Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALM5_LEIMU

TriTrypDb:

LmxM.08_29.1990

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.730
CLV_NRD_NRD_1	229	231	PF00675	0.574
CLV_NRD_NRD_1	97	99	PF00675	0.702
CLV_PCSK_KEX2_1	120	122	PF00082	0.724
CLV_PCSK_KEX2_1	343	345	PF00082	0.737
CLV_PCSK_KEX2_1	97	99	PF00082	0.702
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.737
CLV_PCSK_SKI1_1	356	360	PF00082	0.522
DEG_SPOP_SBC_1	348	352	PF00917	0.742
DEG_SPOP_SBC_1	433	437	PF00917	0.544
DOC_ANK_TNKS_1	451	458	PF00023	0.742
DOC_CKS1_1	256	261	PF01111	0.407
DOC_CKS1_1	6	11	PF01111	0.704
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.795
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.635
DOC_PP2B_LxvP_1	189	192	PF13499	0.678
DOC_PP2B_LxvP_1	273	276	PF13499	0.529
DOC_PP4_FxxP_1	150	153	PF00568	0.805
DOC_PP4_FxxP_1	6	9	PF00568	0.794
DOC_SPAK_OSR1_1	238	242	PF12202	0.751
DOC_USP7_MATH_1	161	165	PF00917	0.832
DOC_USP7_MATH_1	198	202	PF00917	0.749
DOC_USP7_MATH_1	348	352	PF00917	0.742
DOC_USP7_MATH_1	433	437	PF00917	0.727
DOC_USP7_MATH_1	438	442	PF00917	0.698
DOC_USP7_MATH_1	66	70	PF00917	0.772
DOC_WW_Pin1_4	127	132	PF00397	0.718
DOC_WW_Pin1_4	165	170	PF00397	0.674
DOC_WW_Pin1_4	172	177	PF00397	0.607
DOC_WW_Pin1_4	255	260	PF00397	0.602
DOC_WW_Pin1_4	41	46	PF00397	0.746
DOC_WW_Pin1_4	434	439	PF00397	0.831
DOC_WW_Pin1_4	5	10	PF00397	0.806
LIG_14-3-3_CanoR_1	230	236	PF00244	0.670
LIG_14-3-3_CanoR_1	394	402	PF00244	0.645
LIG_14-3-3_CanoR_1	64	74	PF00244	0.846
LIG_APCC_ABBA_1	90	95	PF00400	0.766
LIG_BIR_II_1	1	5	PF00653	0.816
LIG_BIR_III_4	480	484	PF00653	0.721
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.691
LIG_FHA_1	166	172	PF00498	0.728
LIG_FHA_1	370	376	PF00498	0.685
LIG_FHA_1	386	392	PF00498	0.469
LIG_FHA_1	397	403	PF00498	0.594
LIG_FHA_1	42	48	PF00498	0.721
LIG_FHA_1	448	454	PF00498	0.723
LIG_FHA_1	58	64	PF00498	0.545
LIG_LIR_Nem_3	13	18	PF02991	0.788
LIG_LIR_Nem_3	140	145	PF02991	0.626
LIG_LIR_Nem_3	91	96	PF02991	0.696
LIG_MYND_1	517	521	PF01753	0.651
LIG_PCNA_PIPBox_1	498	507	PF02747	0.690
LIG_PDZ_Class_2	531	536	PF00595	0.464
LIG_SH2_PTP2	270	273	PF00017	0.541
LIG_SH2_STAT3	324	327	PF00017	0.612
LIG_SH2_STAT5	181	184	PF00017	0.605
LIG_SH2_STAT5	270	273	PF00017	0.504
LIG_SH2_STAT5	33	36	PF00017	0.742
LIG_SH3_3	166	172	PF00018	0.522
LIG_SH3_3	185	191	PF00018	0.400
LIG_SH3_3	295	301	PF00018	0.682
LIG_SH3_3	443	449	PF00018	0.746
LIG_SH3_3	514	520	PF00018	0.696
LIG_TRFH_1	187	191	PF08558	0.438
LIG_UBA3_1	379	387	PF00899	0.633
LIG_WW_1	520	523	PF00397	0.566
MOD_CDK_SPK_2	41	46	PF00069	0.746
MOD_CK1_1	126	132	PF00069	0.794
