LeishMANIAdb
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WW domain-containing oxidoreductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WW domain-containing oxidoreductase
Gene product:
short chain dehydrogenase, putative
Species:
Leishmania mexicana
UniProt:
E9ALL5_LEIMU
TriTrypDb:
LmxM.08_29.2080
Length:
451

Annotations

LeishMANIAdb annotations

The closest related human enzyme is a retinol dehydrogenase. Anchored to the membrane from the inner side.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9ALL5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALL5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 441 445 PF00656 0.500
CLV_NRD_NRD_1 372 374 PF00675 0.337
CLV_NRD_NRD_1 88 90 PF00675 0.461
CLV_PCSK_KEX2_1 372 374 PF00082 0.308
CLV_PCSK_KEX2_1 46 48 PF00082 0.365
CLV_PCSK_KEX2_1 88 90 PF00082 0.461
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.405
CLV_PCSK_SKI1_1 142 146 PF00082 0.363
CLV_PCSK_SKI1_1 23 27 PF00082 0.336
CLV_PCSK_SKI1_1 75 79 PF00082 0.435
DEG_APCC_DBOX_1 22 30 PF00400 0.207
DEG_Nend_Nbox_1 1 3 PF02207 0.422
DOC_CYCLIN_RxL_1 136 147 PF00134 0.528
DOC_CYCLIN_yCln2_LP_2 248 254 PF00134 0.493
DOC_PP1_RVXF_1 8 14 PF00149 0.356
DOC_PP2B_LxvP_1 248 251 PF13499 0.521
DOC_USP7_MATH_1 295 299 PF00917 0.477
DOC_USP7_MATH_1 329 333 PF00917 0.543
DOC_USP7_MATH_1 417 421 PF00917 0.568
DOC_USP7_MATH_1 67 71 PF00917 0.618
DOC_USP7_MATH_1 99 103 PF00917 0.557
DOC_WW_Pin1_4 201 206 PF00397 0.471
DOC_WW_Pin1_4 354 359 PF00397 0.461
DOC_WW_Pin1_4 63 68 PF00397 0.607
LIG_14-3-3_CanoR_1 207 213 PF00244 0.531
LIG_14-3-3_CanoR_1 240 250 PF00244 0.584
LIG_14-3-3_CanoR_1 446 451 PF00244 0.577
LIG_Actin_WH2_2 179 195 PF00022 0.508
LIG_Actin_WH2_2 339 357 PF00022 0.580
LIG_APCC_ABBA_1 153 158 PF00400 0.614
LIG_BRCT_BRCA1_1 407 411 PF00533 0.559
LIG_eIF4E_1 116 122 PF01652 0.438
LIG_FHA_1 144 150 PF00498 0.430
LIG_FHA_1 174 180 PF00498 0.449
LIG_FHA_1 217 223 PF00498 0.453
LIG_FHA_1 317 323 PF00498 0.462
LIG_FHA_1 355 361 PF00498 0.480
LIG_FHA_1 37 43 PF00498 0.583
LIG_FHA_1 429 435 PF00498 0.511
LIG_FHA_1 437 443 PF00498 0.496
LIG_FHA_1 74 80 PF00498 0.599
LIG_FHA_2 270 276 PF00498 0.549
LIG_FHA_2 69 75 PF00498 0.651
LIG_Integrin_isoDGR_2 134 136 PF01839 0.315
LIG_Integrin_isoDGR_2 160 162 PF01839 0.376
LIG_Integrin_RGD_1 55 57 PF01839 0.441
LIG_LIR_Gen_1 16 26 PF02991 0.334
LIG_LIR_Gen_1 283 292 PF02991 0.590
LIG_LIR_Gen_1 76 86 PF02991 0.589
LIG_LIR_Nem_3 109 113 PF02991 0.466
LIG_LIR_Nem_3 16 21 PF02991 0.334
LIG_LIR_Nem_3 283 289 PF02991 0.532
LIG_LIR_Nem_3 31 36 PF02991 0.202
LIG_LIR_Nem_3 408 414 PF02991 0.630
LIG_LIR_Nem_3 76 81 PF02991 0.590
LIG_NRBOX 118 124 PF00104 0.527
LIG_OCRL_FandH_1 308 320 PF00620 0.475
LIG_PCNA_PIPBox_1 279 288 PF02747 0.476
LIG_PCNA_yPIPBox_3 157 167 PF02747 0.585
LIG_PCNA_yPIPBox_3 279 288 PF02747 0.580
LIG_PCNA_yPIPBox_3 294 308 PF02747 0.492
LIG_Pex14_1 13 17 PF04695 0.299
LIG_Pex14_2 17 21 PF04695 0.201
LIG_REV1ctd_RIR_1 18 27 PF16727 0.150
LIG_REV1ctd_RIR_1 379 387 PF16727 0.490
LIG_SH2_CRK 110 114 PF00017 0.456
