LeishMANIAdb
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tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA-uridine aminocarboxypropyltransferase
Gene product:
DTW domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9ALK6_LEIMU
TriTrypDb:
LmxM.08_29.2170
Length:
608

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK6

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 8
GO:0006396 RNA processing 6 8
GO:0006399 tRNA metabolic process 7 8
GO:0006725 cellular aromatic compound metabolic process 3 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008033 tRNA processing 8 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016070 RNA metabolic process 5 8
GO:0034470 ncRNA processing 7 8
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 8
GO:0016432 tRNA-uridine aminocarboxypropyltransferase activity 4 8
GO:0016740 transferase activity 2 8
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 8
GO:0140098 catalytic activity, acting on RNA 3 8
GO:0140101 catalytic activity, acting on a tRNA 4 8
GO:0140640 catalytic activity, acting on a nucleic acid 2 8
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 112 116 PF00656 0.580
CLV_C14_Caspase3-7 456 460 PF00656 0.357
CLV_C14_Caspase3-7 483 487 PF00656 0.374
CLV_NRD_NRD_1 168 170 PF00675 0.328
CLV_NRD_NRD_1 374 376 PF00675 0.508
CLV_NRD_NRD_1 418 420 PF00675 0.317
CLV_NRD_NRD_1 491 493 PF00675 0.411
CLV_NRD_NRD_1 497 499 PF00675 0.456
CLV_NRD_NRD_1 502 504 PF00675 0.550
CLV_NRD_NRD_1 578 580 PF00675 0.511
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I6V5 Leptomonas seymouri 55% 100%
A0A0S4JPN0 Bodo saltans 37% 100%
A0A3Q8IHF3 Leishmania donovani 87% 99%
A4HHL7 Leishmania braziliensis 74% 100%
A4I4S6 Leishmania infantum 87% 99%
E9AE79 Leishmania major 86% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS