UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XPC-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALR5_LEIMU

TriTrypDb:

LmxM.08_29.1580

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	3
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ALR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALR5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006289	nucleotide-excision repair	6	10
GO:0006508	proteolysis	4	10
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0010498	proteasomal protein catabolic process	5	10
GO:0019538	protein metabolic process	3	10
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0030163	protein catabolic process	4	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901565	organonitrogen compound catabolic process	4	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003684	damaged DNA binding	5	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0005515	protein binding	2	3
GO:0031593	polyubiquitin modification-dependent protein binding	4	3
GO:0032182	ubiquitin-like protein binding	3	3
GO:0043130	ubiquitin binding	4	3
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140030	modification-dependent protein binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.743
CLV_C14_Caspase3-7	321	325	PF00656	0.755
CLV_C14_Caspase3-7	65	69	PF00656	0.785
CLV_NRD_NRD_1	60	62	PF00675	0.420
CLV_PCSK_KEX2_1	135	137	PF00082	0.806
CLV_PCSK_KEX2_1	340	342	PF00082	0.625
CLV_PCSK_KEX2_1	60	62	PF00082	0.420
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.806
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.625
CLV_PCSK_SKI1_1	25	29	PF00082	0.609
CLV_PCSK_SKI1_1	375	379	PF00082	0.344
CLV_PCSK_SKI1_1	89	93	PF00082	0.494
DEG_Nend_UBRbox_1	1	4	PF02207	0.424
DEG_SPOP_SBC_1	71	75	PF00917	0.729
DOC_MAPK_MEF2A_6	40	47	PF00069	0.422
DOC_PP1_RVXF_1	373	379	PF00149	0.344
DOC_PP1_RVXF_1	48	55	PF00149	0.499
DOC_PP4_FxxP_1	393	396	PF00568	0.512
DOC_USP7_MATH_1	170	174	PF00917	0.715
DOC_USP7_MATH_1	296	300	PF00917	0.692
DOC_USP7_MATH_1	330	334	PF00917	0.754
DOC_USP7_MATH_1	70	74	PF00917	0.713
DOC_USP7_UBL2_3	104	108	PF12436	0.503
DOC_WW_Pin1_4	124	129	PF00397	0.803
DOC_WW_Pin1_4	72	77	PF00397	0.783
LIG_14-3-3_CanoR_1	33	37	PF00244	0.518
LIG_14-3-3_CanoR_1	341	349	PF00244	0.586
LIG_14-3-3_CanoR_1	40	44	PF00244	0.453
LIG_Actin_WH2_2	36	52	PF00022	0.496
LIG_Actin_WH2_2	99	116	PF00022	0.356
LIG_BIR_III_4	178	182	PF00653	0.646
LIG_BRCT_BRCA1_1	285	289	PF00533	0.560
LIG_BRCT_BRCA1_1	301	305	PF00533	0.466
LIG_EH1_1	2	10	PF00400	0.506
LIG_FHA_1	132	138	PF00498	0.673
LIG_FHA_1	22	28	PF00498	0.349
LIG_FHA_1	4	10	PF00498	0.494
LIG_FHA_1	40	46	PF00498	0.377
LIG_FHA_2	207	213	PF00498	0.383
LIG_FHA_2	63	69	PF00498	0.692
LIG_LIR_Gen_1	184	194	PF02991	0.596
LIG_LIR_Gen_1	220	226	PF02991	0.522
LIG_LIR_Gen_1	230	236	PF02991	0.455
LIG_LIR_Nem_3	184	189	PF02991	0.588
LIG_LIR_Nem_3	220	225	PF02991	0.511
LIG_LIR_Nem_3	230	235	PF02991	0.464
LIG_LIR_Nem_3	286	292	PF02991	0.633
