Integral membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein S linking to the trans Golgi network, putative

Species:

Leishmania mexicana

UniProt:

E9ALR0_LEIMU

TriTrypDb:

LmxM.08_29.1610

Length:

375

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, involved in protein trafficking.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	7
GO:0005802	trans-Golgi network	4	1
GO:0005829	cytosol	2	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

E9ALR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALR0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0006895	Golgi to endosome transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.664
CLV_NRD_NRD_1	192	194	PF00675	0.365
CLV_NRD_NRD_1	215	217	PF00675	0.278
CLV_NRD_NRD_1	239	241	PF00675	0.539
CLV_NRD_NRD_1	268	270	PF00675	0.398
CLV_PCSK_KEX2_1	192	194	PF00082	0.365
CLV_PCSK_KEX2_1	215	217	PF00082	0.278
CLV_PCSK_KEX2_1	239	241	PF00082	0.539
CLV_PCSK_KEX2_1	268	270	PF00082	0.289
CLV_PCSK_SKI1_1	217	221	PF00082	0.278
CLV_PCSK_SKI1_1	239	243	PF00082	0.457
CLV_PCSK_SKI1_1	34	38	PF00082	0.342
DEG_APCC_DBOX_1	192	200	PF00400	0.478
DEG_APCC_DBOX_1	268	276	PF00400	0.604
DEG_ODPH_VHL_1	113	125	PF01847	0.643
DOC_CKS1_1	76	81	PF01111	0.674
DOC_CYCLIN_RxL_1	213	221	PF00134	0.537
DOC_CYCLIN_RxL_1	31	41	PF00134	0.492
DOC_MAPK_DCC_7	52	62	PF00069	0.565
DOC_MAPK_gen_1	215	222	PF00069	0.478
DOC_MAPK_gen_1	268	277	PF00069	0.477
DOC_MAPK_MEF2A_6	215	222	PF00069	0.537
DOC_MAPK_NFAT4_5	215	223	PF00069	0.537
DOC_PP4_FxxP_1	132	135	PF00568	0.592
DOC_PP4_FxxP_1	140	143	PF00568	0.626
DOC_USP7_MATH_1	118	122	PF00917	0.720
DOC_USP7_MATH_1	135	139	PF00917	0.564
DOC_USP7_MATH_1	329	333	PF00917	0.756
DOC_USP7_MATH_1	339	343	PF00917	0.744
DOC_USP7_MATH_1	362	366	PF00917	0.693
DOC_WW_Pin1_4	139	144	PF00397	0.587
DOC_WW_Pin1_4	347	352	PF00397	0.651
DOC_WW_Pin1_4	75	80	PF00397	0.672
DOC_WW_Pin1_4	8	13	PF00397	0.352
LIG_14-3-3_CanoR_1	343	351	PF00244	0.619
LIG_14-3-3_CanoR_1	363	370	PF00244	0.698
LIG_14-3-3_CanoR_1	7	12	PF00244	0.400
LIG_APCC_ABBA_1	99	104	PF00400	0.614
LIG_BIR_II_1	1	5	PF00653	0.422
LIG_BIR_III_4	328	332	PF00653	0.721
LIG_BIR_III_4	337	341	PF00653	0.720
LIG_BRCT_BRCA1_1	10	14	PF00533	0.346
LIG_BRCT_BRCA1_1	120	124	PF00533	0.634
LIG_BRCT_BRCA1_1	128	132	PF00533	0.576
LIG_BRCT_BRCA1_1	23	27	PF00533	0.348
LIG_Clathr_ClatBox_1	122	126	PF01394	0.535
LIG_eIF4E_1	207	213	PF01652	0.478
LIG_eIF4E_1	227	233	PF01652	0.398
LIG_FHA_1	108	114	PF00498	0.738
LIG_FHA_1	163	169	PF00498	0.653
LIG_FHA_1	223	229	PF00498	0.316
LIG_FHA_1	261	267	PF00498	0.322
LIG_FHA_1	292	298	PF00498	0.652
LIG_FHA_1	31	37	PF00498	0.572
LIG_FHA_1	44	50	PF00498	0.566
LIG_FHA_2	148	154	PF00498	0.700
LIG_FHA_2	45	51	PF00498	0.634
LIG_LIR_Apic_2	129	135	PF02991	0.597
LIG_LIR_Apic_2	137	143	PF02991	0.622
LIG_LIR_Apic_2	68	74	PF02991	0.615
LIG_LIR_Gen_1	11	20	PF02991	0.268
LIG_LIR_Gen_1	24	35	PF02991	0.348
LIG_LIR_Nem_3	11	17	PF02991	0.268
LIG_LIR_Nem_3	225	230	PF02991	0.316
LIG_LIR_Nem_3	24	30	PF02991	0.348
LIG_MLH1_MIPbox_1	120	124	PF16413	0.535
LIG_MLH1_MIPbox_1	23	27	PF16413	0.316
LIG_NRBOX	237	243	PF00104	0.344
LIG_REV1ctd_RIR_1	121	131	PF16727	0.623
LIG_SH2_CRK	71	75	PF00017	0.669
LIG_SH2_NCK_1	71	75	PF00017	0.621
LIG_SH2_SRC	93	96	PF00017	0.613
LIG_SH2_STAT5	130	133	PF00017	0.596
LIG_SH2_STAT5	195	198	PF00017	0.489
LIG_SH2_STAT5	227	230	PF00017	0.316
LIG_SH2_STAT5	264	267	PF00017	0.349
LIG_SH3_3	112	118	PF00018	0.755
LIG_SH3_3	70	76	PF00018	0.665
LIG_SUMO_SIM_par_1	58	63	PF11976	0.566
LIG_TRAF2_1	307	310	PF00917	0.561
LIG_TRAF2_1	364	367	PF00917	0.688
LIG_TYR_ITIM	228	233	PF00017	0.316
LIG_Vh1_VBS_1	92	110	PF01044	0.597
MOD_CK1_1	109	115	PF00069	0.732
MOD_CK1_1	315	321	PF00069	0.674
MOD_CK1_1	347	353	PF00069	0.683
MOD_CK1_1	43	49	PF00069	0.655
MOD_CK2_1	147	153	PF00069	0.622
MOD_CK2_1	44	50	PF00069	0.625
MOD_GlcNHglycan	175	178	PF01048	0.412
MOD_GlcNHglycan	277	280	PF01048	0.447
MOD_GlcNHglycan	284	287	PF01048	0.452
MOD_GlcNHglycan	323	326	PF01048	0.517
MOD_GlcNHglycan	331	334	PF01048	0.434
MOD_GlcNHglycan	346	349	PF01048	0.478
MOD_GSK3_1	103	110	PF00069	0.768
MOD_GSK3_1	135	142	PF00069	0.678
MOD_GSK3_1	275	282	PF00069	0.704
MOD_GSK3_1	40	47	PF00069	0.626
MOD_N-GLC_1	321	326	PF02516	0.472
MOD_NEK2_1	103	108	PF00069	0.702
MOD_NEK2_1	203	208	PF00069	0.537
MOD_NEK2_1	222	227	PF00069	0.316
MOD_NEK2_1	254	259	PF00069	0.316
MOD_NEK2_1	30	35	PF00069	0.394
MOD_NEK2_1	42	47	PF00069	0.586
MOD_NEK2_1	5	10	PF00069	0.410
MOD_NEK2_1	60	65	PF00069	0.628
MOD_NEK2_2	118	123	PF00069	0.686
MOD_NEK2_2	135	140	PF00069	0.587
MOD_PIKK_1	315	321	PF00454	0.728
MOD_PKA_2	275	281	PF00069	0.701
MOD_PKA_2	315	321	PF00069	0.747
MOD_PKA_2	362	368	PF00069	0.641
MOD_Plk_1	103	109	PF00069	0.698
MOD_Plk_1	40	46	PF00069	0.633
MOD_Plk_4	118	124	PF00069	0.716
MOD_Plk_4	135	141	PF00069	0.550
MOD_Plk_4	208	214	PF00069	0.614
MOD_Plk_4	21	27	PF00069	0.316
MOD_Plk_4	222	228	PF00069	0.193
MOD_Plk_4	254	260	PF00069	0.297
MOD_Plk_4	291	297	PF00069	0.711
MOD_Plk_4	60	66	PF00069	0.607
MOD_ProDKin_1	139	145	PF00069	0.590
MOD_ProDKin_1	347	353	PF00069	0.651
MOD_ProDKin_1	75	81	PF00069	0.673
MOD_ProDKin_1	8	14	PF00069	0.347
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.344
TRG_ENDOCYTIC_2	230	233	PF00928	0.316
TRG_ER_diArg_1	157	160	PF00400	0.680
TRG_ER_diArg_1	192	194	PF00400	0.565
TRG_ER_diArg_1	238	240	PF00400	0.339
TRG_ER_diArg_1	341	344	PF00400	0.686
TRG_ER_diLys_1	371	375	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAN0	Leptomonas seymouri	45%	100%
A0A3Q8IDS8	Leishmania donovani	85%	100%
A4HHH5	Leishmania braziliensis	69%	100%
A4I4M5	Leishmania infantum	86%	100%
E9AE23	Leishmania major	84%	94%