LIG_SH2_CRK 116 120 PF00017 0.439
LIG_SH2_STAT5 116 119 PF00017 0.435
LIG_SH2_STAT5 143 146 PF00017 0.526
LIG_SH2_STAT5 285 288 PF00017 0.556
LIG_SH2_STAT5 3 6 PF00017 0.350
LIG_SH2_STAT5 33 36 PF00017 0.401
LIG_SH2_STAT5 364 367 PF00017 0.455
LIG_SH2_STAT5 436 439 PF00017 0.457
LIG_SH3_3 243 249 PF00018 0.644
LIG_SH3_3 321 327 PF00018 0.443
LIG_SH3_3 409 415 PF00018 0.645
LIG_SUMO_SIM_anti_2 225 230 PF11976 0.355
LIG_SUMO_SIM_par_1 25 31 PF11976 0.191
LIG_SUMO_SIM_par_1 253 259 PF11976 0.512
LIG_TRAF2_1 278 281 PF00917 0.549
LIG_TYR_ITIM 108 113 PF00017 0.459
LIG_WRC_WIRS_1 270 275 PF05994 0.457
LIG_WW_3 204 208 PF00397 0.523
MOD_CDC14_SPxK_1 204 207 PF00782 0.543
MOD_CDK_SPxK_1 201 207 PF00069 0.518
MOD_CK1_1 241 247 PF00069 0.591
MOD_CK2_1 269 275 PF00069 0.581
MOD_CK2_1 68 74 PF00069 0.635
MOD_Cter_Amidation 44 47 PF01082 0.399
MOD_GlcNHglycan 101 104 PF01048 0.316
MOD_GlcNHglycan 123 126 PF01048 0.339
MOD_GlcNHglycan 146 149 PF01048 0.399
MOD_GlcNHglycan 258 261 PF01048 0.344
MOD_GlcNHglycan 402 405 PF01048 0.419
MOD_GSK3_1 236 243 PF00069 0.626
MOD_GSK3_1 261 268 PF00069 0.565
MOD_GSK3_1 63 70 PF00069 0.605
MOD_GSK3_1 99 106 PF00069 0.460
MOD_N-GLC_1 180 185 PF02516 0.344
MOD_N-GLC_1 406 411 PF02516 0.459
MOD_N-GLC_1 81 86 PF02516 0.358
MOD_NEK2_1 121 126 PF00069 0.530
MOD_NEK2_1 144 149 PF00069 0.520
MOD_NEK2_1 173 178 PF00069 0.429
MOD_NEK2_1 231 236 PF00069 0.549
MOD_NEK2_1 302 307 PF00069 0.472
MOD_NEK2_1 316 321 PF00069 0.545
MOD_NEK2_1 368 373 PF00069 0.542
MOD_NEK2_1 405 410 PF00069 0.653
MOD_NEK2_1 62 67 PF00069 0.679
MOD_NEK2_1 81 86 PF00069 0.562
MOD_NEK2_2 269 274 PF00069 0.545
MOD_PIKK_1 206 212 PF00454 0.549
MOD_PIKK_1 238 244 PF00454 0.579
MOD_PIKK_1 275 281 PF00454 0.562
MOD_PIKK_1 335 341 PF00454 0.601
MOD_PKA_2 206 212 PF00069 0.569
MOD_PKB_1 47 55 PF00069 0.627
MOD_Plk_1 386 392 PF00069 0.525
MOD_Plk_1 406 412 PF00069 0.660
MOD_Plk_1 73 79 PF00069 0.629
MOD_Plk_1 81 87 PF00069 0.508
MOD_Plk_4 222 228 PF00069 0.442
MOD_Plk_4 359 365 PF00069 0.550
MOD_Plk_4 386 392 PF00069 0.525
MOD_Plk_4 406 412 PF00069 0.621
MOD_Plk_4 49 55 PF00069 0.652
MOD_Plk_4 73 79 PF00069 0.653
MOD_ProDKin_1 201 207 PF00069 0.476
MOD_ProDKin_1 354 360 PF00069 0.460
MOD_ProDKin_1 63 69 PF00069 0.610
TRG_DiLeu_BaEn_1 349 354 PF01217 0.594
TRG_DiLeu_BaEn_2 73 79 PF01217 0.639
TRG_DiLeu_BaLyEn_6 227 232 PF01217 0.428
TRG_ENDOCYTIC_2 110 113 PF00928 0.463
TRG_ENDOCYTIC_2 116 119 PF00928 0.435
TRG_ENDOCYTIC_2 392 395 PF00928 0.630
TRG_ER_diArg_1 140 143 PF00400 0.536
TRG_ER_diArg_1 312 315 PF00400 0.543
TRG_ER_diArg_1 330 333 PF00400 0.459
TRG_ER_diArg_1 88 90 PF00400 0.660

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKI4 Leptomonas seymouri 73% 100%
A0A1X0P177 Trypanosomatidae 49% 100%
A0A3Q8IBK9 Leishmania donovani 94% 100%
A0A3R7NQF7 Trypanosoma rangeli 50% 100%
A4HHK7 Leishmania braziliensis 83% 100%
A4I4R8 Leishmania infantum 94% 100%
E9AE70 Leishmania major 94% 100%
Q9ERI6 Mus musculus 26% 100%
V5BBW8 Trypanosoma cruzi 49% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS