Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALR9_LEIMU

TriTrypDb:

LmxM.08_29.1550

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	512	516	PF00656	0.654
CLV_C14_Caspase3-7	524	528	PF00656	0.728
CLV_NRD_NRD_1	142	144	PF00675	0.706
CLV_NRD_NRD_1	208	210	PF00675	0.442
CLV_NRD_NRD_1	214	216	PF00675	0.443
CLV_NRD_NRD_1	368	370	PF00675	0.504
CLV_NRD_NRD_1	552	554	PF00675	0.637
CLV_NRD_NRD_1	563	565	PF00675	0.534
CLV_NRD_NRD_1	58	60	PF00675	0.462
CLV_PCSK_KEX2_1	142	144	PF00082	0.727
CLV_PCSK_KEX2_1	208	210	PF00082	0.464
CLV_PCSK_KEX2_1	214	216	PF00082	0.422
CLV_PCSK_KEX2_1	368	370	PF00082	0.504
CLV_PCSK_KEX2_1	552	554	PF00082	0.637
CLV_PCSK_KEX2_1	563	565	PF00082	0.534
CLV_PCSK_KEX2_1	58	60	PF00082	0.462
CLV_PCSK_SKI1_1	240	244	PF00082	0.496
CLV_PCSK_SKI1_1	330	334	PF00082	0.563
CLV_PCSK_SKI1_1	368	372	PF00082	0.499
CLV_PCSK_SKI1_1	409	413	PF00082	0.542
CLV_PCSK_SKI1_1	58	62	PF00082	0.462
CLV_PCSK_SKI1_1	625	629	PF00082	0.605
DEG_APCC_DBOX_1	57	65	PF00400	0.457
DEG_COP1_1	191	200	PF00400	0.441
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DEG_SCF_FBW7_1	67	74	PF00400	0.428
DOC_CKS1_1	425	430	PF01111	0.532
DOC_CKS1_1	68	73	PF01111	0.466
DOC_CYCLIN_RxL_1	363	373	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.482
DOC_MAPK_gen_1	214	221	PF00069	0.445
DOC_PP1_RVXF_1	238	245	PF00149	0.686
DOC_PP2B_LxvP_1	279	282	PF13499	0.499
DOC_PP4_FxxP_1	425	428	PF00568	0.540
DOC_PP4_FxxP_1	436	439	PF00568	0.554
DOC_USP7_MATH_1	155	159	PF00917	0.564
DOC_USP7_MATH_1	171	175	PF00917	0.561
DOC_USP7_MATH_1	176	180	PF00917	0.592
DOC_USP7_MATH_1	272	276	PF00917	0.627
DOC_USP7_MATH_1	29	33	PF00917	0.562
DOC_USP7_MATH_1	345	349	PF00917	0.534
DOC_USP7_MATH_1	520	524	PF00917	0.744
DOC_USP7_MATH_1	526	530	PF00917	0.646
DOC_USP7_MATH_1	568	572	PF00917	0.603
DOC_USP7_MATH_1	60	64	PF00917	0.512
DOC_WW_Pin1_4	196	201	PF00397	0.403
DOC_WW_Pin1_4	424	429	PF00397	0.561
DOC_WW_Pin1_4	576	581	PF00397	0.807
DOC_WW_Pin1_4	595	600	PF00397	0.458
DOC_WW_Pin1_4	67	72	PF00397	0.478
LIG_14-3-3_CanoR_1	117	122	PF00244	0.540
LIG_14-3-3_CanoR_1	231	237	PF00244	0.509
LIG_14-3-3_CanoR_1	350	358	PF00244	0.477
LIG_14-3-3_CanoR_1	415	420	PF00244	0.569
LIG_14-3-3_CanoR_1	59	65	PF00244	0.463
LIG_14-3-3_CanoR_1	625	633	PF00244	0.598
LIG_CaM_IQ_9	248	264	PF13499	0.568
LIG_EH1_1	655	663	PF00400	0.537
LIG_FHA_1	136	142	PF00498	0.601
LIG_FHA_1	147	153	PF00498	0.392
LIG_FHA_1	15	21	PF00498	0.477
LIG_FHA_1	191	197	PF00498	0.465
LIG_FHA_1	350	356	PF00498	0.628
LIG_FHA_1	546	552	PF00498	0.637
LIG_FHA_1	626	632	PF00498	0.635
LIG_FHA_1	643	649	PF00498	0.572
LIG_FHA_1	93	99	PF00498	0.341
LIG_FHA_2	233	239	PF00498	0.541
LIG_FHA_2	331	337	PF00498	0.508
LIG_FHA_2	399	405	PF00498	0.573
LIG_FHA_2	510	516	PF00498	0.677
LIG_FHA_2	612	618	PF00498	0.638
LIG_FHA_2	68	74	PF00498	0.431
LIG_LIR_Apic_2	422	428	PF02991	0.742
LIG_LIR_Apic_2	434	439	PF02991	0.555
LIG_LIR_Gen_1	92	101	PF02991	0.579
LIG_LIR_Nem_3	337	343	PF02991	0.584
LIG_LIR_Nem_3	373	379	PF02991	0.476
LIG_LIR_Nem_3	66	72	PF02991	0.426
LIG_LIR_Nem_3	92	97	PF02991	0.583
LIG_NRBOX	366	372	PF00104	0.558
LIG_NRBOX	63	69	PF00104	0.452
LIG_PCNA_yPIPBox_3	285	296	PF02747	0.539
LIG_SH2_CRK	377	381	PF00017	0.506
LIG_SH2_CRK	608	612	PF00017	0.587
LIG_SH2_CRK	94	98	PF00017	0.444
LIG_SH2_NCK_1	69	73	PF00017	0.484
LIG_SH2_STAP1	420	424	PF00017	0.587
LIG_SH2_STAP1	94	98	PF00017	0.444
LIG_SH2_STAT3	420	423	PF00017	0.583
LIG_SH2_STAT5	212	215	PF00017	0.506
LIG_SH2_STAT5	356	359	PF00017	0.510
LIG_SH2_STAT5	656	659	PF00017	0.539
LIG_SH2_STAT5	69	72	PF00017	0.478
LIG_SH2_STAT5	94	97	PF00017	0.343
LIG_SH3_2	547	552	PF14604	0.633
LIG_SH3_3	107	113	PF00018	0.562
LIG_SH3_3	194	200	PF00018	0.411
LIG_SH3_3	536	542	PF00018	0.750
LIG_SH3_3	544	550	PF00018	0.547
LIG_SH3_3	80	86	PF00018	0.540
LIG_Sin3_3	461	468	PF02671	0.545
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.391
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.511
LIG_SUMO_SIM_par_1	199	205	PF11976	0.477
LIG_SUMO_SIM_par_1	298	304	PF11976	0.482
LIG_SUMO_SIM_par_1	608	617	PF11976	0.574
LIG_TRAF2_1	316	319	PF00917	0.488
LIG_TRAF2_1	614	617	PF00917	0.638
LIG_TRFH_1	277	281	PF08558	0.504
LIG_TRFH_1	424	428	PF08558	0.541
LIG_TYR_ITIM	221	226	PF00017	0.459
LIG_TYR_ITIM	606	611	PF00017	0.570
LIG_TYR_ITIM	67	72	PF00017	0.465
LIG_WRC_WIRS_1	322	327	PF05994	0.495
MOD_CK1_1	129	135	PF00069	0.691
MOD_CK1_1	174	180	PF00069	0.572
MOD_CK1_1	234	240	PF00069	0.500
MOD_CK1_1	32	38	PF00069	0.460
MOD_CK1_1	396	402	PF00069	0.604
MOD_CK2_1	129	135	PF00069	0.543
MOD_CK2_1	232	238	PF00069	0.547
MOD_CK2_1	330	336	PF00069	0.570
MOD_CK2_1	398	404	PF00069	0.579
MOD_CK2_1	611	617	PF00069	0.634
MOD_CMANNOS	486	489	PF00535	0.616
MOD_GlcNHglycan	162	165	PF01048	0.553
MOD_GlcNHglycan	166	169	PF01048	0.559
MOD_GlcNHglycan	173	176	PF01048	0.458
MOD_GlcNHglycan	273	277	PF01048	0.635
MOD_GlcNHglycan	395	398	PF01048	0.553
MOD_GlcNHglycan	498	501	PF01048	0.515
MOD_GlcNHglycan	527	531	PF01048	0.680
MOD_GlcNHglycan	532	535	PF01048	0.644
MOD_GlcNHglycan	571	574	PF01048	0.632
MOD_GlcNHglycan	592	595	PF01048	0.643
MOD_GlcNHglycan	634	637	PF01048	0.500
MOD_GlcNHglycan	73	77	PF01048	0.477
MOD_GSK3_1	117	124	PF00069	0.544
MOD_GSK3_1	126	133	PF00069	0.524
MOD_GSK3_1	14	21	PF00069	0.453
MOD_GSK3_1	156	163	PF00069	0.548
MOD_GSK3_1	29	36	PF00069	0.533
MOD_GSK3_1	330	337	PF00069	0.613
MOD_GSK3_1	345	352	PF00069	0.502
MOD_GSK3_1	389	396	PF00069	0.596
MOD_GSK3_1	516	523	PF00069	0.710
MOD_GSK3_1	526	533	PF00069	0.591
MOD_GSK3_1	569	576	PF00069	0.666
MOD_GSK3_1	67	74	PF00069	0.491
MOD_N-GLC_1	14	19	PF02516	0.456
MOD_NEK2_1	116	121	PF00069	0.519
MOD_NEK2_1	146	151	PF00069	0.496
MOD_NEK2_1	321	326	PF00069	0.503
MOD_NEK2_1	382	387	PF00069	0.480
MOD_NEK2_1	389	394	PF00069	0.526
MOD_NEK2_1	398	403	PF00069	0.456
MOD_NEK2_1	454	459	PF00069	0.521
MOD_PIKK_1	39	45	PF00454	0.446
MOD_PKA_2	116	122	PF00069	0.525
MOD_PKA_2	349	355	PF00069	0.533
MOD_PKB_1	16	24	PF00069	0.501
MOD_PKB_1	543	551	PF00069	0.603
MOD_Plk_1	136	142	PF00069	0.495
MOD_Plk_1	190	196	PF00069	0.383
MOD_Plk_1	330	336	PF00069	0.575
MOD_Plk_1	494	500	PF00069	0.477
MOD_Plk_2-3	617	623	PF00069	0.505
MOD_Plk_4	301	307	PF00069	0.550
MOD_Plk_4	321	327	PF00069	0.496
MOD_Plk_4	415	421	PF00069	0.653
MOD_Plk_4	470	476	PF00069	0.514
MOD_Plk_4	93	99	PF00069	0.586
MOD_ProDKin_1	196	202	PF00069	0.405
MOD_ProDKin_1	424	430	PF00069	0.554
MOD_ProDKin_1	576	582	PF00069	0.806
MOD_ProDKin_1	595	601	PF00069	0.458
MOD_ProDKin_1	67	73	PF00069	0.485
MOD_SUMO_for_1	501	504	PF00179	0.633
MOD_SUMO_rev_2	129	138	PF00179	0.540
TRG_DiLeu_BaEn_1	470	475	PF01217	0.512
TRG_DiLeu_BaEn_4	449	455	PF01217	0.498
TRG_DiLeu_BaEn_4	493	499	PF01217	0.474
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.538
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.555
TRG_ENDOCYTIC_2	223	226	PF00928	0.460
TRG_ENDOCYTIC_2	603	606	PF00928	0.575
TRG_ENDOCYTIC_2	608	611	PF00928	0.569
TRG_ENDOCYTIC_2	69	72	PF00928	0.478
TRG_ENDOCYTIC_2	94	97	PF00928	0.448
TRG_ER_diArg_1	141	143	PF00400	0.588
TRG_ER_diArg_1	208	210	PF00400	0.440
TRG_ER_diArg_1	213	215	PF00400	0.446
TRG_ER_diArg_1	367	369	PF00400	0.501
TRG_ER_diArg_1	542	545	PF00400	0.661
TRG_ER_diArg_1	551	553	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM3	Leptomonas seymouri	48%	84%
A0A3Q8IHB4	Leishmania donovani	86%	85%
A4I4L6	Leishmania infantum	86%	78%
E9AE14	Leishmania major	87%	100%