Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALN8_LEIMU

TriTrypDb:

LmxM.08_29.1860

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.437
CLV_NRD_NRD_1	261	263	PF00675	0.688
CLV_NRD_NRD_1	445	447	PF00675	0.474
CLV_NRD_NRD_1	454	456	PF00675	0.462
CLV_NRD_NRD_1	482	484	PF00675	0.455
CLV_PCSK_KEX2_1	445	447	PF00082	0.432
CLV_PCSK_KEX2_1	453	455	PF00082	0.397
CLV_PCSK_KEX2_1	482	484	PF00082	0.297
CLV_PCSK_SKI1_1	375	379	PF00082	0.466
CLV_PCSK_SKI1_1	466	470	PF00082	0.410
DEG_APCC_DBOX_1	136	144	PF00400	0.412
DOC_MAPK_gen_1	134	142	PF00069	0.411
DOC_MAPK_gen_1	262	273	PF00069	0.612
DOC_MAPK_gen_1	482	489	PF00069	0.448
DOC_MAPK_JIP1_4	15	21	PF00069	0.527
DOC_MAPK_MEF2A_6	266	275	PF00069	0.494
DOC_MAPK_MEF2A_6	466	473	PF00069	0.383
DOC_PP2B_LxvP_1	206	209	PF13499	0.373
DOC_PP2B_LxvP_1	273	276	PF13499	0.495
DOC_PP4_FxxP_1	119	122	PF00568	0.406
DOC_PP4_FxxP_1	179	182	PF00568	0.339
DOC_PP4_FxxP_1	238	241	PF00568	0.635
DOC_USP7_MATH_1	194	198	PF00917	0.387
DOC_USP7_MATH_1	231	235	PF00917	0.438
DOC_USP7_MATH_1	302	306	PF00917	0.649
DOC_USP7_MATH_1	318	322	PF00917	0.623
DOC_USP7_MATH_1	329	333	PF00917	0.544
DOC_USP7_MATH_1	526	530	PF00917	0.313
DOC_USP7_MATH_1	549	553	PF00917	0.625
DOC_WW_Pin1_4	178	183	PF00397	0.338
DOC_WW_Pin1_4	252	257	PF00397	0.665
DOC_WW_Pin1_4	264	269	PF00397	0.527
DOC_WW_Pin1_4	307	312	PF00397	0.676
DOC_WW_Pin1_4	545	550	PF00397	0.641
LIG_14-3-3_CanoR_1	103	111	PF00244	0.440
LIG_14-3-3_CanoR_1	446	452	PF00244	0.395
LIG_14-3-3_CanoR_1	472	478	PF00244	0.372
LIG_14-3-3_CanoR_1	74	79	PF00244	0.487
LIG_APCC_ABBA_1	115	120	PF00400	0.391
LIG_eIF4E_1	347	353	PF01652	0.533
LIG_FHA_1	103	109	PF00498	0.416
LIG_FHA_1	172	178	PF00498	0.345
LIG_FHA_1	225	231	PF00498	0.522
LIG_FHA_1	234	240	PF00498	0.624
LIG_FHA_1	379	385	PF00498	0.450
LIG_FHA_1	421	427	PF00498	0.615
LIG_FHA_1	458	464	PF00498	0.425
LIG_LIR_Apic_2	178	182	PF02991	0.338
LIG_LIR_Apic_2	236	241	PF02991	0.630
LIG_LIR_Gen_1	67	73	PF02991	0.355
LIG_LIR_LC3C_4	467	471	PF02991	0.295
LIG_LIR_Nem_3	150	155	PF02991	0.390
LIG_LIR_Nem_3	438	443	PF02991	0.468
LIG_LIR_Nem_3	67	72	PF02991	0.361
LIG_LIR_Nem_3	83	88	PF02991	0.327
LIG_MYND_1	26	30	PF01753	0.431
LIG_PDZ_Class_1	549	554	PF00595	0.610
LIG_Pex14_1	151	155	PF04695	0.376
LIG_SH2_CRK	44	48	PF00017	0.307
LIG_SH2_SRC	462	465	PF00017	0.417
LIG_SH2_STAP1	44	48	PF00017	0.367
LIG_SH2_STAT3	118	121	PF00017	0.467
LIG_SH2_STAT5	118	121	PF00017	0.408
LIG_SH2_STAT5	155	158	PF00017	0.313
LIG_SH2_STAT5	205	208	PF00017	0.369
LIG_SH2_STAT5	221	224	PF00017	0.349
LIG_SH2_STAT5	347	350	PF00017	0.472
LIG_SH2_STAT5	351	354	PF00017	0.486
LIG_SH2_STAT5	366	369	PF00017	0.490
LIG_SH2_STAT5	440	443	PF00017	0.439
LIG_SH2_STAT5	449	452	PF00017	0.361
LIG_SH2_STAT5	462	465	PF00017	0.365
LIG_SH2_STAT5	504	507	PF00017	0.345
LIG_SH2_STAT5	508	511	PF00017	0.357
LIG_SH2_STAT5	518	521	PF00017	0.301
LIG_SH2_STAT5	52	55	PF00017	0.380
LIG_SH2_STAT5	85	88	PF00017	0.313
LIG_SH2_STAT5	90	93	PF00017	0.333
LIG_SH3_3	227	233	PF00018	0.518
LIG_SH3_3	238	244	PF00018	0.623
LIG_SH3_3	308	314	PF00018	0.664
LIG_SH3_3	520	526	PF00018	0.422
LIG_SH3_3	60	66	PF00018	0.459
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.543
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.445
LIG_SUMO_SIM_anti_2	467	472	PF11976	0.327
LIG_SUMO_SIM_par_1	15	20	PF11976	0.576
LIG_SUMO_SIM_par_1	171	178	PF11976	0.408
LIG_SUMO_SIM_par_1	221	227	PF11976	0.437
LIG_SUMO_SIM_par_1	271	279	PF11976	0.486
LIG_SUMO_SIM_par_1	485	491	PF11976	0.433
LIG_TRAF2_1	169	172	PF00917	0.378
LIG_WRC_WIRS_1	339	344	PF05994	0.586
MOD_CDC14_SPxK_1	548	551	PF00782	0.650
MOD_CDK_SPK_2	252	257	PF00069	0.665
MOD_CDK_SPxK_1	264	270	PF00069	0.494
MOD_CDK_SPxK_1	545	551	PF00069	0.644
MOD_CDK_SPxxK_3	178	185	PF00069	0.323
MOD_CK1_1	255	261	PF00069	0.630
MOD_CK1_1	274	280	PF00069	0.734
MOD_CK1_1	291	297	PF00069	0.728
MOD_CK1_1	321	327	PF00069	0.626
MOD_CK1_1	386	392	PF00069	0.480
MOD_CK1_1	476	482	PF00069	0.273
MOD_CK2_1	194	200	PF00069	0.498
MOD_DYRK1A_RPxSP_1	309	313	PF00069	0.624
MOD_GlcNHglycan	147	150	PF01048	0.448
MOD_GlcNHglycan	233	236	PF01048	0.610
MOD_GlcNHglycan	257	260	PF01048	0.675
MOD_GlcNHglycan	281	284	PF01048	0.609
MOD_GlcNHglycan	323	326	PF01048	0.632
MOD_GlcNHglycan	331	334	PF01048	0.594
MOD_GlcNHglycan	527	531	PF01048	0.404
MOD_GlcNHglycan	9	12	PF01048	0.604
MOD_GSK3_1	147	154	PF00069	0.478
MOD_GSK3_1	171	178	PF00069	0.350
MOD_GSK3_1	188	195	PF00069	0.417
MOD_GSK3_1	262	269	PF00069	0.623
MOD_GSK3_1	271	278	PF00069	0.692
MOD_GSK3_1	287	294	PF00069	0.706
MOD_GSK3_1	298	305	PF00069	0.743
MOD_GSK3_1	3	10	PF00069	0.488
MOD_GSK3_1	312	319	PF00069	0.602
MOD_GSK3_1	504	511	PF00069	0.332
MOD_GSK3_1	537	544	PF00069	0.549
MOD_GSK3_1	545	552	PF00069	0.580
MOD_GSK3_1	98	105	PF00069	0.401
MOD_N-GLC_1	279	284	PF02516	0.525
MOD_N-GLC_1	321	326	PF02516	0.730
MOD_N-GLC_1	420	425	PF02516	0.461
MOD_NEK2_1	192	197	PF00069	0.457
MOD_NEK2_1	287	292	PF00069	0.521
MOD_NEK2_1	3	8	PF00069	0.594
MOD_NEK2_1	36	41	PF00069	0.316
MOD_NEK2_1	378	383	PF00069	0.459
MOD_NEK2_1	419	424	PF00069	0.454
MOD_NEK2_1	73	78	PF00069	0.406
MOD_NEK2_2	211	216	PF00069	0.385
MOD_NEK2_2	233	238	PF00069	0.616
MOD_NMyristoyl	1	7	PF02799	0.570
MOD_PIKK_1	224	230	PF00454	0.498
MOD_PIKK_1	378	384	PF00454	0.457
MOD_PKA_1	262	268	PF00069	0.576
MOD_PKA_2	102	108	PF00069	0.366
MOD_PKA_2	73	79	PF00069	0.503
MOD_PKA_2	92	98	PF00069	0.364
MOD_PKB_1	336	344	PF00069	0.584
MOD_Plk_1	188	194	PF00069	0.544
MOD_Plk_1	31	37	PF00069	0.411
MOD_Plk_1	526	532	PF00069	0.287
MOD_Plk_4	147	153	PF00069	0.459
MOD_Plk_4	233	239	PF00069	0.619
MOD_Plk_4	31	37	PF00069	0.389
MOD_Plk_4	485	491	PF00069	0.439
MOD_Plk_4	504	510	PF00069	0.236
MOD_ProDKin_1	178	184	PF00069	0.339
MOD_ProDKin_1	252	258	PF00069	0.668
MOD_ProDKin_1	264	270	PF00069	0.529
MOD_ProDKin_1	307	313	PF00069	0.671
MOD_ProDKin_1	545	551	PF00069	0.644
MOD_SUMO_for_1	26	29	PF00179	0.374
MOD_SUMO_rev_2	10	17	PF00179	0.532
MOD_SUMO_rev_2	488	495	PF00179	0.412
TRG_ENDOCYTIC_2	221	224	PF00928	0.408
TRG_ENDOCYTIC_2	44	47	PF00928	0.308
TRG_ENDOCYTIC_2	440	443	PF00928	0.396
TRG_ENDOCYTIC_2	85	88	PF00928	0.372
TRG_ER_diArg_1	444	446	PF00400	0.465
TRG_ER_diArg_1	452	455	PF00400	0.459
TRG_NES_CRM1_1	346	362	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.488
TRG_PTS1	551	554	PF00515	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS69	Leptomonas seymouri	63%	94%
A0A0S4KE41	Bodo saltans	43%	100%
A0A3Q8IEE2	Leishmania donovani	94%	100%
A4HIZ0	Leishmania braziliensis	82%	100%
A4I4P4	Leishmania infantum	94%	100%
E9AE47	Leishmania major	93%	100%