DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 37

Species:

Leishmania mexicana

UniProt:

E9ALL3_LEIMU

TriTrypDb:

LmxM.08_29.2100

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ALL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.698
CLV_C14_Caspase3-7	547	551	PF00656	0.184
CLV_NRD_NRD_1	140	142	PF00675	0.446
CLV_NRD_NRD_1	217	219	PF00675	0.445
CLV_NRD_NRD_1	335	337	PF00675	0.341
CLV_NRD_NRD_1	40	42	PF00675	0.412
CLV_NRD_NRD_1	597	599	PF00675	0.317
CLV_NRD_NRD_1	613	615	PF00675	0.270
CLV_PCSK_KEX2_1	140	142	PF00082	0.574
CLV_PCSK_KEX2_1	217	219	PF00082	0.495
CLV_PCSK_KEX2_1	335	337	PF00082	0.341
CLV_PCSK_KEX2_1	383	385	PF00082	0.316
CLV_PCSK_KEX2_1	395	397	PF00082	0.449
CLV_PCSK_KEX2_1	40	42	PF00082	0.412
CLV_PCSK_KEX2_1	508	510	PF00082	0.301
CLV_PCSK_KEX2_1	543	545	PF00082	0.327
CLV_PCSK_KEX2_1	597	599	PF00082	0.333
CLV_PCSK_KEX2_1	613	615	PF00082	0.416
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.188
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.254
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.320
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.306
CLV_PCSK_SKI1_1	218	222	PF00082	0.521
CLV_PCSK_SKI1_1	224	228	PF00082	0.462
CLV_PCSK_SKI1_1	267	271	PF00082	0.608
CLV_PCSK_SKI1_1	383	387	PF00082	0.184
CLV_PCSK_SKI1_1	508	512	PF00082	0.309
CLV_PCSK_SKI1_1	543	547	PF00082	0.395
CLV_PCSK_SKI1_1	86	90	PF00082	0.479
CLV_Separin_Metazoa	219	223	PF03568	0.641
DEG_APCC_DBOX_1	427	435	PF00400	0.341
DEG_Nend_UBRbox_3	1	3	PF02207	0.628
DOC_CKS1_1	356	361	PF01111	0.310
DOC_CKS1_1	47	52	PF01111	0.538
DOC_CKS1_1	6	11	PF01111	0.493
DOC_CYCLIN_RxL_1	213	225	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.399
DOC_MAPK_gen_1	40	47	PF00069	0.448
DOC_MAPK_gen_1	554	563	PF00069	0.364
DOC_MAPK_gen_1	613	623	PF00069	0.438
DOC_MAPK_MEF2A_6	15	23	PF00069	0.413
DOC_MAPK_MEF2A_6	231	240	PF00069	0.400
DOC_MAPK_MEF2A_6	616	625	PF00069	0.341
DOC_MAPK_MEF2A_6	72	79	PF00069	0.458
DOC_PP2B_LxvP_1	434	437	PF13499	0.329
DOC_PP2B_LxvP_1	465	468	PF13499	0.399
DOC_PP4_FxxP_1	412	415	PF00568	0.306
DOC_PP4_FxxP_1	47	50	PF00568	0.593
DOC_USP7_MATH_1	119	123	PF00917	0.765
DOC_USP7_MATH_1	446	450	PF00917	0.360
DOC_USP7_MATH_1	490	494	PF00917	0.416
DOC_USP7_MATH_1	501	505	PF00917	0.272
DOC_USP7_MATH_1	545	549	PF00917	0.486
DOC_USP7_MATH_1	562	566	PF00917	0.220
DOC_USP7_MATH_1	617	621	PF00917	0.341
DOC_USP7_UBL2_3	527	531	PF12436	0.368
DOC_WW_Pin1_4	243	248	PF00397	0.655
DOC_WW_Pin1_4	352	357	PF00397	0.485
DOC_WW_Pin1_4	46	51	PF00397	0.523
DOC_WW_Pin1_4	5	10	PF00397	0.778
DOC_WW_Pin1_4	572	577	PF00397	0.399
LIG_Actin_WH2_2	255	272	PF00022	0.587
LIG_APCC_ABBA_1	471	476	PF00400	0.399
LIG_APCC_ABBA_1	577	582	PF00400	0.410
LIG_APCC_ABBA_1	583	588	PF00400	0.390
LIG_BIR_III_4	125	129	PF00653	0.609
LIG_BRCT_BRCA1_1	460	464	PF00533	0.203
LIG_FHA_1	105	111	PF00498	0.595
LIG_FHA_1	169	175	PF00498	0.496
LIG_FHA_1	18	24	PF00498	0.581
LIG_FHA_1	188	194	PF00498	0.419
LIG_FHA_1	263	269	PF00498	0.588
LIG_FHA_1	301	307	PF00498	0.399
LIG_FHA_1	341	347	PF00498	0.368
LIG_FHA_1	404	410	PF00498	0.304
LIG_FHA_1	424	430	PF00498	0.378
LIG_FHA_1	544	550	PF00498	0.370
LIG_FHA_2	190	196	PF00498	0.569
LIG_FHA_2	255	261	PF00498	0.624
LIG_LIR_Apic_2	283	287	PF02991	0.306
LIG_LIR_Apic_2	46	50	PF02991	0.594
LIG_LIR_Gen_1	441	450	PF02991	0.293
LIG_LIR_Gen_1	461	472	PF02991	0.393
LIG_LIR_Nem_3	288	294	PF02991	0.346
LIG_LIR_Nem_3	441	445	PF02991	0.313
LIG_LIR_Nem_3	461	467	PF02991	0.393
LIG_PDZ_Class_2	635	640	PF00595	0.466
LIG_Pex14_1	291	295	PF04695	0.319
LIG_Pex14_2	79	83	PF04695	0.463
LIG_SH2_CRK	284	288	PF00017	0.271
LIG_SH2_GRB2like	309	312	PF00017	0.306
LIG_SH2_GRB2like	33	36	PF00017	0.437
LIG_SH2_PTP2	442	445	PF00017	0.261
LIG_SH2_STAP1	170	174	PF00017	0.489
LIG_SH2_STAP1	295	299	PF00017	0.354
LIG_SH2_STAP1	533	537	PF00017	0.328
LIG_SH2_STAT5	170	173	PF00017	0.412
LIG_SH2_STAT5	281	284	PF00017	0.312
LIG_SH2_STAT5	442	445	PF00017	0.314
LIG_SH2_STAT5	479	482	PF00017	0.374
LIG_SH2_STAT5	498	501	PF00017	0.196
LIG_SH2_STAT5	522	525	PF00017	0.340
LIG_SH3_1	270	276	PF00018	0.449
LIG_SH3_3	265	271	PF00018	0.516
LIG_SH3_3	3	9	PF00018	0.496
LIG_SH3_3	348	354	PF00018	0.392
LIG_SH3_3	440	446	PF00018	0.365
LIG_SH3_3	53	59	PF00018	0.551
LIG_SH3_3	573	579	PF00018	0.348
LIG_SH3_3	626	632	PF00018	0.362
LIG_Sin3_3	397	404	PF02671	0.184
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.493
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.463
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.399
LIG_SUMO_SIM_par_1	104	111	PF11976	0.616
LIG_SUMO_SIM_par_1	169	177	PF11976	0.374
LIG_SUMO_SIM_par_1	260	265	PF11976	0.573
LIG_SUMO_SIM_par_1	606	612	PF11976	0.424
LIG_TRAF2_1	564	567	PF00917	0.327
LIG_TRFH_1	464	468	PF08558	0.399
LIG_TYR_ITIM	440	445	PF00017	0.283
MOD_CDC14_SPxK_1	575	578	PF00782	0.399
MOD_CDK_SPK_2	243	248	PF00069	0.541
MOD_CDK_SPxK_1	572	578	PF00069	0.399
MOD_CK1_1	104	110	PF00069	0.536
MOD_CK1_1	246	252	PF00069	0.645
MOD_CK1_1	355	361	PF00069	0.389
MOD_CK1_1	441	447	PF00069	0.318
MOD_CK1_1	46	52	PF00069	0.533
MOD_CK1_1	633	639	PF00069	0.534
MOD_CK2_1	174	180	PF00069	0.557
MOD_CK2_1	441	447	PF00069	0.372
MOD_CK2_1	561	567	PF00069	0.316
MOD_Cter_Amidation	524	527	PF01082	0.465
MOD_GlcNHglycan	119	122	PF01048	0.779
MOD_GlcNHglycan	135	138	PF01048	0.469
MOD_GlcNHglycan	176	179	PF01048	0.504
MOD_GlcNHglycan	248	251	PF01048	0.687
MOD_GlcNHglycan	287	290	PF01048	0.421
MOD_GlcNHglycan	330	333	PF01048	0.290
MOD_GlcNHglycan	380	383	PF01048	0.200
MOD_GlcNHglycan	388	391	PF01048	0.184
MOD_GlcNHglycan	490	493	PF01048	0.376
MOD_GSK3_1	1	8	PF00069	0.723
MOD_GSK3_1	117	124	PF00069	0.697
MOD_GSK3_1	207	214	PF00069	0.547
