Putative ABC transporter domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALQ7_LEIMU

TriTrypDb:

LmxM.08_29.1640

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.665
CLV_C14_Caspase3-7	430	434	PF00656	0.485
CLV_NRD_NRD_1	126	128	PF00675	0.403
CLV_NRD_NRD_1	288	290	PF00675	0.491
CLV_PCSK_KEX2_1	126	128	PF00082	0.403
CLV_PCSK_KEX2_1	288	290	PF00082	0.515
CLV_PCSK_SKI1_1	222	226	PF00082	0.346
CLV_PCSK_SKI1_1	317	321	PF00082	0.575
CLV_PCSK_SKI1_1	344	348	PF00082	0.610
CLV_PCSK_SKI1_1	88	92	PF00082	0.498
DEG_APCC_DBOX_1	221	229	PF00400	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DOC_CYCLIN_RxL_1	178	189	PF00134	0.316
DOC_CYCLIN_RxL_1	218	226	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.638
DOC_MAPK_gen_1	126	133	PF00069	0.403
DOC_MAPK_gen_1	218	227	PF00069	0.314
DOC_MAPK_gen_1	288	297	PF00069	0.406
DOC_PP1_RVXF_1	179	186	PF00149	0.346
DOC_PP2B_LxvP_1	118	121	PF13499	0.622
DOC_PP2B_LxvP_1	23	26	PF13499	0.531
DOC_PP2B_LxvP_1	413	416	PF13499	0.634
DOC_PP4_MxPP_1	399	402	PF00568	0.501
DOC_USP7_MATH_1	402	406	PF00917	0.708
DOC_USP7_MATH_1	95	99	PF00917	0.686
DOC_USP7_UBL2_3	211	215	PF12436	0.340
DOC_WW_Pin1_4	120	125	PF00397	0.442
DOC_WW_Pin1_4	14	19	PF00397	0.668
DOC_WW_Pin1_4	27	32	PF00397	0.611
DOC_WW_Pin1_4	446	451	PF00397	0.503
DOC_WW_Pin1_4	6	11	PF00397	0.749
LIG_14-3-3_CanoR_1	222	228	PF00244	0.403
LIG_14-3-3_CanoR_1	288	297	PF00244	0.422
LIG_14-3-3_CanoR_1	8	14	PF00244	0.769
LIG_APCC_ABBAyCdc20_2	41	47	PF00400	0.493
LIG_Clathr_ClatBox_1	261	265	PF01394	0.260
LIG_FHA_1	140	146	PF00498	0.346
LIG_FHA_1	156	162	PF00498	0.346
LIG_FHA_1	187	193	PF00498	0.346
LIG_FHA_1	266	272	PF00498	0.445
LIG_FHA_1	274	280	PF00498	0.419
LIG_FHA_1	290	296	PF00498	0.416
LIG_FHA_1	32	38	PF00498	0.613
LIG_FHA_1	334	340	PF00498	0.488
LIG_FHA_1	362	368	PF00498	0.513
LIG_FHA_2	195	201	PF00498	0.333
LIG_FHA_2	2	8	PF00498	0.489
LIG_FHA_2	31	37	PF00498	0.722
LIG_FHA_2	352	358	PF00498	0.498
LIG_FHA_2	428	434	PF00498	0.559
LIG_FHA_2	89	95	PF00498	0.513
LIG_LIR_Gen_1	129	136	PF02991	0.365
LIG_LIR_Gen_1	189	198	PF02991	0.346
LIG_LIR_Gen_1	321	330	PF02991	0.485
LIG_LIR_Nem_3	129	133	PF02991	0.365
LIG_LIR_Nem_3	189	193	PF02991	0.346
LIG_LIR_Nem_3	321	326	PF02991	0.444
LIG_LIR_Nem_3	333	338	PF02991	0.446
LIG_PTB_Apo_2	179	186	PF02174	0.360
LIG_SH2_STAP1	306	310	PF00017	0.361
LIG_SH2_STAP1	335	339	PF00017	0.487
LIG_SH2_STAT5	312	315	PF00017	0.421
LIG_SH2_STAT5	335	338	PF00017	0.440
LIG_SH3_2	121	126	PF14604	0.504
LIG_SH3_3	118	124	PF00018	0.569
LIG_SH3_3	199	205	PF00018	0.319
LIG_SH3_3	375	381	PF00018	0.563
LIG_SH3_3	392	398	PF00018	0.491
LIG_SH3_3	409	415	PF00018	0.640
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.350
LIG_SUMO_SIM_anti_2	276	281	PF11976	0.483
LIG_SUMO_SIM_par_1	19	27	PF11976	0.494
LIG_SUMO_SIM_par_1	260	266	PF11976	0.350
LIG_SUMO_SIM_par_1	275	281	PF11976	0.473
LIG_SUMO_SIM_par_1	80	89	PF11976	0.471
LIG_TRAF2_1	103	106	PF00917	0.554
LIG_TRAF2_1	33	36	PF00917	0.695
LIG_UBA3_1	208	215	PF00899	0.403
LIG_UBA3_1	282	291	PF00899	0.481
LIG_WRC_WIRS_1	187	192	PF05994	0.346
MOD_CDC14_SPxK_1	123	126	PF00782	0.268
MOD_CDK_SPxK_1	120	126	PF00069	0.304
MOD_CDK_SPxxK_3	120	127	PF00069	0.306
MOD_CK1_1	150	156	PF00069	0.355
MOD_CK1_1	17	23	PF00069	0.512
MOD_CK1_1	239	245	PF00069	0.346
MOD_CK1_1	3	9	PF00069	0.702
MOD_CK1_1	30	36	PF00069	0.617
MOD_CK1_1	40	46	PF00069	0.646
MOD_CK1_1	423	429	PF00069	0.555
MOD_CK1_1	446	452	PF00069	0.652
MOD_CK1_1	51	57	PF00069	0.631
MOD_CK2_1	1	7	PF00069	0.490
MOD_CK2_1	150	156	PF00069	0.392
MOD_CK2_1	194	200	PF00069	0.346
MOD_CK2_1	239	245	PF00069	0.311
MOD_CK2_1	30	36	PF00069	0.712
MOD_CK2_1	386	392	PF00069	0.567
MOD_CK2_1	46	52	PF00069	0.486
MOD_CK2_1	88	94	PF00069	0.495
MOD_GlcNHglycan	136	139	PF01048	0.326
MOD_GlcNHglycan	19	22	PF01048	0.660
MOD_GlcNHglycan	212	215	PF01048	0.340
MOD_GlcNHglycan	240	244	PF01048	0.342
MOD_GlcNHglycan	406	409	PF01048	0.598
MOD_GSK3_1	101	108	PF00069	0.624
MOD_GSK3_1	17	24	PF00069	0.723
MOD_GSK3_1	247	254	PF00069	0.354
MOD_GSK3_1	27	34	PF00069	0.646
MOD_GSK3_1	356	363	PF00069	0.725
MOD_GSK3_1	423	430	PF00069	0.607
MOD_N-GLC_1	27	32	PF02516	0.671
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	109	114	PF00069	0.547
MOD_NEK2_1	192	197	PF00069	0.337
MOD_NEK2_1	386	391	PF00069	0.629
MOD_NEK2_1	420	425	PF00069	0.567
MOD_NEK2_1	432	437	PF00069	0.702
MOD_PIKK_1	101	107	PF00454	0.585
MOD_PIKK_1	425	431	PF00454	0.643
MOD_PKA_2	247	253	PF00069	0.346
MOD_PKA_2	287	293	PF00069	0.431
MOD_PKA_2	40	46	PF00069	0.765
MOD_Plk_1	105	111	PF00069	0.613
MOD_Plk_1	46	52	PF00069	0.714
MOD_Plk_1	88	94	PF00069	0.490
MOD_Plk_4	140	146	PF00069	0.311
MOD_Plk_4	170	176	PF00069	0.391
MOD_Plk_4	204	210	PF00069	0.403
MOD_Plk_4	223	229	PF00069	0.403
MOD_Plk_4	257	263	PF00069	0.362
MOD_Plk_4	427	433	PF00069	0.557
MOD_ProDKin_1	120	126	PF00069	0.436
MOD_ProDKin_1	14	20	PF00069	0.668
MOD_ProDKin_1	27	33	PF00069	0.612
MOD_ProDKin_1	446	452	PF00069	0.502
MOD_ProDKin_1	6	12	PF00069	0.750
MOD_SUMO_for_1	330	333	PF00179	0.289
MOD_SUMO_rev_2	167	173	PF00179	0.391
TRG_DiLeu_BaEn_1	278	283	PF01217	0.465
TRG_ER_diArg_1	125	127	PF00400	0.403
TRG_ER_diArg_1	217	220	PF00400	0.346
TRG_ER_diArg_1	230	233	PF00400	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICD4	Leptomonas seymouri	74%	99%
A0A0S4J9X9	Bodo saltans	58%	100%
A0A3S7X2I8	Leishmania donovani	86%	100%
A4HHH8	Leishmania braziliensis	70%	96%
A4I4M8	Leishmania infantum	85%	100%
C9ZQV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	89%
E9AE26	Leishmania major	83%	100%