Pentatricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALM2_LEIMU

TriTrypDb:

LmxM.08_29.2010

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.591
CLV_NRD_NRD_1	182	184	PF00675	0.373
CLV_NRD_NRD_1	2	4	PF00675	0.686
CLV_NRD_NRD_1	25	27	PF00675	0.633
CLV_NRD_NRD_1	444	446	PF00675	0.406
CLV_NRD_NRD_1	463	465	PF00675	0.260
CLV_NRD_NRD_1	609	611	PF00675	0.628
CLV_NRD_NRD_1	81	83	PF00675	0.432
CLV_PCSK_KEX2_1	182	184	PF00082	0.373
CLV_PCSK_KEX2_1	2	4	PF00082	0.692
CLV_PCSK_KEX2_1	25	27	PF00082	0.582
CLV_PCSK_KEX2_1	444	446	PF00082	0.400
CLV_PCSK_KEX2_1	463	465	PF00082	0.260
CLV_PCSK_KEX2_1	470	472	PF00082	0.464
CLV_PCSK_KEX2_1	539	541	PF00082	0.665
CLV_PCSK_KEX2_1	609	611	PF00082	0.615
CLV_PCSK_KEX2_1	81	83	PF00082	0.474
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.555
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.491
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.424
CLV_PCSK_PC7_1	440	446	PF00082	0.404
CLV_PCSK_SKI1_1	314	318	PF00082	0.334
CLV_PCSK_SKI1_1	539	543	PF00082	0.663
CLV_PCSK_SKI1_1	57	61	PF00082	0.519
CLV_PCSK_SKI1_1	609	613	PF00082	0.613
CLV_PCSK_SKI1_1	94	98	PF00082	0.571
CLV_Separin_Metazoa	211	215	PF03568	0.325
CLV_Separin_Metazoa	64	68	PF03568	0.370
DEG_APCC_DBOX_1	313	321	PF00400	0.341
DEG_Nend_UBRbox_1	1	4	PF02207	0.615
DEG_SCF_FBW7_2	541	546	PF00400	0.586
DOC_CKS1_1	520	525	PF01111	0.576
DOC_CYCLIN_RxL_1	116	127	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.579
DOC_MAPK_DCC_7	164	174	PF00069	0.386
DOC_MAPK_DCC_7	668	677	PF00069	0.526
DOC_MAPK_gen_1	463	469	PF00069	0.494
DOC_MAPK_gen_1	81	90	PF00069	0.372
DOC_MAPK_MEF2A_6	203	212	PF00069	0.405
DOC_MAPK_MEF2A_6	653	661	PF00069	0.514
DOC_MAPK_MEF2A_6	668	677	PF00069	0.526
DOC_PP1_RVXF_1	118	125	PF00149	0.529
DOC_PP2B_LxvP_1	304	307	PF13499	0.408
DOC_PP2B_LxvP_1	657	660	PF13499	0.502
DOC_PP4_MxPP_1	670	673	PF00568	0.514
DOC_USP7_MATH_1	36	40	PF00917	0.530
DOC_USP7_MATH_1	435	439	PF00917	0.374
DOC_USP7_MATH_1	591	595	PF00917	0.565
DOC_USP7_MATH_1	99	103	PF00917	0.515
DOC_USP7_MATH_2	66	72	PF00917	0.294
DOC_WW_Pin1_4	44	49	PF00397	0.476
DOC_WW_Pin1_4	496	501	PF00397	0.596
DOC_WW_Pin1_4	516	521	PF00397	0.446
DOC_WW_Pin1_4	539	544	PF00397	0.703
DOC_WW_Pin1_4	587	592	PF00397	0.624
DOC_WW_Pin1_4	604	609	PF00397	0.546
LIG_14-3-3_CanoR_1	116	124	PF00244	0.346
LIG_14-3-3_CanoR_1	2	6	PF00244	0.693
LIG_14-3-3_CanoR_1	32	40	PF00244	0.411
LIG_14-3-3_CanoR_1	609	615	PF00244	0.491
LIG_14-3-3_CanoR_1	616	624	PF00244	0.425
LIG_Actin_WH2_2	449	465	PF00022	0.351
LIG_APCC_ABBA_1	191	196	PF00400	0.413
LIG_BRCT_BRCA1_1	418	422	PF00533	0.509
LIG_FHA_1	2	8	PF00498	0.624
LIG_FHA_1	275	281	PF00498	0.492
LIG_FHA_1	347	353	PF00498	0.568
LIG_FHA_1	388	394	PF00498	0.517
LIG_FHA_1	39	45	PF00498	0.517
LIG_FHA_1	47	53	PF00498	0.493
LIG_FHA_1	510	516	PF00498	0.664
LIG_FHA_1	567	573	PF00498	0.617
LIG_FHA_1	84	90	PF00498	0.501
LIG_FHA_2	418	424	PF00498	0.502
LIG_FHA_2	45	51	PF00498	0.568
LIG_FHA_2	610	616	PF00498	0.473
LIG_IRF3_LxIS_1	672	678	PF10401	0.532
LIG_LIR_Gen_1	102	112	PF02991	0.362
LIG_LIR_Gen_1	263	273	PF02991	0.374
LIG_LIR_Gen_1	419	429	PF02991	0.439
LIG_LIR_Gen_1	472	482	PF02991	0.562
LIG_LIR_Nem_3	102	108	PF02991	0.367
LIG_LIR_Nem_3	310	316	PF02991	0.338
LIG_LIR_Nem_3	419	425	PF02991	0.434
LIG_LIR_Nem_3	430	436	PF02991	0.370
LIG_LIR_Nem_3	472	477	PF02991	0.544
LIG_LIR_Nem_3	598	604	PF02991	0.541
LIG_PCNA_yPIPBox_3	379	391	PF02747	0.537
LIG_PDZ_Class_1	693	698	PF00595	0.511
LIG_SH2_CRK	105	109	PF00017	0.356
LIG_SH2_CRK	246	250	PF00017	0.460
LIG_SH2_CRK	313	317	PF00017	0.339
LIG_SH2_CRK	429	433	PF00017	0.398
LIG_SH2_NCK_1	429	433	PF00017	0.528
LIG_SH2_STAP1	429	433	PF00017	0.383
LIG_SH2_STAP1	482	486	PF00017	0.517
LIG_SH2_STAT3	482	485	PF00017	0.514
LIG_SH2_STAT3	663	666	PF00017	0.610
LIG_SH2_STAT5	105	108	PF00017	0.383
LIG_SH2_STAT5	209	212	PF00017	0.317
LIG_SH2_STAT5	491	494	PF00017	0.493
LIG_SH3_3	165	171	PF00018	0.468
LIG_SH3_3	429	435	PF00018	0.470
LIG_SH3_3	494	500	PF00018	0.544
LIG_SH3_3	514	520	PF00018	0.735
LIG_SH3_3	594	600	PF00018	0.696
LIG_SH3_3	658	664	PF00018	0.432
LIG_SH3_3	670	676	PF00018	0.498
LIG_SH3_3	688	694	PF00018	0.480
LIG_SUMO_SIM_par_1	349	355	PF11976	0.535
LIG_TRAF2_1	267	270	PF00917	0.321
LIG_TYR_ITIM	207	212	PF00017	0.418
LIG_TYR_ITSM	309	316	PF00017	0.485
LIG_UBA3_1	212	220	PF00899	0.470
LIG_WRC_WIRS_1	375	380	PF05994	0.483
MOD_CDC14_SPxK_1	607	610	PF00782	0.552
MOD_CDK_SPK_2	587	592	PF00069	0.489
MOD_CDK_SPK_2	604	609	PF00069	0.543
MOD_CDK_SPxK_1	604	610	PF00069	0.542
MOD_CDK_SPxxK_3	44	51	PF00069	0.483
MOD_CK1_1	276	282	PF00069	0.396
MOD_CK1_1	519	525	PF00069	0.707
MOD_CK1_1	587	593	PF00069	0.696
MOD_CK1_1	595	601	PF00069	0.619
MOD_CK2_1	264	270	PF00069	0.473
MOD_CK2_1	417	423	PF00069	0.494
MOD_CK2_1	44	50	PF00069	0.512
MOD_CK2_1	609	615	PF00069	0.445
MOD_Cter_Amidation	23	26	PF01082	0.552
MOD_GlcNHglycan	395	398	PF01048	0.592
MOD_GlcNHglycan	530	533	PF01048	0.634
MOD_GlcNHglycan	594	597	PF01048	0.514
MOD_GlcNHglycan	688	691	PF01048	0.463
MOD_GlcNHglycan	70	73	PF01048	0.528
MOD_GSK3_1	235	242	PF00069	0.557
MOD_GSK3_1	346	353	PF00069	0.462
MOD_GSK3_1	417	424	PF00069	0.482
MOD_GSK3_1	580	587	PF00069	0.642
MOD_GSK3_1	591	598	PF00069	0.625
MOD_GSK3_1	634	641	PF00069	0.477
MOD_N-GLC_1	638	643	PF02516	0.435
MOD_N-GLC_2	179	181	PF02516	0.318
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	142	147	PF00069	0.409
MOD_NEK2_1	264	269	PF00069	0.411
MOD_NEK2_1	348	353	PF00069	0.467
MOD_NEK2_1	393	398	PF00069	0.673
MOD_NEK2_1	417	422	PF00069	0.561
MOD_NEK2_1	487	492	PF00069	0.642
MOD_NEK2_1	623	628	PF00069	0.438
MOD_NEK2_1	686	691	PF00069	0.404
MOD_NEK2_2	435	440	PF00069	0.385
MOD_PIKK_1	327	333	PF00454	0.535
MOD_PIKK_1	509	515	PF00454	0.599
MOD_PIKK_1	638	644	PF00454	0.479
MOD_PIKK_1	99	105	PF00454	0.454
MOD_PK_1	610	616	PF00069	0.584
MOD_PKA_1	609	615	PF00069	0.614
MOD_PKA_2	1	7	PF00069	0.666
MOD_PKA_2	115	121	PF00069	0.466
MOD_PKA_2	31	37	PF00069	0.438
MOD_PKA_2	561	567	PF00069	0.700
MOD_PKA_2	609	615	PF00069	0.484
MOD_Plk_1	235	241	PF00069	0.470
MOD_Plk_1	327	333	PF00069	0.510
MOD_Plk_1	472	478	PF00069	0.327
MOD_Plk_1	638	644	PF00069	0.502
MOD_Plk_2-3	561	567	PF00069	0.769
MOD_Plk_4	158	164	PF00069	0.355
MOD_Plk_4	308	314	PF00069	0.438
MOD_Plk_4	421	427	PF00069	0.406
MOD_Plk_4	428	434	PF00069	0.408
MOD_Plk_4	487	493	PF00069	0.502
MOD_Plk_4	511	517	PF00069	0.685
MOD_Plk_4	584	590	PF00069	0.673
MOD_ProDKin_1	44	50	PF00069	0.481
MOD_ProDKin_1	496	502	PF00069	0.594
MOD_ProDKin_1	516	522	PF00069	0.444
MOD_ProDKin_1	539	545	PF00069	0.703
MOD_ProDKin_1	587	593	PF00069	0.624
MOD_ProDKin_1	604	610	PF00069	0.550
MOD_SUMO_for_1	469	472	PF00179	0.567
MOD_SUMO_rev_2	127	134	PF00179	0.413
MOD_SUMO_rev_2	334	339	PF00179	0.507
MOD_SUMO_rev_2	34	39	PF00179	0.657
TRG_DiLeu_BaEn_1	211	216	PF01217	0.453
TRG_DiLeu_BaEn_1	400	405	PF01217	0.542
TRG_DiLeu_BaEn_1	511	516	PF01217	0.656
TRG_DiLeu_BaEn_4	472	478	PF01217	0.555
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.613
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.422
TRG_DiLeu_LyEn_5	211	216	PF01217	0.372
TRG_ENDOCYTIC_2	105	108	PF00928	0.358
TRG_ENDOCYTIC_2	209	212	PF00928	0.317
TRG_ENDOCYTIC_2	246	249	PF00928	0.461
TRG_ENDOCYTIC_2	313	316	PF00928	0.327
TRG_ENDOCYTIC_2	375	378	PF00928	0.566
TRG_ENDOCYTIC_2	429	432	PF00928	0.384
TRG_ER_diArg_1	1	3	PF00400	0.654
TRG_ER_diArg_1	182	184	PF00400	0.503
TRG_ER_diArg_1	443	445	PF00400	0.412
TRG_ER_diArg_1	462	464	PF00400	0.413
TRG_ER_diArg_1	608	610	PF00400	0.649
TRG_ER_diArg_1	80	82	PF00400	0.499
TRG_NES_CRM1_1	50	64	PF08389	0.550
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.648
TRG_PTS1	695	698	PF00515	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R0	Leptomonas seymouri	70%	97%
A0A0S4IQD8	Bodo saltans	34%	94%
A0A1X0P086	Trypanosomatidae	45%	100%
A0A3S7X2T2	Leishmania donovani	93%	100%
A0A422NKV6	Trypanosoma rangeli	44%	100%
A4HHK0	Leishmania braziliensis	85%	100%
A4I4Q8	Leishmania infantum	93%	100%
C9ZLE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AE63	Leishmania major	93%	100%
V5BGI2	Trypanosoma cruzi	47%	95%