Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ALL6_LEIMU

TriTrypDb:

LmxM.08_29.2070

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.606
CLV_NRD_NRD_1	221	223	PF00675	0.822
CLV_NRD_NRD_1	235	237	PF00675	0.539
CLV_NRD_NRD_1	287	289	PF00675	0.725
CLV_NRD_NRD_1	30	32	PF00675	0.687
CLV_NRD_NRD_1	309	311	PF00675	0.652
CLV_PCSK_KEX2_1	221	223	PF00082	0.822
CLV_PCSK_KEX2_1	235	237	PF00082	0.539
CLV_PCSK_KEX2_1	286	288	PF00082	0.747
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.673
CLV_PCSK_SKI1_1	250	254	PF00082	0.688
CLV_PCSK_SKI1_1	31	35	PF00082	0.582
CLV_PCSK_SKI1_1	430	434	PF00082	0.675
CLV_PCSK_SKI1_1	58	62	PF00082	0.492
DEG_SPOP_SBC_1	419	423	PF00917	0.464
DEG_SPOP_SBC_1	6	10	PF00917	0.501
DOC_CKS1_1	381	386	PF01111	0.552
DOC_MAPK_DCC_7	37	46	PF00069	0.752
DOC_MAPK_gen_1	245	255	PF00069	0.588
DOC_MAPK_gen_1	406	414	PF00069	0.603
DOC_MAPK_MEF2A_6	192	201	PF00069	0.728
DOC_MAPK_MEF2A_6	248	257	PF00069	0.615
DOC_MAPK_MEF2A_6	37	46	PF00069	0.752
DOC_MAPK_NFAT4_5	250	258	PF00069	0.583
DOC_PP4_FxxP_1	440	443	PF00568	0.652
DOC_USP7_MATH_1	102	106	PF00917	0.675
DOC_USP7_MATH_1	328	332	PF00917	0.783
DOC_USP7_MATH_1	35	39	PF00917	0.618
DOC_USP7_MATH_1	357	361	PF00917	0.707
DOC_USP7_MATH_1	377	381	PF00917	0.739
DOC_USP7_MATH_1	404	408	PF00917	0.684
DOC_USP7_MATH_1	47	51	PF00917	0.604
DOC_USP7_MATH_1	76	80	PF00917	0.775
DOC_WW_Pin1_4	191	196	PF00397	0.739
DOC_WW_Pin1_4	373	378	PF00397	0.630
DOC_WW_Pin1_4	380	385	PF00397	0.585
DOC_WW_Pin1_4	420	425	PF00397	0.667
LIG_14-3-3_CanoR_1	235	244	PF00244	0.676
LIG_14-3-3_CanoR_1	295	301	PF00244	0.705
LIG_14-3-3_CanoR_1	31	40	PF00244	0.652
LIG_14-3-3_CanoR_1	313	322	PF00244	0.721
LIG_14-3-3_CanoR_1	356	365	PF00244	0.523
LIG_14-3-3_CanoR_1	371	377	PF00244	0.579
LIG_14-3-3_CanoR_1	430	435	PF00244	0.664
LIG_14-3-3_CanoR_1	98	102	PF00244	0.718
LIG_Actin_WH2_2	358	373	PF00022	0.516
LIG_FAT_LD_1	130	138	PF03623	0.552
LIG_FHA_1	198	204	PF00498	0.714
LIG_FHA_1	314	320	PF00498	0.753
LIG_FHA_1	395	401	PF00498	0.734
LIG_FHA_1	87	93	PF00498	0.565
LIG_FHA_2	114	120	PF00498	0.592
LIG_FHA_2	180	186	PF00498	0.745
LIG_FHA_2	202	208	PF00498	0.706
LIG_FHA_2	315	321	PF00498	0.741
LIG_FHA_2	6	12	PF00498	0.530
LIG_GBD_Chelix_1	129	137	PF00786	0.382
LIG_LIR_Apic_2	437	443	PF02991	0.450
LIG_LIR_Gen_1	212	218	PF02991	0.511
LIG_LIR_Nem_3	212	216	PF02991	0.611
LIG_MAD2	16	24	PF02301	0.657
LIG_NRBOX	92	98	PF00104	0.646
LIG_PTB_Apo_2	256	263	PF02174	0.521
LIG_PTB_Phospho_1	256	262	PF10480	0.437
LIG_SH2_CRK	22	26	PF00017	0.474
LIG_SH2_SRC	22	25	PF00017	0.473
LIG_SH2_STAP1	238	242	PF00017	0.620
LIG_SH3_3	103	109	PF00018	0.650
LIG_SH3_3	18	24	PF00018	0.625
LIG_SH3_3	196	202	PF00018	0.675
LIG_SH3_3	324	330	PF00018	0.775
LIG_SH3_3	413	419	PF00018	0.654
LIG_SUMO_SIM_anti_2	315	324	PF11976	0.526
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.510
LIG_SUMO_SIM_par_1	200	207	PF11976	0.672
LIG_TRAF2_1	182	185	PF00917	0.745
LIG_WRC_WIRS_1	345	350	PF05994	0.504
MOD_CDK_SPK_2	380	385	PF00069	0.598
MOD_CK1_1	167	173	PF00069	0.674
MOD_CK1_1	223	229	PF00069	0.690
MOD_CK1_1	266	272	PF00069	0.712
MOD_CK1_1	349	355	PF00069	0.763
MOD_CK1_1	373	379	PF00069	0.725
MOD_CK1_1	380	386	PF00069	0.767
MOD_CK1_1	394	400	PF00069	0.734
MOD_CK1_1	45	51	PF00069	0.735
MOD_CK2_1	113	119	PF00069	0.667
MOD_CK2_1	179	185	PF00069	0.738
MOD_CK2_1	275	281	PF00069	0.537
MOD_CK2_1	306	312	PF00069	0.765
MOD_CK2_1	328	334	PF00069	0.787
MOD_CK2_1	5	11	PF00069	0.529
MOD_GlcNHglycan	142	145	PF01048	0.559
MOD_GlcNHglycan	188	191	PF01048	0.743
MOD_GlcNHglycan	231	234	PF01048	0.711
MOD_GlcNHglycan	265	268	PF01048	0.645
MOD_GlcNHglycan	351	354	PF01048	0.697
MOD_GlcNHglycan	359	362	PF01048	0.733
MOD_GlcNHglycan	372	375	PF01048	0.787
MOD_GSK3_1	160	167	PF00069	0.479
MOD_GSK3_1	197	204	PF00069	0.682
MOD_GSK3_1	262	269	PF00069	0.598
MOD_GSK3_1	31	38	PF00069	0.635
MOD_GSK3_1	352	359	PF00069	0.707
MOD_GSK3_1	366	373	PF00069	0.623
MOD_GSK3_1	430	437	PF00069	0.479
MOD_GSK3_1	6	13	PF00069	0.655
MOD_GSK3_1	72	79	PF00069	0.687
MOD_N-GLC_1	197	202	PF02516	0.601
MOD_N-GLC_1	236	241	PF02516	0.493
MOD_N-GLC_1	434	439	PF02516	0.465
MOD_NEK2_1	370	375	PF00069	0.631
MOD_NEK2_1	97	102	PF00069	0.775
MOD_NEK2_2	386	391	PF00069	0.649
MOD_PIKK_1	132	138	PF00454	0.597
MOD_PIKK_1	377	383	PF00454	0.837
MOD_PIKK_1	91	97	PF00454	0.625
MOD_PK_1	56	62	PF00069	0.493
MOD_PKA_1	31	37	PF00069	0.584
MOD_PKA_2	220	226	PF00069	0.811
MOD_PKA_2	296	302	PF00069	0.764
MOD_PKA_2	312	318	PF00069	0.538
MOD_PKA_2	36	42	PF00069	0.755
MOD_PKA_2	370	376	PF00069	0.826
MOD_PKA_2	394	400	PF00069	0.707
MOD_PKA_2	97	103	PF00069	0.716
MOD_Plk_1	113	119	PF00069	0.762
MOD_Plk_1	167	173	PF00069	0.674
MOD_Plk_1	197	203	PF00069	0.601
MOD_Plk_1	434	440	PF00069	0.459
MOD_Plk_2-3	113	119	PF00069	0.727
MOD_Plk_4	337	343	PF00069	0.507
MOD_Plk_4	36	42	PF00069	0.672
MOD_Plk_4	69	75	PF00069	0.487
MOD_ProDKin_1	191	197	PF00069	0.739
MOD_ProDKin_1	373	379	PF00069	0.633
MOD_ProDKin_1	380	386	PF00069	0.586
MOD_ProDKin_1	420	426	PF00069	0.671
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.741
TRG_ER_diArg_1	221	224	PF00400	0.726
TRG_ER_diArg_1	234	236	PF00400	0.523
TRG_ER_diArg_1	287	290	PF00400	0.764
TRG_NLS_MonoCore_2	283	288	PF00514	0.622
TRG_NLS_MonoExtC_3	283	288	PF00514	0.719
TRG_NLS_MonoExtN_4	284	290	PF00514	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW7	Leptomonas seymouri	30%	100%
A0A3Q8IRH8	Leishmania donovani	79%	100%
A4HHK6	Leishmania braziliensis	53%	94%
A4I4R7	Leishmania infantum	79%	100%
E9AE69	Leishmania major	76%	99%