Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALS5_LEIMU

TriTrypDb:

LmxM.08_29.1480

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ALS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.447
CLV_NRD_NRD_1	301	303	PF00675	0.668
CLV_PCSK_KEX2_1	301	303	PF00082	0.668
CLV_PCSK_SKI1_1	24	28	PF00082	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.622
DEG_SPOP_SBC_1	35	39	PF00917	0.604
DEG_SPOP_SBC_1	9	13	PF00917	0.624
DOC_MAPK_gen_1	203	211	PF00069	0.709
DOC_MAPK_MEF2A_6	122	131	PF00069	0.712
DOC_PP1_RVXF_1	22	28	PF00149	0.552
DOC_PP2B_LxvP_1	141	144	PF13499	0.707
DOC_PP2B_PxIxI_1	126	132	PF00149	0.707
DOC_PP4_FxxP_1	260	263	PF00568	0.531
DOC_USP7_MATH_1	125	129	PF00917	0.642
DOC_USP7_MATH_1	144	148	PF00917	0.778
DOC_USP7_MATH_1	149	153	PF00917	0.730
DOC_USP7_MATH_1	80	84	PF00917	0.649
DOC_USP7_MATH_1	97	101	PF00917	0.687
DOC_USP7_UBL2_3	10	14	PF12436	0.668
DOC_WW_Pin1_4	123	128	PF00397	0.768
DOC_WW_Pin1_4	263	268	PF00397	0.474
DOC_WW_Pin1_4	78	83	PF00397	0.657
LIG_14-3-3_CanoR_1	101	110	PF00244	0.697
LIG_14-3-3_CanoR_1	122	129	PF00244	0.665
LIG_14-3-3_CanoR_1	30	35	PF00244	0.654
LIG_14-3-3_CanoR_1	65	71	PF00244	0.669
LIG_BRCT_BRCA1_1	60	64	PF00533	0.653
LIG_FHA_1	171	177	PF00498	0.677
LIG_FHA_1	97	103	PF00498	0.679
LIG_FHA_2	283	289	PF00498	0.532
LIG_LIR_Apic_2	78	82	PF02991	0.624
LIG_LIR_Nem_3	235	240	PF02991	0.676
LIG_LIR_Nem_3	266	272	PF02991	0.479
LIG_LIR_Nem_3	29	34	PF02991	0.647
LIG_LIR_Nem_3	61	67	PF02991	0.669
LIG_Pex14_1	237	241	PF04695	0.545
LIG_Pex14_2	27	31	PF04695	0.552
LIG_SH2_CRK	2	6	PF00017	0.645
LIG_SH2_CRK	79	83	PF00017	0.617
LIG_SH2_NCK_1	272	276	PF00017	0.386
LIG_SH2_NCK_1	79	83	PF00017	0.593
LIG_SH2_SRC	243	246	PF00017	0.229
LIG_SH2_STAP1	153	157	PF00017	0.601
LIG_SH2_STAT5	269	272	PF00017	0.566
LIG_SH3_1	272	278	PF00018	0.469
LIG_SH3_3	272	278	PF00018	0.477
LIG_SH3_3	47	53	PF00018	0.630
LIG_SH3_3	71	77	PF00018	0.680
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.708
MOD_CK1_1	156	162	PF00069	0.691
MOD_CK1_1	170	176	PF00069	0.662
MOD_CK1_1	280	286	PF00069	0.529
MOD_CK1_1	68	74	PF00069	0.672
MOD_GlcNHglycan	146	149	PF01048	0.533
MOD_GlcNHglycan	153	156	PF01048	0.483
MOD_GlcNHglycan	173	176	PF01048	0.481
MOD_GlcNHglycan	82	85	PF01048	0.461
MOD_GSK3_1	121	128	PF00069	0.814
MOD_GSK3_1	149	156	PF00069	0.727
MOD_GSK3_1	167	174	PF00069	0.661
MOD_GSK3_1	26	33	PF00069	0.633
MOD_GSK3_1	282	289	PF00069	0.560
MOD_GSK3_1	54	61	PF00069	0.668
MOD_GSK3_1	97	104	PF00069	0.801
MOD_N-GLC_1	102	107	PF02516	0.429
MOD_N-GLC_1	280	285	PF02516	0.701
MOD_NEK2_1	102	107	PF00069	0.661
MOD_NEK2_1	286	291	PF00069	0.508
MOD_NEK2_1	34	39	PF00069	0.615
MOD_NEK2_1	54	59	PF00069	0.635
MOD_NEK2_1	66	71	PF00069	0.640
MOD_NEK2_2	59	64	PF00069	0.569
MOD_PIKK_1	156	162	PF00454	0.684
MOD_PK_1	42	48	PF00069	0.643
MOD_PKA_2	121	127	PF00069	0.673
MOD_PKA_2	134	140	PF00069	0.631
MOD_PKA_2	149	155	PF00069	0.713
MOD_PKB_1	111	119	PF00069	0.632
MOD_Plk_4	30	36	PF00069	0.673
MOD_Plk_4	59	65	PF00069	0.626
MOD_ProDKin_1	123	129	PF00069	0.768
MOD_ProDKin_1	263	269	PF00069	0.474
MOD_ProDKin_1	78	84	PF00069	0.656
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.641
TRG_ENDOCYTIC_2	2	5	PF00928	0.646
TRG_ER_diArg_1	301	303	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7L3	Leishmania donovani	75%	100%
A4HHG0	Leishmania braziliensis	59%	81%
A4I4L0	Leishmania infantum	76%	100%
E9AE07	Leishmania major	81%	100%