LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALL8_LEIMU
TriTrypDb:
LmxM.08_29.2050
Length:
746

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALL8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 699 703 PF00656 0.581
CLV_NRD_NRD_1 240 242 PF00675 0.776
CLV_NRD_NRD_1 389 391 PF00675 0.699
CLV_NRD_NRD_1 491 493 PF00675 0.695
CLV_NRD_NRD_1 586 588 PF00675 0.797
CLV_NRD_NRD_1 662 664 PF00675 0.748
CLV_NRD_NRD_1 697 699 PF00675 0.706
CLV_NRD_NRD_1 710 712 PF00675 0.857
CLV_NRD_NRD_1 721 723 PF00675 0.635
CLV_PCSK_KEX2_1 490 492 PF00082 0.754
CLV_PCSK_KEX2_1 586 588 PF00082 0.764
CLV_PCSK_KEX2_1 650 652 PF00082 0.784
CLV_PCSK_KEX2_1 662 664 PF00082 0.740
CLV_PCSK_KEX2_1 697 699 PF00082 0.721
CLV_PCSK_KEX2_1 710 712 PF00082 0.755
CLV_PCSK_KEX2_1 721 723 PF00082 0.714
CLV_PCSK_KEX2_1 726 728 PF00082 0.683
CLV_PCSK_KEX2_1 9 11 PF00082 0.567
CLV_PCSK_PC1ET2_1 650 652 PF00082 0.558
CLV_PCSK_PC1ET2_1 726 728 PF00082 0.771
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.567
CLV_PCSK_PC7_1 486 492 PF00082 0.773
CLV_PCSK_PC7_1 722 728 PF00082 0.502
CLV_PCSK_SKI1_1 34 38 PF00082 0.603
CLV_PCSK_SKI1_1 486 490 PF00082 0.748
CLV_PCSK_SKI1_1 663 667 PF00082 0.781
CLV_PCSK_SKI1_1 726 730 PF00082 0.682
CLV_PCSK_SKI1_1 733 737 PF00082 0.669
CLV_PCSK_SKI1_1 94 98 PF00082 0.771
DEG_SPOP_SBC_1 269 273 PF00917 0.744
DEG_SPOP_SBC_1 303 307 PF00917 0.627
DEG_SPOP_SBC_1 428 432 PF00917 0.798
DEG_SPOP_SBC_1 609 613 PF00917 0.868
DEG_SPOP_SBC_1 68 72 PF00917 0.577
DEG_SPOP_SBC_1 98 102 PF00917 0.688
DOC_ANK_TNKS_1 697 704 PF00023 0.799
DOC_CKS1_1 45 50 PF01111 0.580
DOC_CYCLIN_RxL_1 483 493 PF00134 0.764
DOC_CYCLIN_RxL_1 660 669 PF00134 0.764
DOC_CYCLIN_RxL_1 91 101 PF00134 0.770
DOC_CYCLIN_yClb1_LxF_4 731 736 PF00134 0.675
DOC_MAPK_DCC_7 111 121 PF00069 0.706
DOC_MAPK_DCC_7 512 522 PF00069 0.757
DOC_PP1_RVXF_1 496 502 PF00149 0.780
DOC_PP1_RVXF_1 731 737 PF00149 0.672
DOC_PP2B_LxvP_1 162 165 PF13499 0.857
DOC_PP4_FxxP_1 92 95 PF00568 0.775
DOC_USP7_MATH_1 155 159 PF00917 0.762
DOC_USP7_MATH_1 183 187 PF00917 0.758
DOC_USP7_MATH_1 19 23 PF00917 0.777
DOC_USP7_MATH_1 225 229 PF00917 0.658
DOC_USP7_MATH_1 260 264 PF00917 0.662
DOC_USP7_MATH_1 269 273 PF00917 0.619
DOC_USP7_MATH_1 303 307 PF00917 0.623
DOC_USP7_MATH_1 365 369 PF00917 0.749
DOC_USP7_MATH_1 428 432 PF00917 0.798
DOC_USP7_MATH_1 447 451 PF00917 0.818
DOC_USP7_MATH_1 55 59 PF00917 0.655
DOC_USP7_MATH_1 562 566 PF00917 0.767
DOC_USP7_MATH_1 577 581 PF00917 0.735
DOC_USP7_MATH_1 609 613 PF00917 0.766
DOC_USP7_MATH_1 661 665 PF00917 0.569
DOC_USP7_MATH_1 696 700 PF00917 0.672
DOC_USP7_MATH_1 705 709 PF00917 0.595
DOC_USP7_MATH_1 98 102 PF00917 0.666
DOC_WW_Pin1_4 171 176 PF00397 0.798
DOC_WW_Pin1_4 216 221 PF00397 0.794
