J domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALN5_LEIMU

TriTrypDb:

LmxM.08_29.1890

Length:

396

Annotations

LeishMANIAdb annotations

Apparently a divergent chaperone with distant Eukaryotic affinities. Topology is very unclear. Likely non-TM

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ALN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.545
CLV_C14_Caspase3-7	308	312	PF00656	0.591
CLV_NRD_NRD_1	126	128	PF00675	0.445
CLV_NRD_NRD_1	16	18	PF00675	0.373
CLV_NRD_NRD_1	199	201	PF00675	0.441
CLV_NRD_NRD_1	206	208	PF00675	0.407
CLV_NRD_NRD_1	256	258	PF00675	0.437
CLV_NRD_NRD_1	264	266	PF00675	0.438
CLV_NRD_NRD_1	331	333	PF00675	0.486
CLV_PCSK_KEX2_1	126	128	PF00082	0.487
CLV_PCSK_KEX2_1	16	18	PF00082	0.373
CLV_PCSK_KEX2_1	199	201	PF00082	0.439
CLV_PCSK_KEX2_1	206	208	PF00082	0.409
CLV_PCSK_KEX2_1	264	266	PF00082	0.416
CLV_PCSK_KEX2_1	330	332	PF00082	0.502
CLV_PCSK_SKI1_1	16	20	PF00082	0.294
CLV_PCSK_SKI1_1	238	242	PF00082	0.389
CLV_PCSK_SKI1_1	33	37	PF00082	0.192
CLV_PCSK_SKI1_1	360	364	PF00082	0.682
CLV_PCSK_SKI1_1	376	380	PF00082	0.629
CLV_PCSK_SKI1_1	39	43	PF00082	0.289
DEG_Nend_Nbox_1	1	3	PF02207	0.707
DEG_SCF_TRCP1_1	83	88	PF00400	0.627
DOC_ANK_TNKS_1	140	147	PF00023	0.667
DOC_CKS1_1	361	366	PF01111	0.561
DOC_CYCLIN_RxL_1	11	23	PF00134	0.543
DOC_MAPK_gen_1	264	273	PF00069	0.653
DOC_PP2B_LxvP_1	278	281	PF13499	0.725
DOC_PP4_FxxP_1	177	180	PF00568	0.601
DOC_USP7_MATH_1	282	286	PF00917	0.549
DOC_USP7_MATH_1	3	7	PF00917	0.512
DOC_USP7_MATH_1	78	82	PF00917	0.724
DOC_USP7_UBL2_3	241	245	PF12436	0.619
DOC_WW_Pin1_4	25	30	PF00397	0.550
DOC_WW_Pin1_4	360	365	PF00397	0.559
LIG_14-3-3_CanoR_1	353	358	PF00244	0.696
LIG_14-3-3_CanoR_1	371	375	PF00244	0.456
LIG_ActinCP_TwfCPI_2	177	186	PF01115	0.683
LIG_BIR_III_2	279	283	PF00653	0.541
LIG_BIR_III_4	46	50	PF00653	0.478
LIG_BRCT_BRCA1_1	156	160	PF00533	0.637
LIG_FHA_2	140	146	PF00498	0.707
LIG_FHA_2	192	198	PF00498	0.604
LIG_FHA_2	26	32	PF00498	0.503
LIG_FHA_2	378	384	PF00498	0.509
LIG_IBAR_NPY_1	187	189	PF08397	0.638
LIG_LIR_Apic_2	174	180	PF02991	0.614
LIG_LIR_Apic_2	183	188	PF02991	0.633
LIG_LIR_Apic_2	244	250	PF02991	0.680
LIG_LIR_Apic_2	88	94	PF02991	0.714
LIG_LIR_Gen_1	111	118	PF02991	0.637
LIG_LIR_Gen_1	194	201	PF02991	0.485
LIG_LIR_Gen_1	251	260	PF02991	0.633
LIG_LIR_Nem_3	173	178	PF02991	0.611
LIG_LIR_Nem_3	194	198	PF02991	0.610
LIG_LIR_Nem_3	251	256	PF02991	0.641
LIG_LIR_Nem_3	52	57	PF02991	0.478
LIG_MAD2	353	361	PF02301	0.692
