LeishMANIAdb
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C2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALS1_LEIMU
TriTrypDb:
LmxM.08_29.1530
Length:
708

Annotations

LeishMANIAdb annotations

A tail-anchored beta-barrel protein family, mostly unique to Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9ALS1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALS1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.557
CLV_C14_Caspase3-7 144 148 PF00656 0.541
CLV_C14_Caspase3-7 196 200 PF00656 0.409
CLV_C14_Caspase3-7 491 495 PF00656 0.377
CLV_NRD_NRD_1 150 152 PF00675 0.412
CLV_NRD_NRD_1 203 205 PF00675 0.561
CLV_NRD_NRD_1 282 284 PF00675 0.660
CLV_NRD_NRD_1 358 360 PF00675 0.600
CLV_NRD_NRD_1 438 440 PF00675 0.568
CLV_NRD_NRD_1 506 508 PF00675 0.613
CLV_NRD_NRD_1 57 59 PF00675 0.380
CLV_NRD_NRD_1 706 708 PF00675 0.357
CLV_PCSK_FUR_1 355 359 PF00082 0.655
CLV_PCSK_KEX2_1 150 152 PF00082 0.412
CLV_PCSK_KEX2_1 203 205 PF00082 0.561
CLV_PCSK_KEX2_1 282 284 PF00082 0.660
CLV_PCSK_KEX2_1 357 359 PF00082 0.597
CLV_PCSK_KEX2_1 437 439 PF00082 0.580
CLV_PCSK_KEX2_1 57 59 PF00082 0.392
CLV_PCSK_KEX2_1 706 708 PF00082 0.357
CLV_PCSK_SKI1_1 13 17 PF00082 0.419
CLV_PCSK_SKI1_1 150 154 PF00082 0.396
CLV_PCSK_SKI1_1 411 415 PF00082 0.642
CLV_PCSK_SKI1_1 438 442 PF00082 0.632
DEG_APCC_DBOX_1 149 157 PF00400 0.588
DEG_APCC_DBOX_1 202 210 PF00400 0.392
DEG_SCF_FBW7_1 478 485 PF00400 0.384
DEG_SPOP_SBC_1 322 326 PF00917 0.429
DEG_SPOP_SBC_1 482 486 PF00917 0.479
DEG_SPOP_SBC_1 487 491 PF00917 0.503
DOC_CKS1_1 86 91 PF01111 0.567
DOC_CYCLIN_RxL_1 10 20 PF00134 0.484
DOC_CYCLIN_RxL_1 344 353 PF00134 0.284
DOC_CYCLIN_yClb5_NLxxxL_5 673 682 PF00134 0.322
DOC_CYCLIN_yCln2_LP_2 406 412 PF00134 0.380
DOC_CYCLIN_yCln2_LP_2 659 665 PF00134 0.548
DOC_CYCLIN_yCln2_LP_2 691 697 PF00134 0.335
DOC_MAPK_gen_1 203 214 PF00069 0.319
DOC_MAPK_MEF2A_6 57 66 PF00069 0.563
DOC_MAPK_MEF2A_6 686 695 PF00069 0.312
DOC_MAPK_RevD_3 691 707 PF00069 0.237
DOC_PP1_RVXF_1 436 443 PF00149 0.429
DOC_PP1_RVXF_1 500 506 PF00149 0.338
DOC_PP1_RVXF_1 684 690 PF00149 0.317
DOC_PP2B_LxvP_1 31 34 PF13499 0.580
DOC_PP2B_LxvP_1 406 409 PF13499 0.378
DOC_PP2B_LxvP_1 659 662 PF13499 0.510
DOC_PP2B_LxvP_1 691 694 PF13499 0.449
DOC_PP4_FxxP_1 174 177 PF00568 0.335
DOC_PP4_FxxP_1 59 62 PF00568 0.581
DOC_USP7_MATH_1 177 181 PF00917 0.527
DOC_USP7_MATH_1 293 297 PF00917 0.337
DOC_USP7_MATH_1 322 326 PF00917 0.460
DOC_USP7_MATH_1 393 397 PF00917 0.365
DOC_USP7_MATH_1 463 467 PF00917 0.304
DOC_USP7_MATH_1 482 486 PF00917 0.440
DOC_USP7_MATH_1 488 492 PF00917 0.538
DOC_USP7_MATH_1 517 521 PF00917 0.384
DOC_USP7_MATH_1 534 538 PF00917 0.341
DOC_USP7_MATH_1 602 606 PF00917 0.297
DOC_USP7_MATH_1 681 685 PF00917 0.430
DOC_USP7_MATH_1 87 91 PF00917 0.718
DOC_USP7_UBL2_3 219 223 PF12436 0.331
DOC_WW_Pin1_4 32 37 PF00397 0.485
DOC_WW_Pin1_4 323 328 PF00397 0.398
DOC_WW_Pin1_4 478 483 PF00397 0.328
DOC_WW_Pin1_4 5 10 PF00397 0.631
DOC_WW_Pin1_4 634 639 PF00397 0.553
DOC_WW_Pin1_4 654 659 PF00397 0.574
DOC_WW_Pin1_4 85 90 PF00397 0.701
DOC_WW_Pin1_4 94 99 PF00397 0.688
LIG_14-3-3_CanoR_1 286 294 PF00244 0.435
LIG_14-3-3_CanoR_1 362 371 PF00244 0.497
LIG_14-3-3_CanoR_1 437 443 PF00244 0.433
LIG_14-3-3_CanoR_1 535 541 PF00244 0.416
LIG_14-3-3_CanoR_1 629 639 PF00244 0.492
LIG_14-3-3_CanoR_1 652 658 PF00244 0.533
LIG_14-3-3_CanoR_1 686 690 PF00244 0.171
LIG_14-3-3_CanoR_1 69 74 PF00244 0.603
LIG_Actin_WH2_2 331 348 PF00022 0.342
LIG_Actin_WH2_2 405 420 PF00022 0.378
LIG_Actin_WH2_2 547 564 PF00022 0.339
LIG_Actin_WH2_2 671 688 PF00022 0.399
LIG_APCC_ABBA_1 521 526 PF00400 0.346
LIG_BIR_II_1 1 5 PF00653 0.755
LIG_BIR_III_2 6 10 PF00653 0.548
LIG_BRCT_BRCA1_1 656 660 PF00533 0.535
LIG_deltaCOP1_diTrp_1 111 120 PF00928 0.491
LIG_eIF4E_1 690 696 PF01652 0.171
LIG_FHA_1 164 170 PF00498 0.257
LIG_FHA_1 346 352 PF00498 0.269
LIG_FHA_1 412 418 PF00498 0.379
LIG_FHA_1 482 488 PF00498 0.455
LIG_FHA_1 545 551 PF00498 0.365
LIG_FHA_1 573 579 PF00498 0.296
LIG_FHA_1 634 640 PF00498 0.366
LIG_FHA_1 673 679 PF00498 0.418
LIG_FHA_1 686 692 PF00498 0.310
LIG_FHA_1 698 704 PF00498 0.201
LIG_FHA_2 194 200 PF00498 0.419
LIG_FHA_2 374 380 PF00498 0.529
LIG_FHA_2 398 404 PF00498 0.314
LIG_FHA_2 504 510 PF00498 0.293
LIG_HP1_1 694 698 PF01393 0.292
LIG_LIR_Apic_2 296 300 PF02991 0.316
LIG_LIR_Apic_2 622 628 PF02991 0.424
LIG_LIR_Gen_1 35 45 PF02991 0.537
LIG_LIR_Gen_1 441 450 PF02991 0.420
LIG_LIR_Gen_1 688 698 PF02991 0.171
LIG_LIR_Nem_3 117 123 PF02991 0.591
LIG_LIR_Nem_3 257 263 PF02991 0.381
LIG_LIR_Nem_3 35 41 PF02991 0.532
LIG_LIR_Nem_3 441 445 PF02991 0.416
LIG_LIR_Nem_3 688 693 PF02991 0.239
LIG_LYPXL_yS_3 590 593 PF13949 0.401
LIG_PTAP_UEV_1 88 93 PF05743 0.562
LIG_PTB_Apo_2 466 473 PF02174 0.304
LIG_PTB_Phospho_1 466 472 PF10480 0.307
LIG_SH2_CRK 38 42 PF00017 0.533
LIG_SH2_CRK 464 468 PF00017 0.331
LIG_SH2_CRK 625 629 PF00017 0.462
LIG_SH2_NCK_1 38 42 PF00017 0.589
LIG_SH2_NCK_1 464 468 PF00017 0.307
