Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALS0_LEIMU

TriTrypDb:

LmxM.08_29.1540

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALS0

PDB structure(s): 7ane_g

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.426
CLV_NRD_NRD_1	151	153	PF00675	0.446
CLV_NRD_NRD_1	159	161	PF00675	0.439
CLV_NRD_NRD_1	58	60	PF00675	0.385
CLV_NRD_NRD_1	97	99	PF00675	0.393
CLV_PCSK_KEX2_1	159	161	PF00082	0.455
CLV_PCSK_KEX2_1	58	60	PF00082	0.405
CLV_PCSK_KEX2_1	96	98	PF00082	0.397
CLV_PCSK_SKI1_1	114	118	PF00082	0.376
DEG_Nend_UBRbox_3	1	3	PF02207	0.667
DOC_MAPK_DCC_7	159	169	PF00069	0.457
DOC_MAPK_HePTP_8	157	169	PF00069	0.456
DOC_MAPK_MEF2A_6	160	169	PF00069	0.435
LIG_14-3-3_CanoR_1	159	165	PF00244	0.499
LIG_14-3-3_CanoR_1	16	24	PF00244	0.563
LIG_FHA_1	113	119	PF00498	0.376
LIG_FHA_1	2	8	PF00498	0.603
LIG_FHA_1	39	45	PF00498	0.479
LIG_LIR_Gen_1	106	113	PF02991	0.398
LIG_LIR_Gen_1	151	161	PF02991	0.456
LIG_LIR_Nem_3	106	110	PF02991	0.379
LIG_LIR_Nem_3	151	157	PF02991	0.479
LIG_Pex14_2	185	189	PF04695	0.402
LIG_PTB_Apo_2	179	186	PF02174	0.364
LIG_SH2_CRK	154	158	PF00017	0.440
LIG_SH2_STAT5	63	66	PF00017	0.376
LIG_SH3_3	46	52	PF00018	0.520
LIG_SUMO_SIM_par_1	51	57	PF11976	0.401
MOD_CK1_1	18	24	PF00069	0.538
MOD_CK1_1	82	88	PF00069	0.427
MOD_GSK3_1	18	25	PF00069	0.442
MOD_LATS_1	15	21	PF00433	0.494
MOD_LATS_1	158	164	PF00433	0.485
MOD_N-GLC_1	38	43	PF02516	0.538
MOD_N-GLC_1	82	87	PF02516	0.422
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	103	108	PF00069	0.409
MOD_NEK2_1	22	27	PF00069	0.471
MOD_NEK2_1	74	79	PF00069	0.420
MOD_PIKK_1	124	130	PF00454	0.533
MOD_PKA_2	15	21	PF00069	0.527
MOD_PKA_2	22	28	PF00069	0.556
MOD_Plk_1	38	44	PF00069	0.539
MOD_Plk_4	103	109	PF00069	0.418
MOD_Plk_4	51	57	PF00069	0.422
MOD_SUMO_rev_2	147	155	PF00179	0.446
MOD_SUMO_rev_2	82	89	PF00179	0.407
TRG_DiLeu_BaEn_1	121	126	PF01217	0.518
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.618
TRG_ENDOCYTIC_2	154	157	PF00928	0.505
TRG_ER_diArg_1	159	161	PF00400	0.459
TRG_ER_diArg_1	58	60	PF00400	0.394
TRG_ER_diArg_1	66	69	PF00400	0.415
TRG_ER_diArg_1	95	98	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P947	Leptomonas seymouri	85%	100%
A0A0S4KFE4	Bodo saltans	62%	100%
A0A1X0P098	Trypanosomatidae	76%	99%
A0A3S7X2N0	Leishmania donovani	97%	100%
A0A422NEG3	Trypanosoma rangeli	78%	100%
A4HHG6	Leishmania braziliensis	93%	100%
A4I4L5	Leishmania infantum	97%	100%
C9ZLA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	99%
E9AE13	Leishmania major	99%	100%