AP complex subunit sigma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sigma adaptin, putative

Species:

Leishmania mexicana

UniProt:

E9ALS9_LEIMU

TriTrypDb:

LmxM.08_29.1440

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	8
GO:0030121	AP-1 adaptor complex	5	8
GO:0030131	clathrin adaptor complex	4	8
GO:0032991	protein-containing complex	1	8
GO:0098796	membrane protein complex	2	8
GO:0016020	membrane	2	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ALS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALS9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0016192	vesicle-mediated transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0030276	clathrin binding	3	8
GO:0030674	protein-macromolecule adaptor activity	2	8
GO:0035615	clathrin adaptor activity	4	8
GO:0060090	molecular adaptor activity	1	8
GO:0140312	cargo adaptor activity	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.381
CLV_NRD_NRD_1	47	49	PF00675	0.342
CLV_NRD_NRD_1	53	55	PF00675	0.309
CLV_PCSK_KEX2_1	121	123	PF00082	0.351
CLV_PCSK_KEX2_1	53	55	PF00082	0.313
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.381
CLV_PCSK_SKI1_1	121	125	PF00082	0.303
DEG_APCC_DBOX_1	121	129	PF00400	0.351
DOC_MAPK_gen_1	53	60	PF00069	0.328
DOC_MAPK_gen_1	8	16	PF00069	0.339
DOC_USP7_MATH_1	135	139	PF00917	0.465
DOC_USP7_UBL2_3	19	23	PF12436	0.328
LIG_14-3-3_CanoR_1	122	126	PF00244	0.409
LIG_14-3-3_CanoR_1	53	59	PF00244	0.285
LIG_BIR_II_1	1	5	PF00653	0.161
LIG_BRCT_BRCA1_1	39	43	PF00533	0.340
LIG_BRCT_BRCA1_1	56	60	PF00533	0.145
LIG_Clathr_ClatBox_1	71	75	PF01394	0.328
LIG_FHA_1	150	156	PF00498	0.579
LIG_FHA_1	20	26	PF00498	0.341
LIG_FHA_1	71	77	PF00498	0.374
LIG_FHA_2	65	71	PF00498	0.420
LIG_LIR_Gen_1	10	20	PF02991	0.453
LIG_LIR_Nem_3	10	16	PF02991	0.453
LIG_LIR_Nem_3	85	91	PF02991	0.308
LIG_MLH1_MIPbox_1	56	60	PF16413	0.308
LIG_SH2_CRK	55	59	PF00017	0.307
LIG_SH2_PTP2	13	16	PF00017	0.381
LIG_SH2_STAP1	55	59	PF00017	0.308
LIG_SH2_STAT5	104	107	PF00017	0.309
LIG_SH2_STAT5	127	130	PF00017	0.308
LIG_SH2_STAT5	13	16	PF00017	0.308
LIG_SH2_STAT5	50	53	PF00017	0.325
LIG_SH2_STAT5	59	62	PF00017	0.283
LIG_SH2_STAT5	79	82	PF00017	0.299
LIG_SH2_STAT5	87	90	PF00017	0.288
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.308
LIG_UBA3_1	42	49	PF00899	0.356
MOD_CK2_1	14	20	PF00069	0.328
MOD_CK2_1	64	70	PF00069	0.420
MOD_Cter_Amidation	46	49	PF01082	0.420
MOD_GlcNHglycan	35	38	PF01048	0.362
MOD_GSK3_1	33	40	PF00069	0.300
MOD_N-GLC_2	90	92	PF02516	0.308
MOD_NEK2_1	116	121	PF00069	0.308
MOD_NEK2_1	142	147	PF00069	0.582
MOD_NEK2_1	33	38	PF00069	0.335
MOD_PIKK_1	14	20	PF00454	0.403
MOD_PIKK_1	26	32	PF00454	0.315
MOD_PKA_1	121	127	PF00069	0.407
MOD_PKA_2	121	127	PF00069	0.407
MOD_PKA_2	37	43	PF00069	0.324
MOD_PKA_2	7	13	PF00069	0.453
MOD_Plk_2-3	143	149	PF00069	0.570
MOD_Plk_2-3	70	76	PF00069	0.351
MOD_Plk_4	143	149	PF00069	0.553
MOD_Plk_4	54	60	PF00069	0.281
TRG_DiLeu_BaEn_2	142	148	PF01217	0.546
TRG_ENDOCYTIC_2	104	107	PF00928	0.308
TRG_ENDOCYTIC_2	13	16	PF00928	0.328
TRG_ENDOCYTIC_2	55	58	PF00928	0.307
TRG_ER_diArg_1	53	55	PF00400	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V4	Leptomonas seymouri	34%	95%
