Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynamin-1-like protein

Species:

Leishmania mexicana

UniProt:

E9ALK3_LEIMU

TriTrypDb:

LmxM.08_29.2200

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005874	microtubule	6	1
GO:0016020	membrane	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0003924	GTPase activity	7	13
GO:0005488	binding	1	13
GO:0005525	GTP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0019001	guanyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032561	guanyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.452
CLV_NRD_NRD_1	242	244	PF00675	0.464
CLV_NRD_NRD_1	250	252	PF00675	0.483
CLV_NRD_NRD_1	463	465	PF00675	0.377
CLV_NRD_NRD_1	653	655	PF00675	0.378
CLV_PCSK_KEX2_1	102	104	PF00082	0.452
CLV_PCSK_KEX2_1	250	252	PF00082	0.421
CLV_PCSK_KEX2_1	295	297	PF00082	0.422
CLV_PCSK_KEX2_1	544	546	PF00082	0.793
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.422
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.637
CLV_PCSK_SKI1_1	125	129	PF00082	0.275
CLV_PCSK_SKI1_1	152	156	PF00082	0.350
CLV_PCSK_SKI1_1	186	190	PF00082	0.397
CLV_PCSK_SKI1_1	350	354	PF00082	0.397
CLV_PCSK_SKI1_1	377	381	PF00082	0.378
CLV_PCSK_SKI1_1	422	426	PF00082	0.466
CLV_PCSK_SKI1_1	457	461	PF00082	0.347
CLV_PCSK_SKI1_1	49	53	PF00082	0.350
CLV_PCSK_SKI1_1	534	538	PF00082	0.806
CLV_PCSK_SKI1_1	573	577	PF00082	0.678
CLV_PCSK_SKI1_1	578	582	PF00082	0.677
CLV_PCSK_SKI1_1	612	616	PF00082	0.363
CLV_PCSK_SKI1_1	638	642	PF00082	0.435
CLV_PCSK_SKI1_1	655	659	PF00082	0.233
DEG_Nend_UBRbox_2	1	3	PF02207	0.520
DOC_ANK_TNKS_1	591	598	PF00023	0.350
DOC_CDC14_PxL_1	132	140	PF14671	0.363
DOC_CYCLIN_RxL_1	274	285	PF00134	0.421
DOC_CYCLIN_RxL_1	455	462	PF00134	0.408
DOC_CYCLIN_RxL_1	638	646	PF00134	0.466
DOC_MAPK_DCC_7	23	31	PF00069	0.435
DOC_MAPK_gen_1	277	284	PF00069	0.397
DOC_MAPK_JIP1_4	116	122	PF00069	0.350
DOC_MAPK_MEF2A_6	125	132	PF00069	0.356
DOC_MAPK_MEF2A_6	165	172	PF00069	0.477
DOC_MAPK_MEF2A_6	19	26	PF00069	0.511
DOC_MAPK_MEF2A_6	61	68	PF00069	0.350
DOC_MAPK_NFAT4_5	125	133	PF00069	0.275
DOC_MAPK_NFAT4_5	165	173	PF00069	0.477
DOC_MAPK_NFAT4_5	19	27	PF00069	0.500
DOC_MAPK_RevD_3	451	465	PF00069	0.207
DOC_PP1_RVXF_1	275	282	PF00149	0.421
DOC_PP1_RVXF_1	420	427	PF00149	0.350
DOC_PP2B_LxvP_1	24	27	PF13499	0.451
DOC_PP2B_LxvP_1	83	86	PF13499	0.477
DOC_PP2B_PxIxI_1	26	32	PF00149	0.350
DOC_USP7_MATH_1	108	112	PF00917	0.340
DOC_USP7_MATH_1	249	253	PF00917	0.484
DOC_USP7_MATH_1	511	515	PF00917	0.820
DOC_USP7_MATH_1	53	57	PF00917	0.372
DOC_USP7_MATH_1	546	550	PF00917	0.706
DOC_USP7_MATH_1	670	674	PF00917	0.418
DOC_USP7_MATH_1	683	687	PF00917	0.695
DOC_USP7_UBL2_3	121	125	PF12436	0.333
DOC_USP7_UBL2_3	19	23	PF12436	0.539
DOC_USP7_UBL2_3	307	311	PF12436	0.388
DOC_USP7_UBL2_3	530	534	PF12436	0.779
DOC_USP7_UBL2_3	537	541	PF12436	0.729
DOC_USP7_UBL2_3	544	548	PF12436	0.690
DOC_WW_Pin1_4	160	165	PF00397	0.349
DOC_WW_Pin1_4	170	175	PF00397	0.350
DOC_WW_Pin1_4	257	262	PF00397	0.477
DOC_WW_Pin1_4	507	512	PF00397	0.753
DOC_WW_Pin1_4	517	522	PF00397	0.636
LIG_14-3-3_CanoR_1	243	247	PF00244	0.473
LIG_14-3-3_CanoR_1	250	257	PF00244	0.482
LIG_14-3-3_CanoR_1	464	474	PF00244	0.415
LIG_Actin_WH2_2	184	199	PF00022	0.275
LIG_Actin_WH2_2	211	228	PF00022	0.378
LIG_APCC_ABBA_1	330	335	PF00400	0.395
LIG_CORNRBOX	283	291	PF00104	0.350
LIG_deltaCOP1_diTrp_1	77	82	PF00928	0.349
LIG_FHA_1	157	163	PF00498	0.350
LIG_FHA_1	165	171	PF00498	0.350
LIG_FHA_1	196	202	PF00498	0.348
LIG_FHA_1	210	216	PF00498	0.342
LIG_FHA_1	270	276	PF00498	0.350
LIG_FHA_1	321	327	PF00498	0.503
LIG_FHA_1	347	353	PF00498	0.408
LIG_FHA_1	374	380	PF00498	0.421
LIG_FHA_2	129	135	PF00498	0.350
LIG_FHA_2	201	207	PF00498	0.350
LIG_FHA_2	412	418	PF00498	0.405
LIG_FHA_2	523	529	PF00498	0.782
LIG_FHA_2	579	585	PF00498	0.651
LIG_IRF3_LxIS_1	168	173	PF10401	0.363
LIG_LIR_Apic_2	159	164	PF02991	0.350
LIG_LIR_Apic_2	462	466	PF02991	0.350
LIG_LIR_Gen_1	252	262	PF02991	0.475
LIG_LIR_Gen_1	380	391	PF02991	0.339
LIG_LIR_Gen_1	402	413	PF02991	0.350
LIG_LIR_Gen_1	425	435	PF02991	0.423
LIG_LIR_Gen_1	478	489	PF02991	0.350
LIG_LIR_Gen_1	596	607	PF02991	0.370
LIG_LIR_Gen_1	624	635	PF02991	0.363
LIG_LIR_Gen_1	81	90	PF02991	0.412
LIG_LIR_Gen_1	92	100	PF02991	0.303
LIG_LIR_Nem_3	13	18	PF02991	0.478
LIG_LIR_Nem_3	252	257	PF02991	0.455
LIG_LIR_Nem_3	260	266	PF02991	0.383
LIG_LIR_Nem_3	364	369	PF02991	0.346
LIG_LIR_Nem_3	380	386	PF02991	0.307
LIG_LIR_Nem_3	402	408	PF02991	0.350
LIG_LIR_Nem_3	425	431	PF02991	0.402
LIG_LIR_Nem_3	443	448	PF02991	0.377
LIG_LIR_Nem_3	478	484	PF02991	0.350
LIG_LIR_Nem_3	596	602	PF02991	0.343
LIG_LIR_Nem_3	624	630	PF02991	0.350
LIG_LIR_Nem_3	77	82	PF02991	0.348
LIG_LIR_Nem_3	92	96	PF02991	0.343
LIG_LYPXL_yS_3	445	448	PF13949	0.445
LIG_NRBOX	278	284	PF00104	0.350
LIG_Pex14_2	362	366	PF04695	0.350
LIG_SH2_CRK	263	267	PF00017	0.363
LIG_SH2_CRK	463	467	PF00017	0.378
LIG_SH2_CRK	627	631	PF00017	0.350
LIG_SH2_GRB2like	586	589	PF00017	0.392
LIG_SH2_NCK_1	263	267	PF00017	0.350
LIG_SH2_PTP2	161	164	PF00017	0.350
LIG_SH2_PTP2	383	386	PF00017	0.350
LIG_SH2_STAP1	123	127	PF00017	0.418
LIG_SH2_STAP1	254	258	PF00017	0.412
LIG_SH2_STAP1	627	631	PF00017	0.363
LIG_SH2_STAT5	161	164	PF00017	0.350
LIG_SH2_STAT5	274	277	PF00017	0.377
LIG_SH2_STAT5	328	331	PF00017	0.421
LIG_SH2_STAT5	360	363	PF00017	0.338
LIG_SH2_STAT5	369	372	PF00017	0.338
LIG_SH2_STAT5	383	386	PF00017	0.343
LIG_SH2_STAT5	598	601	PF00017	0.357
LIG_SH3_3	130	136	PF00018	0.364
LIG_SH3_3	481	487	PF00018	0.338
LIG_SH3_3	66	72	PF00018	0.363
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.435
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.301
LIG_SUMO_SIM_par_1	167	173	PF11976	0.350
LIG_UBA3_1	283	288	PF00899	0.363
LIG_UBA3_1	326	331	PF00899	0.327
LIG_UBA3_1	452	458	PF00899	0.508
LIG_UBA3_1	660	666	PF00899	0.350
MOD_CDK_SPK_2	160	165	PF00069	0.463
MOD_CK1_1	111	117	PF00069	0.340
MOD_CK1_1	565	571	PF00069	0.614
MOD_CK1_1	636	642	PF00069	0.378
MOD_CK2_1	249	255	PF00069	0.421
MOD_CK2_1	38	44	PF00069	0.350
MOD_CK2_1	411	417	PF00069	0.367
MOD_CK2_1	506	512	PF00069	0.624
MOD_CK2_1	578	584	PF00069	0.532
MOD_CK2_1	71	77	PF00069	0.379
MOD_GlcNHglycan	110	113	PF01048	0.340
MOD_GlcNHglycan	373	376	PF01048	0.397
MOD_GlcNHglycan	55	58	PF01048	0.470
MOD_GlcNHglycan	588	591	PF01048	0.475
MOD_GSK3_1	156	163	PF00069	0.349
MOD_GSK3_1	170	177	PF00069	0.351
MOD_GSK3_1	257	264	PF00069	0.448
MOD_GSK3_1	269	276	PF00069	0.366
MOD_GSK3_1	33	40	PF00069	0.350
MOD_GSK3_1	333	340	PF00069	0.370
MOD_GSK3_1	365	372	PF00069	0.450
MOD_GSK3_1	373	380	PF00069	0.435
MOD_GSK3_1	394	401	PF00069	0.378
MOD_GSK3_1	466	473	PF00069	0.449
MOD_GSK3_1	507	514	PF00069	0.825
MOD_GSK3_1	53	60	PF00069	0.168
MOD_GSK3_1	565	572	PF00069	0.641
MOD_GSK3_1	629	636	PF00069	0.463
MOD_GSK3_1	677	684	PF00069	0.653
MOD_N-GLC_1	128	133	PF02516	0.363
MOD_N-GLC_1	337	342	PF02516	0.375
MOD_N-GLC_1	517	522	PF02516	0.786
MOD_N-GLC_1	578	583	PF02516	0.595
MOD_NEK2_1	128	133	PF00069	0.350
MOD_NEK2_1	179	184	PF00069	0.350
MOD_NEK2_1	302	307	PF00069	0.366
MOD_NEK2_1	333	338	PF00069	0.392
MOD_NEK2_1	394	399	PF00069	0.370
MOD_NEK2_2	670	675	PF00069	0.397
MOD_PIKK_1	179	185	PF00454	0.445
MOD_PIKK_1	233	239	PF00454	0.350
MOD_PIKK_1	31	37	PF00454	0.350
MOD_PIKK_1	522	528	PF00454	0.825
MOD_PIKK_1	629	635	PF00454	0.207
MOD_PIKK_1	649	655	PF00454	0.385
MOD_PKA_1	464	470	PF00069	0.207
MOD_PKA_2	101	107	PF00069	0.399
MOD_PKA_2	242	248	PF00069	0.473
MOD_PKA_2	249	255	PF00069	0.482
MOD_PKA_2	53	59	PF00069	0.350
MOD_Plk_1	128	134	PF00069	0.363
MOD_Plk_1	337	343	PF00069	0.397
MOD_Plk_2-3	242	248	PF00069	0.477
MOD_Plk_4	123	129	PF00069	0.362
MOD_Plk_4	164	170	PF00069	0.364
MOD_Plk_4	270	276	PF00069	0.424
MOD_Plk_4	365	371	PF00069	0.378
MOD_Plk_4	38	44	PF00069	0.350
MOD_Plk_4	394	400	PF00069	0.378
MOD_Plk_4	422	428	PF00069	0.477
MOD_Plk_4	562	568	PF00069	0.516
MOD_ProDKin_1	160	166	PF00069	0.349
MOD_ProDKin_1	170	176	PF00069	0.350
MOD_ProDKin_1	257	263	PF00069	0.477
MOD_ProDKin_1	507	513	PF00069	0.756
MOD_ProDKin_1	517	523	PF00069	0.639
MOD_SUMO_rev_2	236	246	PF00179	0.370
TRG_DiLeu_BaEn_3	429	435	PF01217	0.363
TRG_DiLeu_BaEn_3	77	83	PF01217	0.378
TRG_ENDOCYTIC_2	254	257	PF00928	0.400
TRG_ENDOCYTIC_2	263	266	PF00928	0.298
TRG_ENDOCYTIC_2	383	386	PF00928	0.338
TRG_ENDOCYTIC_2	428	431	PF00928	0.378
TRG_ENDOCYTIC_2	445	448	PF00928	0.168
TRG_ENDOCYTIC_2	598	601	PF00928	0.342
TRG_ENDOCYTIC_2	627	630	PF00928	0.350
TRG_NES_CRM1_1	450	462	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD95	Leptomonas seymouri	79%	99%
A0A0S4IST4	Bodo saltans	55%	83%
A0A1X0P9B2	Trypanosomatidae	71%	100%
A0A3Q8IRJ0	Leishmania donovani	92%	99%
A0A422NEK1	Trypanosoma rangeli	67%	100%
A0MWD1	Bubalus bubalis	33%	97%
A1E2I5	Macaca mulatta	33%	97%
A4HHM0	Leishmania braziliensis	84%	100%
A4I4S9	Leishmania infantum	92%	99%
A6H7I5	Bos taurus	44%	80%
A7VK00	Sus scrofa	33%	97%
C9ZLH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZLI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AE82	Leishmania major	90%	100%
O00429	Homo sapiens	36%	94%
O35303	Rattus norvegicus	35%	92%
P09922	Mus musculus	33%	100%
P18589	Rattus norvegicus	34%	100%
P18590	Rattus norvegicus	34%	100%
P21575	Rattus norvegicus	44%	80%
P21576	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	98%
P27594	Sus scrofa	33%	100%
P27619	Drosophila melanogaster	42%	79%
P33237	Ovis aries	34%	100%
P33238	Anas platyrhynchos	32%	96%
P39052	Rattus norvegicus	45%	79%
P39053	Mus musculus	44%	80%
P39054	Mus musculus	44%	79%
P39055	Caenorhabditis elegans	42%	83%
P42697	Arabidopsis thaliana	37%	100%
P50570	Homo sapiens	44%	79%
P54861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	91%
P79135	Bos taurus	34%	100%
Q000A9	Larimichthys crocea	31%	100%
Q05193	Homo sapiens	44%	80%
Q08877	Rattus norvegicus	43%	80%
Q08DF4	Bos taurus	44%	81%
Q09748	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	88%
Q2KIA5	Bos taurus	36%	92%
Q2KTC2	Dicentrarchus labrax	33%	100%
Q39821	Glycine max	38%	100%
Q39828	Glycine max	38%	100%
Q4ADG6	Phoca vitulina	32%	100%
Q5U752	Solea senegalensis	32%	100%
Q6DKF0	Danio rerio	31%	100%
Q7SXN5	Danio rerio	39%	100%
Q7T2P0	Ictalurus punctatus	35%	100%
Q84XF3	Arabidopsis thaliana	36%	100%
Q8BZ98	Mus musculus	43%	80%
Q8K1M6	Mus musculus	36%	93%
Q8LF21	Arabidopsis thaliana	37%	100%
Q8LFT2	Arabidopsis thaliana	36%	89%
Q8S3C9	Arabidopsis thaliana	36%	100%
Q8S944	Arabidopsis thaliana	35%	86%
Q94464	Dictyostelium discoideum	49%	81%
Q9FNX5	Arabidopsis thaliana	35%	100%
Q9LQ55	Arabidopsis thaliana	23%	75%
Q9N0Y2	Canis lupus familiaris	32%	97%
Q9N0Y3	Canis lupus familiaris	34%	100%
Q9SE83	Arabidopsis thaliana	23%	76%
Q9U1M9	Dictyostelium discoideum	40%	75%
Q9UQ16	Homo sapiens	43%	80%
Q9URZ5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q9WVP9	Mus musculus	33%	100%
Q9ZP55	Arabidopsis thaliana	27%	100%
V5DTS8	Trypanosoma cruzi	68%	100%