MOD_CDK_SPK_2	543	548	PF00069	0.682
MOD_CDK_SPxK_1	238	244	PF00069	0.593
MOD_CDK_SPxK_1	531	537	PF00069	0.640
MOD_CDK_SPxxK_3	412	419	PF00069	0.621
MOD_CDK_SPxxK_3	543	550	PF00069	0.682
MOD_CK1_1	139	145	PF00069	0.546
MOD_CK1_1	166	172	PF00069	0.680
MOD_CK1_1	20	26	PF00069	0.615
MOD_CK1_1	228	234	PF00069	0.527
MOD_CK1_1	254	260	PF00069	0.713
MOD_CK1_1	265	271	PF00069	0.582
MOD_CK1_1	27	33	PF00069	0.667
MOD_CK1_1	350	356	PF00069	0.768
MOD_CK1_1	374	380	PF00069	0.681
MOD_CK1_1	420	426	PF00069	0.754
MOD_CK1_1	428	434	PF00069	0.692
MOD_CK1_1	454	460	PF00069	0.711
MOD_CK1_1	46	52	PF00069	0.486
MOD_CK1_1	471	477	PF00069	0.533
MOD_CK1_1	487	493	PF00069	0.681
MOD_CK1_1	506	512	PF00069	0.534
MOD_CK1_1	54	60	PF00069	0.592
MOD_CK1_1	552	558	PF00069	0.768
MOD_CK1_1	622	628	PF00069	0.693
MOD_CK1_1	684	690	PF00069	0.482
MOD_CK1_1	742	748	PF00069	0.617
MOD_CK2_1	249	255	PF00069	0.712
MOD_CK2_1	264	270	PF00069	0.607
MOD_CK2_1	279	285	PF00069	0.367
MOD_CK2_1	44	50	PF00069	0.633
MOD_CK2_1	535	541	PF00069	0.595
MOD_CK2_1	622	628	PF00069	0.523
MOD_CK2_1	78	84	PF00069	0.514
MOD_Cter_Amidation	244	247	PF01082	0.667
MOD_GlcNHglycan	126	129	PF01048	0.346
MOD_GlcNHglycan	19	22	PF01048	0.570
MOD_GlcNHglycan	29	32	PF01048	0.651
MOD_GlcNHglycan	349	352	PF01048	0.686
MOD_GlcNHglycan	405	408	PF01048	0.588
MOD_GlcNHglycan	430	433	PF01048	0.707
MOD_GlcNHglycan	456	459	PF01048	0.652
MOD_GlcNHglycan	486	489	PF01048	0.541
MOD_GlcNHglycan	518	521	PF01048	0.549
MOD_GlcNHglycan	55	59	PF01048	0.636
MOD_GlcNHglycan	554	557	PF01048	0.703
MOD_GlcNHglycan	640	644	PF01048	0.526
MOD_GlcNHglycan	66	69	PF01048	0.417
MOD_GlcNHglycan	722	725	PF01048	0.687
MOD_GlcNHglycan	739	742	PF01048	0.524
MOD_GlcNHglycan	751	754	PF01048	0.592
MOD_GlcNHglycan	9	12	PF01048	0.495
MOD_GSK3_1	163	170	PF00069	0.671
MOD_GSK3_1	20	27	PF00069	0.636
MOD_GSK3_1	216	223	PF00069	0.365
MOD_GSK3_1	250	257	PF00069	0.583
MOD_GSK3_1	262	269	PF00069	0.639
MOD_GSK3_1	297	304	PF00069	0.530
MOD_GSK3_1	346	353	PF00069	0.716
MOD_GSK3_1	355	362	PF00069	0.618
MOD_GSK3_1	405	412	PF00069	0.695
MOD_GSK3_1	417	424	PF00069	0.617
MOD_GSK3_1	428	435	PF00069	0.637
MOD_GSK3_1	468	475	PF00069	0.729
MOD_GSK3_1	497	504	PF00069	0.707
MOD_GSK3_1	512	519	PF00069	0.537
MOD_GSK3_1	531	538	PF00069	0.552
MOD_GSK3_1	539	546	PF00069	0.667
MOD_GSK3_1	561	568	PF00069	0.649
MOD_GSK3_1	619	626	PF00069	0.705
MOD_GSK3_1	700	707	PF00069	0.505
MOD_GSK3_1	720	727	PF00069	0.593
MOD_GSK3_1	737	744	PF00069	0.610
MOD_GSK3_1	745	752	PF00069	0.636
MOD_N-GLC_1	297	302	PF02516	0.522
MOD_N-GLC_1	317	322	PF02516	0.429