MOD_CK1_1	365	371	PF00069	0.699
MOD_CK1_1	53	59	PF00069	0.822
MOD_CK1_1	68	74	PF00069	0.593
MOD_CK2_1	334	340	PF00069	0.692
MOD_CK2_1	349	355	PF00069	0.631
MOD_CK2_1	434	440	PF00069	0.752
MOD_GlcNHglycan	1	4	PF01048	0.626
MOD_GlcNHglycan	202	205	PF01048	0.718
MOD_GlcNHglycan	218	222	PF01048	0.598
MOD_GlcNHglycan	351	354	PF01048	0.799
MOD_GlcNHglycan	412	415	PF01048	0.779
MOD_GlcNHglycan	47	50	PF01048	0.748
MOD_GlcNHglycan	52	55	PF01048	0.828
MOD_GlcNHglycan	70	73	PF01048	0.652
MOD_GlcNHglycan	77	80	PF01048	0.843
MOD_GlcNHglycan	86	90	PF01048	0.512
MOD_GSK3_1	122	129	PF00069	0.817
MOD_GSK3_1	161	168	PF00069	0.710
MOD_GSK3_1	334	341	PF00069	0.754
MOD_GSK3_1	343	350	PF00069	0.662
MOD_GSK3_1	365	372	PF00069	0.785
MOD_GSK3_1	398	405	PF00069	0.684
MOD_GSK3_1	41	48	PF00069	0.784
MOD_GSK3_1	434	441	PF00069	0.778
MOD_GSK3_1	50	57	PF00069	0.706
MOD_N-GLC_1	405	410	PF02516	0.749
MOD_N-GLC_1	66	71	PF02516	0.764
MOD_NEK2_1	113	118	PF00069	0.761
MOD_NEK2_1	137	142	PF00069	0.660
MOD_NEK2_1	217	222	PF00069	0.714
MOD_NEK2_1	326	331	PF00069	0.579
MOD_NEK2_1	349	354	PF00069	0.692
MOD_NEK2_1	380	385	PF00069	0.705
MOD_PIKK_1	114	120	PF00454	0.756
MOD_PIKK_1	33	39	PF00454	0.703
MOD_PIKK_1	405	411	PF00454	0.776
MOD_PIKK_1	494	500	PF00454	0.480
MOD_PK_1	280	286	PF00069	0.736
MOD_PKA_1	343	349	PF00069	0.741
MOD_PKA_2	113	119	PF00069	0.677
MOD_PKA_2	229	235	PF00069	0.631
MOD_PKA_2	333	339	PF00069	0.728
MOD_PKA_2	343	349	PF00069	0.685
MOD_PKA_2	45	51	PF00069	0.760
MOD_PKB_1	120	128	PF00069	0.529
MOD_Plk_1	114	120	PF00069	0.541
MOD_Plk_1	280	286	PF00069	0.736
MOD_Plk_1	334	340	PF00069	0.756
MOD_Plk_1	354	360	PF00069	0.486
MOD_Plk_1	85	91	PF00069	0.754
MOD_Plk_4	354	360	PF00069	0.525
MOD_Plk_4	380	386	PF00069	0.706
MOD_Plk_4	387	393	PF00069	0.548
MOD_Plk_4	440	446	PF00069	0.755
MOD_ProDKin_1	127	133	PF00069	0.716
MOD_ProDKin_1	165	171	PF00069	0.671
MOD_ProDKin_1	172	178	PF00069	0.597
MOD_ProDKin_1	255	261	PF00069	0.601
MOD_ProDKin_1	41	47	PF00069	0.748
MOD_ProDKin_1	434	440	PF00069	0.831
MOD_ProDKin_1	5	11	PF00069	0.805
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.741
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.605
TRG_ENDOCYTIC_2	270	273	PF00928	0.563
TRG_ENDOCYTIC_2	523	526	PF00928	0.654
TRG_ENDOCYTIC_2	93	96	PF00928	0.675
TRG_ER_diArg_1	119	122	PF00400	0.707
TRG_ER_diArg_1	96	98	PF00400	0.692
TRG_NES_CRM1_1	456	469	PF08389	0.628
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXW3	Leptomonas seymouri	26%	92%
A0A3Q8IDU7	Leishmania donovani	86%	100%
A4HHJ8	Leishmania braziliensis	71%	100%
A4I4Q7	Leishmania infantum	86%	100%
E9AE60	Leishmania major	84%	100%