Protein farnesyltransferase alpha subunit,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein farnesyltransferase alpha subunit, putative

Species:

Leishmania mexicana

UniProt:

E9ALM9_LEIMU

TriTrypDb:

LmxM.08_29.1950

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005953	CAAX-protein geranylgeranyltransferase complex	3	1
GO:0005965	protein farnesyltransferase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9ALM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALM9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018342	protein prenylation	4	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0097354	prenylation	3	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0018343	protein farnesylation	5	1
GO:0018344	protein geranylgeranylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0004660	protein farnesyltransferase activity	4	4
GO:0008318	protein prenyltransferase activity	3	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	482	486	PF00656	0.405
CLV_C14_Caspase3-7	700	704	PF00656	0.360
CLV_C14_Caspase3-7	739	743	PF00656	0.599
CLV_C14_Caspase3-7	748	752	PF00656	0.359
CLV_C14_Caspase3-7	772	776	PF00656	0.268
CLV_NRD_NRD_1	15	17	PF00675	0.442
CLV_NRD_NRD_1	184	186	PF00675	0.314
CLV_NRD_NRD_1	284	286	PF00675	0.243
CLV_NRD_NRD_1	33	35	PF00675	0.442
CLV_NRD_NRD_1	338	340	PF00675	0.451
CLV_NRD_NRD_1	539	541	PF00675	0.295
CLV_NRD_NRD_1	600	602	PF00675	0.352
CLV_NRD_NRD_1	708	710	PF00675	0.464
CLV_NRD_NRD_1	735	737	PF00675	0.408
CLV_PCSK_FUR_1	598	602	PF00082	0.259
CLV_PCSK_KEX2_1	15	17	PF00082	0.433
CLV_PCSK_KEX2_1	184	186	PF00082	0.314
CLV_PCSK_KEX2_1	33	35	PF00082	0.442
CLV_PCSK_KEX2_1	338	340	PF00082	0.451
CLV_PCSK_KEX2_1	539	541	PF00082	0.295
CLV_PCSK_KEX2_1	600	602	PF00082	0.352
CLV_PCSK_KEX2_1	707	709	PF00082	0.470
CLV_PCSK_PC7_1	596	602	PF00082	0.266
CLV_PCSK_SKI1_1	162	166	PF00082	0.356
CLV_PCSK_SKI1_1	185	189	PF00082	0.440
CLV_PCSK_SKI1_1	199	203	PF00082	0.405
CLV_PCSK_SKI1_1	286	290	PF00082	0.252
CLV_PCSK_SKI1_1	355	359	PF00082	0.483
CLV_PCSK_SKI1_1	460	464	PF00082	0.396
CLV_PCSK_SKI1_1	465	469	PF00082	0.345
CLV_PCSK_SKI1_1	769	773	PF00082	0.471
DEG_APCC_DBOX_1	15	23	PF00400	0.428
DEG_APCC_DBOX_1	198	206	PF00400	0.493
DEG_APCC_DBOX_1	261	269	PF00400	0.299
DEG_APCC_DBOX_1	350	358	PF00400	0.418
DEG_SCF_FBW7_2	93	98	PF00400	0.565
DOC_CDC14_PxL_1	560	568	PF14671	0.446
DOC_CKS1_1	382	387	PF01111	0.462
DOC_CKS1_1	565	570	PF01111	0.406