DOC_WW_Pin1_4 248 253 PF00397 0.760
DOC_WW_Pin1_4 372 377 PF00397 0.566
DOC_WW_Pin1_4 41 46 PF00397 0.857
DOC_WW_Pin1_4 453 458 PF00397 0.813
DOC_WW_Pin1_4 461 466 PF00397 0.716
DOC_WW_Pin1_4 515 520 PF00397 0.798
DOC_WW_Pin1_4 572 577 PF00397 0.746
DOC_WW_Pin1_4 579 584 PF00397 0.748
LIG_14-3-3_CanoR_1 10 20 PF00244 0.583
LIG_14-3-3_CanoR_1 38 45 PF00244 0.761
LIG_14-3-3_CanoR_1 484 489 PF00244 0.749
LIG_14-3-3_CanoR_1 494 502 PF00244 0.745
LIG_14-3-3_CanoR_1 586 592 PF00244 0.791
LIG_14-3-3_CanoR_1 64 69 PF00244 0.694
LIG_14-3-3_CanoR_1 662 666 PF00244 0.598
LIG_14-3-3_CanoR_1 711 719 PF00244 0.587
LIG_14-3-3_CanoR_1 741 746 PF00244 0.784
LIG_APCC_ABBAyCdc20_2 390 396 PF00400 0.686
LIG_BRCT_BRCA1_1 21 25 PF00533 0.697
LIG_BRCT_BRCA1_1 294 298 PF00533 0.595
LIG_BRCT_BRCA1_1 620 624 PF00533 0.734
LIG_BRCT_BRCA1_1 627 631 PF00533 0.704
LIG_BRCT_BRCA1_1 653 657 PF00533 0.640
LIG_EVH1_1 162 166 PF00568 0.855
LIG_FHA_1 208 214 PF00498 0.735
LIG_FHA_1 347 353 PF00498 0.766
LIG_FHA_1 367 373 PF00498 0.793
LIG_FHA_1 45 51 PF00498 0.759
LIG_FHA_1 547 553 PF00498 0.694
LIG_FHA_1 573 579 PF00498 0.723
LIG_FHA_1 586 592 PF00498 0.648
LIG_FHA_1 676 682 PF00498 0.758
LIG_FHA_2 30 36 PF00498 0.801
LIG_FHA_2 303 309 PF00498 0.637
LIG_FHA_2 552 558 PF00498 0.696
LIG_FHA_2 667 673 PF00498 0.781
LIG_LIR_Gen_1 397 407 PF02991 0.687
LIG_LIR_Nem_3 148 153 PF02991 0.834
LIG_LIR_Nem_3 397 403 PF02991 0.686
LIG_LIR_Nem_3 628 634 PF02991 0.656
LIG_LIR_Nem_3 654 660 PF02991 0.568
LIG_LYPXL_yS_3 544 547 PF13949 0.561
LIG_MYND_1 692 696 PF01753 0.577
LIG_NRBOX 555 561 PF00104 0.558
LIG_Pex14_2 735 739 PF04695 0.691
LIG_SH2_GRB2like 602 605 PF00017 0.567
LIG_SH2_STAT5 234 237 PF00017 0.778
LIG_SH2_STAT5 418 421 PF00017 0.665
LIG_SH2_STAT5 482 485 PF00017 0.797
LIG_SH2_STAT5 602 605 PF00017 0.567
LIG_SH3_1 111 117 PF00018 0.587
LIG_SH3_1 422 428 PF00018 0.558
LIG_SH3_2 458 463 PF14604 0.591
LIG_SH3_2 658 663 PF14604 0.701
LIG_SH3_2 693 698 PF14604 0.610
LIG_SH3_3 111 117 PF00018 0.587
LIG_SH3_3 160 166 PF00018 0.755
LIG_SH3_3 42 48 PF00018 0.718
LIG_SH3_3 422 428 PF00018 0.582
LIG_SH3_3 455 461 PF00018 0.593
LIG_SH3_3 573 579 PF00018 0.815
LIG_SH3_3 655 661 PF00018 0.751
LIG_SH3_3 690 696 PF00018 0.824
LIG_SH3_3 92 98 PF00018 0.676
LIG_SUMO_SIM_par_1 568 575 PF11976 0.781
LIG_TRAF2_1 384 387 PF00917 0.705
LIG_UBA3_1 734 743 PF00899 0.598
LIG_WW_2 576 579 PF00397 0.766
MOD_CDC14_SPxK_1 251 254 PF00782 0.609
MOD_CDK_SPK_2 372 377 PF00069 0.566
MOD_CDK_SPxK_1 248 254 PF00069 0.610
MOD_CDK_SPxxK_3 579 586 PF00069 0.789
MOD_CK1_1 107 113 PF00069 0.727
MOD_CK1_1 132 138 PF00069 0.765
MOD_CK1_1 142 148 PF00069 0.681
MOD_CK1_1 151 157 PF00069 0.686
MOD_CK1_1 201 207 PF00069 0.715
MOD_CK1_1 272 278 PF00069 0.728
MOD_CK1_1 29 35 PF00069 0.731
MOD_CK1_1 292 298 PF00069 0.579
MOD_CK1_1 338 344 PF00069 0.696
MOD_CK1_1 375 381 PF00069 0.678
MOD_CK1_1 41 47 PF00069 0.733
MOD_CK1_1 431 437 PF00069 0.816
MOD_CK1_1 450 456 PF00069 0.778
MOD_CK1_1 464 470 PF00069 0.593
MOD_CK1_1 58 64 PF00069 0.708
MOD_CK1_1 613 619 PF00069 0.776
MOD_CK1_1 620 626 PF00069 0.824
MOD_CK1_1 656 662 PF00069 0.631
MOD_CK1_1 67 73 PF00069 0.789
MOD_CK1_1 99 105 PF00069 0.809
MOD_CK2_1 132 138 PF00069 0.784
MOD_CK2_1 155 161 PF00069 0.768
MOD_CK2_1 302 308 PF00069 0.642
MOD_CK2_1 381 387 PF00069 0.732
MOD_CK2_1 551 557 PF00069 0.556
MOD_CK2_1 661 667 PF00069 0.568
MOD_CK2_1 701 707 PF00069 0.787
MOD_CMANNOS 420 423 PF00535 0.661
MOD_Cter_Amidation 648 651 PF01082 0.634
MOD_Cter_Amidation 708 711 PF01082 0.850
MOD_GlcNHglycan 147 150 PF01048 0.706
MOD_GlcNHglycan 153 156 PF01048 0.724
MOD_GlcNHglycan 157 160 PF01048 0.714
MOD_GlcNHglycan 185 188 PF01048 0.783
MOD_GlcNHglycan 192 195 PF01048 0.742
MOD_GlcNHglycan 204 207 PF01048 0.624
MOD_GlcNHglycan 243 246 PF01048 0.651
MOD_GlcNHglycan 285 288 PF01048 0.650
MOD_GlcNHglycan 331 335 PF01048 0.633
MOD_GlcNHglycan 340 343 PF01048 0.780
MOD_GlcNHglycan 344 347 PF01048 0.864
MOD_GlcNHglycan 383 386 PF01048 0.507
MOD_GlcNHglycan 40 43 PF01048 0.886
MOD_GlcNHglycan 431 434 PF01048 0.751
MOD_GlcNHglycan 435 438 PF01048 0.748
MOD_GlcNHglycan 439 442 PF01048 0.720
MOD_GlcNHglycan 466 469 PF01048 0.845
MOD_GlcNHglycan 565 568 PF01048 0.844
MOD_GlcNHglycan 612 615 PF01048 0.771
MOD_GlcNHglycan 645 648 PF01048 0.691
MOD_GlcNHglycan 653 656 PF01048 0.643
MOD_GlcNHglycan 687 690 PF01048 0.824
MOD_GlcNHglycan 702 706 PF01048 0.783
MOD_GlcNHglycan 707 710 PF01048 0.779
MOD_GlcNHglycan 714 717 PF01048 0.798
MOD_GlcNHglycan 86 89 PF01048 0.835
MOD_GSK3_1 115 122 PF00069 0.744
MOD_GSK3_1 139 146 PF00069 0.842
MOD_GSK3_1 151 158 PF00069 0.651
MOD_GSK3_1 179 186 PF00069 0.733
MOD_GSK3_1 19 26 PF00069 0.801
MOD_GSK3_1 198 205 PF00069 0.746
MOD_GSK3_1 260 267 PF00069 0.722
MOD_GSK3_1 268 275 PF00069 0.658
MOD_GSK3_1 330 337 PF00069 0.788
MOD_GSK3_1 338 345 PF00069 0.814
MOD_GSK3_1 354 361 PF00069 0.699
MOD_GSK3_1 375 382 PF00069 0.670
MOD_GSK3_1 427 434 PF00069 0.878
MOD_GSK3_1 446 453 PF00069 0.898
MOD_GSK3_1 506 513 PF00069 0.728
MOD_GSK3_1 546 553 PF00069 0.612
MOD_GSK3_1 568 575 PF00069 0.751
MOD_GSK3_1 609 616 PF00069 0.770
MOD_GSK3_1 618 625 PF00069 0.836
MOD_GSK3_1 639 646 PF00069 0.821
MOD_GSK3_1 64 71 PF00069 0.856
MOD_GSK3_1 697 704 PF00069 0.799
MOD_GSK3_1 73 80 PF00069 0.797
MOD_GSK3_1 737 744 PF00069 0.773
MOD_GSK3_1 96 103 PF00069 0.857
MOD_N-GLC_1 143 148 PF02516 0.695
MOD_N-GLC_1 354 359 PF02516 0.657
MOD_N-GLC_1 428 433 PF02516 0.802
