tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALK6_LEIMU

TriTrypDb:

LmxM.08_29.2170

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK6

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006399	tRNA metabolic process	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008033	tRNA processing	8	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0034470	ncRNA processing	7	8

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140101	catalytic activity, acting on a tRNA	4	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.580
CLV_C14_Caspase3-7	456	460	PF00656	0.357
CLV_C14_Caspase3-7	483	487	PF00656	0.374
CLV_NRD_NRD_1	168	170	PF00675	0.328
CLV_NRD_NRD_1	374	376	PF00675	0.508
CLV_NRD_NRD_1	418	420	PF00675	0.317
CLV_NRD_NRD_1	491	493	PF00675	0.411
CLV_NRD_NRD_1	497	499	PF00675	0.456
CLV_NRD_NRD_1	502	504	PF00675	0.550
CLV_NRD_NRD_1	578	580	PF00675	0.511

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V5	Leptomonas seymouri	55%	100%
A0A0S4JPN0	Bodo saltans	37%	100%
A0A3Q8IHF3	Leishmania donovani	87%	99%
A4HHL7	Leishmania braziliensis	74%	100%
A4I4S6	Leishmania infantum	87%	99%
E9AE79	Leishmania major	86%	100%

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