DOC_CKS1_1	587	592	PF01111	0.453
DOC_CYCLIN_RxL_1	635	646	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	565	571	PF00134	0.523
DOC_MAPK_DCC_7	15	24	PF00069	0.417
DOC_MAPK_DCC_7	199	207	PF00069	0.501
DOC_MAPK_DCC_7	4	14	PF00069	0.415
DOC_MAPK_gen_1	33	39	PF00069	0.448
DOC_MAPK_gen_1	338	345	PF00069	0.476
DOC_MAPK_MEF2A_6	162	169	PF00069	0.420
DOC_MAPK_MEF2A_6	199	207	PF00069	0.501
DOC_MAPK_MEF2A_6	586	594	PF00069	0.345
DOC_MAPK_NFAT4_5	162	170	PF00069	0.420
DOC_PP1_RVXF_1	257	264	PF00149	0.310
DOC_PP1_RVXF_1	598	605	PF00149	0.381
DOC_PP2B_LxvP_1	205	208	PF13499	0.497
DOC_PP2B_LxvP_1	26	29	PF13499	0.429
DOC_PP2B_LxvP_1	383	386	PF13499	0.454
DOC_PP4_FxxP_1	14	17	PF00568	0.430
DOC_USP7_MATH_1	488	492	PF00917	0.648
DOC_USP7_MATH_1	50	54	PF00917	0.598
DOC_USP7_MATH_1	62	66	PF00917	0.664
DOC_USP7_MATH_1	643	647	PF00917	0.634
DOC_WW_Pin1_4	100	105	PF00397	0.648
DOC_WW_Pin1_4	187	192	PF00397	0.432
DOC_WW_Pin1_4	293	298	PF00397	0.461
DOC_WW_Pin1_4	318	323	PF00397	0.536
DOC_WW_Pin1_4	381	386	PF00397	0.394
DOC_WW_Pin1_4	407	412	PF00397	0.480
DOC_WW_Pin1_4	431	436	PF00397	0.557
DOC_WW_Pin1_4	46	51	PF00397	0.640
DOC_WW_Pin1_4	564	569	PF00397	0.395
DOC_WW_Pin1_4	586	591	PF00397	0.517
DOC_WW_Pin1_4	7	12	PF00397	0.510
DOC_WW_Pin1_4	91	96	PF00397	0.568
LIG_14-3-3_CanoR_1	157	165	PF00244	0.431
LIG_14-3-3_CanoR_1	172	181	PF00244	0.426
LIG_14-3-3_CanoR_1	234	244	PF00244	0.412
LIG_14-3-3_CanoR_1	254	259	PF00244	0.223
LIG_14-3-3_CanoR_1	4	8	PF00244	0.470
LIG_14-3-3_CanoR_1	452	461	PF00244	0.558
LIG_14-3-3_CanoR_1	619	629	PF00244	0.524
LIG_14-3-3_CanoR_1	649	656	PF00244	0.710
LIG_14-3-3_CanoR_1	670	676	PF00244	0.485
LIG_14-3-3_CanoR_1	778	782	PF00244	0.528
LIG_Actin_WH2_2	221	238	PF00022	0.478
LIG_Actin_WH2_2	341	357	PF00022	0.421
LIG_Actin_WH2_2	613	630	PF00022	0.453
LIG_APCC_ABBA_1	461	466	PF00400	0.461
LIG_APCC_ABBAyCdc20_2	460	466	PF00400	0.522
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_BIR_III_2	200	204	PF00653	0.466
LIG_BRCT_BRCA1_1	1	5	PF00533	0.426
LIG_BRCT_BRCA1_1	319	323	PF00533	0.481
LIG_CtBP_PxDLS_1	385	389	PF00389	0.247
LIG_deltaCOP1_diTrp_1	248	258	PF00928	0.424
LIG_deltaCOP1_diTrp_1	726	733	PF00928	0.547
LIG_EH1_1	783	791	PF00400	0.303
LIG_FHA_1	132	138	PF00498	0.523
LIG_FHA_1	4	10	PF00498	0.411
LIG_FHA_1	435	441	PF00498	0.311
LIG_FHA_1	587	593	PF00498	0.593
LIG_FHA_1	637	643	PF00498	0.392
LIG_FHA_2	213	219	PF00498	0.607
LIG_FHA_2	330	336	PF00498	0.409
LIG_FHA_2	415	421	PF00498	0.596
LIG_FHA_2	480	486	PF00498	0.405
LIG_FHA_2	487	493	PF00498	0.509
LIG_FHA_2	604	610	PF00498	0.348
LIG_FHA_2	628	634	PF00498	0.455
LIG_FHA_2	664	670	PF00498	0.463
LIG_FHA_2	698	704	PF00498	0.308
LIG_FHA_2	770	776	PF00498	0.437
LIG_FHA_2	92	98	PF00498	0.511
LIG_IRF3_LxIS_1	5	10	PF10401	0.407
LIG_KLC1_Yacidic_2	605	609	PF13176	0.297
LIG_LIR_Apic_2	13	17	PF02991	0.420
LIG_LIR_Apic_2	6	11	PF02991	0.410
LIG_LIR_Apic_2	726	730	PF02991	0.507
LIG_LIR_Gen_1	132	139	PF02991	0.530
LIG_LIR_Gen_1	344	352	PF02991	0.531
LIG_LIR_Gen_1	509	517	PF02991	0.526
LIG_LIR_Gen_1	609	617	PF02991	0.322
LIG_LIR_Gen_1	677	687	PF02991	0.446
LIG_LIR_Gen_1	84	93	PF02991	0.293
LIG_LIR_Nem_3	2	8	PF02991	0.413
LIG_LIR_Nem_3	256	261	PF02991	0.307
LIG_LIR_Nem_3	320	326	PF02991	0.434
LIG_LIR_Nem_3	330	336	PF02991	0.386
LIG_LIR_Nem_3	344	348	PF02991	0.430
LIG_LIR_Nem_3	509	515	PF02991	0.453
LIG_LIR_Nem_3	677	682	PF02991	0.405
LIG_LIR_Nem_3	695	701	PF02991	0.241
LIG_LIR_Nem_3	756	760	PF02991	0.346
LIG_LIR_Nem_3	84	89	PF02991	0.401
LIG_MYND_1	17	21	PF01753	0.426
LIG_MYND_1	425	429	PF01753	0.572
LIG_MYND_1	564	568	PF01753	0.453
LIG_PALB2_WD40_1	159	167	PF16756	0.371
LIG_PDZ_Class_2	793	798	PF00595	0.339
LIG_Pex14_1	457	461	PF04695	0.442
LIG_PTB_Apo_2	785	792	PF02174	0.457
LIG_PTB_Phospho_1	785	791	PF10480	0.459
LIG_Rb_LxCxE_1	75	98	PF01857	0.501
LIG_SH2_CRK	124	128	PF00017	0.387
LIG_SH2_NCK_1	760	764	PF00017	0.433
LIG_SH2_PTP2	514	517	PF00017	0.467
LIG_SH2_PTP2	8	11	PF00017	0.413
LIG_SH2_SRC	375	378	PF00017	0.428
LIG_SH2_SRC	514	517	PF00017	0.467
LIG_SH2_SRC	607	610	PF00017	0.468
LIG_SH2_SRC	78	81	PF00017	0.236
LIG_SH2_STAP1	133	137	PF00017	0.343
LIG_SH2_STAP1	508	512	PF00017	0.329
LIG_SH2_STAP1	760	764	PF00017	0.433
LIG_SH2_STAT3	291	294	PF00017	0.479
LIG_SH2_STAT3	508	511	PF00017	0.342
LIG_SH2_STAT5	133	136	PF00017	0.526
LIG_SH2_STAT5	178	181	PF00017	0.350
LIG_SH2_STAT5	336	339	PF00017	0.359
LIG_SH2_STAT5	375	378	PF00017	0.405
LIG_SH2_STAT5	514	517	PF00017	0.448
LIG_SH2_STAT5	523	526	PF00017	0.506
LIG_SH2_STAT5	559	562	PF00017	0.407
LIG_SH2_STAT5	607	610	PF00017	0.512
LIG_SH2_STAT5	687	690	PF00017	0.363
LIG_SH2_STAT5	8	11	PF00017	0.413
LIG_SH3_3	101	107	PF00018	0.689
LIG_SH3_3	143	149	PF00018	0.598
LIG_SH3_3	200	206	PF00018	0.463
LIG_SH3_3	319	325	PF00018	0.508
LIG_SH3_3	426	432	PF00018	0.407
LIG_SH3_3	584	590	PF00018	0.564
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.402
LIG_TRFH_1	381	385	PF08558	0.447
LIG_ULM_U2AF65_1	600	605	PF00076	0.264
LIG_WRC_WIRS_1	608	613	PF05994	0.348
LIG_WRC_WIRS_1	83	88	PF05994	0.480
MOD_CK1_1	10	16	PF00069	0.566
MOD_CK1_1	176	182	PF00069	0.377
MOD_CK1_1	329	335	PF00069	0.456
MOD_CK1_1	434	440	PF00069	0.410
MOD_CK1_1	48	54	PF00069	0.601
MOD_CK1_1	55	61	PF00069	0.607
MOD_CK1_1	65	71	PF00069	0.548
MOD_CK2_1	212	218	PF00069	0.565
MOD_CK2_1	414	420	PF00069	0.558
MOD_CK2_1	486	492	PF00069	0.710
MOD_CK2_1	603	609	PF00069	0.360
MOD_CK2_1	627	633	PF00069	0.477
MOD_CK2_1	663	669	PF00069	0.516
MOD_DYRK1A_RPxSP_1	586	590	PF00069	0.346
MOD_GlcNHglycan	1	4	PF01048	0.468
MOD_GlcNHglycan	158	161	PF01048	0.393
MOD_GlcNHglycan	26	29	PF01048	0.557
MOD_GlcNHglycan	420	423	PF01048	0.413
MOD_GlcNHglycan	454	457	PF01048	0.227
MOD_GlcNHglycan	494	497	PF01048	0.252
MOD_GlcNHglycan	60	63	PF01048	0.638
MOD_GlcNHglycan	64	67	PF01048	0.651
MOD_GlcNHglycan	651	654	PF01048	0.714
MOD_GlcNHglycan	738	741	PF01048	0.679
MOD_GSK3_1	172	179	PF00069	0.411
MOD_GSK3_1	20	27	PF00069	0.711
MOD_GSK3_1	210	217	PF00069	0.595
MOD_GSK3_1	3	10	PF00069	0.421
MOD_GSK3_1	377	384	PF00069	0.447
MOD_GSK3_1	414	421	PF00069	0.479
MOD_GSK3_1	427	434	PF00069	0.577
MOD_GSK3_1	45	52	PF00069	0.643
MOD_GSK3_1	475	482	PF00069	0.570
MOD_GSK3_1	488	495	PF00069	0.368
MOD_GSK3_1	521	528	PF00069	0.451
MOD_GSK3_1	546	553	PF00069	0.464
MOD_GSK3_1	58	65	PF00069	0.600
MOD_GSK3_1	581	588	PF00069	0.570
MOD_GSK3_1	603	610	PF00069	0.354
MOD_GSK3_1	643	650	PF00069	0.655
MOD_N-GLC_1	176	181	PF02516	0.475
MOD_N-GLC_1	452	457	PF02516	0.242
MOD_N-GLC_1	492	497	PF02516	0.344
MOD_N-GLC_1	506	511	PF02516	0.374
MOD_NEK2_1	131	136	PF00069	0.313
MOD_NEK2_1	212	217	PF00069	0.580
MOD_NEK2_1	235	240	PF00069	0.571
MOD_NEK2_1	24	29	PF00069	0.565
MOD_NEK2_1	370	375	PF00069	0.323
MOD_NEK2_1	396	401	PF00069	0.395
MOD_NEK2_1	440	445	PF00069	0.487
MOD_NEK2_1	45	50	PF00069	0.795
MOD_NEK2_1	506	511	PF00069	0.379
MOD_NEK2_1	532	537	PF00069	0.328
MOD_NEK2_1	697	702	PF00069	0.473
MOD_NEK2_2	3	8	PF00069	0.412
MOD_NEK2_2	494	499	PF00069	0.248
MOD_NEK2_2	636	641	PF00069	0.317
MOD_NEK2_2	663	668	PF00069	0.342
MOD_PIKK_1	131	137	PF00454	0.315
MOD_PIKK_1	236	242	PF00454	0.494
MOD_PIKK_1	50	56	PF00454	0.479
MOD_PIKK_1	65	71	PF00454	0.571
MOD_PIKK_1	669	675	PF00454	0.451
MOD_PKA_1	15	21	PF00069	0.440
MOD_PKA_1	736	742	PF00069	0.451
MOD_PKA_2	15	21	PF00069	0.432
MOD_PKA_2	156	162	PF00069	0.358
MOD_PKA_2	235	241	PF00069	0.443
MOD_PKA_2	253	259	PF00069	0.235
MOD_PKA_2	3	9	PF00069	0.410
MOD_PKA_2	350	356	PF00069	0.486
MOD_PKA_2	427	433	PF00069	0.512
MOD_PKA_2	585	591	PF00069	0.343
MOD_PKA_2	627	633	PF00069	0.490
MOD_PKA_2	648	654	PF00069	0.708
MOD_PKA_2	669	675	PF00069	0.492
MOD_PKA_2	713	719	PF00069	0.528
MOD_PKA_2	735	741	PF00069	0.444
MOD_PKA_2	777	783	PF00069	0.573
MOD_PKB_1	234	242	PF00069	0.260
MOD_PKB_1	601	609	PF00069	0.253
MOD_Plk_1	131	137	PF00069	0.563
MOD_Plk_1	176	182	PF00069	0.419
MOD_Plk_1	263	269	PF00069	0.435
MOD_Plk_1	329	335	PF00069	0.526
MOD_Plk_1	452	458	PF00069	0.449
MOD_Plk_1	506	512	PF00069	0.418
MOD_Plk_4	15	21	PF00069	0.490
MOD_Plk_4	176	182	PF00069	0.368
MOD_Plk_4	370	376	PF00069	0.425
MOD_Plk_4	532	538	PF00069	0.378
MOD_Plk_4	603	609	PF00069	0.360
MOD_Plk_4	663	669	PF00069	0.469
MOD_Plk_4	697	703	PF00069	0.518
MOD_Plk_4	777	783	PF00069	0.258
MOD_Plk_4	82	88	PF00069	0.368
MOD_ProDKin_1	100	106	PF00069	0.646
MOD_ProDKin_1	187	193	PF00069	0.428
MOD_ProDKin_1	293	299	PF00069	0.464
MOD_ProDKin_1	318	324	PF00069	0.523
MOD_ProDKin_1	381	387	PF00069	0.403
MOD_ProDKin_1	407	413	PF00069	0.483
MOD_ProDKin_1	431	437	PF00069	0.551
MOD_ProDKin_1	46	52	PF00069	0.638
MOD_ProDKin_1	564	570	PF00069	0.403
MOD_ProDKin_1	586	592	PF00069	0.510
MOD_ProDKin_1	7	13	PF00069	0.511
MOD_ProDKin_1	91	97	PF00069	0.578
MOD_SUMO_for_1	656	659	PF00179	0.529
MOD_SUMO_rev_2	729	739	PF00179	0.553
TRG_DiLeu_BaEn_1	609	614	PF01217	0.456
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.409
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.442
TRG_ENDOCYTIC_2	124	127	PF00928	0.335
TRG_ENDOCYTIC_2	133	136	PF00928	0.429
TRG_ER_diArg_1	14	16	PF00400	0.430
TRG_ER_diArg_1	143	146	PF00400	0.446
TRG_ER_diArg_1	234	237	PF00400	0.288
TRG_ER_diArg_1	33	36	PF00400	0.489
TRG_ER_diArg_1	337	339	PF00400	0.423
TRG_ER_diArg_1	598	601	PF00400	0.443
TRG_ER_diArg_1	625	628	PF00400	0.464
TRG_ER_diArg_1	707	709	PF00400	0.536
TRG_NES_CRM1_1	505	516	PF08389	0.490
TRG_NES_CRM1_1	79	92	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH9	Leptomonas seymouri	49%	100%
A0A1X0P015	Trypanosomatidae	31%	100%
A0A3S5H7L6	Leishmania donovani	88%	100%
A0A422NNG1	Trypanosoma rangeli	33%	100%
A4HHJ5	Leishmania braziliensis	75%	100%
A4I4Q3	Leishmania infantum	89%	100%
C9ZLE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE56	Leishmania major	88%	100%
V5DCL7	Trypanosoma cruzi	33%	100%