LIG_Pex14_2	54	58	PF04695	0.524
LIG_SH2_CRK	110	114	PF00017	0.642
LIG_SH2_STAT5	110	113	PF00017	0.474
LIG_SH2_STAT5	292	295	PF00017	0.603
LIG_SH2_STAT5	379	382	PF00017	0.408
LIG_SH3_3	142	148	PF00018	0.751
LIG_SH3_3	26	32	PF00018	0.582
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.561
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.511
LIG_TRAF2_1	158	161	PF00917	0.721
LIG_TRAF2_1	188	191	PF00917	0.422
LIG_TRAF2_1	353	356	PF00917	0.520
MOD_CK1_1	11	17	PF00069	0.563
MOD_CK1_1	291	297	PF00069	0.577
MOD_CK1_1	299	305	PF00069	0.562
MOD_CK1_1	74	80	PF00069	0.774
MOD_CK2_1	124	130	PF00069	0.807
MOD_CK2_1	150	156	PF00069	0.629
MOD_CK2_1	206	212	PF00069	0.383
MOD_CK2_1	266	272	PF00069	0.784
MOD_CK2_1	340	346	PF00069	0.622
MOD_GlcNHglycan	285	288	PF01048	0.625
MOD_GlcNHglycan	294	297	PF01048	0.607
MOD_GlcNHglycan	298	301	PF01048	0.659
MOD_GlcNHglycan	314	318	PF01048	0.407
MOD_GlcNHglycan	327	331	PF01048	0.730
MOD_GlcNHglycan	332	335	PF01048	0.734
MOD_GlcNHglycan	68	71	PF01048	0.796
MOD_GlcNHglycan	76	79	PF01048	0.586
MOD_GSK3_1	17	24	PF00069	0.538
MOD_GSK3_1	262	269	PF00069	0.755
MOD_GSK3_1	288	295	PF00069	0.565
MOD_GSK3_1	3	10	PF00069	0.432
MOD_GSK3_1	326	333	PF00069	0.483
MOD_GSK3_1	347	354	PF00069	0.611
MOD_GSK3_1	62	69	PF00069	0.706
MOD_GSK3_1	70	77	PF00069	0.523
MOD_N-GLC_1	108	113	PF02516	0.681
MOD_N-GLC_1	12	17	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.436
MOD_NEK2_1	266	271	PF00069	0.783
MOD_NEK2_1	288	293	PF00069	0.589
MOD_NEK2_1	313	318	PF00069	0.693
MOD_NEK2_1	347	352	PF00069	0.622
MOD_NEK2_1	39	44	PF00069	0.507
MOD_NEK2_1	8	13	PF00069	0.484
MOD_PKA_1	340	346	PF00069	0.599
MOD_PKA_2	123	129	PF00069	0.498
MOD_PKA_2	32	38	PF00069	0.563
MOD_PKA_2	340	346	PF00069	0.599
MOD_PKA_2	386	392	PF00069	0.444
MOD_PKA_2	39	45	PF00069	0.528
MOD_Plk_1	108	114	PF00069	0.689
MOD_Plk_1	12	18	PF00069	0.558
MOD_Plk_1	194	200	PF00069	0.561
MOD_Plk_1	25	31	PF00069	0.583
MOD_Plk_1	266	272	PF00069	0.704
MOD_Plk_2-3	159	165	PF00069	0.748
MOD_Plk_2-3	262	268	PF00069	0.720
MOD_Plk_2-3	62	68	PF00069	0.595
MOD_Plk_4	12	18	PF00069	0.587
MOD_Plk_4	194	200	PF00069	0.561
MOD_Plk_4	206	212	PF00069	0.534
MOD_Plk_4	217	223	PF00069	0.530
MOD_Plk_4	228	234	PF00069	0.525
MOD_Plk_4	288	294	PF00069	0.517
MOD_ProDKin_1	124	130	PF00069	0.804
MOD_ProDKin_1	72	78	PF00069	0.782
MOD_SUMO_rev_2	354	361	PF00179	0.345
MOD_SUMO_rev_2	84	92	PF00179	0.564
TRG_DiLeu_BaEn_2	145	151	PF01217	0.731
TRG_DiLeu_BaEn_4	159	165	PF01217	0.743
TRG_ENDOCYTIC_2	110	113	PF00928	0.610
TRG_ER_diArg_1	136	139	PF00400	0.795
TRG_NLS_MonoExtC_3	134	140	PF00514	0.750
TRG_NLS_MonoExtN_4	132	139	PF00514	0.752
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I958	Leptomonas seymouri	61%	100%
A0A1X0NZX2	Trypanosomatidae	28%	100%
A0A3Q8IFF1	Leishmania donovani	90%	100%
A0A422NEC4	Trypanosoma rangeli	29%	100%
A4HHH1	Leishmania braziliensis	79%	100%
A4I4M0	Leishmania infantum	90%	100%
E9AE18	Leishmania major	89%	98%
V5B988	Trypanosoma cruzi	28%	100%