TIR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALL0_LEIMU

TriTrypDb:

LmxM.08_29.2130

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

E9ALL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.653
CLV_NRD_NRD_1	282	284	PF00675	0.295
CLV_PCSK_FUR_1	13	17	PF00082	0.476
CLV_PCSK_KEX2_1	134	136	PF00082	0.565
CLV_PCSK_KEX2_1	15	17	PF00082	0.653
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.565
CLV_PCSK_SKI1_1	252	256	PF00082	0.512
CLV_PCSK_SKI1_1	284	288	PF00082	0.311
CLV_Separin_Metazoa	231	235	PF03568	0.564
CLV_Separin_Metazoa	365	369	PF03568	0.447
CLV_Separin_Metazoa	382	386	PF03568	0.374
DEG_APCC_DBOX_1	282	290	PF00400	0.548
DEG_SPOP_SBC_1	205	209	PF00917	0.584
DOC_CYCLIN_RxL_1	379	393	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.581
DOC_MAPK_gen_1	283	291	PF00069	0.274
DOC_PP1_RVXF_1	383	390	PF00149	0.285
DOC_PP1_SILK_1	169	174	PF00149	0.387
DOC_PP2B_LxvP_1	172	175	PF13499	0.596
DOC_PP2B_LxvP_1	470	473	PF13499	0.416
DOC_USP7_MATH_1	66	70	PF00917	0.573
DOC_USP7_UBL2_3	58	62	PF12436	0.388
DOC_WW_Pin1_4	298	303	PF00397	0.647
LIG_14-3-3_CanoR_1	135	143	PF00244	0.455
LIG_14-3-3_CanoR_1	234	240	PF00244	0.577
LIG_14-3-3_CanoR_1	283	289	PF00244	0.281
LIG_14-3-3_CanoR_1	326	330	PF00244	0.505
LIG_14-3-3_CanoR_1	379	387	PF00244	0.450
LIG_14-3-3_CanoR_1	60	65	PF00244	0.582
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_FHA_1	106	112	PF00498	0.524
LIG_FHA_1	182	188	PF00498	0.465
LIG_FHA_1	19	25	PF00498	0.616
LIG_FHA_1	206	212	PF00498	0.588
LIG_FHA_1	328	334	PF00498	0.545
LIG_FHA_1	396	402	PF00498	0.422
LIG_FHA_2	160	166	PF00498	0.562
LIG_FHA_2	248	254	PF00498	0.571
LIG_FHA_2	285	291	PF00498	0.264
LIG_FHA_2	330	336	PF00498	0.344
LIG_GBD_Chelix_1	28	36	PF00786	0.555
LIG_IRF3_LxIS_1	261	268	PF10401	0.536
LIG_IRF3_LxIS_1	374	381	PF10401	0.459
LIG_IRF3_LxIS_1	387	393	PF10401	0.361
LIG_LIR_Apic_2	467	471	PF02991	0.673
LIG_LIR_Gen_1	242	251	PF02991	0.350
LIG_LIR_Gen_1	268	276	PF02991	0.297
LIG_LIR_Gen_1	386	397	PF02991	0.275
LIG_LIR_Gen_1	432	443	PF02991	0.438
LIG_LIR_Nem_3	123	129	PF02991	0.519
LIG_LIR_Nem_3	242	246	PF02991	0.344
LIG_LIR_Nem_3	268	272	PF02991	0.447
LIG_LIR_Nem_3	386	392	PF02991	0.394
LIG_LIR_Nem_3	439	443	PF02991	0.428
LIG_LIR_Nem_3	59	64	PF02991	0.581
LIG_PCNA_yPIPBox_3	173	183	PF02747	0.392
LIG_PTB_Apo_2	263	270	PF02174	0.490
LIG_SH2_CRK	243	247	PF00017	0.543
LIG_SH2_CRK	26	30	PF00017	0.375
LIG_SH2_CRK	61	65	PF00017	0.320
LIG_SH2_GRB2like	412	415	PF00017	0.424
LIG_SH2_NCK_1	26	30	PF00017	0.375
LIG_SH2_SRC	26	29	PF00017	0.374
LIG_SH2_STAP1	20	24	PF00017	0.418
LIG_SH2_STAP1	243	247	PF00017	0.570
LIG_SH2_STAP1	26	30	PF00017	0.367
LIG_SH2_STAT5	20	23	PF00017	0.447
LIG_SH2_STAT5	243	246	PF00017	0.535
LIG_SH2_STAT5	323	326	PF00017	0.536
LIG_SH2_STAT5	412	415	PF00017	0.528
LIG_SH2_STAT5	468	471	PF00017	0.670
LIG_SH3_3	180	186	PF00018	0.655
LIG_SH3_3	296	302	PF00018	0.662
LIG_SH3_3	447	453	PF00018	0.426
LIG_SUMO_SIM_par_1	144	151	PF11976	0.579
LIG_SUMO_SIM_par_1	215	220	PF11976	0.500
LIG_SUMO_SIM_par_1	224	231	PF11976	0.542
LIG_SUMO_SIM_par_1	287	292	PF11976	0.427
LIG_SUMO_SIM_par_1	300	306	PF11976	0.543
LIG_TRAF2_1	110	113	PF00917	0.579
LIG_TYR_ITIM	24	29	PF00017	0.385
LIG_TYR_ITIM	241	246	PF00017	0.526
LIG_TYR_ITIM	410	415	PF00017	0.537
MOD_CK1_1	18	24	PF00069	0.603
MOD_CK1_1	310	316	PF00069	0.499
MOD_CK1_1	337	343	PF00069	0.462
MOD_CK2_1	138	144	PF00069	0.314
MOD_CK2_1	159	165	PF00069	0.560
MOD_CK2_1	206	212	PF00069	0.401
MOD_CK2_1	247	253	PF00069	0.582
MOD_CK2_1	289	295	PF00069	0.540
MOD_GlcNHglycan	17	20	PF01048	0.677
MOD_GlcNHglycan	176	179	PF01048	0.644
MOD_GlcNHglycan	21	24	PF01048	0.624
MOD_GlcNHglycan	219	222	PF01048	0.535
MOD_GlcNHglycan	280	283	PF01048	0.539
MOD_GlcNHglycan	290	294	PF01048	0.419
MOD_GlcNHglycan	295	298	PF01048	0.456
MOD_GlcNHglycan	309	312	PF01048	0.362
MOD_GlcNHglycan	402	406	PF01048	0.480
MOD_GlcNHglycan	420	423	PF01048	0.280
MOD_GlcNHglycan	55	58	PF01048	0.626
MOD_GlcNHglycan	84	87	PF01048	0.550
MOD_GlcNHglycan	98	101	PF01048	0.258
MOD_GSK3_1	15	22	PF00069	0.650
MOD_GSK3_1	181	188	PF00069	0.588
MOD_GSK3_1	206	213	PF00069	0.351
MOD_GSK3_1	235	242	PF00069	0.517
MOD_GSK3_1	289	296	PF00069	0.485
MOD_GSK3_1	303	310	PF00069	0.457
MOD_GSK3_1	325	332	PF00069	0.528
MOD_N-GLC_1	265	270	PF02516	0.476
MOD_N-GLC_1	337	342	PF02516	0.502
MOD_N-GLC_1	424	429	PF02516	0.483
MOD_NEK2_1	147	152	PF00069	0.475
MOD_NEK2_1	159	164	PF00069	0.445
MOD_NEK2_1	217	222	PF00069	0.441
MOD_NEK2_1	239	244	PF00069	0.550
MOD_NEK2_1	246	251	PF00069	0.577
MOD_NEK2_1	265	270	PF00069	0.268
MOD_NEK2_1	278	283	PF00069	0.475
MOD_NEK2_1	289	294	PF00069	0.496
MOD_NEK2_1	303	308	PF00069	0.548
MOD_NEK2_1	322	327	PF00069	0.231
MOD_NEK2_1	329	334	PF00069	0.437
MOD_NEK2_1	345	350	PF00069	0.419
MOD_NEK2_1	87	92	PF00069	0.561
MOD_NEK2_1	96	101	PF00069	0.582
MOD_NEK2_2	247	252	PF00069	0.543
MOD_PIKK_1	206	212	PF00454	0.328
MOD_PIKK_1	303	309	PF00454	0.619
MOD_PIKK_1	424	430	PF00454	0.500
MOD_PK_1	60	66	PF00069	0.627
MOD_PKA_1	15	21	PF00069	0.632
MOD_PKA_2	105	111	PF00069	0.580
MOD_PKA_2	136	142	PF00069	0.565
MOD_PKA_2	15	21	PF00069	0.718
MOD_PKA_2	325	331	PF00069	0.501
MOD_PKA_2	378	384	PF00069	0.526
MOD_PKA_2	87	93	PF00069	0.493
MOD_PKB_1	13	21	PF00069	0.458
MOD_Plk_1	265	271	PF00069	0.475
MOD_Plk_1	315	321	PF00069	0.403
MOD_Plk_1	401	407	PF00069	0.507
MOD_Plk_1	424	430	PF00069	0.477
MOD_Plk_4	128	134	PF00069	0.340
MOD_Plk_4	167	173	PF00069	0.603
MOD_Plk_4	260	266	PF00069	0.513
MOD_Plk_4	284	290	PF00069	0.364
MOD_ProDKin_1	298	304	PF00069	0.642
MOD_SUMO_for_1	201	204	PF00179	0.622
TRG_DiLeu_BaEn_2	430	436	PF01217	0.486
TRG_ENDOCYTIC_2	243	246	PF00928	0.535
TRG_ENDOCYTIC_2	26	29	PF00928	0.385
TRG_ENDOCYTIC_2	412	415	PF00928	0.478
TRG_ENDOCYTIC_2	440	443	PF00928	0.456
TRG_ENDOCYTIC_2	61	64	PF00928	0.593
TRG_ER_diArg_1	12	15	PF00400	0.636
TRG_ER_diArg_1	135	138	PF00400	0.554
TRG_NES_CRM1_1	382	394	PF08389	0.555
TRG_NES_CRM1_1	428	439	PF08389	0.485
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P012	Trypanosomatidae	28%	100%
A0A3R7KGL7	Trypanosoma rangeli	29%	100%
A0A3S5H7L7	Leishmania donovani	85%	99%
A4HHL3	Leishmania braziliensis	69%	100%
A4I4S2	Leishmania infantum	84%	99%
E9AE75	Leishmania major	84%	100%
V5BBX4	Trypanosoma cruzi	30%	100%