Complex I-B17

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Complex I-B17

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALT0_LEIMU

TriTrypDb:

LmxM.08_29.1430

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.466
CLV_NRD_NRD_1	188	190	PF00675	0.445
CLV_NRD_NRD_1	20	22	PF00675	0.719
CLV_NRD_NRD_1	436	438	PF00675	0.686
CLV_NRD_NRD_1	479	481	PF00675	0.566
CLV_NRD_NRD_1	487	489	PF00675	0.529
CLV_PCSK_KEX2_1	105	107	PF00082	0.465
CLV_PCSK_KEX2_1	143	145	PF00082	0.585
CLV_PCSK_KEX2_1	188	190	PF00082	0.475
CLV_PCSK_KEX2_1	20	22	PF00082	0.734
CLV_PCSK_KEX2_1	368	370	PF00082	0.568
CLV_PCSK_KEX2_1	487	489	PF00082	0.563
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.465
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.710
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.568
CLV_PCSK_PC7_1	483	489	PF00082	0.517
CLV_PCSK_SKI1_1	158	162	PF00082	0.627
CLV_PCSK_SKI1_1	21	25	PF00082	0.689
CLV_PCSK_SKI1_1	342	346	PF00082	0.337
CLV_PCSK_SKI1_1	349	353	PF00082	0.419
CLV_PCSK_SKI1_1	488	492	PF00082	0.713
DEG_APCC_DBOX_1	188	196	PF00400	0.448
DEG_APCC_DBOX_1	341	349	PF00400	0.383
DEG_ODPH_VHL_1	352	364	PF01847	0.422
DEG_SCF_FBW7_1	441	446	PF00400	0.546
DEG_SPOP_SBC_1	69	73	PF00917	0.462
DOC_ANK_TNKS_1	232	239	PF00023	0.451
DOC_CKS1_1	149	154	PF01111	0.685
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.529
DOC_MAPK_gen_1	105	111	PF00069	0.522
DOC_MAPK_gen_1	158	166	PF00069	0.647
DOC_MAPK_gen_1	188	196	PF00069	0.546
DOC_MAPK_MEF2A_6	105	113	PF00069	0.435
DOC_MAPK_MEF2A_6	188	196	PF00069	0.517
DOC_MAPK_NFAT4_5	106	114	PF00069	0.457
DOC_MAPK_NFAT4_5	189	197	PF00069	0.517
DOC_PP1_RVXF_1	499	506	PF00149	0.532
DOC_PP2B_LxvP_1	164	167	PF13499	0.549
DOC_PP2B_LxvP_1	45	48	PF13499	0.481
DOC_PP2B_LxvP_1	491	494	PF13499	0.491
DOC_USP7_MATH_1	286	290	PF00917	0.529
DOC_USP7_MATH_1	296	300	PF00917	0.748
DOC_USP7_MATH_1	332	336	PF00917	0.592
DOC_USP7_MATH_1	65	69	PF00917	0.654
DOC_USP7_MATH_1	95	99	PF00917	0.501
DOC_WW_Pin1_4	148	153	PF00397	0.641
DOC_WW_Pin1_4	205	210	PF00397	0.472
DOC_WW_Pin1_4	355	360	PF00397	0.529
DOC_WW_Pin1_4	36	41	PF00397	0.656
DOC_WW_Pin1_4	429	434	PF00397	0.676
DOC_WW_Pin1_4	439	444	PF00397	0.521
DOC_WW_Pin1_4	47	52	PF00397	0.743
DOC_WW_Pin1_4	494	499	PF00397	0.718
DOC_WW_Pin1_4	53	58	PF00397	0.689
LIG_14-3-3_CanoR_1	20	26	PF00244	0.677
LIG_14-3-3_CanoR_1	241	250	PF00244	0.374
LIG_14-3-3_CanoR_1	334	339	PF00244	0.543
LIG_14-3-3_CanoR_1	382	390	PF00244	0.420
LIG_14-3-3_CanoR_1	392	400	PF00244	0.372
LIG_14-3-3_CanoR_1	43	48	PF00244	0.630
LIG_14-3-3_CanoR_1	66	70	PF00244	0.778
LIG_Actin_WH2_2	333	351	PF00022	0.494
LIG_AP2alpha_1	176	180	PF02296	0.447
LIG_APCC_ABBA_1	173	178	PF00400	0.598
LIG_APCC_ABBA_1	221	226	PF00400	0.432
LIG_APCC_ABBA_1	473	478	PF00400	0.474
LIG_BIR_III_4	301	305	PF00653	0.603
LIG_BRCT_BRCA1_1	10	14	PF00533	0.732
LIG_BRCT_BRCA1_1	213	217	PF00533	0.245
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.628
LIG_deltaCOP1_diTrp_1	79	88	PF00928	0.470
LIG_EVH1_2	360	364	PF00568	0.464
LIG_FHA_1	20	26	PF00498	0.728
LIG_FHA_1	206	212	PF00498	0.314
LIG_FHA_1	440	446	PF00498	0.701
LIG_FHA_1	69	75	PF00498	0.710
LIG_FHA_2	304	310	PF00498	0.586
LIG_Integrin_RGD_1	182	184	PF01839	0.456
LIG_LIR_Gen_1	128	137	PF02991	0.608
LIG_LIR_Gen_1	79	86	PF02991	0.467
LIG_LIR_Nem_3	128	134	PF02991	0.635
LIG_LIR_Nem_3	387	393	PF02991	0.473
LIG_LIR_Nem_3	79	85	PF02991	0.469
LIG_MYND_1	209	213	PF01753	0.274
LIG_NRBOX	191	197	PF00104	0.511
LIG_NRP_CendR_1	504	506	PF00754	0.545
LIG_Pex14_2	176	180	PF04695	0.598
LIG_SH2_GRB2like	453	456	PF00017	0.503
LIG_SH2_SRC	165	168	PF00017	0.584
LIG_SH2_SRC	396	399	PF00017	0.322
LIG_SH2_SRC	412	415	PF00017	0.438
LIG_SH2_STAT5	141	144	PF00017	0.682
LIG_SH2_STAT5	165	168	PF00017	0.512
LIG_SH2_STAT5	198	201	PF00017	0.457
LIG_SH2_STAT5	372	375	PF00017	0.472
LIG_SH2_STAT5	396	399	PF00017	0.428
LIG_SH2_STAT5	402	405	PF00017	0.452
LIG_SH2_STAT5	412	415	PF00017	0.484
LIG_SH2_STAT5	453	456	PF00017	0.640
LIG_SH3_1	4	10	PF00018	0.456
LIG_SH3_3	146	152	PF00018	0.686
LIG_SH3_3	163	169	PF00018	0.420
LIG_SH3_3	335	341	PF00018	0.455
LIG_SH3_3	4	10	PF00018	0.499
LIG_SH3_3	45	51	PF00018	0.664
LIG_TRAF2_1	289	292	PF00917	0.675
LIG_UBA3_1	194	200	PF00899	0.367
MOD_CDK_SPK_2	36	41	PF00069	0.463
MOD_CDK_SPK_2	429	434	PF00069	0.659
MOD_CDK_SPK_2	53	58	PF00069	0.599
MOD_CDK_SPxxK_3	36	43	PF00069	0.465
MOD_CDK_SPxxK_3	494	501	PF00069	0.543
MOD_CDK_SPxxK_3	51	58	PF00069	0.599
MOD_CK1_1	139	145	PF00069	0.636
MOD_CK1_1	244	250	PF00069	0.357
MOD_CK1_1	285	291	PF00069	0.512
MOD_CK1_1	29	35	PF00069	0.634
MOD_CK1_1	497	503	PF00069	0.683
MOD_CK1_1	50	56	PF00069	0.709
MOD_CK1_1	68	74	PF00069	0.601
MOD_CK2_1	285	291	PF00069	0.545
MOD_CK2_1	303	309	PF00069	0.746
MOD_CK2_1	77	83	PF00069	0.647
MOD_Cter_Amidation	103	106	PF01082	0.453
MOD_DYRK1A_RPxSP_1	429	433	PF00069	0.656
MOD_GlcNHglycan	213	216	PF01048	0.294
MOD_GlcNHglycan	243	246	PF01048	0.403
MOD_GlcNHglycan	28	31	PF01048	0.682
MOD_GlcNHglycan	284	287	PF01048	0.449
MOD_GlcNHglycan	426	429	PF01048	0.609
MOD_GlcNHglycan	45	48	PF01048	0.663
MOD_GSK3_1	19	26	PF00069	0.778
MOD_GSK3_1	244	251	PF00069	0.420
MOD_GSK3_1	282	289	PF00069	0.553
MOD_GSK3_1	296	303	PF00069	0.715
MOD_GSK3_1	323	330	PF00069	0.536
MOD_GSK3_1	39	46	PF00069	0.634
MOD_GSK3_1	439	446	PF00069	0.766
MOD_GSK3_1	447	454	PF00069	0.685
MOD_GSK3_1	47	54	PF00069	0.621
MOD_GSK3_1	493	500	PF00069	0.493
MOD_GSK3_1	65	72	PF00069	0.544
MOD_GSK3_1	77	84	PF00069	0.575
MOD_LATS_1	414	420	PF00433	0.394
MOD_N-GLC_1	463	468	PF02516	0.685
MOD_NEK2_1	136	141	PF00069	0.605
MOD_NEK2_1	463	468	PF00069	0.663
MOD_PIKK_1	244	250	PF00454	0.375
MOD_PIKK_1	8	14	PF00454	0.465
MOD_PK_1	334	340	PF00069	0.255
MOD_PKA_2	19	25	PF00069	0.710
MOD_PKA_2	391	397	PF00069	0.415
MOD_PKA_2	65	71	PF00069	0.677
MOD_PKB_1	41	49	PF00069	0.621
MOD_Plk_1	308	314	PF00069	0.644
MOD_Plk_1	327	333	PF00069	0.431
MOD_Plk_4	269	275	PF00069	0.475
MOD_Plk_4	77	83	PF00069	0.588
MOD_ProDKin_1	148	154	PF00069	0.638
MOD_ProDKin_1	205	211	PF00069	0.476
MOD_ProDKin_1	355	361	PF00069	0.536
MOD_ProDKin_1	36	42	PF00069	0.655
MOD_ProDKin_1	429	435	PF00069	0.675
MOD_ProDKin_1	439	445	PF00069	0.522
MOD_ProDKin_1	47	53	PF00069	0.745
MOD_ProDKin_1	494	500	PF00069	0.716
TRG_DiLeu_BaEn_1	190	195	PF01217	0.530
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.653
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.493
TRG_ENDOCYTIC_2	177	180	PF00928	0.566
TRG_ER_diArg_1	40	43	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	434	439	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	40%	91%
A0A0N1ILX4	Leptomonas seymouri	25%	100%
A0A1X0NTZ8	Trypanosomatidae	27%	100%
A0A1X0NZT5	Trypanosomatidae	30%	100%
A0A3Q8IAB6	Leishmania donovani	24%	93%
A0A3R7KFA4	Trypanosoma rangeli	31%	100%
A0A3S5IRP3	Trypanosoma rangeli	28%	100%
A0A3S7X2J5	Leishmania donovani	90%	94%
A4H889	Leishmania braziliensis	25%	100%
A4HHF5	Leishmania braziliensis	80%	100%
A4HWL2	Leishmania infantum	24%	93%
A4I4K3	Leishmania infantum	90%	94%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AE02	Leishmania major	90%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QF55	Leishmania major	25%	100%
V5B4N1	Trypanosoma cruzi	29%	100%
V5D9T1	Trypanosoma cruzi	30%	100%