LIG_SH2_SRC 472 475 PF00017 0.321
LIG_SH2_STAP1 38 42 PF00017 0.564
LIG_SH2_STAP1 532 536 PF00017 0.470
LIG_SH2_STAT3 205 208 PF00017 0.382
LIG_SH2_STAT3 267 270 PF00017 0.442
LIG_SH2_STAT5 205 208 PF00017 0.382
LIG_SH2_STAT5 360 363 PF00017 0.442
LIG_SH2_STAT5 38 41 PF00017 0.468
LIG_SH2_STAT5 472 475 PF00017 0.321
LIG_SH2_STAT5 524 527 PF00017 0.373
LIG_SH2_STAT5 690 693 PF00017 0.344
LIG_SH3_1 625 631 PF00018 0.436
LIG_SH3_3 625 631 PF00018 0.457
LIG_SH3_3 645 651 PF00018 0.578
LIG_SH3_3 655 661 PF00018 0.440
LIG_SH3_3 83 89 PF00018 0.603
LIG_SH3_CIN85_PxpxPR_1 624 629 PF14604 0.423
LIG_SUMO_SIM_anti_2 166 172 PF11976 0.171
LIG_SUMO_SIM_par_1 231 236 PF11976 0.382
LIG_SUMO_SIM_par_1 347 353 PF11976 0.307
LIG_SUMO_SIM_par_1 396 404 PF11976 0.280
LIG_SUMO_SIM_par_1 694 700 PF11976 0.341
LIG_TRAF2_1 370 373 PF00917 0.440
LIG_TRFH_1 690 694 PF08558 0.394
LIG_TYR_ITSM 686 693 PF00017 0.171
LIG_UBA3_1 405 411 PF00899 0.412
LIG_WRC_WIRS_1 99 104 PF05994 0.490
MOD_CDK_SPK_2 323 328 PF00069 0.498
MOD_CDK_SPxxK_3 634 641 PF00069 0.619
MOD_CK1_1 163 169 PF00069 0.204
MOD_CK1_1 182 188 PF00069 0.800
MOD_CK1_1 323 329 PF00069 0.668
MOD_CK1_1 486 492 PF00069 0.606
MOD_CK1_1 582 588 PF00069 0.498
MOD_CK1_1 632 638 PF00069 0.619
MOD_CK1_1 653 659 PF00069 0.675
MOD_CK1_1 72 78 PF00069 0.492
MOD_CK2_1 373 379 PF00069 0.659
MOD_CK2_1 397 403 PF00069 0.485
MOD_Cter_Amidation 55 58 PF01082 0.442
MOD_GlcNHglycan 124 128 PF01048 0.672
MOD_GlcNHglycan 186 190 PF01048 0.620
MOD_GlcNHglycan 275 278 PF01048 0.678
MOD_GlcNHglycan 368 371 PF01048 0.614
MOD_GlcNHglycan 536 539 PF01048 0.617
MOD_GlcNHglycan 610 613 PF01048 0.447
MOD_GlcNHglycan 632 635 PF01048 0.560
MOD_GlcNHglycan 652 655 PF01048 0.580
MOD_GlcNHglycan 666 669 PF01048 0.633
MOD_GlcNHglycan 74 77 PF01048 0.532
MOD_GlcNHglycan 89 92 PF01048 0.714
MOD_GSK3_1 160 167 PF00069 0.390
MOD_GSK3_1 178 185 PF00069 0.487
MOD_GSK3_1 188 195 PF00069 0.687
MOD_GSK3_1 316 323 PF00069 0.613
MOD_GSK3_1 32 39 PF00069 0.462
MOD_GSK3_1 345 352 PF00069 0.342
MOD_GSK3_1 358 365 PF00069 0.515
MOD_GSK3_1 393 400 PF00069 0.464
MOD_GSK3_1 478 485 PF00069 0.453
MOD_GSK3_1 486 493 PF00069 0.641
MOD_GSK3_1 512 519 PF00069 0.475
MOD_GSK3_1 557 564 PF00069 0.481
MOD_GSK3_1 578 585 PF00069 0.505
MOD_GSK3_1 629 636 PF00069 0.590
MOD_GSK3_1 637 644 PF00069 0.608
MOD_GSK3_1 650 657 PF00069 0.649
MOD_GSK3_1 672 679 PF00069 0.506
MOD_GSK3_1 681 688 PF00069 0.419
MOD_GSK3_1 71 78 PF00069 0.428
MOD_GSK3_1 94 101 PF00069 0.463