MOD_N-GLC_1 603 608 PF02516 0.737
MOD_N-GLC_2 469 471 PF02516 0.812
MOD_NEK2_1 104 109 PF00069 0.665
MOD_NEK2_1 139 144 PF00069 0.703
MOD_NEK2_1 208 213 PF00069 0.708
MOD_NEK2_1 268 273 PF00069 0.834
MOD_NEK2_1 274 279 PF00069 0.527
MOD_NEK2_1 335 340 PF00069 0.769
MOD_NEK2_1 603 608 PF00069 0.830
MOD_NEK2_1 610 615 PF00069 0.769
MOD_NEK2_1 617 622 PF00069 0.565
MOD_NEK2_1 712 717 PF00069 0.545
MOD_NEK2_2 55 60 PF00069 0.615
MOD_NMyristoyl 1 7 PF02799 0.798
MOD_PIKK_1 104 110 PF00454 0.594
MOD_PIKK_1 19 25 PF00454 0.696
MOD_PIKK_1 246 252 PF00454 0.605
MOD_PIKK_1 346 352 PF00454 0.861
MOD_PIKK_1 666 672 PF00454 0.781
MOD_PK_1 639 645 PF00069 0.741
MOD_PK_1 64 70 PF00069 0.794
MOD_PKA_1 241 247 PF00069 0.796
MOD_PKA_1 586 592 PF00069 0.791
MOD_PKA_1 697 703 PF00069 0.703
MOD_PKA_2 338 344 PF00069 0.761
MOD_PKA_2 447 453 PF00069 0.647
MOD_PKA_2 493 499 PF00069 0.848
MOD_PKA_2 506 512 PF00069 0.620
MOD_PKA_2 585 591 PF00069 0.794
MOD_PKA_2 661 667 PF00069 0.730
MOD_PKA_2 696 702 PF00069 0.727
MOD_PKB_1 490 498 PF00069 0.829
MOD_Plk_1 139 145 PF00069 0.842
MOD_Plk_1 225 231 PF00069 0.754
MOD_Plk_1 289 295 PF00069 0.689
MOD_Plk_1 330 336 PF00069 0.661
MOD_Plk_1 394 400 PF00069 0.565
MOD_Plk_1 597 603 PF00069 0.640
MOD_Plk_4 100 106 PF00069 0.654
MOD_Plk_4 204 210 PF00069 0.861
MOD_Plk_4 219 225 PF00069 0.704
MOD_Plk_4 399 405 PF00069 0.601
MOD_Plk_4 416 422 PF00069 0.646
MOD_Plk_4 639 645 PF00069 0.741
MOD_ProDKin_1 171 177 PF00069 0.799
MOD_ProDKin_1 216 222 PF00069 0.796
MOD_ProDKin_1 248 254 PF00069 0.762
MOD_ProDKin_1 372 378 PF00069 0.563
MOD_ProDKin_1 41 47 PF00069 0.857
MOD_ProDKin_1 453 459 PF00069 0.811
MOD_ProDKin_1 461 467 PF00069 0.718
MOD_ProDKin_1 515 521 PF00069 0.799
MOD_ProDKin_1 572 578 PF00069 0.747
MOD_ProDKin_1 579 585 PF00069 0.749
MOD_SUMO_rev_2 599 609 PF00179 0.779
MOD_SUMO_rev_2 730 735 PF00179 0.673
TRG_DiLeu_BaEn_1 331 336 PF01217 0.708
TRG_DiLeu_BaEn_2 395 401 PF01217 0.657
TRG_DiLeu_BaLyEn_6 165 170 PF01217 0.745
TRG_DiLeu_BaLyEn_6 708 713 PF01217 0.558
TRG_ENDOCYTIC_2 418 421 PF00928 0.627
TRG_ENDOCYTIC_2 544 547 PF00928 0.561
TRG_ER_diArg_1 314 317 PF00400 0.467
TRG_ER_diArg_1 37 40 PF00400 0.678
TRG_ER_diArg_1 483 486 PF00400 0.767
TRG_ER_diArg_1 489 492 PF00400 0.732
TRG_ER_diArg_1 661 663 PF00400 0.741
TRG_ER_diArg_1 696 698 PF00400 0.705
TRG_ER_diArg_1 710 712 PF00400 0.740
TRG_Pf-PMV_PEXEL_1 663 667 PF00026 0.781
TRG_Pf-PMV_PEXEL_1 727 731 PF00026 0.677

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HW90 Leptomonas seymouri 30% 88%
A0A3S7X2M1 Leishmania donovani 82% 100%
A4HHK4 Leishmania braziliensis 50% 99%
A4I4R6 Leishmania infantum 82% 100%
E9AE67 Leishmania major 78% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS