Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALN3_LEIMU

TriTrypDb:

LmxM.08_29.1910

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.543
CLV_C14_Caspase3-7	309	313	PF00656	0.593
CLV_C14_Caspase3-7	325	329	PF00656	0.745
CLV_C14_Caspase3-7	335	339	PF00656	0.694
CLV_NRD_NRD_1	207	209	PF00675	0.393
CLV_NRD_NRD_1	321	323	PF00675	0.648
CLV_NRD_NRD_1	376	378	PF00675	0.438
CLV_NRD_NRD_1	435	437	PF00675	0.541
CLV_NRD_NRD_1	70	72	PF00675	0.545
CLV_PCSK_FUR_1	374	378	PF00082	0.455
CLV_PCSK_KEX2_1	207	209	PF00082	0.473
CLV_PCSK_KEX2_1	215	217	PF00082	0.426
CLV_PCSK_KEX2_1	235	237	PF00082	0.377
CLV_PCSK_KEX2_1	323	325	PF00082	0.732
CLV_PCSK_KEX2_1	376	378	PF00082	0.391
CLV_PCSK_KEX2_1	70	72	PF00082	0.491
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.462
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.377
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.732
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.500
CLV_PCSK_PC7_1	374	380	PF00082	0.429
CLV_PCSK_PC7_1	66	72	PF00082	0.436
CLV_PCSK_SKI1_1	175	179	PF00082	0.372
CLV_PCSK_SKI1_1	216	220	PF00082	0.438
CLV_PCSK_SKI1_1	359	363	PF00082	0.470
CLV_PCSK_SKI1_1	370	374	PF00082	0.430
CLV_PCSK_SKI1_1	401	405	PF00082	0.493
CLV_PCSK_SKI1_1	70	74	PF00082	0.462
CLV_Separin_Metazoa	371	375	PF03568	0.487
DOC_CYCLIN_RxL_1	10	24	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.357
DOC_MAPK_gen_1	173	180	PF00069	0.428
DOC_MAPK_gen_1	95	101	PF00069	0.791
DOC_PP1_RVXF_1	14	21	PF00149	0.316
DOC_PP2B_LxvP_1	178	181	PF13499	0.385
DOC_PP4_FxxP_1	258	261	PF00568	0.525
DOC_PP4_FxxP_1	41	44	PF00568	0.478
DOC_USP7_MATH_1	135	139	PF00917	0.638
DOC_USP7_MATH_1	269	273	PF00917	0.652
DOC_USP7_MATH_1	302	306	PF00917	0.651
DOC_USP7_MATH_1	91	95	PF00917	0.682
DOC_USP7_UBL2_3	400	404	PF12436	0.574
DOC_WW_Pin1_4	188	193	PF00397	0.495
LIG_14-3-3_CanoR_1	100	110	PF00244	0.477
LIG_14-3-3_CanoR_1	324	332	PF00244	0.799
LIG_14-3-3_CanoR_1	377	385	PF00244	0.457
LIG_Actin_WH2_2	159	177	PF00022	0.439
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_deltaCOP1_diTrp_1	282	288	PF00928	0.430
LIG_FHA_1	53	59	PF00498	0.404
LIG_FHA_2	323	329	PF00498	0.646
LIG_FHA_2	344	350	PF00498	0.472
LIG_FHA_2	384	390	PF00498	0.396
LIG_FHA_2	393	399	PF00498	0.365
LIG_FHA_2	409	415	PF00498	0.424
LIG_LIR_Apic_2	255	261	PF02991	0.497
LIG_LIR_Apic_2	38	44	PF02991	0.471
LIG_LIR_Gen_1	282	288	PF02991	0.437
LIG_LIR_Nem_3	282	286	PF02991	0.443
LIG_PTB_Apo_2	226	233	PF02174	0.435
LIG_SH2_NCK_1	394	398	PF00017	0.535
LIG_SH2_STAP1	158	162	PF00017	0.505
LIG_SH2_STAT5	360	363	PF00017	0.484
LIG_SH2_STAT5	394	397	PF00017	0.413
LIG_SH3_3	104	110	PF00018	0.726
LIG_SH3_3	178	184	PF00018	0.554
LIG_SH3_3	253	259	PF00018	0.346
LIG_SUMO_SIM_par_1	443	449	PF11976	0.400
LIG_TRAF2_1	109	112	PF00917	0.612
LIG_TRAF2_1	127	130	PF00917	0.460
LIG_WRC_WIRS_1	285	290	PF05994	0.436
MOD_CK1_1	273	279	PF00069	0.709
MOD_CK1_1	305	311	PF00069	0.680
MOD_CK1_1	381	387	PF00069	0.584
MOD_CK1_1	413	419	PF00069	0.438
MOD_CK2_1	118	124	PF00069	0.750
MOD_CK2_1	315	321	PF00069	0.719
MOD_CK2_1	343	349	PF00069	0.607
MOD_CK2_1	381	387	PF00069	0.417
MOD_CK2_1	392	398	PF00069	0.367
MOD_CK2_1	408	414	PF00069	0.427
MOD_CK2_1	443	449	PF00069	0.523
MOD_GlcNHglycan	104	107	PF01048	0.545
MOD_GlcNHglycan	137	140	PF01048	0.527
MOD_GlcNHglycan	267	270	PF01048	0.759
MOD_GlcNHglycan	299	305	PF01048	0.737
MOD_GlcNHglycan	312	316	PF01048	0.735
MOD_GSK3_1	130	137	PF00069	0.584
MOD_GSK3_1	139	146	PF00069	0.558
MOD_GSK3_1	223	230	PF00069	0.518
MOD_GSK3_1	265	272	PF00069	0.710
MOD_GSK3_1	311	318	PF00069	0.675
MOD_GSK3_1	327	334	PF00069	0.679
MOD_GSK3_1	406	413	PF00069	0.529
MOD_GSK3_1	52	59	PF00069	0.515
MOD_GSK3_1	81	88	PF00069	0.529
MOD_GSK3_1	91	98	PF00069	0.657
MOD_N-GLC_1	228	233	PF02516	0.603
MOD_N-GLC_1	269	274	PF02516	0.624
MOD_NEK2_1	21	26	PF00069	0.473
MOD_NEK2_1	228	233	PF00069	0.513
MOD_NEK2_1	99	104	PF00069	0.667
MOD_NEK2_2	443	448	PF00069	0.405
MOD_PIKK_1	315	321	PF00454	0.806
MOD_PKA_1	235	241	PF00069	0.406
MOD_PKA_1	322	328	PF00069	0.774
MOD_PKA_1	378	384	PF00069	0.441
MOD_PKA_1	95	101	PF00069	0.605
MOD_PKA_2	235	241	PF00069	0.406
MOD_PKA_2	330	336	PF00069	0.789
MOD_PKA_2	378	384	PF00069	0.484
MOD_PKA_2	432	438	PF00069	0.539
MOD_PKA_2	99	105	PF00069	0.484
MOD_PKB_1	322	330	PF00069	0.682
MOD_Plk_1	129	135	PF00069	0.729
MOD_Plk_1	228	234	PF00069	0.622
MOD_Plk_1	381	387	PF00069	0.600
MOD_Plk_2-3	119	125	PF00069	0.480
MOD_Plk_4	223	229	PF00069	0.501
MOD_Plk_4	43	49	PF00069	0.464
MOD_Plk_4	81	87	PF00069	0.393
MOD_ProDKin_1	188	194	PF00069	0.487
MOD_SUMO_rev_2	212	217	PF00179	0.515
MOD_SUMO_rev_2	318	325	PF00179	0.748
TRG_DiLeu_BaEn_1	398	403	PF01217	0.523
TRG_DiLeu_BaEn_1	78	83	PF01217	0.390
TRG_DiLeu_BaEn_2	413	419	PF01217	0.595
TRG_ER_diArg_1	172	175	PF00400	0.397
TRG_ER_diArg_1	206	208	PF00400	0.452
TRG_ER_diArg_1	377	380	PF00400	0.396
TRG_ER_diArg_1	69	71	PF00400	0.531
TRG_ER_FFAT_1	413	424	PF00635	0.378
TRG_NLS_MonoExtC_3	322	328	PF00514	0.706
TRG_NLS_MonoExtC_3	376	382	PF00514	0.413
TRG_NLS_MonoExtN_4	322	327	PF00514	0.787
TRG_NLS_MonoExtN_4	374	381	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB34	Leptomonas seymouri	49%	87%
A0A0S4JH57	Bodo saltans	27%	85%
A0A1X0P158	Trypanosomatidae	32%	100%
A0A3R7MJJ2	Trypanosoma rangeli	32%	100%
A0A3S7X2K3	Leishmania donovani	91%	98%
A4HHJ1	Leishmania braziliensis	75%	100%
A4I4P9	Leishmania infantum	91%	98%
C9ZLD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AE52	Leishmania major	88%	100%
V5BGH3	Trypanosoma cruzi	30%	100%