zf-LYAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LYAR-type C2HC zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9ALT2_LEIMU

TriTrypDb:

LmxM.08_29.1400

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9ALT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT2

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0005488	binding	1	9
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.660
CLV_NRD_NRD_1	127	129	PF00675	0.669
CLV_PCSK_KEX2_1	282	284	PF00082	0.515
CLV_PCSK_KEX2_1	286	288	PF00082	0.530
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.515
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.538
CLV_PCSK_SKI1_1	159	163	PF00082	0.662
CLV_PCSK_SKI1_1	211	215	PF00082	0.782
CLV_PCSK_SKI1_1	283	287	PF00082	0.535
DEG_COP1_1	239	247	PF00400	0.549
DOC_MAPK_gen_1	128	137	PF00069	0.708
DOC_MAPK_gen_1	226	233	PF00069	0.578
DOC_MAPK_MEF2A_6	128	137	PF00069	0.756
DOC_PP2B_LxvP_1	231	234	PF13499	0.595
DOC_USP7_MATH_1	113	117	PF00917	0.740
DOC_USP7_MATH_1	133	137	PF00917	0.583
DOC_USP7_MATH_1	201	205	PF00917	0.665
DOC_USP7_MATH_1	299	303	PF00917	0.487
DOC_USP7_UBL2_3	107	111	PF12436	0.539
DOC_USP7_UBL2_3	191	195	PF12436	0.686
DOC_USP7_UBL2_3	274	278	PF12436	0.583
DOC_USP7_UBL2_3	282	286	PF12436	0.497
DOC_USP7_UBL2_3	56	60	PF12436	0.531
DOC_WW_Pin1_4	149	154	PF00397	0.800
DOC_WW_Pin1_4	167	172	PF00397	0.699
DOC_WW_Pin1_4	183	188	PF00397	0.727
DOC_WW_Pin1_4	197	202	PF00397	0.653
DOC_WW_Pin1_4	226	231	PF00397	0.670
LIG_14-3-3_CanoR_1	132	138	PF00244	0.617
LIG_14-3-3_CanoR_1	235	239	PF00244	0.618
LIG_14-3-3_CanoR_1	264	271	PF00244	0.363
LIG_14-3-3_CanoR_1	287	293	PF00244	0.544
LIG_Actin_WH2_2	251	266	PF00022	0.475
LIG_BRCT_BRCA1_1	26	30	PF00533	0.306
LIG_FHA_1	149	155	PF00498	0.651
LIG_FHA_1	271	277	PF00498	0.635
LIG_FHA_1	46	52	PF00498	0.301
LIG_FHA_2	249	255	PF00498	0.562
LIG_FHA_2	29	35	PF00498	0.403
LIG_FHA_2	296	302	PF00498	0.481
LIG_FHA_2	50	56	PF00498	0.322
LIG_LIR_Gen_1	27	38	PF02991	0.312
LIG_LIR_Nem_3	27	33	PF02991	0.312
LIG_SH2_STAP1	284	288	PF00017	0.464
LIG_SH2_STAT5	8	11	PF00017	0.515
LIG_SH3_3	10	16	PF00018	0.417
LIG_SH3_3	150	156	PF00018	0.713
LIG_SH3_3	218	224	PF00018	0.734
LIG_SH3_3	83	89	PF00018	0.657
LIG_SH3_4	15	22	PF00018	0.475
LIG_SH3_4	191	198	PF00018	0.684
LIG_TRAF2_1	251	254	PF00917	0.562
LIG_TRAF2_1	52	55	PF00917	0.430
LIG_UBA3_1	38	45	PF00899	0.316
LIG_WRC_WIRS_1	1	6	PF05994	0.369
LIG_WRC_WIRS_1	244	249	PF05994	0.516
LIG_WW_3	84	88	PF00397	0.579
MOD_CK1_1	136	142	PF00069	0.631
MOD_CK1_1	148	154	PF00069	0.661
MOD_CK1_1	166	172	PF00069	0.575
MOD_CK1_1	236	242	PF00069	0.527
MOD_CK1_1	270	276	PF00069	0.542
MOD_CK1_1	49	55	PF00069	0.322
MOD_CK1_1	96	102	PF00069	0.643
MOD_CK2_1	137	143	PF00069	0.705
MOD_CK2_1	248	254	PF00069	0.527
MOD_CK2_1	295	301	PF00069	0.474
MOD_CK2_1	49	55	PF00069	0.382
MOD_Cter_Amidation	224	227	PF01082	0.643
MOD_GlcNHglycan	108	111	PF01048	0.769
MOD_GlcNHglycan	122	125	PF01048	0.749
MOD_GlcNHglycan	165	168	PF01048	0.689
MOD_GlcNHglycan	301	304	PF01048	0.549
MOD_GlcNHglycan	73	76	PF01048	0.645
MOD_GlcNHglycan	79	82	PF01048	0.670
MOD_GSK3_1	133	140	PF00069	0.631
MOD_GSK3_1	145	152	PF00069	0.809
MOD_GSK3_1	163	170	PF00069	0.651
MOD_GSK3_1	17	24	PF00069	0.385
MOD_GSK3_1	197	204	PF00069	0.672
MOD_GSK3_1	263	270	PF00069	0.574
MOD_GSK3_1	295	302	PF00069	0.441
MOD_GSK3_1	45	52	PF00069	0.322
MOD_GSK3_1	92	99	PF00069	0.661
MOD_N-GLC_1	311	316	PF02516	0.518
MOD_N-GLC_2	23	25	PF02516	0.457
MOD_N-GLC_2	7	9	PF02516	0.447
MOD_NEK2_1	145	150	PF00069	0.615
MOD_OFUCOSY	25	32	PF10250	0.481
MOD_PKA_1	195	201	PF00069	0.782
MOD_PKA_2	234	240	PF00069	0.619
MOD_PKA_2	263	269	PF00069	0.509
MOD_Plk_1	145	151	PF00069	0.614
MOD_Plk_2-3	97	103	PF00069	0.714
MOD_Plk_4	243	249	PF00069	0.521
MOD_ProDKin_1	149	155	PF00069	0.796
MOD_ProDKin_1	167	173	PF00069	0.698
MOD_ProDKin_1	183	189	PF00069	0.730
MOD_ProDKin_1	197	203	PF00069	0.653
MOD_ProDKin_1	226	232	PF00069	0.669
MOD_SUMO_for_1	213	216	PF00179	0.660
MOD_SUMO_rev_2	212	222	PF00179	0.659
TRG_DiLeu_BaEn_3	253	259	PF01217	0.551
TRG_NLS_MonoCore_2	13	18	PF00514	0.410
TRG_NLS_MonoExtN_4	156	163	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGN4	Leptomonas seymouri	54%	100%
A0A3Q8IRD2	Leishmania donovani	86%	100%
A4HHF0	Leishmania braziliensis	70%	99%
A4HHF1	Leishmania braziliensis	66%	99%
A4I4K0	Leishmania infantum	86%	100%
C9ZL83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ADZ9	Leishmania major	88%	100%