LeishMANIAdb
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Folliculin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Folliculin domain-containing protein
Gene product:
Vesicle coat protein involved in Golgi to plasma membrane transport, putative
Species:
Leishmania mexicana
UniProt:
E9ALP3_LEIMU
TriTrypDb:
LmxM.08_29.1810
Length:
619

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005765 lysosomal membrane 7 1
GO:0005774 vacuolar membrane 5 1
GO:0005815 microtubule organizing center 2 1
GO:0005819 spindle 5 1
GO:0005829 cytosol 2 1
GO:0005929 cilium 4 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098852 lytic vacuole membrane 6 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

E9ALP3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALP3

Function

Biological processes
Term Name Level Count
GO:0009966 regulation of signal transduction 4 1
GO:0009967 positive regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010647 positive regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023056 positive regulation of signaling 4 1
GO:0032006 regulation of TOR signaling 6 1
GO:0032008 positive regulation of TOR signaling 7 1
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043087 regulation of GTPase activity 5 1
GO:0043547 positive regulation of GTPase activity 6 1
GO:0044093 positive regulation of molecular function 3 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048584 positive regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051336 regulation of hydrolase activity 4 1
GO:0051345 positive regulation of hydrolase activity 5 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902533 positive regulation of intracellular signal transduction 6 1
GO:1903432 regulation of TORC1 signaling 7 1
GO:1904263 positive regulation of TORC1 signaling 8 1
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 10
GO:0008047 enzyme activator activity 3 10
GO:0030234 enzyme regulator activity 2 10
GO:0030695 GTPase regulator activity 4 10
GO:0060589 nucleoside-triphosphatase regulator activity 3 10
GO:0098772 molecular function regulator activity 1 10
GO:0140677 molecular function activator activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 13 17 PF00656 0.502
CLV_C14_Caspase3-7 188 192 PF00656 0.512
CLV_C14_Caspase3-7 384 388 PF00656 0.387
CLV_NRD_NRD_1 114 116 PF00675 0.271
CLV_NRD_NRD_1 144 146 PF00675 0.390
CLV_NRD_NRD_1 172 174 PF00675 0.351
CLV_PCSK_KEX2_1 113 115 PF00082 0.315
CLV_PCSK_KEX2_1 144 146 PF00082 0.318
CLV_PCSK_KEX2_1 172 174 PF00082 0.351
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.332
CLV_PCSK_PC7_1 110 116 PF00082 0.271
CLV_PCSK_PC7_1 168 174 PF00082 0.404
CLV_PCSK_SKI1_1 177 181 PF00082 0.404
CLV_PCSK_SKI1_1 313 317 PF00082 0.459
CLV_PCSK_SKI1_1 363 367 PF00082 0.509
CLV_PCSK_SKI1_1 374 378 PF00082 0.341
CLV_PCSK_SKI1_1 40 44 PF00082 0.404
CLV_PCSK_SKI1_1 448 452 PF00082 0.523
CLV_PCSK_SKI1_1 49 53 PF00082 0.262
DEG_APCC_DBOX_1 114 122 PF00400 0.404
DEG_APCC_DBOX_1 172 180 PF00400 0.335
DEG_APCC_DBOX_1 39 47 PF00400 0.510
DEG_Nend_Nbox_1 1 3 PF02207 0.490
DEG_SCF_FBW7_1 507 513 PF00400 0.551
DOC_AGCK_PIF_2 24 29 PF00069 0.462
DOC_CKS1_1 2 7 PF01111 0.454
DOC_CKS1_1 507 512 PF01111 0.554
DOC_CYCLIN_RxL_1 270 281 PF00134 0.535
DOC_CYCLIN_RxL_1 309 317 PF00134 0.449
DOC_CYCLIN_RxL_1 34 47 PF00134 0.498
DOC_CYCLIN_yCln2_LP_2 2 8 PF00134 0.398
DOC_CYCLIN_yCln2_LP_2 219 225 PF00134 0.456
DOC_CYCLIN_yCln2_LP_2 452 458 PF00134 0.531
DOC_MAPK_gen_1 110 120 PF00069 0.275
DOC_MAPK_gen_1 459 468 PF00069 0.558
DOC_PP1_RVXF_1 271 278 PF00149 0.533
DOC_PP1_RVXF_1 361 368 PF00149 0.342
DOC_PP1_RVXF_1 410 416 PF00149 0.397
DOC_PP4_FxxP_1 102 105 PF00568 0.404
DOC_PP4_FxxP_1 120 123 PF00568 0.404
DOC_USP7_MATH_1 175 179 PF00917 0.325
DOC_USP7_MATH_1 304 308 PF00917 0.294
DOC_USP7_MATH_1 359 363 PF00917 0.432
DOC_USP7_MATH_1 433 437 PF00917 0.676
DOC_USP7_MATH_1 510 514 PF00917 0.684
DOC_USP7_MATH_1 556 560 PF00917 0.679
DOC_USP7_MATH_1 577 581 PF00917 0.575
DOC_WW_Pin1_4 1 6 PF00397 0.487
DOC_WW_Pin1_4 377 382 PF00397 0.481
DOC_WW_Pin1_4 386 391 PF00397 0.547
DOC_WW_Pin1_4 503 508 PF00397 0.735
DOC_WW_Pin1_4 519 524 PF00397 0.518
DOC_WW_Pin1_4 526 531 PF00397 0.618
DOC_WW_Pin1_4 585 590 PF00397 0.670
LIG_14-3-3_CanoR_1 177 186 PF00244 0.279
LIG_14-3-3_CanoR_1 254 262 PF00244 0.640
LIG_14-3-3_CanoR_1 363 368 PF00244 0.388
LIG_14-3-3_CanoR_1 412 416 PF00244 0.508
LIG_14-3-3_CanoR_1 448 453 PF00244 0.512
LIG_14-3-3_CanoR_1 525 531 PF00244 0.660
LIG_14-3-3_CanoR_1 535 539 PF00244 0.664
LIG_14-3-3_CanoR_1 543 547 PF00244 0.609
LIG_14-3-3_CanoR_1 573 581 PF00244 0.692
LIG_APCC_ABBAyCdc20_2 273 279 PF00400 0.532
LIG_BRCT_BRCA1_1 98 102 PF00533 0.305
LIG_CaM_IQ_9 413 429 PF13499 0.320
LIG_Clathr_ClatBox_1 275 279 PF01394 0.680
LIG_Clathr_ClatBox_1 395 399 PF01394 0.547
LIG_FHA_1 178 184 PF00498 0.370
LIG_FHA_1 380 386 PF00498 0.603
LIG_FHA_1 473 479 PF00498 0.460
LIG_FHA_2 186 192 PF00498 0.560
LIG_FHA_2 296 302 PF00498 0.497
LIG_FHA_2 322 328 PF00498 0.404
LIG_FHA_2 441 447 PF00498 0.557
LIG_FHA_2 76 82 PF00498 0.488
LIG_GBD_Chelix_1 334 342 PF00786 0.343
LIG_LIR_Apic_2 353 359 PF02991 0.392
LIG_LIR_Apic_2 99 105 PF02991 0.404
LIG_LIR_Gen_1 11 20 PF02991 0.349
LIG_LIR_Gen_1 124 130 PF02991 0.331
LIG_LIR_Gen_1 136 143 PF02991 0.223
LIG_LIR_Gen_1 157 164 PF02991 0.307
LIG_LIR_Gen_1 21 32 PF02991 0.353
LIG_LIR_Gen_1 373 383 PF02991 0.568
LIG_LIR_Nem_3 11 15 PF02991 0.361
LIG_LIR_Nem_3 124 128 PF02991 0.331
LIG_LIR_Nem_3 136 141 PF02991 0.223
LIG_LIR_Nem_3 21 27 PF02991 0.320
LIG_LIR_Nem_3 28 32 PF02991 0.398
LIG_LIR_Nem_3 373 378 PF02991 0.542
LIG_NRBOX 178 184 PF00104 0.270
LIG_PCNA_yPIPBox_3 31 43 PF02747 0.552
LIG_PCNA_yPIPBox_3 363 376 PF02747 0.368
LIG_Pex14_1 290 294 PF04695 0.317
LIG_Pex14_1 542 546 PF04695 0.561
LIG_Pex14_2 116 120 PF04695 0.404
LIG_Pex14_2 538 542 PF04695 0.774
LIG_Pex14_2 8 12 PF04695 0.451
LIG_Rb_pABgroove_1 390 398 PF01858 0.551
LIG_SH2_CRK 340 344 PF00017 0.502
LIG_SH2_CRK 356 360 PF00017 0.384
LIG_SH2_CRK 492 496 PF00017 0.496
LIG_SH2_GRB2like 68 71 PF00017 0.474
LIG_SH2_NCK_1 340 344 PF00017 0.447
LIG_SH2_PTP2 375 378 PF00017 0.594
LIG_SH2_SRC 68 71 PF00017 0.454
LIG_SH2_SRC 89 92 PF00017 0.459
LIG_SH2_STAP1 158 162 PF00017 0.335
LIG_SH2_STAP1 22 26 PF00017 0.436
LIG_SH2_STAP1 360 364 PF00017 0.403
LIG_SH2_STAP1 456 460 PF00017 0.443
LIG_SH2_STAT3 591 594 PF00017 0.644
LIG_SH2_STAT5 134 137 PF00017 0.335
LIG_SH2_STAT5 26 29 PF00017 0.479
LIG_SH2_STAT5 340 343 PF00017 0.531
LIG_SH2_STAT5 375 378 PF00017 0.588
LIG_SH2_STAT5 456 459 PF00017 0.505
LIG_SH2_STAT5 485 488 PF00017 0.467
LIG_SH2_STAT5 600 603 PF00017 0.603
LIG_SH2_STAT5 68 71 PF00017 0.474
LIG_SH3_3 210 216 PF00018 0.468
LIG_SH3_3 280 286 PF00018 0.526
LIG_SH3_3 373 379 PF00018 0.441
LIG_SH3_3 504 510 PF00018 0.597
LIG_TRAF2_1 198 201 PF00917 0.540
LIG_TRAF2_1 497 500 PF00917 0.600
LIG_TRAF2_1 82 85 PF00917 0.454
LIG_TRFH_1 340 344 PF08558 0.447
LIG_WRC_WIRS_1 364 369 PF05994 0.333
LIG_WRC_WIRS_1 602 607 PF05994 0.632
LIG_WRC_WIRS_1 97 102 PF05994 0.404
MOD_CDC14_SPxK_1 522 525 PF00782 0.655
MOD_CDK_SPxK_1 519 525 PF00069 0.629
MOD_CK1_1 184 190 PF00069 0.289
MOD_CK1_1 192 198 PF00069 0.559
MOD_CK1_1 307 313 PF00069 0.242
MOD_CK1_1 436 442 PF00069 0.616
MOD_CK1_1 464 470 PF00069 0.533
MOD_CK1_1 529 535 PF00069 0.622
MOD_CK1_1 537 543 PF00069 0.594
MOD_CK1_1 545 551 PF00069 0.549
MOD_CK1_1 554 560 PF00069 0.505
MOD_CK1_1 575 581 PF00069 0.600
MOD_CK1_1 79 85 PF00069 0.449
MOD_CK2_1 121 127 PF00069 0.386
MOD_CK2_1 175 181 PF00069 0.305
MOD_CK2_1 295 301 PF00069 0.567
MOD_CK2_1 440 446 PF00069 0.582
MOD_CK2_1 494 500 PF00069 0.653
MOD_CK2_1 75 81 PF00069 0.418
MOD_GlcNHglycan 305 309 PF01048 0.388
MOD_GlcNHglycan 316 319 PF01048 0.376
MOD_GlcNHglycan 468 471 PF01048 0.494
MOD_GlcNHglycan 512 515 PF01048 0.593
MOD_GlcNHglycan 526 529 PF01048 0.653
MOD_GlcNHglycan 539 542 PF01048 0.718
MOD_GlcNHglycan 556 559 PF01048 0.514
MOD_GlcNHglycan 560 563 PF01048 0.627
MOD_GlcNHglycan 57 60 PF01048 0.404
MOD_GlcNHglycan 583 586 PF01048 0.738
MOD_GlcNHglycan 91 94 PF01048 0.528
MOD_GSK3_1 144 151 PF00069 0.360
MOD_GSK3_1 177 184 PF00069 0.439
MOD_GSK3_1 185 192 PF00069 0.547
MOD_GSK3_1 30 37 PF00069 0.567
MOD_GSK3_1 338 345 PF00069 0.425
MOD_GSK3_1 359 366 PF00069 0.455
MOD_GSK3_1 436 443 PF00069 0.607
MOD_GSK3_1 444 451 PF00069 0.452
MOD_GSK3_1 462 469 PF00069 0.456
MOD_GSK3_1 502 509 PF00069 0.545
MOD_GSK3_1 537 544 PF00069 0.627
MOD_GSK3_1 554 561 PF00069 0.590
MOD_GSK3_1 572 579 PF00069 0.695
MOD_GSK3_1 581 588 PF00069 0.694
MOD_GSK3_1 75 82 PF00069 0.446
MOD_GSK3_1 96 103 PF00069 0.401
MOD_N-GLC_1 503 508 PF02516 0.641
MOD_N-GLC_1 548 553 PF02516 0.449
MOD_N-GLC_1 79 84 PF02516 0.452
MOD_NEK2_1 100 105 PF00069 0.459
MOD_NEK2_1 193 198 PF00069 0.606
MOD_NEK2_1 247 252 PF00069 0.507
MOD_NEK2_1 295 300 PF00069 0.589
MOD_NEK2_1 338 343 PF00069 0.362
MOD_NEK2_1 365 370 PF00069 0.426
MOD_NEK2_1 473 478 PF00069 0.512
MOD_NEK2_1 524 529 PF00069 0.653
MOD_NEK2_2 542 547 PF00069 0.680
MOD_PIKK_1 144 150 PF00454 0.404
MOD_PIKK_1 365 371 PF00454 0.393
MOD_PIKK_1 551 557 PF00454 0.752
MOD_PK_1 34 40 PF00069 0.631
MOD_PKA_1 144 150 PF00069 0.368
MOD_PKA_2 144 150 PF00069 0.368
MOD_PKA_2 30 36 PF00069 0.387
MOD_PKA_2 411 417 PF00069 0.551
MOD_PKA_2 524 530 PF00069 0.717
MOD_PKA_2 534 540 PF00069 0.702
MOD_PKA_2 542 548 PF00069 0.743
MOD_PKA_2 572 578 PF00069 0.692
MOD_PKB_1 459 467 PF00069 0.483
MOD_Plk_1 156 162 PF00069 0.267
MOD_Plk_1 436 442 PF00069 0.721
MOD_Plk_1 461 467 PF00069 0.574
MOD_Plk_1 548 554 PF00069 0.522
MOD_Plk_2-3 441 447 PF00069 0.493
MOD_Plk_4 307 313 PF00069 0.363
MOD_Plk_4 34 40 PF00069 0.613
MOD_Plk_4 342 348 PF00069 0.457
MOD_Plk_4 448 454 PF00069 0.493
MOD_Plk_4 96 102 PF00069 0.327
MOD_ProDKin_1 1 7 PF00069 0.475
MOD_ProDKin_1 377 383 PF00069 0.486
MOD_ProDKin_1 386 392 PF00069 0.541
MOD_ProDKin_1 503 509 PF00069 0.736
MOD_ProDKin_1 519 525 PF00069 0.520
MOD_ProDKin_1 526 532 PF00069 0.618
MOD_ProDKin_1 585 591 PF00069 0.669
TRG_DiLeu_BaEn_1 47 52 PF01217 0.482
TRG_DiLeu_BaLyEn_6 360 365 PF01217 0.480
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.517
TRG_ENDOCYTIC_2 125 128 PF00928 0.404
TRG_ENDOCYTIC_2 158 161 PF00928 0.289
TRG_ENDOCYTIC_2 26 29 PF00928 0.403
TRG_ENDOCYTIC_2 375 378 PF00928 0.439
TRG_ENDOCYTIC_2 492 495 PF00928 0.451
TRG_ER_diArg_1 114 116 PF00400 0.271
TRG_ER_diArg_1 143 145 PF00400 0.418
TRG_ER_diArg_1 487 490 PF00400 0.510
TRG_Pf-PMV_PEXEL_1 177 181 PF00026 0.335
TRG_Pf-PMV_PEXEL_1 239 243 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.473

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2V0 Leptomonas seymouri 58% 97%
A0A1X0NZX4 Trypanosomatidae 26% 100%
A0A3Q8IF87 Leishmania donovani 94% 100%
A0A3R7KI94 Trypanosoma rangeli 30% 100%
A4HIY5 Leishmania braziliensis 85% 99%
A4I4N9 Leishmania infantum 95% 100%
C9ZLC6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AE42 Leishmania major 91% 99%
V5ATT7 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS