LeishMANIAdb
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EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALN1_LEIMU
TriTrypDb:
LmxM.08_29.1930
Length:
603

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

E9ALN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALN1

Function

Biological processes
Term Name Level Count
GO:0019220 regulation of phosphate metabolic process 6 7
GO:0019222 regulation of metabolic process 3 7
GO:0031323 regulation of cellular metabolic process 4 7
GO:0035303 regulation of dephosphorylation 7 7
GO:0050789 regulation of biological process 2 7
GO:0050794 regulation of cellular process 3 7
GO:0051174 regulation of phosphorus metabolic process 5 7
GO:0065007 biological regulation 1 7
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0030865 cortical cytoskeleton organization 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0005509 calcium ion binding 5 6
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.545
CLV_NRD_NRD_1 171 173 PF00675 0.833
CLV_NRD_NRD_1 376 378 PF00675 0.438
CLV_NRD_NRD_1 491 493 PF00675 0.464
CLV_NRD_NRD_1 60 62 PF00675 0.709
CLV_PCSK_KEX2_1 170 172 PF00082 0.810
CLV_PCSK_KEX2_1 240 242 PF00082 0.713
CLV_PCSK_KEX2_1 376 378 PF00082 0.438
CLV_PCSK_KEX2_1 60 62 PF00082 0.605
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.742
CLV_PCSK_SKI1_1 376 380 PF00082 0.440
CLV_PCSK_SKI1_1 387 391 PF00082 0.424
CLV_PCSK_SKI1_1 430 434 PF00082 0.577
DEG_SPOP_SBC_1 152 156 PF00917 0.495
DEG_SPOP_SBC_1 4 8 PF00917 0.649
DOC_CKS1_1 524 529 PF01111 0.467
DOC_CYCLIN_RxL_1 373 383 PF00134 0.443
DOC_CYCLIN_yCln2_LP_2 194 200 PF00134 0.761
DOC_MAPK_MEF2A_6 290 297 PF00069 0.511
DOC_MAPK_MEF2A_6 93 101 PF00069 0.482
DOC_PP1_RVXF_1 374 381 PF00149 0.440
DOC_PP1_RVXF_1 491 498 PF00149 0.442
DOC_PP2B_LxvP_1 150 153 PF13499 0.653
DOC_PP2B_LxvP_1 194 197 PF13499 0.759
DOC_PP2B_LxvP_1 546 549 PF13499 0.504
DOC_USP7_MATH_1 222 226 PF00917 0.750
DOC_USP7_MATH_1 4 8 PF00917 0.691
DOC_USP7_MATH_1 42 46 PF00917 0.586
DOC_USP7_MATH_1 468 472 PF00917 0.545
DOC_USP7_MATH_1 505 509 PF00917 0.489
DOC_USP7_MATH_1 62 66 PF00917 0.375
DOC_USP7_UBL2_3 102 106 PF12436 0.518
DOC_WW_Pin1_4 185 190 PF00397 0.833
DOC_WW_Pin1_4 192 197 PF00397 0.637
DOC_WW_Pin1_4 205 210 PF00397 0.808
DOC_WW_Pin1_4 247 252 PF00397 0.694
DOC_WW_Pin1_4 464 469 PF00397 0.484
DOC_WW_Pin1_4 523 528 PF00397 0.472
DOC_WW_Pin1_4 575 580 PF00397 0.477
LIG_14-3-3_CanoR_1 123 129 PF00244 0.536
LIG_14-3-3_CanoR_1 18 23 PF00244 0.686
LIG_14-3-3_CanoR_1 339 345 PF00244 0.500
LIG_14-3-3_CanoR_1 391 396 PF00244 0.429
LIG_14-3-3_CanoR_1 61 70 PF00244 0.577
LIG_14-3-3_CanoR_1 86 95 PF00244 0.527
LIG_Actin_RPEL_3 570 589 PF02755 0.453
LIG_BIR_II_1 1 5 PF00653 0.790
LIG_BIR_III_4 220 224 PF00653 0.745
LIG_BRCT_BRCA1_1 64 68 PF00533 0.619
LIG_deltaCOP1_diTrp_1 39 46 PF00928 0.707
LIG_eIF4E_1 428 434 PF01652 0.580
LIG_FHA_1 14 20 PF00498 0.653
LIG_FHA_1 206 212 PF00498 0.837
LIG_FHA_1 362 368 PF00498 0.376
LIG_FHA_1 422 428 PF00498 0.460
LIG_FHA_1 437 443 PF00498 0.497
LIG_FHA_1 478 484 PF00498 0.586
LIG_FHA_1 48 54 PF00498 0.605
LIG_FHA_1 520 526 PF00498 0.484
LIG_FHA_1 82 88 PF00498 0.583
LIG_FHA_2 154 160 PF00498 0.684
LIG_FHA_2 34 40 PF00498 0.631
LIG_FHA_2 409 415 PF00498 0.615
LIG_FHA_2 454 460 PF00498 0.571
LIG_FHA_2 483 489 PF00498 0.542
LIG_FHA_2 569 575 PF00498 0.466
LIG_LIR_Gen_1 129 138 PF02991 0.518
LIG_LIR_Gen_1 402 410 PF02991 0.480
LIG_LIR_Gen_1 557 565 PF02991 0.476
LIG_LIR_Nem_3 129 134 PF02991 0.525
LIG_LIR_Nem_3 231 235 PF02991 0.623
LIG_LIR_Nem_3 402 407 PF02991 0.470
LIG_LIR_Nem_3 488 494 PF02991 0.458
LIG_LIR_Nem_3 557 562 PF02991 0.461
LIG_LIR_Nem_3 593 597 PF02991 0.458
LIG_LIR_Nem_3 98 104 PF02991 0.521
LIG_NRBOX 113 119 PF00104 0.512
LIG_NRP_CendR_1 600 603 PF00754 0.583
LIG_PALB2_WD40_1 414 422 PF16756 0.584
LIG_PCNA_yPIPBox_3 269 281 PF02747 0.741
LIG_PTB_Apo_2 276 283 PF02174 0.724
LIG_PTB_Apo_2 528 535 PF02174 0.466
LIG_PTB_Phospho_1 276 282 PF10480 0.725
LIG_REV1ctd_RIR_1 531 539 PF16727 0.462
LIG_SH2_GRB2like 597 600 PF00017 0.464
LIG_SH2_STAP1 131 135 PF00017 0.507
LIG_SH2_STAT3 146 149 PF00017 0.613
LIG_SH2_STAT3 242 245 PF00017 0.678
LIG_SH2_STAT5 282 285 PF00017 0.572
LIG_SH2_STAT5 348 351 PF00017 0.417
LIG_SH2_STAT5 370 373 PF00017 0.424
LIG_SH2_STAT5 477 480 PF00017 0.467
LIG_SH2_STAT5 511 514 PF00017 0.551
LIG_SH3_3 190 196 PF00018 0.740
LIG_SH3_3 197 203 PF00018 0.622
LIG_SH3_3 283 289 PF00018 0.482
LIG_SH3_3 521 527 PF00018 0.476
LIG_SH3_3 573 579 PF00018 0.475
LIG_SUMO_SIM_par_1 10 16 PF11976 0.653
LIG_SUMO_SIM_par_1 496 502 PF11976 0.434
LIG_TRAF2_1 23 26 PF00917 0.617
LIG_TRAF2_1 37 40 PF00917 0.565
LIG_WRC_WIRS_1 19 24 PF05994 0.644
LIG_WRC_WIRS_1 313 318 PF05994 0.473
LIG_WW_3 287 291 PF00397 0.500
MOD_CK1_1 187 193 PF00069 0.806
MOD_CK1_1 2 8 PF00069 0.701
MOD_CK1_1 205 211 PF00069 0.773
MOD_CK1_1 212 218 PF00069 0.725
MOD_CK1_1 253 259 PF00069 0.702
MOD_CK1_1 550 556 PF00069 0.459
MOD_CK1_1 593 599 PF00069 0.465
MOD_CK2_1 158 164 PF00069 0.706
MOD_CK2_1 33 39 PF00069 0.591
MOD_CK2_1 338 344 PF00069 0.507
MOD_CK2_1 482 488 PF00069 0.548
MOD_CK2_1 568 574 PF00069 0.477
MOD_DYRK1A_RPxSP_1 247 251 PF00069 0.602
MOD_GlcNHglycan 118 121 PF01048 0.635
MOD_GlcNHglycan 180 184 PF01048 0.843
MOD_GlcNHglycan 204 207 PF01048 0.762
MOD_GlcNHglycan 211 214 PF01048 0.716
MOD_GlcNHglycan 224 227 PF01048 0.655
MOD_GlcNHglycan 252 255 PF01048 0.682
MOD_GlcNHglycan 397 400 PF01048 0.511
MOD_GlcNHglycan 64 67 PF01048 0.613
MOD_GSK3_1 179 186 PF00069 0.754
MOD_GSK3_1 192 199 PF00069 0.623
MOD_GSK3_1 205 212 PF00069 0.633
MOD_GSK3_1 224 231 PF00069 0.678
MOD_GSK3_1 253 260 PF00069 0.727
MOD_GSK3_1 391 398 PF00069 0.472
MOD_GSK3_1 464 471 PF00069 0.576
MOD_GSK3_1 519 526 PF00069 0.481
MOD_GSK3_1 564 571 PF00069 0.514
MOD_NEK2_1 204 209 PF00069 0.814
MOD_NEK2_1 257 262 PF00069 0.658
MOD_NEK2_1 295 300 PF00069 0.516
MOD_NEK2_1 3 8 PF00069 0.655
MOD_NEK2_1 32 37 PF00069 0.608
MOD_NEK2_1 331 336 PF00069 0.466
MOD_NEK2_1 395 400 PF00069 0.464
MOD_NEK2_1 433 438 PF00069 0.603
MOD_NEK2_1 519 524 PF00069 0.510
MOD_NEK2_1 534 539 PF00069 0.500
MOD_NEK2_1 87 92 PF00069 0.549
MOD_NEK2_2 468 473 PF00069 0.542
MOD_PIKK_1 13 19 PF00454 0.647
MOD_PIKK_1 224 230 PF00454 0.654
MOD_PIKK_1 421 427 PF00454 0.448
MOD_PKA_2 122 128 PF00069 0.540
MOD_PKA_2 338 344 PF00069 0.507
MOD_PKA_2 436 442 PF00069 0.492
MOD_PKA_2 534 540 PF00069 0.461
MOD_PKA_2 550 556 PF00069 0.481
MOD_Plk_1 121 127 PF00069 0.571
MOD_Plk_1 82 88 PF00069 0.579
MOD_Plk_4 153 159 PF00069 0.682
MOD_Plk_4 253 259 PF00069 0.608
MOD_Plk_4 318 324 PF00069 0.459
MOD_Plk_4 391 397 PF00069 0.475
MOD_Plk_4 453 459 PF00069 0.673
MOD_Plk_4 468 474 PF00069 0.390
MOD_Plk_4 479 485 PF00069 0.469
MOD_Plk_4 550 556 PF00069 0.481
MOD_Plk_4 564 570 PF00069 0.491
MOD_Plk_4 590 596 PF00069 0.448
MOD_Plk_4 64 70 PF00069 0.617
MOD_ProDKin_1 185 191 PF00069 0.834
MOD_ProDKin_1 192 198 PF00069 0.640
MOD_ProDKin_1 205 211 PF00069 0.811
MOD_ProDKin_1 247 253 PF00069 0.695
MOD_ProDKin_1 464 470 PF00069 0.476
MOD_ProDKin_1 523 529 PF00069 0.469
MOD_ProDKin_1 575 581 PF00069 0.470
MOD_SUMO_for_1 323 326 PF00179 0.452
TRG_DiLeu_BaEn_1 479 484 PF01217 0.526
TRG_DiLeu_BaEn_1 557 562 PF01217 0.461
TRG_DiLeu_BaEn_1 83 88 PF01217 0.577
TRG_DiLeu_LyEn_5 83 88 PF01217 0.577
TRG_ENDOCYTIC_2 131 134 PF00928 0.513
TRG_ENDOCYTIC_2 313 316 PF00928 0.481
TRG_ENDOCYTIC_2 428 431 PF00928 0.467
TRG_ENDOCYTIC_2 491 494 PF00928 0.454
TRG_ER_diArg_1 169 172 PF00400 0.529
TRG_ER_diArg_1 376 378 PF00400 0.438
TRG_ER_diArg_1 74 77 PF00400 0.709
TRG_Pf-PMV_PEXEL_1 376 381 PF00026 0.442
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.708

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC66 Leptomonas seymouri 68% 96%
A0A3Q8IFG2 Leishmania donovani 95% 100%
A4HHJ3 Leishmania braziliensis 86% 100%
A4I4Q1 Leishmania infantum 95% 100%
E9AE54 Leishmania major 94% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS