Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9ALS2_LEIMU

TriTrypDb:

LmxM.08_29.1520

Length:

648

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 107
NetGPI	no	yes: 0, no: 107

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	101
GO:0110165	cellular anatomical entity	1	101
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9ALS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	50
GO:0022857	transmembrane transporter activity	2	50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.566
CLV_NRD_NRD_1	216	218	PF00675	0.253
CLV_NRD_NRD_1	437	439	PF00675	0.656
CLV_NRD_NRD_1	617	619	PF00675	0.354
CLV_PCSK_FUR_1	615	619	PF00082	0.436
CLV_PCSK_KEX2_1	215	217	PF00082	0.247
CLV_PCSK_KEX2_1	316	318	PF00082	0.334
CLV_PCSK_KEX2_1	617	619	PF00082	0.350
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.333
CLV_PCSK_SKI1_1	149	153	PF00082	0.365
CLV_PCSK_SKI1_1	216	220	PF00082	0.342
CLV_PCSK_SKI1_1	316	320	PF00082	0.540
CLV_PCSK_SKI1_1	330	334	PF00082	0.423
CLV_PCSK_SKI1_1	528	532	PF00082	0.282
CLV_PCSK_SKI1_1	564	568	PF00082	0.571
CLV_PCSK_SKI1_1	618	622	PF00082	0.358
DOC_CYCLIN_RxL_1	525	534	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.207
DOC_MAPK_DCC_7	105	113	PF00069	0.184
DOC_MAPK_gen_1	205	214	PF00069	0.459
DOC_MAPK_MEF2A_6	105	113	PF00069	0.314
DOC_MAPK_MEF2A_6	264	273	PF00069	0.299
DOC_PP2B_LxvP_1	496	499	PF13499	0.407
DOC_PP2B_PxIxI_1	474	480	PF00149	0.390
DOC_SPAK_OSR1_1	14	18	PF12202	0.526
DOC_USP7_MATH_1	257	261	PF00917	0.334
DOC_USP7_MATH_1	421	425	PF00917	0.519
DOC_USP7_MATH_1	482	486	PF00917	0.373
DOC_USP7_MATH_1	499	503	PF00917	0.379
DOC_USP7_UBL2_3	293	297	PF12436	0.687
DOC_USP7_UBL2_3	316	320	PF12436	0.648
DOC_USP7_UBL2_3	347	351	PF12436	0.588
DOC_USP7_UBL2_3	435	439	PF12436	0.276
DOC_USP7_UBL2_3	533	537	PF12436	0.491
DOC_WW_Pin1_4	576	581	PF00397	0.440
LIG_14-3-3_CanoR_1	168	176	PF00244	0.357
LIG_14-3-3_CanoR_1	215	224	PF00244	0.486
LIG_14-3-3_CanoR_1	264	270	PF00244	0.341
LIG_14-3-3_CanoR_1	380	390	PF00244	0.676
LIG_14-3-3_CanoR_1	438	444	PF00244	0.395
LIG_14-3-3_CanoR_1	456	460	PF00244	0.288
LIG_AP2alpha_1	510	514	PF02296	0.200
LIG_deltaCOP1_diTrp_1	402	408	PF00928	0.367
LIG_EH1_1	175	183	PF00400	0.440
LIG_FHA_1	108	114	PF00498	0.322
LIG_FHA_1	125	131	PF00498	0.315
LIG_FHA_1	185	191	PF00498	0.381
LIG_FHA_1	266	272	PF00498	0.380
LIG_FHA_1	471	477	PF00498	0.585
LIG_FHA_1	55	61	PF00498	0.345
LIG_FHA_1	602	608	PF00498	0.394
LIG_FHA_1	64	70	PF00498	0.290
LIG_FHA_2	320	326	PF00498	0.693
LIG_FHA_2	46	52	PF00498	0.265
LIG_GBD_Chelix_1	272	280	PF00786	0.346
LIG_LIR_Gen_1	112	120	PF02991	0.358
LIG_LIR_Gen_1	13	22	PF02991	0.496
LIG_LIR_Gen_1	171	182	PF02991	0.299
LIG_LIR_Gen_1	392	403	PF02991	0.516
LIG_LIR_Gen_1	442	451	PF02991	0.332
LIG_LIR_Gen_1	609	619	PF02991	0.351
LIG_LIR_Nem_3	112	117	PF02991	0.314
LIG_LIR_Nem_3	13	18	PF02991	0.509
LIG_LIR_Nem_3	150	154	PF02991	0.357
LIG_LIR_Nem_3	171	177	PF02991	0.269
LIG_LIR_Nem_3	231	237	PF02991	0.521
LIG_LIR_Nem_3	29	34	PF02991	0.340
LIG_LIR_Nem_3	392	398	PF02991	0.530
LIG_LIR_Nem_3	442	447	PF02991	0.354
LIG_LIR_Nem_3	609	614	PF02991	0.328
LIG_LYPXL_yS_3	227	230	PF13949	0.390
LIG_NRBOX	491	497	PF00104	0.393
LIG_NRBOX	90	96	PF00104	0.293
LIG_Pex14_2	233	237	PF04695	0.334
LIG_Pex14_2	510	514	PF04695	0.347
LIG_PTB_Apo_2	160	167	PF02174	0.308
LIG_PTB_Apo_2	430	437	PF02174	0.348
LIG_PTB_Phospho_1	430	436	PF10480	0.395
LIG_REV1ctd_RIR_1	164	173	PF16727	0.286
LIG_SH2_CRK	428	432	PF00017	0.303
LIG_SH2_CRK	444	448	PF00017	0.410
LIG_SH2_NCK_1	256	260	PF00017	0.322
LIG_SH2_NCK_1	96	100	PF00017	0.447
LIG_SH2_SRC	256	259	PF00017	0.370
LIG_SH2_STAP1	444	448	PF00017	0.385
LIG_SH2_STAP1	562	566	PF00017	0.315
LIG_SH2_STAP1	96	100	PF00017	0.422
LIG_SH2_STAT3	223	226	PF00017	0.450
LIG_SH2_STAT3	562	565	PF00017	0.371
LIG_SH2_STAT5	223	226	PF00017	0.465
LIG_SH2_STAT5	234	237	PF00017	0.324
LIG_SH2_STAT5	246	249	PF00017	0.303
LIG_SH2_STAT5	337	340	PF00017	0.524
LIG_SH2_STAT5	543	546	PF00017	0.375
LIG_SH3_1	297	303	PF00018	0.631
LIG_SH3_3	297	303	PF00018	0.601
LIG_SH3_3	395	401	PF00018	0.571
LIG_SH3_3	577	583	PF00018	0.380
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.425
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.374
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.310
LIG_SUMO_SIM_par_1	366	376	PF11976	0.664
LIG_SUMO_SIM_par_1	445	452	PF11976	0.335
LIG_TRAF2_1	322	325	PF00917	0.688
LIG_TYR_ITIM	244	249	PF00017	0.377
LIG_TYR_ITSM	440	447	PF00017	0.351
LIG_UBA3_1	495	503	PF00899	0.407
LIG_WRC_WIRS_1	148	153	PF05994	0.381
LIG_WRC_WIRS_1	249	254	PF05994	0.455
LIG_WRC_WIRS_1	28	33	PF05994	0.447
LIG_WRC_WIRS_1	307	312	PF05994	0.392
LIG_WRC_WIRS_1	511	516	PF05994	0.388
MOD_CK1_1	107	113	PF00069	0.341
MOD_CK1_1	124	130	PF00069	0.354
MOD_CK1_1	449	455	PF00069	0.343
MOD_CK2_1	319	325	PF00069	0.634
MOD_CMANNOS	404	407	PF00535	0.358
MOD_Cter_Amidation	348	351	PF01082	0.496
MOD_GlcNHglycan	178	181	PF01048	0.327
MOD_GlcNHglycan	261	264	PF01048	0.407
MOD_GlcNHglycan	423	426	PF01048	0.399
MOD_GlcNHglycan	444	447	PF01048	0.330
MOD_GlcNHglycan	451	454	PF01048	0.317
MOD_GSK3_1	120	127	PF00069	0.350
MOD_GSK3_1	133	140	PF00069	0.318
MOD_GSK3_1	22	29	PF00069	0.341
MOD_GSK3_1	390	397	PF00069	0.453
MOD_GSK3_1	442	449	PF00069	0.353
MOD_GSK3_1	50	57	PF00069	0.313
MOD_GSK3_1	516	523	PF00069	0.347
MOD_N-GLC_1	162	167	PF02516	0.338
MOD_N-GLC_1	45	50	PF02516	0.383
MOD_N-GLC_1	601	606	PF02516	0.291
MOD_NEK2_1	120	125	PF00069	0.339
MOD_NEK2_1	154	159	PF00069	0.375
MOD_NEK2_1	176	181	PF00069	0.305
MOD_NEK2_1	265	270	PF00069	0.312
MOD_NEK2_1	394	399	PF00069	0.386
MOD_NEK2_1	45	50	PF00069	0.357
MOD_NEK2_1	510	515	PF00069	0.339
MOD_NEK2_2	109	114	PF00069	0.356
MOD_NEK2_2	27	32	PF00069	0.333
MOD_PIKK_1	222	228	PF00454	0.346
MOD_PIKK_1	633	639	PF00454	0.510
MOD_PKA_1	216	222	PF00069	0.423
MOD_PKA_2	167	173	PF00069	0.415
MOD_PKA_2	216	222	PF00069	0.327
MOD_PKA_2	437	443	PF00069	0.550
MOD_PKA_2	455	461	PF00069	0.316
MOD_Plk_1	10	16	PF00069	0.528
MOD_Plk_1	162	168	PF00069	0.365
MOD_Plk_1	50	56	PF00069	0.313
MOD_Plk_1	601	607	PF00069	0.310
MOD_Plk_2-3	306	312	PF00069	0.625
MOD_Plk_4	109	115	PF00069	0.303
MOD_Plk_4	126	132	PF00069	0.325
MOD_Plk_4	154	160	PF00069	0.366
MOD_Plk_4	162	168	PF00069	0.372
MOD_Plk_4	265	271	PF00069	0.351
MOD_Plk_4	27	33	PF00069	0.325
MOD_Plk_4	390	396	PF00069	0.425
MOD_Plk_4	439	445	PF00069	0.316
MOD_Plk_4	607	613	PF00069	0.281
MOD_ProDKin_1	576	582	PF00069	0.556
MOD_SUMO_rev_2	309	318	PF00179	0.601
MOD_SUMO_rev_2	324	332	PF00179	0.505
MOD_SUMO_rev_2	374	379	PF00179	0.590
MOD_SUMO_rev_2	432	440	PF00179	0.308
TRG_DiLeu_BaEn_2	10	16	PF01217	0.462
TRG_ENDOCYTIC_2	164	167	PF00928	0.342
TRG_ENDOCYTIC_2	174	177	PF00928	0.280
TRG_ENDOCYTIC_2	198	201	PF00928	0.370
TRG_ENDOCYTIC_2	227	230	PF00928	0.391
TRG_ENDOCYTIC_2	234	237	PF00928	0.354
TRG_ENDOCYTIC_2	246	249	PF00928	0.303
TRG_ENDOCYTIC_2	428	431	PF00928	0.371
TRG_ENDOCYTIC_2	444	447	PF00928	0.322
TRG_ENDOCYTIC_2	539	542	PF00928	0.321
TRG_ENDOCYTIC_2	616	619	PF00928	0.400
TRG_ER_diArg_1	214	217	PF00400	0.360
TRG_ER_diArg_1	616	618	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	29%	100%
A0A0N1HZC2	Leptomonas seymouri	29%	100%
A0A0N1IKC5	Leptomonas seymouri	31%	100%
A0A0N1PB63	Leptomonas seymouri	26%	98%
A0A0N1PD04	Leptomonas seymouri	25%	100%
A0A0N1PFR4	Leptomonas seymouri	32%	98%
A0A0S4JR45	Bodo saltans	31%	100%
A0A1X0NKK0	Trypanosomatidae	30%	100%
A0A1X0NM09	Trypanosomatidae	29%	100%
A0A1X0NV27	Trypanosomatidae	33%	100%
A0A1X0NVF9	Trypanosomatidae	23%	97%
A0A1X0NVH8	Trypanosomatidae	28%	98%
A0A1X0NVM7	Trypanosomatidae	30%	100%
A0A1X0NWQ1	Trypanosomatidae	33%	100%
A0A1X0NZE6	Trypanosomatidae	29%	100%
A0A1X0NZU2	Trypanosomatidae	33%	100%
A0A1X0NZU5	Trypanosomatidae	54%	100%
A0A1X0NZW1	Trypanosomatidae	31%	100%
A0A1X0P0M7	Trypanosomatidae	28%	100%
A0A381MMW5	Leishmania infantum	93%	99%
A0A3Q8IEC4	Leishmania donovani	93%	100%
A0A3Q8IF95	Leishmania donovani	28%	100%
A0A3Q8IIT5	Leishmania donovani	31%	96%
A0A3Q8ISY9	Leishmania donovani	29%	100%
A0A3R7KKN8	Trypanosoma rangeli	32%	100%
A0A3R7MAQ7	Trypanosoma rangeli	27%	92%
A0A3R7N3S6	Trypanosoma rangeli	25%	100%
A0A3R7N415	Trypanosoma rangeli	31%	100%
A0A3R7N921	Trypanosoma rangeli	30%	100%
A0A3R7R443	Trypanosoma rangeli	30%	100%
A0A3S7WRJ4	Leishmania donovani	29%	100%
A0A3S7WRJ5	Leishmania donovani	33%	93%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WSR4	Leishmania donovani	31%	100%
A0A3S7WWU1	Leishmania donovani	26%	98%
A0A3S7X2G0	Leishmania donovani	93%	99%
A0A3S7X2K5	Leishmania donovani	90%	100%
A0A3S7XB11	Leishmania donovani	30%	100%
A0A422MSE4	Trypanosoma rangeli	35%	100%
A0A422MSP6	Trypanosoma rangeli	48%	100%
A0A422MST9	Trypanosoma rangeli	30%	100%
A0A422MU68	Trypanosoma rangeli	30%	100%
A4H6J0	Leishmania braziliensis	30%	100%
A4H6J1	Leishmania braziliensis	32%	100%
A4H6Q5	Leishmania braziliensis	26%	100%
A4HC19	Leishmania braziliensis	27%	100%
A4HHG2	Leishmania braziliensis	30%	100%
A4HHG3	Leishmania braziliensis	82%	100%
A4HHG4	Leishmania braziliensis	72%	100%
A4HJW3	Leishmania braziliensis	29%	100%
A4HPE2	Leishmania braziliensis	30%	99%
A4HUX5	Leishmania infantum	30%	100%
A4HUX6	Leishmania infantum	33%	93%
A4HV40	Leishmania infantum	24%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	26%	98%
A4I4L2	Leishmania infantum	31%	96%
A4I7C5	Leishmania infantum	28%	100%
A4ICI3	Leishmania infantum	30%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AE01	Leishmania major	92%	100%
E9AE09	Leishmania major	30%	100%
E9AE10	Leishmania major	30%	100%
E9AE11	Leishmania major	85%	100%
E9AGK5	Leishmania infantum	31%	100%
E9AHJ0	Leishmania infantum	94%	100%
E9AHJ1	Leishmania infantum	90%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	96%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q1E4	Leishmania major	29%	98%
Q4Q5T8	Leishmania major	28%	100%
Q4QC27	Leishmania major	26%	100%
Q4QC28	Leishmania major	27%	96%
Q4QFY5	Leishmania major	31%	99%
Q4QGU8	Leishmania major	25%	100%
Q4QH14	Leishmania major	30%	100%
Q4QH15	Leishmania major	30%	100%
V5B647	Trypanosoma cruzi	31%	100%
V5B983	Trypanosoma cruzi	47%	100%
V5BBB1	Trypanosoma cruzi	31%	100%
V5BFV8	Trypanosoma cruzi	32%	97%
V5BQY6	Trypanosoma cruzi	30%	92%
V5BVP0	Trypanosoma cruzi	30%	100%
V5DT25	Trypanosoma cruzi	30%	100%