LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania mexicana

UniProt:

E9ALK2_LEIMU

TriTrypDb:

LmxM.08_29.2210

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9ALK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK2

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.511
CLV_NRD_NRD_1	11	13	PF00675	0.221
CLV_NRD_NRD_1	224	226	PF00675	0.431
CLV_NRD_NRD_1	358	360	PF00675	0.502
CLV_PCSK_KEX2_1	10	12	PF00082	0.211
CLV_PCSK_KEX2_1	247	249	PF00082	0.532
CLV_PCSK_KEX2_1	358	360	PF00082	0.502
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.532
CLV_PCSK_SKI1_1	267	271	PF00082	0.383
CLV_PCSK_SKI1_1	370	374	PF00082	0.581
CLV_PCSK_SKI1_1	63	67	PF00082	0.232
CLV_Separin_Metazoa	7	11	PF03568	0.467
DEG_APCC_DBOX_1	362	370	PF00400	0.545
DEG_APCC_DBOX_1	403	411	PF00400	0.701
DEG_SPOP_SBC_1	384	388	PF00917	0.613
DOC_CDC14_PxL_1	136	144	PF14671	0.467
DOC_CKS1_1	231	236	PF01111	0.567
DOC_CKS1_1	477	482	PF01111	0.585
DOC_CYCLIN_RxL_1	262	273	PF00134	0.449
DOC_MAPK_gen_1	262	270	PF00069	0.553
DOC_MAPK_gen_1	317	325	PF00069	0.334
DOC_MAPK_gen_1	63	73	PF00069	0.432
DOC_MAPK_HePTP_8	156	168	PF00069	0.573
DOC_MAPK_MEF2A_6	159	168	PF00069	0.541
DOC_MAPK_MEF2A_6	271	278	PF00069	0.430
DOC_MAPK_MEF2A_6	317	325	PF00069	0.334
DOC_MAPK_MEF2A_6	66	75	PF00069	0.411
DOC_MAPK_MEF2A_6	92	99	PF00069	0.411
DOC_MAPK_NFAT4_5	92	100	PF00069	0.411
DOC_MAPK_RevD_3	345	359	PF00069	0.466
DOC_PP1_RVXF_1	61	68	PF00149	0.504
DOC_PP2B_LxvP_1	321	324	PF13499	0.398
DOC_USP7_MATH_1	391	395	PF00917	0.529
DOC_USP7_MATH_1	402	406	PF00917	0.579
DOC_USP7_MATH_1	432	436	PF00917	0.671
DOC_USP7_MATH_1	483	487	PF00917	0.724
DOC_USP7_UBL2_3	197	201	PF12436	0.558
DOC_USP7_UBL2_3	434	438	PF12436	0.498
DOC_WW_Pin1_4	206	211	PF00397	0.410
DOC_WW_Pin1_4	230	235	PF00397	0.560
DOC_WW_Pin1_4	385	390	PF00397	0.631
DOC_WW_Pin1_4	416	421	PF00397	0.649
DOC_WW_Pin1_4	451	456	PF00397	0.622
DOC_WW_Pin1_4	476	481	PF00397	0.586
LIG_14-3-3_CanoR_1	3	7	PF00244	0.424
LIG_14-3-3_CanoR_1	338	347	PF00244	0.472
LIG_14-3-3_CanoR_1	404	408	PF00244	0.650
LIG_14-3-3_CanoR_1	427	432	PF00244	0.498
LIG_AP2alpha_2	192	194	PF02296	0.456
LIG_Clathr_ClatBox_1	407	411	PF01394	0.707
LIG_EH_1	111	115	PF12763	0.504
LIG_FHA_1	298	304	PF00498	0.401
LIG_FHA_1	3	9	PF00498	0.411
LIG_FHA_1	390	396	PF00498	0.498
LIG_FHA_1	428	434	PF00498	0.651
LIG_FHA_1	457	463	PF00498	0.624
LIG_FHA_1	473	479	PF00498	0.467
LIG_FHA_2	124	130	PF00498	0.467
LIG_FHA_2	207	213	PF00498	0.397
LIG_FHA_2	255	261	PF00498	0.474
LIG_FHA_2	404	410	PF00498	0.651
LIG_FHA_2	77	83	PF00498	0.418
LIG_Integrin_RGD_1	359	361	PF01839	0.319
LIG_LIR_Nem_3	128	134	PF02991	0.425
LIG_LIR_Nem_3	263	268	PF02991	0.564
LIG_RPA_C_Fungi	354	366	PF08784	0.546
LIG_SH2_GRB2like	70	73	PF00017	0.249
LIG_SH2_SRC	134	137	PF00017	0.328
LIG_SH2_STAT5	134	137	PF00017	0.267
LIG_SH2_STAT5	50	53	PF00017	0.266
LIG_SH2_STAT5	55	58	PF00017	0.281
LIG_SH2_STAT5	70	73	PF00017	0.175
LIG_SH3_1	271	277	PF00018	0.433
LIG_SH3_3	190	196	PF00018	0.420
LIG_SH3_3	271	277	PF00018	0.433
LIG_SH3_3	344	350	PF00018	0.374
LIG_SH3_3	452	458	PF00018	0.493
LIG_SH3_3	474	480	PF00018	0.608
LIG_SUMO_SIM_anti_2	308	313	PF11976	0.406
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.249
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.267
LIG_SUMO_SIM_par_1	162	172	PF11976	0.474
LIG_SUMO_SIM_par_1	287	293	PF11976	0.437
LIG_SUMO_SIM_par_1	405	412	PF11976	0.707
LIG_TRAF2_1	169	172	PF00917	0.486
LIG_TRAF2_1	209	212	PF00917	0.401
LIG_TRAF2_1	257	260	PF00917	0.462
LIG_TYR_ITIM	68	73	PF00017	0.249
LIG_WW_1	195	198	PF00397	0.468
MOD_CDK_SPxxK_3	206	213	PF00069	0.400
MOD_CK1_1	105	111	PF00069	0.338
MOD_CK1_1	377	383	PF00069	0.718
MOD_CK1_1	418	424	PF00069	0.658
MOD_CK2_1	123	129	PF00069	0.314
MOD_CK2_1	206	212	PF00069	0.423
MOD_CK2_1	254	260	PF00069	0.477
MOD_CK2_1	403	409	PF00069	0.650
MOD_CK2_1	54	60	PF00069	0.267
MOD_GlcNHglycan	377	380	PF01048	0.722
MOD_GlcNHglycan	435	438	PF01048	0.751
MOD_GlcNHglycan	443	446	PF01048	0.534
MOD_GlcNHglycan	448	451	PF01048	0.632
MOD_GlcNHglycan	462	465	PF01048	0.617
MOD_GSK3_1	101	108	PF00069	0.348
MOD_GSK3_1	114	121	PF00069	0.285
MOD_GSK3_1	250	257	PF00069	0.641
MOD_GSK3_1	297	304	PF00069	0.509
MOD_GSK3_1	370	377	PF00069	0.620
MOD_GSK3_1	380	387	PF00069	0.690
MOD_GSK3_1	414	421	PF00069	0.699
MOD_GSK3_1	433	440	PF00069	0.462
MOD_GSK3_1	456	463	PF00069	0.666
MOD_GSK3_1	464	471	PF00069	0.611
MOD_GSK3_1	472	479	PF00069	0.705
MOD_N-GLC_1	438	443	PF02516	0.560
MOD_N-GLC_1	76	81	PF02516	0.267
MOD_NEK2_1	114	119	PF00069	0.259
MOD_NEK2_1	297	302	PF00069	0.410
MOD_NEK2_1	345	350	PF00069	0.376
MOD_NEK2_1	414	419	PF00069	0.739
MOD_NEK2_1	433	438	PF00069	0.461
MOD_NEK2_1	93	98	PF00069	0.249
MOD_PIKK_1	250	256	PF00454	0.586
MOD_PIKK_1	468	474	PF00454	0.671
MOD_PKA_2	2	8	PF00069	0.267
MOD_PKA_2	254	260	PF00069	0.521
MOD_PKA_2	337	343	PF00069	0.540
MOD_PKA_2	403	409	PF00069	0.650
MOD_PKA_2	426	432	PF00069	0.497
MOD_Plk_1	464	470	PF00069	0.468
MOD_Plk_1	76	82	PF00069	0.264
MOD_Plk_1	93	99	PF00069	0.194
MOD_Plk_4	105	111	PF00069	0.338
MOD_Plk_4	298	304	PF00069	0.415
MOD_Plk_4	403	409	PF00069	0.650
MOD_Plk_4	456	462	PF00069	0.489
MOD_ProDKin_1	206	212	PF00069	0.404
MOD_ProDKin_1	230	236	PF00069	0.566
MOD_ProDKin_1	385	391	PF00069	0.626
MOD_ProDKin_1	416	422	PF00069	0.652
MOD_ProDKin_1	451	457	PF00069	0.618
MOD_ProDKin_1	476	482	PF00069	0.586
MOD_SUMO_for_1	182	185	PF00179	0.383
TRG_DiLeu_BaEn_1	34	39	PF01217	0.328
TRG_DiLeu_BaEn_2	292	298	PF01217	0.464
TRG_DiLeu_BaEn_3	211	217	PF01217	0.386
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.433
TRG_ENDOCYTIC_2	70	73	PF00928	0.232
TRG_ER_diArg_1	174	177	PF00400	0.387
TRG_ER_diArg_1	362	365	PF00400	0.497
TRG_ER_diArg_1	9	12	PF00400	0.249
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R7	Leptomonas seymouri	75%	99%
A0A0S4IYI1	Bodo saltans	61%	100%
A0A1L8G016	Xenopus laevis	36%	100%
A0A1X0P946	Trypanosomatidae	65%	100%
A0A3Q8IBL9	Leishmania donovani	95%	100%
A0A3R7LV56	Trypanosoma rangeli	63%	100%
A4HHM1	Leishmania braziliensis	83%	100%
A4I4T0	Leishmania infantum	92%	100%
B3DH20	Danio rerio	35%	100%
C9ZLH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AE83	Leishmania major	94%	100%
O88978	Mus musculus	35%	100%
Q1RMR5	Bos taurus	36%	100%
Q28FY0	Xenopus tropicalis	38%	100%
Q4R3F0	Macaca fascicularis	34%	100%
Q86X45	Homo sapiens	34%	100%
Q9NJE9	Trypanosoma brucei brucei	61%	100%
Q9VR52	Drosophila melanogaster	36%	100%