tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALK6_LEIMU

TriTrypDb:

LmxM.08_29.2170

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006399	tRNA metabolic process	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008033	tRNA processing	8	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140101	catalytic activity, acting on a tRNA	4	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.580
CLV_C14_Caspase3-7	456	460	PF00656	0.357
CLV_C14_Caspase3-7	483	487	PF00656	0.374
CLV_NRD_NRD_1	168	170	PF00675	0.328
CLV_NRD_NRD_1	374	376	PF00675	0.508
CLV_NRD_NRD_1	418	420	PF00675	0.317
CLV_NRD_NRD_1	491	493	PF00675	0.411
CLV_NRD_NRD_1	497	499	PF00675	0.456
CLV_NRD_NRD_1	502	504	PF00675	0.550
CLV_NRD_NRD_1	578	580	PF00675	0.511
CLV_NRD_NRD_1	84	86	PF00675	0.541
CLV_NRD_NRD_1	91	93	PF00675	0.524
CLV_PCSK_FUR_1	576	580	PF00082	0.625
CLV_PCSK_KEX2_1	168	170	PF00082	0.323
CLV_PCSK_KEX2_1	31	33	PF00082	0.412
CLV_PCSK_KEX2_1	420	422	PF00082	0.371
CLV_PCSK_KEX2_1	491	493	PF00082	0.399
CLV_PCSK_KEX2_1	496	498	PF00082	0.472
CLV_PCSK_KEX2_1	502	504	PF00082	0.594
CLV_PCSK_KEX2_1	578	580	PF00082	0.544
CLV_PCSK_KEX2_1	584	586	PF00082	0.765
CLV_PCSK_KEX2_1	83	85	PF00082	0.548
CLV_PCSK_KEX2_1	91	93	PF00082	0.517
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.397
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.351
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.496
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.561
CLV_PCSK_PC7_1	492	498	PF00082	0.440
CLV_PCSK_SKI1_1	150	154	PF00082	0.405
CLV_PCSK_SKI1_1	32	36	PF00082	0.405
CLV_PCSK_SKI1_1	394	398	PF00082	0.400
CLV_PCSK_SKI1_1	468	472	PF00082	0.433
CLV_PCSK_SKI1_1	551	555	PF00082	0.453
CLV_Separin_Metazoa	224	228	PF03568	0.292
CLV_Separin_Metazoa	97	101	PF03568	0.470
DEG_APCC_DBOX_1	31	39	PF00400	0.392
DEG_APCC_DBOX_1	518	526	PF00400	0.520
DEG_COP1_1	566	574	PF00400	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DOC_CDC14_PxL_1	520	528	PF14671	0.341
DOC_CKS1_1	46	51	PF01111	0.461
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.351
DOC_MAPK_DCC_7	132	141	PF00069	0.428
DOC_MAPK_gen_1	168	174	PF00069	0.305
DOC_MAPK_gen_1	31	37	PF00069	0.388
DOC_MAPK_gen_1	375	382	PF00069	0.349
DOC_MAPK_gen_1	83	89	PF00069	0.516
DOC_MAPK_MEF2A_6	132	141	PF00069	0.486
DOC_MAPK_MEF2A_6	398	407	PF00069	0.292
DOC_PP2B_LxvP_1	239	242	PF13499	0.351
DOC_PP4_FxxP_1	574	577	PF00568	0.591
DOC_USP7_MATH_1	111	115	PF00917	0.656
DOC_USP7_MATH_1	119	123	PF00917	0.623
DOC_USP7_MATH_1	127	131	PF00917	0.618
DOC_USP7_MATH_1	18	22	PF00917	0.478
DOC_USP7_MATH_1	266	270	PF00917	0.305
DOC_USP7_MATH_1	348	352	PF00917	0.277
DOC_USP7_MATH_1	401	405	PF00917	0.357