LIG_PDZ_Class_3	391	396	PF00595	0.462
LIG_Pex14_1	109	113	PF04695	0.667
LIG_Pex14_2	151	155	PF04695	0.736
LIG_SH2_CRK	185	189	PF00017	0.660
LIG_SH2_CRK	91	95	PF00017	0.557
LIG_SH2_GRB2like	182	185	PF00017	0.677
LIG_SH2_STAP1	381	385	PF00017	0.510
LIG_SH2_STAP1	61	65	PF00017	0.520
LIG_SH2_STAT3	252	255	PF00017	0.647
LIG_SH2_STAT5	113	116	PF00017	0.643
LIG_SH2_STAT5	176	179	PF00017	0.616
LIG_SH2_STAT5	228	231	PF00017	0.591
LIG_SH2_STAT5	27	30	PF00017	0.487
LIG_SH3_3	346	352	PF00018	0.476
LIG_SH3_3	358	364	PF00018	0.512
LIG_Sin3_3	210	217	PF02671	0.453
LIG_TRAF2_1	194	197	PF00917	0.605
LIG_TRAF2_1	201	204	PF00917	0.590
LIG_WRPW_2	178	181	PF00400	0.601
MOD_CK1_1	81	87	PF00069	0.680
MOD_CK2_1	139	145	PF00069	0.711
MOD_CK2_1	191	197	PF00069	0.592
MOD_Cter_Amidation	70	73	PF01082	0.466
MOD_DYRK1A_RPxSP_1	360	364	PF00069	0.560
MOD_GlcNHglycan	13	16	PF01048	0.359
MOD_GlcNHglycan	220	223	PF01048	0.426
MOD_GlcNHglycan	345	348	PF01048	0.364
MOD_GlcNHglycan	82	86	PF01048	0.491
MOD_GlcNHglycan	87	90	PF01048	0.493
MOD_GSK3_1	167	174	PF00069	0.735
MOD_GSK3_1	314	321	PF00069	0.737
MOD_GSK3_1	370	377	PF00069	0.575
MOD_GSK3_1	81	88	PF00069	0.696
MOD_N-GLC_1	170	175	PF02516	0.427
MOD_N-GLC_2	121	123	PF02516	0.486
MOD_NEK2_1	155	160	PF00069	0.675
MOD_NEK2_1	370	375	PF00069	0.520
MOD_PIKK_1	101	107	PF00454	0.692
MOD_PIKK_1	165	171	PF00454	0.681
MOD_PIKK_1	318	324	PF00454	0.710
MOD_PKA_2	3	9	PF00069	0.608
MOD_PKA_2	370	376	PF00069	0.521
MOD_PKB_1	37	45	PF00069	0.533
MOD_Plk_1	170	176	PF00069	0.684
MOD_Plk_1	383	389	PF00069	0.484
MOD_Plk_1	66	72	PF00069	0.592
MOD_Plk_2-3	383	389	PF00069	0.495
MOD_Plk_4	171	177	PF00069	0.683
MOD_Plk_4	3	9	PF00069	0.626
MOD_ProDKin_1	25	31	PF00069	0.550
MOD_ProDKin_1	360	366	PF00069	0.561
MOD_SUMO_rev_2	149	158	PF00179	0.627
MOD_SUMO_rev_2	26	35	PF00179	0.487
TRG_ENDOCYTIC_2	113	116	PF00928	0.643
TRG_ENDOCYTIC_2	61	64	PF00928	0.478
TRG_ER_diArg_1	134	137	PF00400	0.633
TRG_ER_diArg_1	16	18	PF00400	0.578
TRG_ER_diArg_1	198	200	PF00400	0.595
TRG_ER_diArg_1	330	332	PF00400	0.691
TRG_NLS_MonoExtN_4	264	269	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P346	Leptomonas seymouri	54%	100%
A0A1X0NJW8	Trypanosomatidae	32%	100%
A0A3Q8IEI2	Leishmania donovani	86%	100%
A0A422P027	Trypanosoma rangeli	30%	100%
A4HHI9	Leishmania braziliensis	70%	100%
A4I4P7	Leishmania infantum	86%	100%
E9AE50	Leishmania major	87%	100%
E9B1H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q6N7	Leishmania major	29%	100%
V5BN31	Trypanosoma cruzi	31%	100%