Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein 70, putative

Species:

Leishmania mexicana

UniProt:

E9ALR2_LEIMU

TriTrypDb:

LmxM.08_29.1600

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 1
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

E9ALR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALR2

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.508
CLV_NRD_NRD_1	232	234	PF00675	0.497
CLV_NRD_NRD_1	413	415	PF00675	0.444
CLV_NRD_NRD_1	671	673	PF00675	0.278
CLV_PCSK_KEX2_1	137	139	PF00082	0.480
CLV_PCSK_KEX2_1	413	415	PF00082	0.444
CLV_PCSK_KEX2_1	671	673	PF00082	0.358
CLV_PCSK_SKI1_1	120	124	PF00082	0.454
CLV_PCSK_SKI1_1	142	146	PF00082	0.462
CLV_PCSK_SKI1_1	182	186	PF00082	0.495
CLV_PCSK_SKI1_1	204	208	PF00082	0.521
CLV_PCSK_SKI1_1	21	25	PF00082	0.596
CLV_PCSK_SKI1_1	270	274	PF00082	0.506
CLV_PCSK_SKI1_1	280	284	PF00082	0.560
CLV_PCSK_SKI1_1	299	303	PF00082	0.531
CLV_PCSK_SKI1_1	414	418	PF00082	0.458
CLV_PCSK_SKI1_1	449	453	PF00082	0.231
DEG_APCC_KENBOX_2	292	296	PF00400	0.221
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DOC_CYCLIN_RxL_1	18	27	PF00134	0.305
DOC_MAPK_gen_1	150	158	PF00069	0.267
DOC_MAPK_gen_1	178	186	PF00069	0.306
DOC_MAPK_gen_1	19	28	PF00069	0.414
DOC_MAPK_gen_1	233	240	PF00069	0.325
DOC_MAPK_gen_1	520	530	PF00069	0.332
DOC_MAPK_gen_1	53	63	PF00069	0.384
DOC_MAPK_gen_1	671	679	PF00069	0.489
DOC_MAPK_JIP1_4	19	25	PF00069	0.309
DOC_MAPK_MEF2A_6	19	28	PF00069	0.483
DOC_MAPK_MEF2A_6	233	242	PF00069	0.277
DOC_MAPK_NFAT4_5	21	29	PF00069	0.287
DOC_PP1_RVXF_1	243	250	PF00149	0.306
DOC_PP2B_LxvP_1	194	197	PF13499	0.275
DOC_PP4_FxxP_1	374	377	PF00568	0.408
DOC_PP4_FxxP_1	408	411	PF00568	0.208
DOC_PP4_FxxP_1	45	48	PF00568	0.373
DOC_PP4_FxxP_1	456	459	PF00568	0.396
DOC_PP4_FxxP_1	84	87	PF00568	0.223
DOC_SPAK_OSR1_1	62	66	PF12202	0.184
DOC_USP7_MATH_1	51	55	PF00917	0.414
DOC_USP7_MATH_1	529	533	PF00917	0.466
DOC_USP7_MATH_2	252	258	PF00917	0.176
DOC_USP7_UBL2_3	142	146	PF12436	0.293
DOC_USP7_UBL2_3	178	182	PF12436	0.278
DOC_WW_Pin1_4	37	42	PF00397	0.539
DOC_WW_Pin1_4	407	412	PF00397	0.208
LIG_14-3-3_CanoR_1	105	111	PF00244	0.253
LIG_14-3-3_CanoR_1	120	125	PF00244	0.258
LIG_14-3-3_CanoR_1	351	360	PF00244	0.497
LIG_14-3-3_CanoR_1	69	77	PF00244	0.317
LIG_APCC_ABBA_1	236	241	PF00400	0.266
LIG_BRCT_BRCA1_1	506	510	PF00533	0.280
LIG_BRCT_BRCA1_1	570	574	PF00533	0.325
LIG_BRCT_BRCA1_1	623	627	PF00533	0.326
LIG_BRCT_BRCA1_1	665	669	PF00533	0.328
LIG_BRCT_BRCA1_1	71	75	PF00533	0.379
LIG_CaM_NSCaTE_8	304	311	PF13499	0.325
LIG_EH1_1	321	329	PF00400	0.394
LIG_eIF4E_1	434	440	PF01652	0.296
LIG_FHA_1	131	137	PF00498	0.269
LIG_FHA_1	143	149	PF00498	0.207
LIG_FHA_1	25	31	PF00498	0.443
LIG_FHA_1	285	291	PF00498	0.255
LIG_FHA_1	394	400	PF00498	0.280
LIG_FHA_1	417	423	PF00498	0.322
LIG_FHA_1	426	432	PF00498	0.257
LIG_FHA_1	477	483	PF00498	0.255
LIG_FHA_1	490	496	PF00498	0.271
LIG_FHA_1	576	582	PF00498	0.309
LIG_FHA_2	129	135	PF00498	0.158
LIG_FHA_2	164	170	PF00498	0.290
LIG_FHA_2	225	231	PF00498	0.266
LIG_FHA_2	300	306	PF00498	0.216
LIG_FHA_2	484	490	PF00498	0.266
LIG_GBD_Chelix_1	552	560	PF00786	0.289
LIG_LIR_Apic_2	246	252	PF02991	0.287
LIG_LIR_Apic_2	372	377	PF02991	0.408
LIG_LIR_Apic_2	43	48	PF02991	0.463
LIG_LIR_Apic_2	453	459	PF02991	0.270
LIG_LIR_Gen_1	232	242	PF02991	0.244
LIG_LIR_Gen_1	424	435	PF02991	0.370
LIG_LIR_Gen_1	492	501	PF02991	0.323
LIG_LIR_Gen_1	571	581	PF02991	0.302
LIG_LIR_Gen_1	78	87	PF02991	0.325
LIG_LIR_LC3C_4	27	31	PF02991	0.336
LIG_LIR_LC3C_4	546	551	PF02991	0.276
LIG_LIR_Nem_3	232	238	PF02991	0.224
LIG_LIR_Nem_3	283	288	PF02991	0.307
LIG_LIR_Nem_3	302	307	PF02991	0.140
LIG_LIR_Nem_3	348	352	PF02991	0.423
LIG_LIR_Nem_3	363	369	PF02991	0.408
LIG_LIR_Nem_3	424	430	PF02991	0.348
LIG_LIR_Nem_3	445	451	PF02991	0.337
LIG_LIR_Nem_3	492	497	PF02991	0.323
LIG_LIR_Nem_3	571	577	PF02991	0.299
LIG_LIR_Nem_3	592	598	PF02991	0.301
LIG_NRBOX	24	30	PF00104	0.552
LIG_NRBOX	417	423	PF00104	0.296
LIG_Pex14_1	151	155	PF04695	0.266
LIG_Pex14_1	382	386	PF04695	0.525
LIG_Pex14_1	448	452	PF04695	0.408
LIG_Pex14_1	606	610	PF04695	0.408
LIG_Pex14_2	452	456	PF04695	0.360
LIG_Pex14_2	539	543	PF04695	0.327
LIG_PTB_Apo_2	105	112	PF02174	0.258
LIG_PTB_Apo_2	123	130	PF02174	0.258
LIG_PTB_Apo_2	146	153	PF02174	0.297
LIG_PTB_Phospho_1	105	111	PF10480	0.258
LIG_PTB_Phospho_1	146	152	PF10480	0.297
LIG_SH2_CRK	674	678	PF00017	0.473
LIG_SH2_GRB2like	155	158	PF00017	0.325
LIG_SH2_GRB2like	379	382	PF00017	0.515
LIG_SH2_GRB2like	442	445	PF00017	0.458
LIG_SH2_GRB2like	600	603	PF00017	0.458
LIG_SH2_PTP2	235	238	PF00017	0.304
LIG_SH2_PTP2	466	469	PF00017	0.396
LIG_SH2_SRC	442	445	PF00017	0.332
LIG_SH2_SRC	46	49	PF00017	0.372
LIG_SH2_SRC	600	603	PF00017	0.458
LIG_SH2_SRC	652	655	PF00017	0.199
LIG_SH2_STAP1	111	115	PF00017	0.258
LIG_SH2_STAP1	288	292	PF00017	0.234
LIG_SH2_STAP1	379	383	PF00017	0.515
LIG_SH2_STAT3	288	291	PF00017	0.287
LIG_SH2_STAT3	558	561	PF00017	0.410
LIG_SH2_STAT5	235	238	PF00017	0.307
LIG_SH2_STAT5	307	310	PF00017	0.224
LIG_SH2_STAT5	434	437	PF00017	0.254
LIG_SH2_STAT5	442	445	PF00017	0.408
LIG_SH2_STAT5	46	49	PF00017	0.350
LIG_SH2_STAT5	466	469	PF00017	0.280
LIG_SH2_STAT5	558	561	PF00017	0.295
LIG_SH2_STAT5	596	599	PF00017	0.424
LIG_SH2_STAT5	610	613	PF00017	0.265
LIG_SH2_STAT5	652	655	PF00017	0.190
LIG_SH3_3	262	268	PF00018	0.326
LIG_SH3_3	370	376	PF00018	0.447
LIG_SH3_3	494	500	PF00018	0.337
LIG_SH3_3	539	545	PF00018	0.311
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.458
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.250
LIG_SUMO_SIM_par_1	21	27	PF11976	0.469
LIG_SUMO_SIM_par_1	419	424	PF11976	0.251
LIG_SUMO_SIM_par_1	549	555	PF11976	0.294
LIG_SUMO_SIM_par_1	587	592	PF11976	0.355
LIG_SxIP_EBH_1	474	488	PF03271	0.266
LIG_TRAF2_1	229	232	PF00917	0.316
LIG_TRAF2_1	88	91	PF00917	0.230
LIG_TYR_ITIM	464	469	PF00017	0.370
LIG_UBA3_1	106	114	PF00899	0.167
LIG_UBA3_1	341	347	PF00899	0.268
LIG_UBA3_1	467	474	PF00899	0.323
LIG_UBA3_1	74	81	PF00899	0.266
LIG_WRC_WIRS_1	427	432	PF05994	0.208
LIG_WRC_WIRS_1	569	574	PF05994	0.293
LIG_WRC_WIRS_1	634	639	PF05994	0.241
LIG_WW_1	376	379	PF00397	0.515
MOD_CDC14_SPxK_1	410	413	PF00782	0.244
MOD_CDK_SPxK_1	407	413	PF00069	0.244
MOD_CDK_SPxxK_3	407	414	PF00069	0.208
MOD_CK1_1	10	16	PF00069	0.649
MOD_CK1_1	130	136	PF00069	0.276
MOD_CK1_1	222	228	PF00069	0.303
MOD_CK1_1	429	435	PF00069	0.352
MOD_CK1_1	630	636	PF00069	0.261
MOD_CK1_1	67	73	PF00069	0.256
MOD_CK2_1	128	134	PF00069	0.192
MOD_CK2_1	163	169	PF00069	0.303
MOD_CK2_1	224	230	PF00069	0.266
MOD_CK2_1	483	489	PF00069	0.266
MOD_CK2_1	67	73	PF00069	0.331
MOD_CK2_1	93	99	PF00069	0.249
MOD_GlcNHglycan	334	337	PF01048	0.354
MOD_GlcNHglycan	42	45	PF01048	0.654
MOD_GlcNHglycan	431	434	PF01048	0.380
MOD_GlcNHglycan	638	641	PF01048	0.534
MOD_GSK3_1	138	145	PF00069	0.234
MOD_GSK3_1	163	170	PF00069	0.286
MOD_GSK3_1	219	226	PF00069	0.319
MOD_GSK3_1	243	250	PF00069	0.281
MOD_GSK3_1	280	287	PF00069	0.221
MOD_GSK3_1	417	424	PF00069	0.410
MOD_GSK3_1	425	432	PF00069	0.382
MOD_GSK3_1	450	457	PF00069	0.508
MOD_GSK3_1	489	496	PF00069	0.294
MOD_GSK3_1	632	639	PF00069	0.238
MOD_GSK3_1	64	71	PF00069	0.373
MOD_N-GLC_1	127	132	PF02516	0.406
MOD_N-GLC_1	142	147	PF02516	0.416
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	106	111	PF00069	0.298
MOD_NEK2_1	122	127	PF00069	0.314
MOD_NEK2_1	212	217	PF00069	0.264
MOD_NEK2_1	24	29	PF00069	0.469
MOD_NEK2_1	306	311	PF00069	0.235
MOD_NEK2_1	332	337	PF00069	0.312
MOD_NEK2_1	417	422	PF00069	0.341
MOD_NEK2_1	452	457	PF00069	0.379
MOD_NEK2_1	493	498	PF00069	0.232
MOD_NEK2_1	504	509	PF00069	0.291
MOD_NEK2_1	575	580	PF00069	0.377
MOD_NEK2_1	621	626	PF00069	0.291
MOD_NEK2_1	627	632	PF00069	0.271
MOD_NEK2_1	64	69	PF00069	0.341
MOD_NEK2_1	642	647	PF00069	0.210
MOD_OFUCOSY	586	593	PF10250	0.410
MOD_PIKK_1	168	174	PF00454	0.351
MOD_PIKK_1	2	8	PF00454	0.605
MOD_PK_1	243	249	PF00069	0.266
MOD_PK_1	93	99	PF00069	0.297
MOD_PKA_1	138	144	PF00069	0.230
MOD_PKA_2	68	74	PF00069	0.372
MOD_Plk_1	168	174	PF00069	0.355
MOD_Plk_1	212	218	PF00069	0.266
MOD_Plk_1	51	57	PF00069	0.403
MOD_Plk_1	93	99	PF00069	0.315
MOD_Plk_4	106	112	PF00069	0.242
MOD_Plk_4	24	30	PF00069	0.480
MOD_Plk_4	280	286	PF00069	0.291
MOD_Plk_4	323	329	PF00069	0.288
MOD_Plk_4	417	423	PF00069	0.341
MOD_Plk_4	426	432	PF00069	0.253
MOD_Plk_4	483	489	PF00069	0.253
MOD_Plk_4	499	505	PF00069	0.174
MOD_Plk_4	529	535	PF00069	0.460
MOD_Plk_4	621	627	PF00069	0.275
MOD_Plk_4	663	669	PF00069	0.372
MOD_ProDKin_1	37	43	PF00069	0.544
MOD_ProDKin_1	407	413	PF00069	0.208
MOD_SUMO_for_1	92	95	PF00179	0.325
MOD_SUMO_rev_2	134	144	PF00179	0.152
MOD_SUMO_rev_2	226	236	PF00179	0.176
MOD_SUMO_rev_2	254	262	PF00179	0.292
TRG_DiLeu_BaEn_2	58	64	PF01217	0.350
TRG_DiLeu_BaEn_3	59	65	PF01217	0.228
TRG_ENDOCYTIC_2	155	158	PF00928	0.252
TRG_ENDOCYTIC_2	235	238	PF00928	0.275
TRG_ENDOCYTIC_2	466	469	PF00928	0.340
TRG_ENDOCYTIC_2	557	560	PF00928	0.329
TRG_ENDOCYTIC_2	569	572	PF00928	0.165
TRG_ENDOCYTIC_2	595	598	PF00928	0.408
TRG_ENDOCYTIC_2	646	649	PF00928	0.282
TRG_ENDOCYTIC_2	674	677	PF00928	0.460
TRG_ENDOCYTIC_2	79	82	PF00928	0.233
TRG_ER_diArg_1	136	138	PF00400	0.315
TRG_ER_diArg_1	670	672	PF00400	0.555
TRG_NES_CRM1_1	104	118	PF08389	0.278
TRG_NES_CRM1_1	264	276	PF08389	0.176
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.208

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	61%	100%
A0A0N1I2B1	Leptomonas seymouri	28%	100%
A0A0N1I6Y7	Leptomonas seymouri	30%	100%
A0A0N1IME8	Leptomonas seymouri	21%	100%
A0A0S4IV41	Bodo saltans	33%	100%
A0A0S4J9X2	Bodo saltans	40%	100%
A0A0S4JBB1	Bodo saltans	33%	100%
A0A0S4JCH7	Bodo saltans	33%	99%
A0A0S4JEU5	Bodo saltans	28%	100%
A0A0S4JIF4	Bodo saltans	36%	100%
A0A0S4JWZ9	Bodo saltans	21%	100%
A0A1X0NJN3	Trypanosomatidae	23%	100%
A0A1X0NK64	Trypanosomatidae	29%	100%
A0A1X0NZX5	Trypanosomatidae	48%	100%
A0A1X0P2G3	Trypanosomatidae	31%	100%
A0A1X0P6M4	Trypanosomatidae	28%	89%
A0A1X0PA12	Trypanosomatidae	33%	100%
A0A3Q8IBT4	Leishmania donovani	26%	100%
A0A3Q8IFM1	Leishmania donovani	30%	100%
A0A3Q8IHT3	Leishmania donovani	28%	100%
A0A3R7MBZ3	Trypanosoma rangeli	31%	100%
A0A3S7X2L7	Leishmania donovani	93%	100%
A0A422NED2	Trypanosoma rangeli	49%	100%
A0A422NMS9	Trypanosoma rangeli	31%	100%
A4H7C1	Leishmania braziliensis	25%	100%
A4HB85	Leishmania braziliensis	29%	100%
A4HHH4	Leishmania braziliensis	83%	100%
A4HHY3	Leishmania braziliensis	29%	100%
A4HVR6	Leishmania infantum	26%	100%
A4I4M3	Leishmania infantum	93%	100%
A4I563	Leishmania infantum	30%	100%
A4IAD3	Leishmania infantum	29%	100%
A4IFE9	Bos taurus	27%	100%
A5D7E2	Bos taurus	32%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	93%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AE21	Leishmania major	92%	100%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	89%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4HW17	Arabidopsis thaliana	26%	100%
F4JRE0	Arabidopsis thaliana	30%	100%
F4KIB2	Arabidopsis thaliana	32%	100%
O15321	Homo sapiens	26%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P58021	Mus musculus	30%	100%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4KLL4	Rattus norvegicus	33%	100%
Q4Q2H8	Leishmania major	29%	100%
Q4Q7S3	Leishmania major	29%	97%
Q4QG16	Leishmania major	23%	90%
Q54ZW0	Dictyostelium discoideum	26%	100%
Q55FP0	Dictyostelium discoideum	30%	100%
Q5R8F1	Pongo abelii	26%	100%
Q5R8Y6	Pongo abelii	30%	100%
Q5RDY2	Pongo abelii	32%	100%
Q66HF2	Rattus norvegicus	26%	100%
Q66HG5	Rattus norvegicus	29%	100%
Q7YTA6	Dictyostelium discoideum	21%	100%
Q8BH24	Mus musculus	33%	100%
Q8RWW1	Arabidopsis thaliana	32%	100%
Q92544	Homo sapiens	32%	100%
Q940G0	Arabidopsis thaliana	27%	100%
Q940S0	Arabidopsis thaliana	27%	100%
Q99805	Homo sapiens	30%	100%
Q9C5N2	Arabidopsis thaliana	33%	100%
Q9C720	Arabidopsis thaliana	32%	100%
Q9DBU0	Mus musculus	27%	100%
Q9FHT4	Arabidopsis thaliana	28%	100%
Q9FYQ8	Arabidopsis thaliana	29%	100%
Q9LIC2	Arabidopsis thaliana	32%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9ZPS7	Arabidopsis thaliana	27%	100%
V5BCD5	Trypanosoma cruzi	31%	100%
V5BHS7	Trypanosoma cruzi	28%	100%
V5D9U0	Trypanosoma cruzi	48%	100%
V5DII3	Trypanosoma cruzi	23%	100%