DOC_USP7_MATH_1	451	455	PF00917	0.355
DOC_USP7_MATH_1	513	517	PF00917	0.509
DOC_USP7_MATH_1	55	59	PF00917	0.473
DOC_WW_Pin1_4	23	28	PF00397	0.420
DOC_WW_Pin1_4	316	321	PF00397	0.357
DOC_WW_Pin1_4	45	50	PF00397	0.464
LIG_14-3-3_CanoR_1	168	173	PF00244	0.321
LIG_14-3-3_CanoR_1	202	206	PF00244	0.302
LIG_14-3-3_CanoR_1	402	406	PF00244	0.435
LIG_14-3-3_CanoR_1	50	54	PF00244	0.501
LIG_14-3-3_CanoR_1	56	64	PF00244	0.438
LIG_14-3-3_CanoR_1	585	591	PF00244	0.482
LIG_14-3-3_CanoR_1	92	102	PF00244	0.461
LIG_Actin_WH2_2	458	474	PF00022	0.351
LIG_APCC_ABBA_1	218	223	PF00400	0.292
LIG_Clathr_ClatBox_1	379	383	PF01394	0.351
LIG_deltaCOP1_diTrp_1	148	152	PF00928	0.346
LIG_EVH1_1	359	363	PF00568	0.247
LIG_FHA_1	136	142	PF00498	0.488
LIG_FHA_1	215	221	PF00498	0.292
LIG_FHA_1	395	401	PF00498	0.357
LIG_FHA_2	110	116	PF00498	0.683
LIG_FHA_2	118	124	PF00498	0.728
LIG_FHA_2	317	323	PF00498	0.313
LIG_FHA_2	454	460	PF00498	0.357
LIG_FHA_2	478	484	PF00498	0.436
LIG_FHA_2	55	61	PF00498	0.500
LIG_FHA_2	550	556	PF00498	0.480
LIG_HP1_1	401	405	PF01393	0.351
LIG_IBAR_NPY_1	28	30	PF08397	0.430
LIG_LIR_Apic_2	573	577	PF02991	0.584
LIG_LIR_Gen_1	138	147	PF02991	0.389
LIG_LIR_Gen_1	409	418	PF02991	0.365
LIG_LIR_Nem_3	138	143	PF02991	0.380
LIG_LIR_Nem_3	146	152	PF02991	0.324
LIG_LIR_Nem_3	197	201	PF02991	0.242
LIG_LIR_Nem_3	409	414	PF02991	0.303
LIG_PTB_Apo_2	472	479	PF02174	0.397
LIG_PTB_Apo_2	524	531	PF02174	0.454
LIG_PTB_Phospho_1	524	530	PF10480	0.462
LIG_SH2_CRK	46	50	PF00017	0.509
LIG_SH2_CRK	528	532	PF00017	0.372
LIG_SH2_GRB2like	473	476	PF00017	0.399
LIG_SH2_NCK_1	473	477	PF00017	0.414
LIG_SH2_SRC	473	476	PF00017	0.438
LIG_SH2_STAP1	411	415	PF00017	0.351
LIG_SH2_STAP1	446	450	PF00017	0.351
LIG_SH2_STAT3	254	257	PF00017	0.357
LIG_SH2_STAT5	140	143	PF00017	0.387
LIG_SH2_STAT5	237	240	PF00017	0.357
LIG_SH2_STAT5	254	257	PF00017	0.486
LIG_SH2_STAT5	293	296	PF00017	0.399
LIG_SH2_STAT5	528	531	PF00017	0.350
LIG_SH3_3	339	345	PF00018	0.508
LIG_SH3_3	357	363	PF00018	0.383
LIG_SH3_3	566	572	PF00018	0.565
LIG_SUMO_SIM_par_1	378	385	PF11976	0.326
LIG_SxIP_EBH_1	556	567	PF03271	0.326
LIG_TRAF2_1	142	145	PF00917	0.468
LIG_TRAF2_1	320	323	PF00917	0.307
LIG_TRAF2_1	57	60	PF00917	0.510
LIG_TYR_ITIM	526	531	PF00017	0.387
LIG_UBA3_1	414	420	PF00899	0.292
LIG_WW_3	53	57	PF00397	0.471
MOD_CDK_SPK_2	45	50	PF00069	0.449
MOD_CK1_1	109	115	PF00069	0.613
MOD_CK1_1	122	128	PF00069	0.747
MOD_CK1_1	228	234	PF00069	0.351
MOD_CK1_1	4	10	PF00069	0.524
MOD_CK1_1	563	569	PF00069	0.442
MOD_CK2_1	139	145	PF00069	0.483
MOD_CK2_1	316	322	PF00069	0.274
MOD_CK2_1	348	354	PF00069	0.285
MOD_CK2_1	425	431	PF00069	0.331
MOD_CK2_1	477	483	PF00069	0.379
MOD_CK2_1	54	60	PF00069	0.502
MOD_CK2_1	549	555	PF00069	0.500
MOD_GlcNHglycan	108	111	PF01048	0.586
MOD_GlcNHglycan	230	233	PF01048	0.356
MOD_GlcNHglycan	268	271	PF01048	0.263
MOD_GlcNHglycan	330	333	PF01048	0.290
MOD_GlcNHglycan	368	371	PF01048	0.502
MOD_GlcNHglycan	480	483	PF01048	0.489
MOD_GlcNHglycan	514	518	PF01048	0.524
MOD_GlcNHglycan	562	565	PF01048	0.459
MOD_GlcNHglycan	9	12	PF01048	0.692
MOD_GSK3_1	135	142	PF00069	0.371
MOD_GSK3_1	19	26	PF00069	0.521
MOD_GSK3_1	2	9	PF00069	0.516
MOD_GSK3_1	277	284	PF00069	0.440
MOD_GSK3_1	346	353	PF00069	0.464
MOD_GSK3_1	366	373	PF00069	0.289
MOD_GSK3_1	422	429	PF00069	0.313
MOD_GSK3_1	45	52	PF00069	0.529
MOD_GSK3_1	451	458	PF00069	0.376
MOD_GSK3_1	556	563	PF00069	0.551
MOD_N-GLC_2	527	529	PF02516	0.413
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	19	24	PF00069	0.591
MOD_NEK2_1	225	230	PF00069	0.292
MOD_NEK2_1	299	304	PF00069	0.236
MOD_NEK2_1	381	386	PF00069	0.339
MOD_NEK2_1	430	435	PF00069	0.292
MOD_NEK2_1	565	570	PF00069	0.495
MOD_NEK2_2	277	282	PF00069	0.351
MOD_PIKK_1	299	305	PF00454	0.335
MOD_PIKK_1	370	376	PF00454	0.274
MOD_PIKK_1	451	457	PF00454	0.300
MOD_PK_1	168	174	PF00069	0.393
MOD_PKA_1	168	174	PF00069	0.388
MOD_PKA_1	419	425	PF00069	0.292
MOD_PKA_1	584	590	PF00069	0.480
MOD_PKA_2	168	174	PF00069	0.388
MOD_PKA_2	201	207	PF00069	0.357
MOD_PKA_2	226	232	PF00069	0.292
MOD_PKA_2	401	407	PF00069	0.435
MOD_PKA_2	422	428	PF00069	0.272
MOD_PKA_2	49	55	PF00069	0.513
MOD_PKA_2	584	590	PF00069	0.655
MOD_Plk_1	143	149	PF00069	0.592
MOD_Plk_1	214	220	PF00069	0.399
MOD_Plk_1	250	256	PF00069	0.313
MOD_Plk_1	382	388	PF00069	0.361
MOD_Plk_1	430	436	PF00069	0.292
MOD_Plk_4	135	141	PF00069	0.419
MOD_Plk_4	214	220	PF00069	0.292
MOD_Plk_4	250	256	PF00069	0.313
MOD_Plk_4	277	283	PF00069	0.351
MOD_Plk_4	410	416	PF00069	0.351
MOD_ProDKin_1	23	29	PF00069	0.404
MOD_ProDKin_1	316	322	PF00069	0.357
MOD_ProDKin_1	45	51	PF00069	0.460
MOD_SUMO_rev_2	142	152	PF00179	0.426
TRG_DiLeu_BaEn_1	215	220	PF01217	0.351
TRG_DiLeu_BaEn_2	147	153	PF01217	0.408
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.415
TRG_ENDOCYTIC_2	140	143	PF00928	0.433
TRG_ENDOCYTIC_2	411	414	PF00928	0.324
TRG_ENDOCYTIC_2	528	531	PF00928	0.386
TRG_ER_diArg_1	167	169	PF00400	0.361
TRG_ER_diArg_1	418	421	PF00400	0.351
TRG_ER_diArg_1	496	498	PF00400	0.555
TRG_ER_diArg_1	519	522	PF00400	0.519
TRG_ER_diArg_1	576	579	PF00400	0.526
TRG_ER_diArg_1	82	85	PF00400	0.495
TRG_NLS_MonoExtC_3	418	423	PF00514	0.351
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V5	Leptomonas seymouri	55%	100%
A0A0S4JPN0	Bodo saltans	37%	100%
A0A3Q8IHF3	Leishmania donovani	87%	99%
A4HHL7	Leishmania braziliensis	74%	100%
A4I4S6	Leishmania infantum	87%	99%
E9AE79	Leishmania major	86%	100%