Putative fumarate hydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fumarate hydratase, putative

Species:

Leishmania mexicana

UniProt:

E9ALM8_LEIMU

TriTrypDb:

LmxM.08_29.1960

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALM8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004333	fumarate hydratase activity	5	2
GO:0005488	binding	1	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051539	4 iron, 4 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.549
CLV_NRD_NRD_1	12	14	PF00675	0.773
CLV_NRD_NRD_1	64	66	PF00675	0.654
CLV_NRD_NRD_1	90	92	PF00675	0.549
CLV_NRD_NRD_1	99	101	PF00675	0.392
CLV_PCSK_KEX2_1	12	14	PF00082	0.773
CLV_PCSK_KEX2_1	144	146	PF00082	0.549
CLV_PCSK_KEX2_1	99	101	PF00082	0.549
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.549
CLV_PCSK_SKI1_1	65	69	PF00082	0.620
DOC_PP2B_LxvP_1	199	202	PF13499	0.549
DOC_USP7_MATH_1	105	109	PF00917	0.549
DOC_USP7_UBL2_3	157	161	PF12436	0.549
LIG_14-3-3_CanoR_1	173	183	PF00244	0.549
LIG_14-3-3_CanoR_1	81	90	PF00244	0.549
LIG_APCC_ABBA_1	180	185	PF00400	0.549
LIG_APCC_Cbox_2	111	117	PF00515	0.549
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_BRCT_BRCA1_1	31	35	PF00533	0.672
LIG_eIF4E_1	113	119	PF01652	0.549
LIG_FHA_1	114	120	PF00498	0.549
LIG_FHA_1	136	142	PF00498	0.549
LIG_FHA_1	175	181	PF00498	0.549
LIG_FHA_2	149	155	PF00498	0.549
LIG_FHA_2	46	52	PF00498	0.687
LIG_LIR_Gen_1	204	212	PF02991	0.549
LIG_LIR_Gen_1	28	37	PF02991	0.677
LIG_LIR_Gen_1	45	54	PF02991	0.379
LIG_LIR_Nem_3	204	209	PF02991	0.549
LIG_LIR_Nem_3	28	34	PF02991	0.676
LIG_LIR_Nem_3	45	50	PF02991	0.392
LIG_Pex14_2	31	35	PF04695	0.672
LIG_PTB_Apo_2	168	175	PF02174	0.549
LIG_PTB_Phospho_1	168	174	PF10480	0.549
LIG_REV1ctd_RIR_1	87	96	PF16727	0.549
LIG_SH2_CRK	169	173	PF00017	0.549
LIG_SH2_GRB2like	169	172	PF00017	0.549
LIG_SH2_STAP1	174	178	PF00017	0.549
LIG_SH2_STAP1	206	210	PF00017	0.549
LIG_SH2_STAT5	113	116	PF00017	0.549
LIG_SH2_STAT5	158	161	PF00017	0.549
LIG_SH2_STAT5	56	59	PF00017	0.638
LIG_SH3_3	34	40	PF00018	0.672
LIG_SH3_5	202	206	PF00018	0.549
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.598
MOD_CK2_1	148	154	PF00069	0.549
MOD_CK2_1	201	207	PF00069	0.549
MOD_CK2_1	45	51	PF00069	0.692
MOD_Cter_Amidation	142	145	PF01082	0.549
MOD_Cter_Amidation	63	66	PF01082	0.662
MOD_GlcNHglycan	20	25	PF01048	0.727
MOD_GlcNHglycan	216	219	PF01048	0.549
MOD_GlcNHglycan	31	34	PF01048	0.475
MOD_GSK3_1	129	136	PF00069	0.549
MOD_N-GLC_2	121	123	PF02516	0.549
MOD_NEK2_1	148	153	PF00069	0.549
MOD_NEK2_1	172	177	PF00069	0.549
MOD_NEK2_1	29	34	PF00069	0.673
MOD_PIKK_1	172	178	PF00454	0.549
MOD_PKA_2	172	178	PF00069	0.549
MOD_Plk_1	20	26	PF00069	0.728
MOD_Plk_4	114	120	PF00069	0.549
MOD_Plk_4	136	142	PF00069	0.549
MOD_Plk_4	73	79	PF00069	0.598
MOD_SUMO_rev_2	154	159	PF00179	0.549
TRG_ENDOCYTIC_2	169	172	PF00928	0.549
TRG_ENDOCYTIC_2	206	209	PF00928	0.549
TRG_ER_diArg_1	98	100	PF00400	0.549
TRG_NES_CRM1_1	190	205	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AE57	LEIMA	96%	39%
P0AC33	ECOLI	51%	40%
P0AC34	ECOL6	51%	40%
P14407	ECOLI	57%	40%
P40720	SALTY	53%	38%
Q4QAU9	LEIMA	45%	40%
Q8X4P8	ECO57	51%	40%