MOD_N-GLC_1 345 350 PF02516 0.439
MOD_N-GLC_1 468 473 PF02516 0.351
MOD_N-GLC_1 582 587 PF02516 0.672
MOD_N-GLC_1 676 681 PF02516 0.460
MOD_NEK2_1 123 128 PF00069 0.546
MOD_NEK2_1 345 350 PF00069 0.437
MOD_NEK2_1 412 417 PF00069 0.351
MOD_NEK2_1 483 488 PF00069 0.677
MOD_NEK2_1 639 644 PF00069 0.507
MOD_NEK2_1 685 690 PF00069 0.301
MOD_NEK2_1 697 702 PF00069 0.250
MOD_NEK2_2 557 562 PF00069 0.493
MOD_PKA_1 358 364 PF00069 0.551
MOD_PKA_1 438 444 PF00069 0.473
MOD_PKA_2 358 364 PF00069 0.524
MOD_PKA_2 438 444 PF00069 0.538
MOD_PKA_2 534 540 PF00069 0.643
MOD_PKA_2 561 567 PF00069 0.588
MOD_PKA_2 578 584 PF00069 0.373
MOD_PKA_2 685 691 PF00069 0.171
MOD_PKB_1 577 585 PF00069 0.358
MOD_Plk_1 304 310 PF00069 0.434
MOD_Plk_1 345 351 PF00069 0.321
MOD_Plk_1 468 474 PF00069 0.353
MOD_Plk_1 582 588 PF00069 0.494
MOD_Plk_4 116 122 PF00069 0.375
MOD_Plk_4 164 170 PF00069 0.306
MOD_Plk_4 345 351 PF00069 0.434
MOD_Plk_4 394 400 PF00069 0.414
MOD_Plk_4 468 474 PF00069 0.383
MOD_Plk_4 492 498 PF00069 0.400
MOD_Plk_4 685 691 PF00069 0.414
MOD_ProDKin_1 32 38 PF00069 0.338
MOD_ProDKin_1 323 329 PF00069 0.490
MOD_ProDKin_1 478 484 PF00069 0.416
MOD_ProDKin_1 5 11 PF00069 0.542
MOD_ProDKin_1 634 640 PF00069 0.714
MOD_ProDKin_1 654 660 PF00069 0.743
MOD_ProDKin_1 85 91 PF00069 0.639
MOD_ProDKin_1 94 100 PF00069 0.607
MOD_SUMO_rev_2 124 133 PF00179 0.594
MOD_SUMO_rev_2 213 221 PF00179 0.421
TRG_ENDOCYTIC_2 38 41 PF00928 0.405
TRG_ENDOCYTIC_2 464 467 PF00928 0.364
TRG_ENDOCYTIC_2 590 593 PF00928 0.501
TRG_ENDOCYTIC_2 690 693 PF00928 0.328
TRG_ER_diArg_1 150 152 PF00400 0.530
TRG_ER_diArg_1 203 205 PF00400 0.446
TRG_ER_diArg_1 263 266 PF00400 0.439
TRG_ER_diArg_1 282 284 PF00400 0.585
TRG_ER_diArg_1 285 288 PF00400 0.543
TRG_ER_diArg_1 354 357 PF00400 0.442
TRG_ER_diArg_1 358 360 PF00400 0.514
TRG_ER_diArg_1 436 439 PF00400 0.459
TRG_ER_diArg_1 57 59 PF00400 0.489
TRG_ER_diArg_1 577 580 PF00400 0.424
TRG_ER_diArg_1 706 708 PF00400 0.555
TRG_Pf-PMV_PEXEL_1 204 208 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 438 443 PF00026 0.442

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P9G4 Leptomonas seymouri 53% 98%
A0A1X0NZU7 Trypanosomatidae 31% 93%
A0A3S7X2G1 Leishmania donovani 88% 100%
A0A422NEG1 Trypanosoma rangeli 33% 100%
A4HHG5 Leishmania braziliensis 78% 100%
A4I4L4 Leishmania infantum 88% 100%
C9ZLA2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AE12 Leishmania major 88% 100%
V5ATS3 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS