Homologous to fungal ERG2 sterol isomerase and the mammalian sigma receptor 1. A lipid modifying enzyme family. Related to fungal C-8 sterol isomerases, but the catalytic activity of animal orthologs is unclear. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 1, no: 8 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | 5 | 10 |
| GO:0016020 | membrane | 2 | 10 |
| GO:0043226 | organelle | 2 | 10 |
| GO:0043227 | membrane-bounded organelle | 3 | 10 |
| GO:0043229 | intracellular organelle | 3 | 10 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 10 |
| GO:0110165 | cellular anatomical entity | 1 | 10 |
Related structures:
AlphaFold database: E9ALK9
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 10 |
| GO:0016853 | isomerase activity | 2 | 10 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_SKI1_1 | 60 | 64 | PF00082 | 0.489 |
| CLV_PCSK_SKI1_1 | 68 | 72 | PF00082 | 0.423 |
| DOC_MAPK_MEF2A_6 | 5 | 14 | PF00069 | 0.445 |
| DOC_USP7_MATH_1 | 42 | 46 | PF00917 | 0.265 |
| DOC_USP7_MATH_1 | 92 | 96 | PF00917 | 0.224 |
| DOC_USP7_UBL2_3 | 56 | 60 | PF12436 | 0.202 |
| LIG_AP2alpha_1 | 190 | 194 | PF02296 | 0.250 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.633 |
| LIG_BRCT_BRCA1_1 | 183 | 187 | PF00533 | 0.224 |
| LIG_FHA_1 | 195 | 201 | PF00498 | 0.244 |
| LIG_FHA_1 | 214 | 220 | PF00498 | 0.144 |
| LIG_FHA_1 | 5 | 11 | PF00498 | 0.497 |
| LIG_FHA_1 | 64 | 70 | PF00498 | 0.280 |
| LIG_FHA_2 | 204 | 210 | PF00498 | 0.256 |
| LIG_LIR_Gen_1 | 104 | 114 | PF02991 | 0.224 |
| LIG_LIR_Gen_1 | 127 | 134 | PF02991 | 0.224 |
| LIG_LIR_Gen_1 | 136 | 144 | PF02991 | 0.224 |
| LIG_LIR_Gen_1 | 202 | 211 | PF02991 | 0.209 |
| LIG_LIR_Nem_3 | 102 | 106 | PF02991 | 0.245 |
| LIG_LIR_Nem_3 | 127 | 133 | PF02991 | 0.224 |
| LIG_LIR_Nem_3 | 136 | 141 | PF02991 | 0.224 |
| LIG_LIR_Nem_3 | 184 | 190 | PF02991 | 0.231 |
| LIG_LIR_Nem_3 | 202 | 207 | PF02991 | 0.209 |
| LIG_Pex14_1 | 125 | 129 | PF04695 | 0.242 |
| LIG_Pex14_1 | 173 | 177 | PF04695 | 0.242 |
| LIG_Pex14_2 | 190 | 194 | PF04695 | 0.268 |
| LIG_SH2_CRK | 204 | 208 | PF00017 | 0.250 |
| LIG_SH2_CRK | 33 | 37 | PF00017 | 0.292 |
| LIG_SH2_SRC | 106 | 109 | PF00017 | 0.224 |
| LIG_SH2_SRC | 33 | 36 | PF00017 | 0.306 |
| LIG_SH2_STAT3 | 24 | 27 | PF00017 | 0.378 |
| LIG_SH2_STAT5 | 106 | 109 | PF00017 | 0.224 |
| LIG_SH2_STAT5 | 24 | 27 | PF00017 | 0.395 |
| LIG_SH2_STAT5 | 80 | 83 | PF00017 | 0.318 |
| LIG_SH3_3 | 146 | 152 | PF00018 | 0.267 |
| LIG_SH3_3 | 22 | 28 | PF00018 | 0.282 |
| LIG_SH3_3 | 29 | 35 | PF00018 | 0.187 |
| LIG_SUMO_SIM_anti_2 | 195 | 202 | PF11976 | 0.225 |
| LIG_SUMO_SIM_anti_2 | 7 | 13 | PF11976 | 0.323 |
| LIG_SUMO_SIM_par_1 | 195 | 202 | PF11976 | 0.242 |
| LIG_SUMO_SIM_par_1 | 7 | 13 | PF11976 | 0.332 |
| LIG_TYR_ITSM | 200 | 207 | PF00017 | 0.250 |
| MOD_CK1_1 | 113 | 119 | PF00069 | 0.316 |
| MOD_CK2_1 | 203 | 209 | PF00069 | 0.252 |
| MOD_CK2_1 | 99 | 105 | PF00069 | 0.224 |
| MOD_GlcNHglycan | 209 | 212 | PF01048 | 0.467 |
| MOD_GSK3_1 | 109 | 116 | PF00069 | 0.224 |
| MOD_GSK3_1 | 199 | 206 | PF00069 | 0.231 |
| MOD_GSK3_1 | 74 | 81 | PF00069 | 0.261 |
| MOD_NEK2_1 | 110 | 115 | PF00069 | 0.321 |
| MOD_NEK2_1 | 159 | 164 | PF00069 | 0.165 |
| MOD_NEK2_1 | 193 | 198 | PF00069 | 0.242 |
| MOD_NEK2_1 | 99 | 104 | PF00069 | 0.239 |
| MOD_PK_1 | 5 | 11 | PF00069 | 0.344 |
| MOD_PKA_2 | 159 | 165 | PF00069 | 0.287 |
| MOD_PKA_2 | 78 | 84 | PF00069 | 0.259 |
| MOD_Plk_1 | 63 | 69 | PF00069 | 0.279 |
| MOD_Plk_4 | 181 | 187 | PF00069 | 0.223 |
| MOD_Plk_4 | 199 | 205 | PF00069 | 0.225 |
| MOD_Plk_4 | 215 | 221 | PF00069 | 0.335 |
| MOD_Plk_4 | 5 | 11 | PF00069 | 0.451 |
| MOD_Plk_4 | 94 | 100 | PF00069 | 0.242 |
| TRG_DiLeu_BaEn_1 | 65 | 70 | PF01217 | 0.292 |
| TRG_DiLeu_BaEn_4 | 170 | 176 | PF01217 | 0.241 |
| TRG_DiLeu_LyEn_5 | 65 | 70 | PF01217 | 0.250 |
| TRG_ENDOCYTIC_2 | 106 | 109 | PF00928 | 0.224 |
| TRG_ENDOCYTIC_2 | 204 | 207 | PF00928 | 0.250 |
| TRG_ENDOCYTIC_2 | 33 | 36 | PF00928 | 0.292 |
| TRG_Pf-PMV_PEXEL_1 | 68 | 72 | PF00026 | 0.450 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I584 | Leptomonas seymouri | 81% | 100% |
| A0A1D8PCB9 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 44% | 100% |
| A0A1X0P040 | Trypanosomatidae | 65% | 100% |
| A0A3Q8IDV8 | Leishmania donovani | 92% | 100% |
| A0A3R7RKQ2 | Trypanosoma rangeli | 66% | 100% |
| A4HHL4 | Leishmania braziliensis | 84% | 100% |
| A4I4S3 | Leishmania infantum | 93% | 100% |
| C9ZLG7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 58% | 100% |
| E9AE76 | Leishmania major | 91% | 100% |
| I1RT23 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 46% | 95% |
| P32352 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 47% | 100% |
| P32360 | Ustilago maydis (strain 521 / FGSC 9021) | 42% | 93% |
| P33281 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 49% | 100% |
| P87113 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 46% | 100% |
| Q4WJU9 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 45% | 93% |
| Q55BU8 | Dictyostelium discoideum | 30% | 96% |
| Q7ZWG9 | Danio rerio | 32% | 100% |
| Q92254 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 46% | 87% |