Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALQ5_LEIMU

TriTrypDb:

LmxM.08_29.1660

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.350
CLV_NRD_NRD_1	186	188	PF00675	0.361
CLV_NRD_NRD_1	48	50	PF00675	0.561
CLV_PCSK_FUR_1	46	50	PF00082	0.374
CLV_PCSK_KEX2_1	186	188	PF00082	0.345
CLV_PCSK_KEX2_1	48	50	PF00082	0.561
CLV_PCSK_SKI1_1	155	159	PF00082	0.429
CLV_PCSK_SKI1_1	187	191	PF00082	0.308
CLV_PCSK_SKI1_1	210	214	PF00082	0.294
CLV_PCSK_SKI1_1	51	55	PF00082	0.539
DEG_APCC_DBOX_1	186	194	PF00400	0.303
DOC_CYCLIN_RxL_1	46	55	PF00134	0.268
DOC_MAPK_gen_1	186	193	PF00069	0.335
DOC_MAPK_gen_1	46	56	PF00069	0.377
DOC_MAPK_MEF2A_6	186	195	PF00069	0.314
DOC_MAPK_MEF2A_6	48	56	PF00069	0.430
DOC_MAPK_NFAT4_5	49	57	PF00069	0.382
DOC_USP7_MATH_1	146	150	PF00917	0.547
LIG_14-3-3_CanoR_1	151	159	PF00244	0.602
LIG_APCC_ABBA_1	109	114	PF00400	0.536
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_deltaCOP1_diTrp_1	252	260	PF00928	0.351
LIG_FHA_1	142	148	PF00498	0.400
LIG_FHA_1	213	219	PF00498	0.519
LIG_FHA_1	23	29	PF00498	0.476
LIG_FHA_2	1	7	PF00498	0.508
LIG_FHA_2	124	130	PF00498	0.475
LIG_FHA_2	244	250	PF00498	0.392
LIG_FHA_2	45	51	PF00498	0.556
LIG_LIR_Gen_1	115	124	PF02991	0.419
LIG_LIR_Gen_1	204	212	PF02991	0.413
LIG_LIR_Gen_1	232	242	PF02991	0.349
LIG_LIR_Gen_1	252	261	PF02991	0.270
LIG_LIR_Gen_1	80	90	PF02991	0.452
LIG_LIR_Nem_3	115	121	PF02991	0.413
LIG_LIR_Nem_3	204	209	PF02991	0.441
LIG_LIR_Nem_3	232	237	PF02991	0.342
LIG_LIR_Nem_3	252	256	PF02991	0.336
LIG_LIR_Nem_3	55	61	PF02991	0.425
LIG_LIR_Nem_3	80	85	PF02991	0.437
LIG_NRBOX	189	195	PF00104	0.382
LIG_Pex14_1	234	238	PF04695	0.413
LIG_Pex14_4	78	83	PF04695	0.349
LIG_SH2_NCK_1	265	269	PF00017	0.444
LIG_SH2_NCK_1	72	76	PF00017	0.419
LIG_SH2_STAT5	206	209	PF00017	0.391
LIG_SH2_STAT5	265	268	PF00017	0.492
LIG_SH2_STAT5	95	98	PF00017	0.588
LIG_SUMO_SIM_par_1	192	197	PF11976	0.290
LIG_TRAF2_1	246	249	PF00917	0.442
LIG_UBA3_1	131	136	PF00899	0.322
LIG_WRC_WIRS_1	147	152	PF05994	0.416
MOD_CK1_1	141	147	PF00069	0.549
MOD_CK1_1	153	159	PF00069	0.604
MOD_CK1_1	161	167	PF00069	0.624
MOD_CK2_1	119	125	PF00069	0.413
MOD_CK2_1	2	8	PF00069	0.555
MOD_CK2_1	218	224	PF00069	0.551
MOD_CK2_1	243	249	PF00069	0.394
MOD_CK2_1	44	50	PF00069	0.554
MOD_CK2_1	85	91	PF00069	0.458
MOD_GlcNHglycan	11	14	PF01048	0.591
MOD_GlcNHglycan	120	124	PF01048	0.475
MOD_GlcNHglycan	155	158	PF01048	0.561
MOD_GlcNHglycan	174	177	PF01048	0.515
MOD_GSK3_1	119	126	PF00069	0.488
MOD_GSK3_1	146	153	PF00069	0.643
MOD_GSK3_1	161	168	PF00069	0.702
MOD_GSK3_1	208	215	PF00069	0.338
MOD_NEK2_1	150	155	PF00069	0.544
MOD_NEK2_1	158	163	PF00069	0.503
MOD_NEK2_1	194	199	PF00069	0.304
MOD_NEK2_1	208	213	PF00069	0.391
MOD_NEK2_1	261	266	PF00069	0.418
MOD_NEK2_1	52	57	PF00069	0.446
MOD_NEK2_1	85	90	PF00069	0.365
MOD_PKA_2	150	156	PF00069	0.619
MOD_PKA_2	85	91	PF00069	0.430
MOD_Plk_1	213	219	PF00069	0.299
MOD_Plk_2-3	102	108	PF00069	0.481
MOD_Plk_4	123	129	PF00069	0.502
MOD_Plk_4	229	235	PF00069	0.371
MOD_Plk_4	85	91	PF00069	0.509
TRG_ENDOCYTIC_2	118	121	PF00928	0.379
TRG_ENDOCYTIC_2	206	209	PF00928	0.391
TRG_ER_diArg_1	46	49	PF00400	0.329
TRG_NES_CRM1_1	188	204	PF08389	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM1	Leptomonas seymouri	56%	100%
A0A0S4ING2	Bodo saltans	23%	100%
A0A1X0NZY4	Trypanosomatidae	31%	100%
A0A3Q8IIV0	Leishmania donovani	88%	100%
A0A3R7KCM5	Trypanosoma rangeli	34%	100%
A4HHI0	Leishmania braziliensis	70%	100%
A4I4K6	Leishmania infantum	88%	100%
C9ZLB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AE28	Leishmania major	88%	100%
V5B997	Trypanosoma cruzi	32%	100%