Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALP0_LEIMU

TriTrypDb:

LmxM.08_29.1840

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.607
CLV_C14_Caspase3-7	220	224	PF00656	0.334
CLV_C14_Caspase3-7	3	7	PF00656	0.666
CLV_NRD_NRD_1	102	104	PF00675	0.459
CLV_NRD_NRD_1	320	322	PF00675	0.707
CLV_NRD_NRD_1	330	332	PF00675	0.738
CLV_PCSK_FUR_1	111	115	PF00082	0.434
CLV_PCSK_KEX2_1	102	104	PF00082	0.450
CLV_PCSK_KEX2_1	113	115	PF00082	0.433
CLV_PCSK_KEX2_1	212	214	PF00082	0.522
CLV_PCSK_KEX2_1	319	321	PF00082	0.696
CLV_PCSK_KEX2_1	329	331	PF00082	0.716
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.400
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.525
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.602
CLV_PCSK_PC7_1	109	115	PF00082	0.433
CLV_PCSK_SKI1_1	237	241	PF00082	0.624
CLV_PCSK_SKI1_1	255	259	PF00082	0.424
CLV_PCSK_SKI1_1	295	299	PF00082	0.665
CLV_PCSK_SKI1_1	85	89	PF00082	0.391
DEG_APCC_DBOX_1	225	233	PF00400	0.460
DEG_APCC_DBOX_1	62	70	PF00400	0.550
DEG_SCF_FBW7_2	297	302	PF00400	0.589
DOC_MAPK_gen_1	212	218	PF00069	0.455
DOC_MAPK_gen_1	255	261	PF00069	0.483
DOC_USP7_MATH_1	19	23	PF00917	0.663
DOC_USP7_MATH_1	270	274	PF00917	0.572
DOC_USP7_MATH_1	40	44	PF00917	0.622
DOC_WW_Pin1_4	295	300	PF00397	0.666
LIG_Actin_WH2_2	225	242	PF00022	0.568
LIG_Clathr_ClatBox_1	189	193	PF01394	0.450
LIG_eIF4E_1	254	260	PF01652	0.520
LIG_FHA_1	117	123	PF00498	0.403
LIG_FHA_1	270	276	PF00498	0.492
LIG_FHA_1	40	46	PF00498	0.605
LIG_FHA_1	68	74	PF00498	0.460
LIG_FHA_1	82	88	PF00498	0.329
LIG_GBD_Chelix_1	141	149	PF00786	0.517
LIG_LIR_Gen_1	157	167	PF02991	0.440
LIG_LIR_Gen_1	305	315	PF02991	0.665
LIG_LIR_Nem_3	157	163	PF02991	0.442
LIG_LIR_Nem_3	251	257	PF02991	0.404
LIG_LIR_Nem_3	305	311	PF02991	0.657
LIG_SH2_CRK	254	258	PF00017	0.406
LIG_SH2_CRK	308	312	PF00017	0.671
LIG_SH2_NCK_1	4	8	PF00017	0.538
LIG_SH2_SRC	4	7	PF00017	0.544
LIG_SH2_STAP1	4	8	PF00017	0.538
LIG_SH2_STAT3	32	35	PF00017	0.733
LIG_SH2_STAT5	8	11	PF00017	0.571
LIG_TRAF2_1	58	61	PF00917	0.470
LIG_TRAF2_1	92	95	PF00917	0.537
LIG_TYR_ITIM	252	257	PF00017	0.430
LIG_UBA3_1	258	266	PF00899	0.444
MOD_CK1_1	178	184	PF00069	0.488
MOD_CK2_1	270	276	PF00069	0.474
MOD_CK2_1	89	95	PF00069	0.543
MOD_GlcNHglycan	149	152	PF01048	0.468
MOD_GlcNHglycan	244	247	PF01048	0.493
MOD_GlcNHglycan	42	45	PF01048	0.614
MOD_GSK3_1	19	26	PF00069	0.696
MOD_GSK3_1	200	207	PF00069	0.460
MOD_GSK3_1	238	245	PF00069	0.470
MOD_GSK3_1	291	298	PF00069	0.608
MOD_GSK3_1	69	76	PF00069	0.459
MOD_N-GLC_1	81	86	PF02516	0.386
MOD_NEK2_1	239	244	PF00069	0.509
MOD_NEK2_1	69	74	PF00069	0.559
MOD_NEK2_1	81	86	PF00069	0.401
MOD_NEK2_1	89	94	PF00069	0.267
MOD_PIKK_1	197	203	PF00454	0.568
MOD_PIKK_1	87	93	PF00454	0.482
MOD_PKA_2	175	181	PF00069	0.567
MOD_Plk_1	81	87	PF00069	0.480
MOD_Plk_4	270	276	PF00069	0.503
MOD_ProDKin_1	295	301	PF00069	0.669
MOD_SUMO_rev_2	247	257	PF00179	0.395
MOD_SUMO_rev_2	302	307	PF00179	0.572
MOD_SUMO_rev_2	72	81	PF00179	0.428
MOD_SUMO_rev_2	90	99	PF00179	0.323
TRG_DiLeu_BaEn_1	48	53	PF01217	0.587
TRG_ENDOCYTIC_2	254	257	PF00928	0.409
TRG_ENDOCYTIC_2	308	311	PF00928	0.619
TRG_ER_diArg_1	101	103	PF00400	0.455
TRG_ER_diArg_1	108	111	PF00400	0.515
TRG_ER_diArg_1	14	17	PF00400	0.565
TRG_ER_diArg_1	329	331	PF00400	0.741

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC73	Leptomonas seymouri	70%	100%
A0A0S4J6B5	Bodo saltans	31%	70%
A0A1X0P000	Trypanosomatidae	30%	91%
A0A3S7X2L2	Leishmania donovani	96%	100%
A0A422NND5	Trypanosoma rangeli	29%	91%
A4HIY8	Leishmania braziliensis	88%	100%
A4I4P2	Leishmania infantum	96%	100%
C9ZLD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	86%
E9AE45	Leishmania major	97%	100%
V5BKZ3	Trypanosoma cruzi	28%	91%