A0A0N1I965	Leptomonas seymouri	83%	96%
A0A0N1PDE8	Leptomonas seymouri	34%	98%
A0A0N1PDX0	Leptomonas seymouri	41%	100%
A0A0S4J0F7	Bodo saltans	28%	95%
A0A0S4J161	Bodo saltans	58%	94%
A0A0S4JCD4	Bodo saltans	43%	100%
A0A0S4JQI5	Bodo saltans	42%	100%
A0A1X0NVQ0	Trypanosomatidae	33%	96%
A0A1X0P093	Trypanosomatidae	71%	95%
A0A1X0P9M2	Trypanosomatidae	45%	100%
A0A3Q8IMU4	Leishmania donovani	34%	95%
A0A3Q8INE3	Leishmania donovani	41%	100%
A0A3R7MTZ7	Trypanosoma rangeli	42%	100%
A0A3R7N944	Trypanosoma rangeli	37%	96%
A0A3R7NTN2	Trypanosoma rangeli	30%	84%
A0A3S7X2E9	Leishmania donovani	96%	96%
A0A422N1J3	Trypanosoma rangeli	67%	95%
A4HAU5	Leishmania braziliensis	41%	100%
A4HDI7	Leishmania braziliensis	35%	100%
A4HHF6	Leishmania braziliensis	91%	100%
A4I4K2	Leishmania infantum	96%	96%
A4IA12	Leishmania infantum	41%	100%
B0G185	Dictyostelium discoideum	52%	100%
C9ZL88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
C9ZWF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
D0A005	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
E9AE03	Leishmania major	94%	100%
E9AH61	Leishmania infantum	34%	95%
E9AWZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
E9B519	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
O23685	Arabidopsis thaliana	51%	98%
O50016	Zea mays	50%	100%
O82201	Arabidopsis thaliana	37%	100%
P35181	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P47064	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	81%
P53680	Homo sapiens	50%	100%
P56377	Homo sapiens	55%	100%
P59780	Homo sapiens	37%	82%
P61966	Homo sapiens	50%	100%
P61967	Mus musculus	50%	100%
P62743	Mus musculus	50%	100%
P62744	Rattus norvegicus	50%	100%
Q00381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q09905	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	96%
Q17QC5	Bos taurus	50%	100%
Q1JQ98	Bos taurus	50%	100%
Q1JQA3	Bos taurus	37%	82%
Q2YDH6	Bos taurus	40%	82%
Q3ZBB6	Bos taurus	39%	100%
Q3ZBS3	Bos taurus	56%	99%
Q4ICG5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	51%	100%
Q4Q2W7	Leishmania major	41%	100%
Q4QAH7	Leishmania major	34%	100%
Q4WS49	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	52%	100%
Q54H39	Dictyostelium discoideum	50%	100%
Q54NZ4	Dictyostelium discoideum	36%	100%
Q54WW3	Dictyostelium discoideum	44%	100%
Q553S2	Dictyostelium discoideum	40%	92%
Q59QC5	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	90%
Q5BFF8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	53%	100%
Q5R940	Pongo abelii	50%	100%
Q5RDP9	Pongo abelii	37%	82%
Q75F71	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	85%
Q7SAQ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	52%	100%
Q7TN05	Mus musculus	49%	100%
Q84WL9	Arabidopsis thaliana	50%	100%
Q8BSZ2	Mus musculus	37%	82%
Q8LEZ8	Arabidopsis thaliana	52%	98%
Q8VZ37	Arabidopsis thaliana	33%	95%
Q92572	Homo sapiens	40%	82%
Q96PC3	Homo sapiens	53%	100%
Q9DB50	Mus musculus	56%	99%
Q9DCR2	Mus musculus	40%	82%
Q9P7N2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	98%
Q9WVL1	Mus musculus	38%	100%
Q9Y587	Homo sapiens	38%	100%
Q9Y7L6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
V5DBK5	Trypanosoma cruzi	36%	96%