DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania mexicana

UniProt:

E9ALK5_LEIMU

TriTrypDb:

LmxM.08_29.2180

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.690
CLV_C14_Caspase3-7	178	182	PF00656	0.821
CLV_C14_Caspase3-7	187	191	PF00656	0.675
CLV_NRD_NRD_1	115	117	PF00675	0.793
CLV_NRD_NRD_1	196	198	PF00675	0.796
CLV_NRD_NRD_1	200	202	PF00675	0.672
CLV_NRD_NRD_1	33	35	PF00675	0.822
CLV_NRD_NRD_1	447	449	PF00675	0.461
CLV_NRD_NRD_1	99	101	PF00675	0.732
CLV_PCSK_FUR_1	197	201	PF00082	0.820
CLV_PCSK_FUR_1	445	449	PF00082	0.417
CLV_PCSK_KEX2_1	115	117	PF00082	0.793
CLV_PCSK_KEX2_1	196	198	PF00082	0.791
CLV_PCSK_KEX2_1	199	201	PF00082	0.687
CLV_PCSK_KEX2_1	33	35	PF00082	0.822
CLV_PCSK_KEX2_1	447	449	PF00082	0.437
CLV_PCSK_KEX2_1	99	101	PF00082	0.688
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.590
CLV_PCSK_PC7_1	111	117	PF00082	0.734
CLV_PCSK_PC7_1	196	202	PF00082	0.702
CLV_PCSK_SKI1_1	201	205	PF00082	0.699
CLV_PCSK_SKI1_1	283	287	PF00082	0.459
CLV_PCSK_SKI1_1	298	302	PF00082	0.303
CLV_PCSK_SKI1_1	457	461	PF00082	0.719
DEG_APCC_DBOX_1	319	327	PF00400	0.430
DEG_APCC_DBOX_1	446	454	PF00400	0.424
DEG_SPOP_SBC_1	203	207	PF00917	0.787
DEG_SPOP_SBC_1	28	32	PF00917	0.599
DOC_CYCLIN_RxL_1	241	252	PF00134	0.626
DOC_MAPK_gen_1	318	326	PF00069	0.501
DOC_MAPK_JIP1_4	320	326	PF00069	0.430
DOC_PP1_RVXF_1	418	424	PF00149	0.382
DOC_PP4_FxxP_1	140	143	PF00568	0.811
DOC_PP4_FxxP_1	335	338	PF00568	0.376
DOC_USP7_MATH_1	224	228	PF00917	0.737
DOC_USP7_MATH_1	27	31	PF00917	0.727
DOC_USP7_MATH_1	46	50	PF00917	0.518
DOC_USP7_MATH_1	77	81	PF00917	0.836
DOC_USP7_MATH_1	94	98	PF00917	0.470
DOC_WW_Pin1_4	217	222	PF00397	0.736
DOC_WW_Pin1_4	410	415	PF00397	0.501
LIG_14-3-3_CanoR_1	100	106	PF00244	0.739
LIG_14-3-3_CanoR_1	312	317	PF00244	0.551
LIG_14-3-3_CanoR_1	381	388	PF00244	0.543
LIG_14-3-3_CanoR_1	45	51	PF00244	0.831
LIG_BRCT_BRCA1_1	136	140	PF00533	0.835
LIG_BRCT_BRCA1_1	292	296	PF00533	0.501
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.357
LIG_EH_1	332	336	PF12763	0.430
LIG_FHA_1	127	133	PF00498	0.744
LIG_FHA_1	232	238	PF00498	0.738
LIG_FHA_1	311	317	PF00498	0.630
LIG_FHA_1	435	441	PF00498	0.440
LIG_FHA_1	458	464	PF00498	0.681
LIG_FHA_2	176	182	PF00498	0.739
LIG_LIR_Apic_2	137	143	PF02991	0.821
LIG_LIR_Apic_2	348	354	PF02991	0.368
LIG_LIR_Nem_3	104	108	PF02991	0.515
LIG_LIR_Nem_3	398	402	PF02991	0.344
LIG_MYND_1	334	338	PF01753	0.430
LIG_SH2_NCK_1	257	261	PF00017	0.430
LIG_SH2_STAP1	360	364	PF00017	0.426
LIG_SH2_STAT5	245	248	PF00017	0.576
LIG_SH3_3	218	224	PF00018	0.528
LIG_SH3_3	369	375	PF00018	0.472
LIG_TRAF2_1	223	226	PF00917	0.650
LIG_TRAF2_1	389	392	PF00917	0.690
LIG_TRAF2_1	73	76	PF00917	0.712
LIG_TRAF2_1	80	83	PF00917	0.702
MOD_CK1_1	134	140	PF00069	0.542
MOD_CK1_1	342	348	PF00069	0.435
MOD_CK1_1	390	396	PF00069	0.627
MOD_CK2_1	171	177	PF00069	0.691
MOD_CK2_1	181	187	PF00069	0.726
MOD_CK2_1	219	225	PF00069	0.766
MOD_CK2_1	69	75	PF00069	0.705
MOD_CK2_1	77	83	PF00069	0.738
MOD_GlcNHglycan	112	115	PF01048	0.673
MOD_GlcNHglycan	133	136	PF01048	0.541
MOD_GlcNHglycan	149	152	PF01048	0.641
MOD_GlcNHglycan	166	169	PF01048	0.700
MOD_GlcNHglycan	171	174	PF01048	0.719
MOD_GlcNHglycan	275	278	PF01048	0.417
MOD_GlcNHglycan	292	295	PF01048	0.283
MOD_GlcNHglycan	340	344	PF01048	0.320
MOD_GlcNHglycan	383	386	PF01048	0.561
MOD_GlcNHglycan	40	43	PF01048	0.762
MOD_GlcNHglycan	96	99	PF01048	0.770
MOD_GSK3_1	134	141	PF00069	0.839
MOD_GSK3_1	169	176	PF00069	0.752
MOD_GSK3_1	215	222	PF00069	0.767
MOD_GSK3_1	410	417	PF00069	0.455
MOD_GSK3_1	46	53	PF00069	0.760
MOD_LATS_1	455	461	PF00433	0.706
MOD_N-GLC_1	215	220	PF02516	0.540
MOD_N-GLC_1	310	315	PF02516	0.651
MOD_N-GLC_2	303	305	PF02516	0.382
MOD_N-GLC_2	91	93	PF02516	0.646
MOD_NEK2_1	117	122	PF00069	0.595
MOD_NEK2_1	273	278	PF00069	0.501
MOD_NEK2_1	379	384	PF00069	0.499
MOD_NEK2_1	60	65	PF00069	0.698
MOD_PIKK_1	181	187	PF00454	0.824
MOD_PIKK_1	379	385	PF00454	0.659
MOD_PKA_1	101	107	PF00069	0.737
MOD_PKA_2	101	107	PF00069	0.740
MOD_PKA_2	110	116	PF00069	0.741
MOD_PKA_2	164	170	PF00069	0.752
MOD_PKA_2	311	317	PF00069	0.558
MOD_PKA_2	356	362	PF00069	0.385
MOD_PKA_2	68	74	PF00069	0.753
MOD_PKA_2	7	13	PF00069	0.730
MOD_Plk_1	390	396	PF00069	0.598
MOD_Plk_1	432	438	PF00069	0.376
MOD_Plk_1	60	66	PF00069	0.704
MOD_Plk_2-3	142	148	PF00069	0.799
MOD_Plk_2-3	62	68	PF00069	0.515
MOD_Plk_4	345	351	PF00069	0.399
MOD_Plk_4	390	396	PF00069	0.666
MOD_Plk_4	62	68	PF00069	0.539
MOD_ProDKin_1	217	223	PF00069	0.735
MOD_ProDKin_1	410	416	PF00069	0.501
MOD_SUMO_for_1	16	19	PF00179	0.639
MOD_SUMO_rev_2	19	28	PF00179	0.699
MOD_SUMO_rev_2	340	348	PF00179	0.376
MOD_SUMO_rev_2	410	419	PF00179	0.410
TRG_DiLeu_BaEn_4	391	397	PF01217	0.660
TRG_ENDOCYTIC_2	245	248	PF00928	0.528
TRG_ER_diArg_1	108	111	PF00400	0.719
TRG_ER_diArg_1	115	117	PF00400	0.802
TRG_ER_diArg_1	196	199	PF00400	0.791
TRG_ER_diArg_1	445	448	PF00400	0.445
TRG_NLS_MonoCore_2	98	103	PF00514	0.511
TRG_NLS_MonoExtN_4	99	104	PF00514	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX8	Leptomonas seymouri	51%	98%
A0A0S4JTC6	Bodo saltans	37%	100%
A0A3Q8IEK2	Leishmania donovani	85%	100%
A4HHL8	Leishmania braziliensis	73%	100%
A4I4S7	Leishmania infantum	86%	100%
E9AE80	Leishmania major	86%	100%