SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALM3_LEIMU

TriTrypDb:

LmxM.08_29.2000

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALM3

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0032259	methylation	2	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043414	macromolecule methylation	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.346
CLV_C14_Caspase3-7	305	309	PF00656	0.574
CLV_NRD_NRD_1	198	200	PF00675	0.485
CLV_NRD_NRD_1	319	321	PF00675	0.453
CLV_NRD_NRD_1	448	450	PF00675	0.727
CLV_NRD_NRD_1	48	50	PF00675	0.586
CLV_NRD_NRD_1	548	550	PF00675	0.287
CLV_NRD_NRD_1	619	621	PF00675	0.610
CLV_PCSK_KEX2_1	124	126	PF00082	0.629
CLV_PCSK_KEX2_1	318	320	PF00082	0.494
CLV_PCSK_KEX2_1	335	337	PF00082	0.547
CLV_PCSK_KEX2_1	47	49	PF00082	0.607
CLV_PCSK_KEX2_1	548	550	PF00082	0.371
CLV_PCSK_KEX2_1	619	621	PF00082	0.574
CLV_PCSK_KEX2_1	683	685	PF00082	0.437
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.449
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.623
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.437
CLV_PCSK_SKI1_1	39	43	PF00082	0.649
CLV_PCSK_SKI1_1	548	552	PF00082	0.287
CLV_PCSK_SKI1_1	577	581	PF00082	0.396
CLV_Separin_Metazoa	574	578	PF03568	0.533
DEG_APCC_DBOX_1	137	145	PF00400	0.531
DEG_SPOP_SBC_1	438	442	PF00917	0.500
DOC_CKS1_1	388	393	PF01111	0.484
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.502
DOC_MAPK_gen_1	199	207	PF00069	0.506
DOC_MAPK_gen_1	47	53	PF00069	0.577
DOC_MAPK_MEF2A_6	133	141	PF00069	0.481
DOC_MAPK_MEF2A_6	459	467	PF00069	0.624
DOC_PP4_FxxP_1	163	166	PF00568	0.486
DOC_USP7_MATH_1	117	121	PF00917	0.616
DOC_USP7_MATH_1	132	136	PF00917	0.341
DOC_USP7_MATH_1	148	152	PF00917	0.503
DOC_USP7_MATH_1	237	241	PF00917	0.642
DOC_USP7_MATH_1	379	383	PF00917	0.673
DOC_USP7_MATH_1	407	411	PF00917	0.479
DOC_USP7_MATH_1	431	435	PF00917	0.644
DOC_USP7_MATH_1	480	484	PF00917	0.825
DOC_USP7_MATH_1	491	495	PF00917	0.736
DOC_USP7_MATH_1	503	507	PF00917	0.535
DOC_USP7_MATH_1	512	516	PF00917	0.536
DOC_USP7_MATH_1	534	538	PF00917	0.576
DOC_USP7_MATH_1	661	665	PF00917	0.523
DOC_USP7_MATH_1	688	692	PF00917	0.489
DOC_WW_Pin1_4	108	113	PF00397	0.705
DOC_WW_Pin1_4	229	234	PF00397	0.675
DOC_WW_Pin1_4	235	240	PF00397	0.634
DOC_WW_Pin1_4	272	277	PF00397	0.596
DOC_WW_Pin1_4	352	357	PF00397	0.703
DOC_WW_Pin1_4	387	392	PF00397	0.673
DOC_WW_Pin1_4	432	437	PF00397	0.617
DOC_WW_Pin1_4	476	481	PF00397	0.529
DOC_WW_Pin1_4	487	492	PF00397	0.783
DOC_WW_Pin1_4	499	504	PF00397	0.707
DOC_WW_Pin1_4	85	90	PF00397	0.603
LIG_14-3-3_CanoR_1	103	112	PF00244	0.677
LIG_14-3-3_CanoR_1	133	137	PF00244	0.292
LIG_14-3-3_CanoR_1	260	264	PF00244	0.509
LIG_14-3-3_CanoR_1	432	436	PF00244	0.635
LIG_14-3-3_CanoR_1	567	576	PF00244	0.698
LIG_14-3-3_CanoR_1	577	585	PF00244	0.372
LIG_14-3-3_CanoR_1	669	678	PF00244	0.457
LIG_14-3-3_CanoR_1	80	89	PF00244	0.720
LIG_14-3-3_CanoR_1	93	99	PF00244	0.523
LIG_Actin_WH2_2	510	528	PF00022	0.496
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_Clathr_ClatBox_1	182	186	PF01394	0.464
LIG_CSL_BTD_1	156	159	PF09270	0.505
LIG_EVH1_2	31	35	PF00568	0.526
LIG_FHA_1	578	584	PF00498	0.521
LIG_FHA_1	81	87	PF00498	0.693
LIG_FHA_2	312	318	PF00498	0.434
LIG_FHA_2	569	575	PF00498	0.747
LIG_LIR_Gen_1	535	546	PF02991	0.568
LIG_LIR_Gen_1	641	649	PF02991	0.658
LIG_LIR_Gen_1	673	681	PF02991	0.389
LIG_LIR_LC3C_4	243	247	PF02991	0.441
LIG_LIR_Nem_3	519	525	PF02991	0.492
LIG_LIR_Nem_3	535	541	PF02991	0.497
LIG_LIR_Nem_3	632	636	PF02991	0.536
LIG_LIR_Nem_3	641	646	PF02991	0.611
LIG_LIR_Nem_3	664	670	PF02991	0.495
LIG_LIR_Nem_3	673	678	PF02991	0.384
LIG_MAD2	203	211	PF02301	0.489
LIG_Pex14_1	667	671	PF04695	0.482
LIG_Pex14_2	163	167	PF04695	0.528
LIG_Pex14_2	671	675	PF04695	0.427
LIG_PTB_Apo_2	171	178	PF02174	0.575
LIG_SH2_CRK	522	526	PF00017	0.476
LIG_SH2_CRK	538	542	PF00017	0.476
LIG_SH2_CRK	633	637	PF00017	0.568
LIG_SH2_PTP2	50	53	PF00017	0.432
LIG_SH2_SRC	362	365	PF00017	0.522
LIG_SH2_SRC	643	646	PF00017	0.648
LIG_SH2_STAP1	589	593	PF00017	0.602
LIG_SH2_STAT5	50	53	PF00017	0.412
LIG_SH2_STAT5	540	543	PF00017	0.527
LIG_SH2_STAT5	545	548	PF00017	0.525
LIG_SH2_STAT5	645	648	PF00017	0.727
LIG_SH2_STAT5	677	680	PF00017	0.488
LIG_SH3_3	358	364	PF00018	0.526
LIG_SH3_3	389	395	PF00018	0.651
LIG_SH3_3	579	585	PF00018	0.539
LIG_Sin3_3	579	586	PF02671	0.382
LIG_TRAF2_1	88	91	PF00917	0.598
LIG_UBA3_1	510	516	PF00899	0.550
MOD_CK1_1	111	117	PF00069	0.704
MOD_CK1_1	232	238	PF00069	0.681
MOD_CK1_1	292	298	PF00069	0.542
MOD_CK1_1	440	446	PF00069	0.760
MOD_CK1_1	504	510	PF00069	0.616
MOD_CK1_1	568	574	PF00069	0.703
MOD_CK1_1	603	609	PF00069	0.507
MOD_CK2_1	311	317	PF00069	0.432
MOD_CK2_1	568	574	PF00069	0.744
MOD_CK2_1	652	658	PF00069	0.708
MOD_CK2_1	85	91	PF00069	0.629
MOD_GlcNHglycan	17	20	PF01048	0.597
MOD_GlcNHglycan	234	237	PF01048	0.613
MOD_GlcNHglycan	294	297	PF01048	0.534
MOD_GlcNHglycan	304	307	PF01048	0.449
MOD_GlcNHglycan	337	341	PF01048	0.738
MOD_GlcNHglycan	442	445	PF01048	0.722
MOD_GlcNHglycan	493	496	PF01048	0.632
MOD_GlcNHglycan	506	509	PF01048	0.679
MOD_GlcNHglycan	598	601	PF01048	0.699
MOD_GlcNHglycan	654	657	PF01048	0.696
MOD_GSK3_1	104	111	PF00069	0.666
MOD_GSK3_1	352	359	PF00069	0.641
MOD_GSK3_1	386	393	PF00069	0.740
MOD_GSK3_1	407	414	PF00069	0.467
MOD_GSK3_1	427	434	PF00069	0.467
MOD_GSK3_1	439	446	PF00069	0.754
MOD_GSK3_1	476	483	PF00069	0.774
MOD_GSK3_1	487	494	PF00069	0.798
MOD_GSK3_1	495	502	PF00069	0.708
MOD_GSK3_1	532	539	PF00069	0.479
MOD_GSK3_1	596	603	PF00069	0.497
MOD_GSK3_1	81	88	PF00069	0.635
MOD_GSK3_1	94	101	PF00069	0.508
MOD_N-GLC_1	325	330	PF02516	0.582
MOD_N-GLC_1	432	437	PF02516	0.581
MOD_N-GLC_1	603	608	PF02516	0.597
MOD_NEK2_1	178	183	PF00069	0.398
MOD_NEK2_1	256	261	PF00069	0.533
MOD_NEK2_1	300	305	PF00069	0.561
MOD_NEK2_1	481	486	PF00069	0.804
MOD_NEK2_1	670	675	PF00069	0.444
MOD_NEK2_1	81	86	PF00069	0.713
MOD_NEK2_1	94	99	PF00069	0.570
MOD_NEK2_2	444	449	PF00069	0.692
MOD_PIKK_1	117	123	PF00454	0.670
MOD_PIKK_1	379	385	PF00454	0.626
MOD_PIKK_1	481	487	PF00454	0.823
MOD_PKA_2	132	138	PF00069	0.578
MOD_PKA_2	259	265	PF00069	0.549
MOD_PKA_2	431	437	PF00069	0.714
MOD_PKA_2	568	574	PF00069	0.663
MOD_PKB_1	336	344	PF00069	0.710
MOD_Plk_1	249	255	PF00069	0.444
MOD_Plk_1	603	609	PF00069	0.548
MOD_Plk_4	132	138	PF00069	0.461
MOD_Plk_4	178	184	PF00069	0.461
MOD_Plk_4	356	362	PF00069	0.537
MOD_Plk_4	506	512	PF00069	0.401
MOD_Plk_4	527	533	PF00069	0.476
MOD_Plk_4	536	542	PF00069	0.476
MOD_Plk_4	671	677	PF00069	0.527
MOD_Plk_4	82	88	PF00069	0.711
MOD_ProDKin_1	108	114	PF00069	0.703
MOD_ProDKin_1	229	235	PF00069	0.673
MOD_ProDKin_1	272	278	PF00069	0.579
MOD_ProDKin_1	352	358	PF00069	0.683
MOD_ProDKin_1	387	393	PF00069	0.673
MOD_ProDKin_1	432	438	PF00069	0.616
MOD_ProDKin_1	476	482	PF00069	0.529
MOD_ProDKin_1	487	493	PF00069	0.784
MOD_ProDKin_1	499	505	PF00069	0.705
MOD_ProDKin_1	85	91	PF00069	0.593
MOD_SUMO_rev_2	588	598	PF00179	0.638
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.646
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.635
TRG_ENDOCYTIC_2	50	53	PF00928	0.424
TRG_ENDOCYTIC_2	522	525	PF00928	0.476
TRG_ENDOCYTIC_2	538	541	PF00928	0.476
TRG_ENDOCYTIC_2	633	636	PF00928	0.532
TRG_ENDOCYTIC_2	643	646	PF00928	0.602
TRG_ER_diArg_1	318	320	PF00400	0.508
TRG_ER_diArg_1	47	49	PF00400	0.514
TRG_ER_diArg_1	547	549	PF00400	0.491
TRG_ER_diArg_1	567	570	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B6	Leptomonas seymouri	45%	100%
A0A1X0P1I1	Trypanosomatidae	33%	100%
A0A3S7X2L4	Leishmania donovani	88%	100%
A0A422NNK7	Trypanosoma rangeli	31%	100%
A4HHJ9	Leishmania braziliensis	68%	100%
C9ZLE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AE62	Leishmania major	86%	100%
V5DCM2	Trypanosoma cruzi	30%	100%