Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALR6_LEIMU

TriTrypDb:

LmxM.08_29.1575

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0019898	extrinsic component of membrane	2	1
GO:0034045	phagophore assembly site membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALR6

Function

Biological processes
Term	Name	Level	Count
GO:0000422	autophagy of mitochondrion	4	1
GO:0006497	protein lipidation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1
GO:0022411	cellular component disassembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0034497	protein localization to phagophore assembly site	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044804	autophagy of nucleus	4	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0061726	mitochondrion disassembly	6	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903008	organelle disassembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032266	phosphatidylinositol-3-phosphate binding	6	1
GO:0035091	phosphatidylinositol binding	4	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1
GO:1902936	phosphatidylinositol bisphosphate binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.511
CLV_NRD_NRD_1	222	224	PF00675	0.689
CLV_NRD_NRD_1	259	261	PF00675	0.762
CLV_NRD_NRD_1	457	459	PF00675	0.794
CLV_PCSK_KEX2_1	146	148	PF00082	0.511
CLV_PCSK_KEX2_1	259	261	PF00082	0.817
CLV_PCSK_KEX2_1	457	459	PF00082	0.794
CLV_PCSK_SKI1_1	211	215	PF00082	0.514
CLV_PCSK_SKI1_1	533	537	PF00082	0.807
DEG_SCF_FBW7_1	46	53	PF00400	0.511
DEG_SPOP_SBC_1	452	456	PF00917	0.599
DEG_SPOP_SBC_1	480	484	PF00917	0.682
DEG_SPOP_SBC_1	96	100	PF00917	0.597
DOC_ANK_TNKS_1	322	329	PF00023	0.593
DOC_CKS1_1	125	130	PF01111	0.524
DOC_CKS1_1	47	52	PF01111	0.529
DOC_MAPK_gen_1	240	248	PF00069	0.465
DOC_MAPK_gen_1	357	367	PF00069	0.518
DOC_MAPK_gen_1	401	411	PF00069	0.423
DOC_MAPK_gen_1	68	75	PF00069	0.536
DOC_MAPK_MEF2A_6	360	369	PF00069	0.519
DOC_MAPK_MEF2A_6	68	75	PF00069	0.536
DOC_PP4_FxxP_1	549	552	PF00568	0.690
DOC_USP7_MATH_1	133	137	PF00917	0.707
DOC_USP7_MATH_1	17	21	PF00917	0.611
DOC_USP7_MATH_1	175	179	PF00917	0.577
DOC_USP7_MATH_1	219	223	PF00917	0.620
DOC_USP7_MATH_1	23	27	PF00917	0.621
DOC_USP7_MATH_1	283	287	PF00917	0.677
DOC_USP7_MATH_1	294	298	PF00917	0.694
DOC_USP7_MATH_1	332	336	PF00917	0.559
DOC_USP7_MATH_1	403	407	PF00917	0.689
DOC_USP7_MATH_1	424	428	PF00917	0.785
DOC_USP7_MATH_1	443	447	PF00917	0.489
DOC_USP7_MATH_1	467	471	PF00917	0.779
DOC_USP7_MATH_1	480	484	PF00917	0.658
DOC_USP7_MATH_1	531	535	PF00917	0.689
DOC_USP7_MATH_1	57	61	PF00917	0.508
DOC_USP7_MATH_1	97	101	PF00917	0.601
DOC_USP7_UBL2_3	434	438	PF12436	0.529
DOC_WW_Pin1_4	113	118	PF00397	0.787
DOC_WW_Pin1_4	124	129	PF00397	0.549
DOC_WW_Pin1_4	165	170	PF00397	0.500
DOC_WW_Pin1_4	281	286	PF00397	0.677
DOC_WW_Pin1_4	301	306	PF00397	0.702
DOC_WW_Pin1_4	413	418	PF00397	0.678
DOC_WW_Pin1_4	46	51	PF00397	0.546
DOC_WW_Pin1_4	533	538	PF00397	0.803
DOC_WW_Pin1_4	550	555	PF00397	0.509
DOC_WW_Pin1_4	561	566	PF00397	0.635
LIG_14-3-3_CanoR_1	200	205	PF00244	0.537
LIG_14-3-3_CanoR_1	329	337	PF00244	0.485
LIG_14-3-3_CanoR_1	404	410	PF00244	0.593
LIG_Actin_WH2_2	183	199	PF00022	0.494
LIG_AP_GAE_1	501	507	PF02883	0.704
LIG_APCC_ABBA_1	409	414	PF00400	0.489
LIG_BRCT_BRCA1_1	296	300	PF00533	0.803
LIG_deltaCOP1_diTrp_1	495	504	PF00928	0.729
LIG_FHA_1	338	344	PF00498	0.461
LIG_FHA_1	346	352	PF00498	0.500
LIG_FHA_1	382	388	PF00498	0.505
LIG_FHA_1	508	514	PF00498	0.636
LIG_FHA_1	51	57	PF00498	0.449
LIG_FHA_1	76	82	PF00498	0.599
LIG_FHA_2	125	131	PF00498	0.514
LIG_FHA_2	331	337	PF00498	0.482
LIG_FHA_2	80	86	PF00498	0.636
LIG_Integrin_RGD_1	243	245	PF01839	0.445
LIG_LIR_Apic_2	44	50	PF02991	0.549
LIG_LIR_Apic_2	547	552	PF02991	0.784
LIG_LIR_Gen_1	186	196	PF02991	0.456
LIG_LIR_Nem_3	186	191	PF02991	0.405
LIG_LIR_Nem_3	203	208	PF02991	0.510
LIG_PDZ_Class_2	573	578	PF00595	0.689
LIG_SH2_CRK	205	209	PF00017	0.546
LIG_SH2_NCK_1	231	235	PF00017	0.478
LIG_SH2_PTP2	148	151	PF00017	0.492
LIG_SH2_PTP2	575	578	PF00017	0.786
LIG_SH2_SRC	479	482	PF00017	0.808
LIG_SH2_STAP1	231	235	PF00017	0.486
LIG_SH2_STAP1	52	56	PF00017	0.449
LIG_SH2_STAT3	198	201	PF00017	0.524
LIG_SH2_STAT5	148	151	PF00017	0.492
LIG_SH2_STAT5	198	201	PF00017	0.524
LIG_SH2_STAT5	52	55	PF00017	0.472
LIG_SH2_STAT5	575	578	PF00017	0.786
LIG_SH3_3	120	126	PF00018	0.553
LIG_SH3_3	204	210	PF00018	0.567
LIG_SH3_3	230	236	PF00018	0.483
LIG_SH3_3	70	76	PF00018	0.579
LIG_SH3_3	8	14	PF00018	0.589
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.562
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.474
LIG_SUMO_SIM_par_1	189	195	PF11976	0.496
LIG_SUMO_SIM_par_1	212	217	PF11976	0.495
MOD_CDC14_SPxK_1	553	556	PF00782	0.785
MOD_CDK_SPK_2	535	540	PF00069	0.793
MOD_CDK_SPxK_1	550	556	PF00069	0.786
MOD_CDK_SPxxK_3	533	540	PF00069	0.798
MOD_CDK_SPxxK_3	561	568	PF00069	0.808
MOD_CK1_1	27	33	PF00069	0.610
MOD_CK1_1	272	278	PF00069	0.798
MOD_CK1_1	284	290	PF00069	0.708
MOD_CK1_1	396	402	PF00069	0.580
MOD_CK1_1	448	454	PF00069	0.791
MOD_CK1_1	561	567	PF00069	0.672
MOD_CK1_1	99	105	PF00069	0.602
MOD_CK2_1	124	130	PF00069	0.560
MOD_CK2_1	330	336	PF00069	0.475
MOD_CK2_1	475	481	PF00069	0.805
MOD_CK2_1	561	567	PF00069	0.571
MOD_GlcNHglycan	103	106	PF01048	0.694
MOD_GlcNHglycan	135	138	PF01048	0.604
MOD_GlcNHglycan	215	219	PF01048	0.457
MOD_GlcNHglycan	237	240	PF01048	0.508
MOD_GlcNHglycan	274	277	PF01048	0.720
MOD_GlcNHglycan	296	299	PF01048	0.800
MOD_GlcNHglycan	379	382	PF01048	0.512
MOD_GlcNHglycan	405	408	PF01048	0.684
MOD_GlcNHglycan	445	448	PF01048	0.772
MOD_GlcNHglycan	450	453	PF01048	0.763
MOD_GlcNHglycan	460	463	PF01048	0.581
MOD_GlcNHglycan	475	478	PF01048	0.557
MOD_GlcNHglycan	483	486	PF01048	0.738
MOD_GlcNHglycan	501	504	PF01048	0.686
MOD_GlcNHglycan	533	536	PF01048	0.809
MOD_GlcNHglycan	558	561	PF01048	0.819
MOD_GlcNHglycan	59	62	PF01048	0.511
MOD_GSK3_1	23	30	PF00069	0.801
MOD_GSK3_1	281	288	PF00069	0.760
MOD_GSK3_1	33	40	PF00069	0.638
MOD_GSK3_1	332	339	PF00069	0.465
MOD_GSK3_1	377	384	PF00069	0.508
MOD_GSK3_1	393	400	PF00069	0.496
MOD_GSK3_1	448	455	PF00069	0.783
MOD_GSK3_1	46	53	PF00069	0.520
MOD_GSK3_1	475	482	PF00069	0.804
MOD_GSK3_1	525	532	PF00069	0.828
MOD_GSK3_1	75	82	PF00069	0.617
MOD_GSK3_1	95	102	PF00069	0.478
MOD_LATS_1	16	22	PF00433	0.632
MOD_N-GLC_1	133	138	PF02516	0.701
MOD_N-GLC_1	175	180	PF02516	0.573
MOD_N-GLC_1	381	386	PF02516	0.517
MOD_N-GLC_1	473	478	PF02516	0.704
MOD_NEK2_1	214	219	PF00069	0.497
MOD_NEK2_1	330	335	PF00069	0.441
MOD_NEK2_1	337	342	PF00069	0.476
MOD_NEK2_1	343	348	PF00069	0.472
MOD_NEK2_2	381	386	PF00069	0.517
MOD_NEK2_2	544	549	PF00069	0.781
MOD_OFUCOSY	542	548	PF10250	0.778
MOD_PIKK_1	254	260	PF00454	0.625
MOD_PK_1	18	24	PF00069	0.636
MOD_PKA_2	17	23	PF00069	0.558
MOD_PKA_2	272	278	PF00069	0.789
MOD_PKA_2	403	409	PF00069	0.574
MOD_PKB_1	556	564	PF00069	0.538
MOD_Plk_1	133	139	PF00069	0.689
MOD_Plk_1	175	181	PF00069	0.584
MOD_Plk_1	244	250	PF00069	0.474
MOD_Plk_4	175	181	PF00069	0.584
MOD_Plk_4	200	206	PF00069	0.494
MOD_Plk_4	244	250	PF00069	0.474
MOD_Plk_4	415	421	PF00069	0.721
MOD_Plk_4	7	13	PF00069	0.588
MOD_ProDKin_1	113	119	PF00069	0.790
MOD_ProDKin_1	124	130	PF00069	0.543
MOD_ProDKin_1	165	171	PF00069	0.497
MOD_ProDKin_1	281	287	PF00069	0.678
MOD_ProDKin_1	301	307	PF00069	0.690
MOD_ProDKin_1	413	419	PF00069	0.680
MOD_ProDKin_1	46	52	PF00069	0.538
MOD_ProDKin_1	533	539	PF00069	0.798
MOD_ProDKin_1	550	556	PF00069	0.510
MOD_ProDKin_1	561	567	PF00069	0.633
TRG_DiLeu_BaEn_4	120	126	PF01217	0.553
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.495
TRG_ENDOCYTIC_2	148	151	PF00928	0.492
TRG_ENDOCYTIC_2	205	208	PF00928	0.562
TRG_ENDOCYTIC_2	575	578	PF00928	0.786
TRG_ER_diArg_1	146	148	PF00400	0.511
TRG_ER_diArg_1	457	459	PF00400	0.780
TRG_ER_diArg_1	67	70	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER0	Leptomonas seymouri	46%	91%
A0A3S7X2H0	Leishmania donovani	93%	100%
A4I4L9	Leishmania infantum	93%	100%
E9AE17	Leishmania major	92%	100%