MOD_N-GLC_1	44	49	PF02516	0.632
MOD_N-GLC_1	772	777	PF02516	0.488
MOD_N-GLC_2	649	651	PF02516	0.564
MOD_N-GLC_2	7	9	PF02516	0.695
MOD_NEK2_1	405	410	PF00069	0.744
MOD_NEK2_1	43	48	PF00069	0.655
MOD_NEK2_1	473	478	PF00069	0.699
MOD_NEK2_1	53	58	PF00069	0.600
MOD_NEK2_1	563	568	PF00069	0.532
MOD_NEK2_1	704	709	PF00069	0.498
MOD_NEK2_1	766	771	PF00069	0.626
MOD_NEK2_2	225	230	PF00069	0.327
MOD_NEK2_2	351	356	PF00069	0.502
MOD_NEK2_2	535	540	PF00069	0.593
MOD_NEK2_2	665	670	PF00069	0.498
MOD_NEK2_2	751	756	PF00069	0.579
MOD_PIKK_1	175	181	PF00454	0.521
MOD_PIKK_1	207	213	PF00454	0.514
MOD_PIKK_1	216	222	PF00454	0.402
MOD_PIKK_1	374	380	PF00454	0.704
MOD_PIKK_1	417	423	PF00454	0.687
MOD_PIKK_1	426	432	PF00454	0.656
MOD_PIKK_1	554	560	PF00454	0.654
MOD_PIKK_1	715	721	PF00454	0.595
MOD_PIKK_1	739	745	PF00454	0.642
MOD_PKA_2	265	271	PF00069	0.521
MOD_PKA_2	273	279	PF00069	0.331
MOD_PKA_2	371	377	PF00069	0.649
MOD_PKA_2	442	448	PF00069	0.639
MOD_PKB_1	161	169	PF00069	0.554
MOD_Plk_1	225	231	PF00069	0.504
MOD_Plk_1	44	50	PF00069	0.633
MOD_Plk_1	603	609	PF00069	0.658
MOD_Plk_1	639	645	PF00069	0.641
MOD_Plk_4	273	279	PF00069	0.521
MOD_Plk_4	351	357	PF00069	0.501
MOD_Plk_4	405	411	PF00069	0.645
MOD_Plk_4	460	466	PF00069	0.642
MOD_Plk_4	468	474	PF00069	0.614
MOD_Plk_4	665	671	PF00069	0.501
MOD_ProDKin_1	167	173	PF00069	0.551
MOD_ProDKin_1	20	26	PF00069	0.678
MOD_ProDKin_1	238	244	PF00069	0.672
MOD_ProDKin_1	297	303	PF00069	0.531
MOD_ProDKin_1	359	365	PF00069	0.681
MOD_ProDKin_1	412	418	PF00069	0.681
MOD_ProDKin_1	421	427	PF00069	0.724
MOD_ProDKin_1	451	457	PF00069	0.763
MOD_ProDKin_1	463	469	PF00069	0.614
MOD_ProDKin_1	475	481	PF00069	0.556
MOD_ProDKin_1	531	537	PF00069	0.620
MOD_ProDKin_1	539	545	PF00069	0.780
MOD_ProDKin_1	549	555	PF00069	0.613
MOD_ProDKin_1	569	575	PF00069	0.640
MOD_ProDKin_1	724	730	PF00069	0.626
MOD_ProDKin_1	743	749	PF00069	0.561
MOD_ProDKin_1	772	778	PF00069	0.670
TRG_DiLeu_BaEn_3	272	278	PF01217	0.501
TRG_ENDOCYTIC_2	352	355	PF00928	0.503
TRG_ENDOCYTIC_2	370	373	PF00928	0.652
TRG_ENDOCYTIC_2	389	392	PF00928	0.587
TRG_ER_diArg_1	154	157	PF00400	0.546
TRG_ER_diArg_1	160	163	PF00400	0.443
TRG_ER_diArg_1	244	247	PF00400	0.667
TRG_ER_diArg_1	442	444	PF00400	0.688
TRG_ER_diArg_1	491	493	PF00400	0.706
TRG_ER_diArg_1	547	550	PF00400	0.684
TRG_ER_diArg_1	582	584	PF00400	0.652
TRG_ER_diArg_1	659	661	PF00400	0.688
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEF2	Leishmania donovani	86%	100%
A4HHE9	Leishmania braziliensis	63%	99%
A4I4J9	Leishmania infantum	86%	100%
E9ADZ8	Leishmania major	83%	100%