Putative GTPase activator protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activator protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALR8_LEIMU

TriTrypDb:

LmxM.08_29.1560

Length:

717

Annotations

LeishMANIAdb annotations

Related to animal TBC proteins. Likely cytosolic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALR8

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0003925	G protein activity	2	4
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.637
CLV_NRD_NRD_1	160	162	PF00675	0.515
CLV_NRD_NRD_1	280	282	PF00675	0.603
CLV_NRD_NRD_1	376	378	PF00675	0.522
CLV_NRD_NRD_1	444	446	PF00675	0.414
CLV_NRD_NRD_1	673	675	PF00675	0.510
CLV_NRD_NRD_1	697	699	PF00675	0.533
CLV_NRD_NRD_1	704	706	PF00675	0.448
CLV_PCSK_KEX2_1	160	162	PF00082	0.515
CLV_PCSK_KEX2_1	280	282	PF00082	0.603
CLV_PCSK_KEX2_1	378	380	PF00082	0.517
CLV_PCSK_KEX2_1	444	446	PF00082	0.414
CLV_PCSK_KEX2_1	673	675	PF00082	0.510
CLV_PCSK_KEX2_1	697	699	PF00082	0.533
CLV_PCSK_KEX2_1	704	706	PF00082	0.448
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.517
CLV_PCSK_SKI1_1	161	165	PF00082	0.520
CLV_PCSK_SKI1_1	327	331	PF00082	0.433
DEG_SCF_TRCP1_1	308	314	PF00400	0.643
DEG_SPOP_SBC_1	108	112	PF00917	0.657
DEG_SPOP_SBC_1	55	59	PF00917	0.641
DOC_CKS1_1	262	267	PF01111	0.802
DOC_CKS1_1	330	335	PF01111	0.738
DOC_CKS1_1	353	358	PF01111	0.680
DOC_CYCLIN_yClb3_PxF_3	466	474	PF00134	0.580
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.575
DOC_MAPK_gen_1	160	167	PF00069	0.715
DOC_MAPK_gen_1	382	392	PF00069	0.674
DOC_MAPK_gen_1	563	571	PF00069	0.435
DOC_MAPK_gen_1	673	681	PF00069	0.647
DOC_MAPK_MEF2A_6	160	167	PF00069	0.715
DOC_MAPK_MEF2A_6	418	425	PF00069	0.636
DOC_MAPK_MEF2A_6	517	525	PF00069	0.435
DOC_MAPK_MEF2A_6	609	618	PF00069	0.636
DOC_MAPK_NFAT4_5	418	426	PF00069	0.636
DOC_PP1_RVXF_1	348	354	PF00149	0.706
DOC_PP1_RVXF_1	416	423	PF00149	0.636
DOC_PP4_FxxP_1	105	108	PF00568	0.659
DOC_PP4_FxxP_1	353	356	PF00568	0.730
DOC_PP4_FxxP_1	83	86	PF00568	0.629
DOC_USP7_MATH_1	109	113	PF00917	0.642
DOC_USP7_MATH_1	114	118	PF00917	0.628
DOC_USP7_MATH_1	138	142	PF00917	0.666
DOC_USP7_MATH_1	171	175	PF00917	0.687
DOC_USP7_MATH_1	244	248	PF00917	0.813
DOC_USP7_MATH_1	250	254	PF00917	0.790
DOC_USP7_MATH_1	269	273	PF00917	0.818
DOC_USP7_MATH_1	286	290	PF00917	0.641
DOC_USP7_MATH_1	304	308	PF00917	0.640
DOC_USP7_MATH_1	335	339	PF00917	0.746
DOC_USP7_MATH_1	354	358	PF00917	0.517
DOC_USP7_MATH_1	37	41	PF00917	0.638
DOC_USP7_MATH_1	50	54	PF00917	0.621
DOC_USP7_MATH_1	55	59	PF00917	0.617
DOC_USP7_MATH_1	710	714	PF00917	0.713
DOC_USP7_MATH_1	99	103	PF00917	0.650
DOC_USP7_MATH_2	265	271	PF00917	0.663
DOC_USP7_UBL2_3	378	382	PF12436	0.715
DOC_WW_Pin1_4	103	108	PF00397	0.627
DOC_WW_Pin1_4	130	135	PF00397	0.659
DOC_WW_Pin1_4	151	156	PF00397	0.676
DOC_WW_Pin1_4	258	263	PF00397	0.848
DOC_WW_Pin1_4	318	323	PF00397	0.802
DOC_WW_Pin1_4	329	334	PF00397	0.654
DOC_WW_Pin1_4	352	357	PF00397	0.677
DOC_WW_Pin1_4	394	399	PF00397	0.699
DOC_WW_Pin1_4	600	605	PF00397	0.636
DOC_WW_Pin1_4	607	612	PF00397	0.553
DOC_WW_Pin1_4	62	67	PF00397	0.651
DOC_WW_Pin1_4	662	667	PF00397	0.649
DOC_WW_Pin1_4	86	91	PF00397	0.623
DOC_WW_Pin1_4	97	102	PF00397	0.631
LIG_14-3-3_CanoR_1	146	155	PF00244	0.690
LIG_14-3-3_CanoR_1	160	166	PF00244	0.637
LIG_14-3-3_CanoR_1	245	249	PF00244	0.717
LIG_14-3-3_CanoR_1	291	297	PF00244	0.669
LIG_14-3-3_CanoR_1	388	393	PF00244	0.705
LIG_14-3-3_CanoR_1	643	650	PF00244	0.667
LIG_14-3-3_CanoR_1	657	663	PF00244	0.512
LIG_Actin_WH2_2	403	420	PF00022	0.620
LIG_Actin_WH2_2	688	706	PF00022	0.520
LIG_APCC_ABBA_1	523	528	PF00400	0.366
LIG_BRCT_BRCA1_1	101	105	PF00533	0.634
LIG_BRCT_BRCA1_1	499	503	PF00533	0.530
LIG_BRCT_BRCA1_1	79	83	PF00533	0.626
LIG_BRCT_BRCA1_1	88	92	PF00533	0.617
LIG_Clathr_ClatBox_1	509	513	PF01394	0.530
LIG_deltaCOP1_diTrp_1	28	32	PF00928	0.645
LIG_eIF4E_1	437	443	PF01652	0.636
LIG_eIF4E_1	650	656	PF01652	0.603
LIG_FHA_1	162	168	PF00498	0.681
LIG_FHA_1	175	181	PF00498	0.650
LIG_FHA_1	188	194	PF00498	0.634
LIG_FHA_1	480	486	PF00498	0.521
LIG_FHA_1	516	522	PF00498	0.380
LIG_FHA_1	644	650	PF00498	0.660
LIG_FHA_1	68	74	PF00498	0.604
LIG_FHA_2	182	188	PF00498	0.741
LIG_FHA_2	194	200	PF00498	0.825
LIG_FHA_2	262	268	PF00498	0.692
LIG_FHA_2	353	359	PF00498	0.683
LIG_FHA_2	360	366	PF00498	0.613
LIG_GBD_Chelix_1	504	512	PF00786	0.530
LIG_LIR_Apic_2	102	108	PF02991	0.655
LIG_LIR_Apic_2	60	66	PF02991	0.653
LIG_LIR_Apic_2	80	86	PF02991	0.587
LIG_LIR_Gen_1	344	353	PF02991	0.712
LIG_LIR_Gen_1	500	509	PF02991	0.530
LIG_LIR_Gen_1	518	526	PF02991	0.223
LIG_LIR_Gen_1	581	590	PF02991	0.530
LIG_LIR_Nem_3	26	32	PF02991	0.657
LIG_LIR_Nem_3	344	348	PF02991	0.709
LIG_LIR_Nem_3	380	386	PF02991	0.651
LIG_LIR_Nem_3	500	504	PF02991	0.400
LIG_LIR_Nem_3	516	522	PF02991	0.268
LIG_LIR_Nem_3	581	586	PF02991	0.530
LIG_PCNA_yPIPBox_3	546	559	PF02747	0.380
LIG_Pex14_1	596	600	PF04695	0.636
LIG_Pex14_2	503	507	PF04695	0.369
LIG_Pex14_2	583	587	PF04695	0.530
LIG_PTB_Apo_2	529	536	PF02174	0.435
LIG_PTB_Phospho_1	529	535	PF10480	0.435
LIG_SH2_NCK_1	650	654	PF00017	0.607
LIG_SH2_STAP1	650	654	PF00017	0.607
LIG_SH2_STAT5	437	440	PF00017	0.636
LIG_SH2_STAT5	448	451	PF00017	0.506
LIG_SH2_STAT5	470	473	PF00017	0.636
LIG_SH2_STAT5	497	500	PF00017	0.530
LIG_SH2_STAT5	598	601	PF00017	0.636
LIG_SH2_STAT5	623	626	PF00017	0.636
LIG_SH3_1	259	265	PF00018	0.722
LIG_SH3_1	463	469	PF00018	0.636
LIG_SH3_3	259	265	PF00018	0.806
LIG_SH3_3	353	359	PF00018	0.738
LIG_SH3_3	446	452	PF00018	0.588
LIG_SH3_3	463	469	PF00018	0.482
LIG_SH3_3	98	104	PF00018	0.633
LIG_Sin3_3	652	659	PF02671	0.660
LIG_SUMO_SIM_par_1	162	169	PF11976	0.740
LIG_SUMO_SIM_par_1	507	516	PF11976	0.530
LIG_SUMO_SIM_par_1	677	682	PF11976	0.654
MOD_CDK_SPK_2	662	667	PF00069	0.649
MOD_CK1_1	116	122	PF00069	0.642
MOD_CK1_1	147	153	PF00069	0.692
MOD_CK1_1	174	180	PF00069	0.726
MOD_CK1_1	183	189	PF00069	0.743
MOD_CK1_1	204	210	PF00069	0.717
MOD_CK1_1	317	323	PF00069	0.706
MOD_CK1_1	338	344	PF00069	0.748
MOD_CK1_1	53	59	PF00069	0.655
MOD_CK2_1	181	187	PF00069	0.705
MOD_CK2_1	261	267	PF00069	0.688
MOD_CK2_1	359	365	PF00069	0.671
MOD_GlcNHglycan	118	121	PF01048	0.442
MOD_GlcNHglycan	140	143	PF01048	0.491
MOD_GlcNHglycan	238	241	PF01048	0.604
MOD_GlcNHglycan	24	28	PF01048	0.442
MOD_GlcNHglycan	277	280	PF01048	0.613
MOD_GlcNHglycan	282	285	PF01048	0.574
MOD_GlcNHglycan	308	311	PF01048	0.490
MOD_GlcNHglycan	337	340	PF01048	0.472
MOD_GlcNHglycan	38	42	PF01048	0.412
MOD_GlcNHglycan	394	397	PF01048	0.488
MOD_GlcNHglycan	52	55	PF01048	0.420
MOD_GlcNHglycan	59	62	PF01048	0.428
MOD_GlcNHglycan	712	715	PF01048	0.551
MOD_GlcNHglycan	86	89	PF01048	0.415
MOD_GSK3_1	103	110	PF00069	0.634
MOD_GSK3_1	146	153	PF00069	0.692
MOD_GSK3_1	174	181	PF00069	0.771
MOD_GSK3_1	183	190	PF00069	0.721
MOD_GSK3_1	194	201	PF00069	0.761
MOD_GSK3_1	311	318	PF00069	0.836
MOD_GSK3_1	334	341	PF00069	0.593
MOD_GSK3_1	388	395	PF00069	0.702
MOD_GSK3_1	421	428	PF00069	0.541
MOD_GSK3_1	46	53	PF00069	0.652
MOD_GSK3_1	493	500	PF00069	0.508
MOD_GSK3_1	658	665	PF00069	0.623
MOD_GSK3_1	710	717	PF00069	0.676
MOD_GSK3_1	93	100	PF00069	0.649
MOD_N-GLC_1	114	119	PF02516	0.458
MOD_N-GLC_1	187	192	PF02516	0.444
MOD_NEK2_1	113	118	PF00069	0.661
MOD_NEK2_1	193	198	PF00069	0.748
MOD_NEK2_1	243	248	PF00069	0.786
MOD_NEK2_1	392	397	PF00069	0.687
MOD_NEK2_1	421	426	PF00069	0.636
MOD_NEK2_1	46	51	PF00069	0.655
MOD_NEK2_1	614	619	PF00069	0.636
MOD_NEK2_1	638	643	PF00069	0.660
MOD_NEK2_1	658	663	PF00069	0.438
MOD_NEK2_2	286	291	PF00069	0.795
MOD_NEK2_2	578	583	PF00069	0.369
MOD_PIKK_1	114	120	PF00454	0.644
MOD_PIKK_1	365	371	PF00454	0.752
MOD_PKA_1	280	286	PF00069	0.799
MOD_PKA_2	159	165	PF00069	0.715
MOD_PKA_2	193	199	PF00069	0.670
MOD_PKA_2	244	250	PF00069	0.716
MOD_PKA_2	280	286	PF00069	0.745
MOD_Plk_1	181	187	PF00069	0.686
MOD_Plk_1	201	207	PF00069	0.715
MOD_Plk_1	343	349	PF00069	0.626
MOD_Plk_1	515	521	PF00069	0.395
MOD_Plk_1	614	620	PF00069	0.636
MOD_Plk_4	250	256	PF00069	0.697
MOD_Plk_4	388	394	PF00069	0.702
MOD_Plk_4	535	541	PF00069	0.435
MOD_Plk_4	570	576	PF00069	0.313
MOD_Plk_4	578	584	PF00069	0.422
MOD_Plk_4	588	594	PF00069	0.365
MOD_ProDKin_1	130	136	PF00069	0.657
MOD_ProDKin_1	151	157	PF00069	0.676
MOD_ProDKin_1	258	264	PF00069	0.850
MOD_ProDKin_1	318	324	PF00069	0.802
MOD_ProDKin_1	329	335	PF00069	0.647
MOD_ProDKin_1	352	358	PF00069	0.676
MOD_ProDKin_1	394	400	PF00069	0.696
MOD_ProDKin_1	600	606	PF00069	0.636
MOD_ProDKin_1	607	613	PF00069	0.553
MOD_ProDKin_1	62	68	PF00069	0.649
MOD_ProDKin_1	662	668	PF00069	0.650
MOD_ProDKin_1	86	92	PF00069	0.626
MOD_ProDKin_1	97	103	PF00069	0.634
MOD_SUMO_rev_2	227	234	PF00179	0.768
MOD_SUMO_rev_2	550	558	PF00179	0.380
TRG_DiLeu_BaEn_1	229	234	PF01217	0.633
TRG_DiLeu_BaEn_4	229	235	PF01217	0.662
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.636
TRG_ER_diArg_1	443	445	PF00400	0.614
TRG_ER_diArg_1	672	674	PF00400	0.702
TRG_ER_diArg_1	697	699	PF00400	0.733
TRG_ER_diArg_1	703	705	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEG1	Leishmania donovani	91%	100%
A4HHG8	Leishmania braziliensis	73%	100%
A4I4L7	Leishmania infantum	91%	100%
E9AE15	Leishmania major	89%	100%