MOD_GSK3_1	323	330	PF00069	0.393
MOD_GSK3_1	386	393	PF00069	0.337
MOD_GSK3_1	525	532	PF00069	0.351
MOD_GSK3_1	545	552	PF00069	0.166
MOD_N-GLC_1	207	212	PF02516	0.438
MOD_N-GLC_1	34	39	PF02516	0.417
MOD_N-GLC_1	459	464	PF02516	0.323
MOD_N-GLC_1	633	638	PF02516	0.598
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	174	179	PF00069	0.575
MOD_NEK2_1	187	192	PF00069	0.698
MOD_NEK2_1	327	332	PF00069	0.331
MOD_NEK2_1	362	367	PF00069	0.350
MOD_NEK2_1	386	391	PF00069	0.329
MOD_NEK2_1	45	50	PF00069	0.631
MOD_NEK2_2	189	194	PF00069	0.460
MOD_NEK2_2	535	540	PF00069	0.306
MOD_PIKK_1	142	148	PF00454	0.455
MOD_PKA_1	543	549	PF00069	0.306
MOD_PKA_1	597	603	PF00069	0.227
MOD_PKA_2	28	34	PF00069	0.485
MOD_PKA_2	535	541	PF00069	0.350
MOD_PKA_2	543	549	PF00069	0.446
MOD_PKA_2	597	603	PF00069	0.262
MOD_PKA_2	71	77	PF00069	0.455
MOD_Plk_1	110	116	PF00069	0.520
MOD_Plk_1	168	174	PF00069	0.537
MOD_Plk_1	323	329	PF00069	0.271
MOD_Plk_1	34	40	PF00069	0.465
MOD_Plk_1	446	452	PF00069	0.292
MOD_Plk_1	633	639	PF00069	0.538
MOD_Plk_4	28	34	PF00069	0.423
MOD_Plk_4	280	286	PF00069	0.276
MOD_Plk_4	342	348	PF00069	0.360
MOD_Plk_4	364	370	PF00069	0.189
MOD_Plk_4	416	422	PF00069	0.438
MOD_Plk_4	518	524	PF00069	0.429
MOD_Plk_4	633	639	PF00069	0.549
MOD_ProDKin_1	243	249	PF00069	0.659
MOD_ProDKin_1	352	358	PF00069	0.480
MOD_ProDKin_1	46	52	PF00069	0.527
MOD_ProDKin_1	5	11	PF00069	0.777
MOD_ProDKin_1	572	578	PF00069	0.399
MOD_SUMO_rev_2	145	154	PF00179	0.338
MOD_SUMO_rev_2	230	238	PF00179	0.480
MOD_SUMO_rev_2	318	325	PF00179	0.219
MOD_SUMO_rev_2	502	510	PF00179	0.368
MOD_SUMO_rev_2	78	88	PF00179	0.561
TRG_DiLeu_BaEn_1	619	624	PF01217	0.271
TRG_DiLeu_BaEn_2	469	475	PF01217	0.306
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.205
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.306
TRG_ENDOCYTIC_2	442	445	PF00928	0.291
TRG_ER_diArg_1	334	336	PF00400	0.377
TRG_ER_diArg_1	481	484	PF00400	0.260
TRG_ER_diArg_1	613	616	PF00400	0.407
TRG_NES_CRM1_1	146	158	PF08389	0.479
TRG_NLS_Bipartite_1	508	530	PF00514	0.207
TRG_NLS_MonoExtC_3	541	547	PF00514	0.283
TRG_NLS_MonoExtN_4	524	530	PF00514	0.286
TRG_NLS_MonoExtN_4	540	546	PF00514	0.373
TRG_NLS_MonoExtN_4	597	602	PF00514	0.271
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W3	Leptomonas seymouri	60%	100%
A0A0S4JNB4	Bodo saltans	22%	100%
A0A3Q8IFG9	Leishmania donovani	91%	100%
A0A3Q8IHT6	Leishmania donovani	26%	100%
A0A3R7LIT5	Trypanosoma rangeli	31%	100%
A4HHL0	Leishmania braziliensis	77%	100%
A4HI48	Leishmania braziliensis	25%	100%
A4I4S0	Leishmania infantum	91%	100%
A4I5C4	Leishmania infantum	26%	100%
C9ZUB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
E9AE72	Leishmania major	90%	100%
E9B0M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q7L0	Leishmania major	25%	100%
V5DQS5	Trypanosoma cruzi	25%	100%