ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALS6_LEIMU

TriTrypDb:

LmxM.08_29.1470

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.495
CLV_C14_Caspase3-7	331	335	PF00656	0.544
CLV_C14_Caspase3-7	376	380	PF00656	0.584
CLV_C14_Caspase3-7	611	615	PF00656	0.571
CLV_NRD_NRD_1	479	481	PF00675	0.385
CLV_NRD_NRD_1	574	576	PF00675	0.530
CLV_NRD_NRD_1	606	608	PF00675	0.601
CLV_NRD_NRD_1	690	692	PF00675	0.566
CLV_PCSK_KEX2_1	159	161	PF00082	0.415
CLV_PCSK_KEX2_1	479	481	PF00082	0.387
CLV_PCSK_KEX2_1	574	576	PF00082	0.530
CLV_PCSK_KEX2_1	690	692	PF00082	0.566
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.417
CLV_PCSK_SKI1_1	11	15	PF00082	0.481
CLV_PCSK_SKI1_1	169	173	PF00082	0.457
CLV_PCSK_SKI1_1	199	203	PF00082	0.371
CLV_PCSK_SKI1_1	230	234	PF00082	0.392
CLV_PCSK_SKI1_1	357	361	PF00082	0.574
CLV_PCSK_SKI1_1	479	483	PF00082	0.395
CLV_PCSK_SKI1_1	652	656	PF00082	0.407
CLV_Separin_Metazoa	505	509	PF03568	0.525
DOC_ANK_TNKS_1	689	696	PF00023	0.501
DOC_CKS1_1	231	236	PF01111	0.387
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.543
DOC_MAPK_gen_1	635	644	PF00069	0.392
DOC_MAPK_MEF2A_6	230	239	PF00069	0.440
DOC_PP1_RVXF_1	350	356	PF00149	0.555
DOC_PP2B_LxvP_1	221	224	PF13499	0.547
DOC_PP2B_LxvP_1	654	657	PF13499	0.404
DOC_PP2B_LxvP_1	704	707	PF13499	0.437
DOC_USP7_MATH_1	123	127	PF00917	0.750
DOC_USP7_MATH_1	135	139	PF00917	0.669
DOC_USP7_MATH_1	259	263	PF00917	0.582
DOC_USP7_MATH_1	26	30	PF00917	0.652
DOC_USP7_MATH_1	343	347	PF00917	0.526
DOC_USP7_MATH_1	373	377	PF00917	0.423
DOC_USP7_MATH_1	399	403	PF00917	0.524
DOC_USP7_MATH_1	423	427	PF00917	0.441
DOC_USP7_MATH_1	489	493	PF00917	0.513
DOC_USP7_MATH_1	591	595	PF00917	0.438
DOC_USP7_UBL2_3	297	301	PF12436	0.707
DOC_USP7_UBL2_3	400	404	PF12436	0.412
DOC_WW_Pin1_4	153	158	PF00397	0.672
DOC_WW_Pin1_4	230	235	PF00397	0.392
DOC_WW_Pin1_4	36	41	PF00397	0.605
DOC_WW_Pin1_4	683	688	PF00397	0.434
LIG_14-3-3_CanoR_1	117	122	PF00244	0.620
LIG_14-3-3_CanoR_1	337	347	PF00244	0.602
LIG_14-3-3_CanoR_1	574	578	PF00244	0.519
LIG_AP2alpha_1	104	108	PF02296	0.606
LIG_BH_BH3_1	162	178	PF00452	0.539
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_FHA_1	315	321	PF00498	0.660
LIG_FHA_1	387	393	PF00498	0.486
LIG_FHA_1	413	419	PF00498	0.552
LIG_FHA_1	594	600	PF00498	0.376
LIG_FHA_2	190	196	PF00498	0.559
LIG_FHA_2	231	237	PF00498	0.414
LIG_FHA_2	244	250	PF00498	0.484
LIG_FHA_2	331	337	PF00498	0.639
LIG_FHA_2	536	542	PF00498	0.571
LIG_FHA_2	634	640	PF00498	0.253
LIG_FHA_2	661	667	PF00498	0.442
LIG_FHA_2	687	693	PF00498	0.557
LIG_GBD_Chelix_1	433	441	PF00786	0.475
LIG_LIR_Apic_2	354	358	PF02991	0.445
LIG_LIR_Gen_1	105	113	PF02991	0.595
LIG_LIR_Gen_1	164	173	PF02991	0.429
LIG_LIR_Gen_1	249	259	PF02991	0.515
LIG_LIR_Gen_1	491	501	PF02991	0.542
LIG_LIR_Gen_1	531	537	PF02991	0.469
LIG_LIR_Gen_1	623	633	PF02991	0.433
LIG_LIR_Gen_1	678	688	PF02991	0.295
LIG_LIR_LC3C_4	596	600	PF02991	0.377
LIG_LIR_Nem_3	105	111	PF02991	0.694
LIG_LIR_Nem_3	164	168	PF02991	0.446
LIG_LIR_Nem_3	249	255	PF02991	0.524
LIG_LIR_Nem_3	491	497	PF02991	0.512
LIG_LIR_Nem_3	499	503	PF02991	0.468
LIG_LIR_Nem_3	531	535	PF02991	0.418
LIG_LIR_Nem_3	623	629	PF02991	0.410
LIG_LIR_Nem_3	678	684	PF02991	0.353
LIG_PCNA_yPIPBox_3	588	599	PF02747	0.490
LIG_PDZ_Class_2	706	711	PF00595	0.407
LIG_Pex14_2	104	108	PF04695	0.642
LIG_SH2_CRK	252	256	PF00017	0.504
LIG_SH2_PTP2	681	684	PF00017	0.227
LIG_SH2_SRC	486	489	PF00017	0.428
LIG_SH2_SRC	503	506	PF00017	0.458
LIG_SH2_SRC	681	684	PF00017	0.378
LIG_SH2_STAP1	204	208	PF00017	0.518
LIG_SH2_STAP1	252	256	PF00017	0.504
LIG_SH2_STAP1	503	507	PF00017	0.424
LIG_SH2_STAT5	225	228	PF00017	0.447
LIG_SH2_STAT5	486	489	PF00017	0.539
LIG_SH2_STAT5	577	580	PF00017	0.464
LIG_SH2_STAT5	586	589	PF00017	0.362
LIG_SH2_STAT5	681	684	PF00017	0.381
LIG_SH3_3	285	291	PF00018	0.555
LIG_SH3_3	59	65	PF00018	0.770
LIG_SH3_3	681	687	PF00018	0.299
LIG_SH3_3	74	80	PF00018	0.752
LIG_SH3_4	297	304	PF00018	0.702
LIG_SH3_CIN85_PxpxPR_1	63	68	PF14604	0.673
LIG_Sin3_3	509	516	PF02671	0.431
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.448
LIG_SUMO_SIM_par_1	652	658	PF11976	0.423
LIG_UBA3_1	641	647	PF00899	0.437
LIG_WRC_WIRS_1	546	551	PF05994	0.487
MOD_CDK_SPxK_1	153	159	PF00069	0.455
MOD_CDK_SPxxK_3	153	160	PF00069	0.662
MOD_CDK_SPxxK_3	683	690	PF00069	0.500
MOD_CK1_1	138	144	PF00069	0.634
MOD_CK1_1	245	251	PF00069	0.501
MOD_CK1_1	262	268	PF00069	0.342
MOD_CK1_1	314	320	PF00069	0.603
MOD_CK1_1	412	418	PF00069	0.480
MOD_CK1_1	428	434	PF00069	0.462
MOD_CK1_1	556	562	PF00069	0.568
MOD_CK1_1	609	615	PF00069	0.720
MOD_CK1_1	686	692	PF00069	0.564
MOD_CK2_1	122	128	PF00069	0.678
MOD_CK2_1	241	247	PF00069	0.523
MOD_CK2_1	267	273	PF00069	0.630
MOD_CK2_1	278	284	PF00069	0.529
MOD_CK2_1	330	336	PF00069	0.550
MOD_CK2_1	535	541	PF00069	0.444
MOD_CK2_1	686	692	PF00069	0.513
MOD_GlcNHglycan	1	4	PF01048	0.675
MOD_GlcNHglycan	137	140	PF01048	0.728
MOD_GlcNHglycan	209	212	PF01048	0.419
MOD_GlcNHglycan	261	264	PF01048	0.530
MOD_GlcNHglycan	28	31	PF01048	0.593
MOD_GlcNHglycan	327	330	PF01048	0.534
MOD_GlcNHglycan	361	364	PF01048	0.502
MOD_GlcNHglycan	411	414	PF01048	0.474
MOD_GlcNHglycan	460	463	PF01048	0.498
MOD_GlcNHglycan	491	494	PF01048	0.528
MOD_GlcNHglycan	608	611	PF01048	0.718
MOD_GlcNHglycan	649	652	PF01048	0.447
MOD_GlcNHglycan	98	101	PF01048	0.740
MOD_GSK3_1	149	156	PF00069	0.708
MOD_GSK3_1	241	248	PF00069	0.606
MOD_GSK3_1	293	300	PF00069	0.713
MOD_GSK3_1	303	310	PF00069	0.576
MOD_GSK3_1	312	319	PF00069	0.453
MOD_GSK3_1	378	385	PF00069	0.650
MOD_GSK3_1	582	589	PF00069	0.485
MOD_GSK3_1	643	650	PF00069	0.514
MOD_NEK2_1	173	178	PF00069	0.566
MOD_NEK2_1	21	26	PF00069	0.586
MOD_NEK2_1	293	298	PF00069	0.584
MOD_NEK2_1	311	316	PF00069	0.556
MOD_NEK2_1	458	463	PF00069	0.488
MOD_NEK2_1	545	550	PF00069	0.398
MOD_NEK2_1	573	578	PF00069	0.435
MOD_NEK2_1	628	633	PF00069	0.446
MOD_NEK2_1	643	648	PF00069	0.387
MOD_NEK2_2	399	404	PF00069	0.519
MOD_NEK2_2	471	476	PF00069	0.475
MOD_PIKK_1	21	27	PF00454	0.460
MOD_PIKK_1	373	379	PF00454	0.447
MOD_PIKK_1	460	466	PF00454	0.613
MOD_PK_1	117	123	PF00069	0.448
MOD_PKA_1	409	415	PF00069	0.451
MOD_PKA_2	21	27	PF00069	0.369
MOD_PKA_2	278	284	PF00069	0.660
MOD_PKA_2	573	579	PF00069	0.508
MOD_PKA_2	603	609	PF00069	0.501
MOD_Plk_2-3	175	181	PF00069	0.447
MOD_Plk_2-3	536	542	PF00069	0.517
MOD_Plk_4	278	284	PF00069	0.620
MOD_Plk_4	517	523	PF00069	0.496
MOD_Plk_4	545	551	PF00069	0.481
MOD_Plk_4	655	661	PF00069	0.340
MOD_ProDKin_1	153	159	PF00069	0.671
MOD_ProDKin_1	230	236	PF00069	0.391
MOD_ProDKin_1	36	42	PF00069	0.603
MOD_ProDKin_1	683	689	PF00069	0.447
TRG_DiLeu_BaEn_1	107	112	PF01217	0.602
TRG_DiLeu_BaEn_1	541	546	PF01217	0.451
TRG_DiLeu_BaEn_4	92	98	PF01217	0.730
TRG_DiLeu_LyEn_5	107	112	PF01217	0.515
TRG_ENDOCYTIC_2	252	255	PF00928	0.567
TRG_ENDOCYTIC_2	494	497	PF00928	0.418
TRG_ENDOCYTIC_2	503	506	PF00928	0.386
TRG_ENDOCYTIC_2	626	629	PF00928	0.355
TRG_ENDOCYTIC_2	681	684	PF00928	0.237
TRG_ER_diArg_1	19	22	PF00400	0.449
TRG_ER_diArg_1	441	444	PF00400	0.508
TRG_ER_diArg_1	478	480	PF00400	0.379
TRG_ER_diArg_1	573	575	PF00400	0.521
TRG_ER_diArg_1	601	604	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICE2	Leptomonas seymouri	58%	100%
A0A0S4KH65	Bodo saltans	28%	97%
A0A1X0P032	Trypanosomatidae	31%	100%
A0A3Q8IF68	Leishmania donovani	93%	100%
A0A3R7NCZ3	Trypanosoma rangeli	33%	100%
A4HHF9	Leishmania braziliensis	77%	99%
A4I4K9	Leishmania infantum	92%	100%
C9ZL94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AE06	Leishmania major	91%	99%
V5BH81	Trypanosoma cruzi	32%	100%