LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
thioredoxin, putative
Species:
Leishmania mexicana
UniProt:
E9ALQ6_LEIMU
TriTrypDb:
LmxM.08_29.1650
Length:
111

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ALQ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALQ6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 106 108 PF00082 0.764
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.764
DEG_SPOP_SBC_1 101 105 PF00917 0.611
DOC_USP7_MATH_1 19 23 PF00917 0.526
DOC_WW_Pin1_4 80 85 PF00397 0.718
DOC_WW_Pin1_4 92 97 PF00397 0.653
LIG_BRCT_BRCA1_1 11 15 PF00533 0.394
LIG_Clathr_ClatBox_1 29 33 PF01394 0.449
LIG_FHA_1 18 24 PF00498 0.299
LIG_LIR_Nem_3 51 55 PF02991 0.549
LIG_NRBOX 74 80 PF00104 0.501
LIG_SH3_3 95 101 PF00018 0.691
LIG_SUMO_SIM_anti_2 26 31 PF11976 0.549
LIG_SUMO_SIM_par_1 26 31 PF11976 0.549
LIG_WRC_WIRS_1 49 54 PF05994 0.549
MOD_CK1_1 48 54 PF00069 0.418
MOD_GlcNHglycan 108 111 PF01048 0.848
MOD_GSK3_1 102 109 PF00069 0.729
MOD_GSK3_1 19 26 PF00069 0.379
MOD_GSK3_1 5 12 PF00069 0.435
MOD_GSK3_1 80 87 PF00069 0.751
MOD_N-GLC_1 91 96 PF02516 0.705
MOD_N-GLC_2 57 59 PF02516 0.549
MOD_NEK2_1 23 28 PF00069 0.549
MOD_NEK2_2 9 14 PF00069 0.397
MOD_PIKK_1 64 70 PF00454 0.424
MOD_Plk_1 38 44 PF00069 0.549
MOD_Plk_4 23 29 PF00069 0.549
MOD_Plk_4 48 54 PF00069 0.549
MOD_ProDKin_1 80 86 PF00069 0.726
MOD_ProDKin_1 92 98 PF00069 0.650
MOD_SUMO_rev_2 4 8 PF00179 0.655
TRG_DiLeu_BaEn_1 71 76 PF01217 0.549
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A4I4K5 Leishmania infantum 88% 99%
E9AE27 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS