Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALK0_LEIMU

TriTrypDb:

LmxM.08_29.2230

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

E9ALK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALK0

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0046168	glycerol-3-phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0052646	alditol phosphate metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0036094	small molecule binding	2	2
GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	5	1
GO:0051287	NAD binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.430
CLV_NRD_NRD_1	414	416	PF00675	0.541
CLV_NRD_NRD_1	421	423	PF00675	0.571
CLV_PCSK_KEX2_1	107	109	PF00082	0.509
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.509
CLV_PCSK_SKI1_1	131	135	PF00082	0.508
CLV_PCSK_SKI1_1	2	6	PF00082	0.416
CLV_PCSK_SKI1_1	271	275	PF00082	0.651
CLV_PCSK_SKI1_1	315	319	PF00082	0.463
CLV_PCSK_SKI1_1	501	505	PF00082	0.399
CLV_PCSK_SKI1_1	524	528	PF00082	0.521
CLV_Separin_Metazoa	498	502	PF03568	0.447
DEG_Nend_UBRbox_1	1	4	PF02207	0.433
DEG_SCF_FBW7_1	115	121	PF00400	0.411
DEG_SCF_FBW7_1	229	236	PF00400	0.512
DEG_SCF_FBW7_1	79	86	PF00400	0.478
DEG_SPOP_SBC_1	233	237	PF00917	0.424
DEG_SPOP_SBC_1	62	66	PF00917	0.491
DOC_CKS1_1	115	120	PF01111	0.479
DOC_CKS1_1	211	216	PF01111	0.572
DOC_CKS1_1	230	235	PF01111	0.407
DOC_MAPK_gen_1	107	115	PF00069	0.349
DOC_PP1_RVXF_1	313	319	PF00149	0.421
DOC_PP1_RVXF_1	413	420	PF00149	0.619
DOC_PP2B_LxvP_1	243	246	PF13499	0.534
DOC_PP2B_LxvP_1	326	329	PF13499	0.434
DOC_PP2B_LxvP_1	391	394	PF13499	0.406
DOC_USP7_MATH_1	118	122	PF00917	0.433
DOC_USP7_MATH_1	155	159	PF00917	0.640
DOC_USP7_MATH_1	163	167	PF00917	0.511
DOC_USP7_MATH_1	22	26	PF00917	0.525
DOC_USP7_MATH_1	233	237	PF00917	0.510
DOC_USP7_MATH_1	246	250	PF00917	0.722
DOC_USP7_MATH_1	273	277	PF00917	0.719
DOC_USP7_MATH_1	319	323	PF00917	0.415
DOC_USP7_MATH_1	343	347	PF00917	0.384
DOC_USP7_MATH_1	394	398	PF00917	0.452
DOC_USP7_MATH_1	57	61	PF00917	0.774
DOC_USP7_MATH_1	62	66	PF00917	0.762
DOC_USP7_MATH_1	83	87	PF00917	0.500
DOC_WW_Pin1_4	114	119	PF00397	0.427
DOC_WW_Pin1_4	210	215	PF00397	0.584
DOC_WW_Pin1_4	229	234	PF00397	0.324
DOC_WW_Pin1_4	294	299	PF00397	0.473
DOC_WW_Pin1_4	386	391	PF00397	0.403
DOC_WW_Pin1_4	454	459	PF00397	0.374
DOC_WW_Pin1_4	69	74	PF00397	0.733
DOC_WW_Pin1_4	79	84	PF00397	0.642
LIG_14-3-3_CanoR_1	148	156	PF00244	0.520
LIG_14-3-3_CanoR_1	517	525	PF00244	0.436
LIG_BRCT_BRCA1_1	165	169	PF00533	0.559
LIG_BRCT_BRCA1_1	407	411	PF00533	0.433
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.460
LIG_FHA_1	1	7	PF00498	0.399
LIG_FHA_1	115	121	PF00498	0.443
LIG_FHA_1	140	146	PF00498	0.415
LIG_FHA_1	165	171	PF00498	0.474
LIG_FHA_1	211	217	PF00498	0.490
LIG_FHA_1	240	246	PF00498	0.493
LIG_FHA_1	295	301	PF00498	0.444
LIG_FHA_1	373	379	PF00498	0.326
LIG_FHA_1	402	408	PF00498	0.502
LIG_FHA_1	43	49	PF00498	0.623
LIG_FHA_2	325	331	PF00498	0.416
LIG_FHA_2	489	495	PF00498	0.644
LIG_FHA_2	502	508	PF00498	0.507
LIG_GBD_Chelix_1	187	195	PF00786	0.271
LIG_LIR_Gen_1	166	177	PF02991	0.351
LIG_LIR_Gen_1	457	467	PF02991	0.371
LIG_LIR_Nem_3	166	172	PF02991	0.510
LIG_LIR_Nem_3	242	247	PF02991	0.648
LIG_LIR_Nem_3	457	463	PF02991	0.356
LIG_LIR_Nem_3	483	488	PF02991	0.607
LIG_NRBOX	191	197	PF00104	0.323
LIG_PDZ_Class_1	529	534	PF00595	0.588
LIG_Pex14_2	169	173	PF04695	0.452
LIG_SH2_SRC	122	125	PF00017	0.353
LIG_SH2_STAP1	367	371	PF00017	0.486
LIG_SH2_STAP1	460	464	PF00017	0.334
LIG_SH2_STAT5	122	125	PF00017	0.494
LIG_SH2_STAT5	325	328	PF00017	0.473
LIG_SH2_STAT5	356	359	PF00017	0.634
LIG_SH2_STAT5	420	423	PF00017	0.587
LIG_SH3_3	245	251	PF00018	0.639
LIG_SH3_3	452	458	PF00018	0.501
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.509
LIG_SUMO_SIM_par_1	212	219	PF11976	0.421
LIG_SUMO_SIM_par_1	44	51	PF11976	0.563
LIG_TRAF2_2	184	189	PF00917	0.355
LIG_WRC_WIRS_1	344	349	PF05994	0.483
MOD_CK1_1	158	164	PF00069	0.659
MOD_CK1_1	228	234	PF00069	0.568
MOD_CK1_1	236	242	PF00069	0.658
MOD_CK1_1	25	31	PF00069	0.544
MOD_CK1_1	253	259	PF00069	0.709
MOD_CK1_1	275	281	PF00069	0.532
MOD_CK1_1	354	360	PF00069	0.535
MOD_CK1_1	50	56	PF00069	0.715
MOD_CK1_1	64	70	PF00069	0.690
MOD_CK1_1	77	83	PF00069	0.546
MOD_CK2_1	204	210	PF00069	0.651
MOD_CK2_1	275	281	PF00069	0.549
MOD_CK2_1	488	494	PF00069	0.558
MOD_CK2_1	509	515	PF00069	0.517
MOD_CK2_1	57	63	PF00069	0.593
MOD_Cter_Amidation	413	416	PF01082	0.542
MOD_GlcNHglycan	101	104	PF01048	0.636
MOD_GlcNHglycan	201	204	PF01048	0.639
MOD_GlcNHglycan	218	221	PF01048	0.283
MOD_GlcNHglycan	236	239	PF01048	0.705
MOD_GlcNHglycan	252	255	PF01048	0.726
MOD_GlcNHglycan	275	278	PF01048	0.658
MOD_GlcNHglycan	286	289	PF01048	0.393
MOD_GlcNHglycan	452	455	PF01048	0.467
MOD_GlcNHglycan	511	514	PF01048	0.432
MOD_GlcNHglycan	59	62	PF01048	0.710
MOD_GlcNHglycan	85	88	PF01048	0.389
MOD_GSK3_1	114	121	PF00069	0.445
MOD_GSK3_1	144	151	PF00069	0.593
MOD_GSK3_1	194	201	PF00069	0.492
MOD_GSK3_1	2	9	PF00069	0.321
MOD_GSK3_1	206	213	PF00069	0.512
MOD_GSK3_1	225	232	PF00069	0.309
MOD_GSK3_1	233	240	PF00069	0.545
MOD_GSK3_1	246	253	PF00069	0.592
MOD_GSK3_1	263	270	PF00069	0.734
MOD_GSK3_1	292	299	PF00069	0.439
MOD_GSK3_1	350	357	PF00069	0.461
MOD_GSK3_1	401	408	PF00069	0.430
MOD_GSK3_1	42	49	PF00069	0.711
MOD_GSK3_1	450	457	PF00069	0.424
MOD_GSK3_1	57	64	PF00069	0.612
MOD_GSK3_1	67	74	PF00069	0.774
MOD_GSK3_1	75	82	PF00069	0.636
MOD_N-GLC_1	22	27	PF02516	0.453
MOD_N-GLC_1	267	272	PF02516	0.587
MOD_N-GLC_1	57	62	PF02516	0.642
MOD_N-GLC_2	339	341	PF02516	0.316
MOD_NEK2_1	187	192	PF00069	0.488
MOD_NEK2_1	216	221	PF00069	0.484
MOD_NEK2_1	234	239	PF00069	0.472
MOD_NEK2_1	351	356	PF00069	0.524
MOD_NEK2_1	450	455	PF00069	0.414
MOD_NEK2_1	463	468	PF00069	0.369
MOD_NEK2_1	48	53	PF00069	0.515
MOD_NEK2_1	529	534	PF00069	0.586
MOD_PIKK_1	106	112	PF00454	0.443
MOD_PKA_2	149	155	PF00069	0.446
MOD_PKA_2	319	325	PF00069	0.386
MOD_PKA_2	33	39	PF00069	0.674
MOD_PKA_2	471	477	PF00069	0.512
MOD_PKA_2	488	494	PF00069	0.383
MOD_PKA_2	516	522	PF00069	0.608
MOD_Plk_1	22	28	PF00069	0.538
MOD_Plk_1	225	231	PF00069	0.428
MOD_Plk_2-3	206	212	PF00069	0.456
MOD_Plk_4	118	124	PF00069	0.429
MOD_Plk_4	187	193	PF00069	0.368
MOD_Plk_4	2	8	PF00069	0.494
MOD_Plk_4	239	245	PF00069	0.603
MOD_Plk_4	27	33	PF00069	0.438
MOD_Plk_4	321	327	PF00069	0.441
MOD_Plk_4	351	357	PF00069	0.567
MOD_Plk_4	395	401	PF00069	0.475
MOD_Plk_4	466	472	PF00069	0.433
MOD_ProDKin_1	114	120	PF00069	0.427
MOD_ProDKin_1	210	216	PF00069	0.573
MOD_ProDKin_1	229	235	PF00069	0.330
MOD_ProDKin_1	294	300	PF00069	0.473
MOD_ProDKin_1	386	392	PF00069	0.396
MOD_ProDKin_1	454	460	PF00069	0.366
MOD_ProDKin_1	69	75	PF00069	0.732
MOD_ProDKin_1	79	85	PF00069	0.628
MOD_SUMO_rev_2	86	96	PF00179	0.520
TRG_DiLeu_BaEn_1	212	217	PF01217	0.410
TRG_ENDOCYTIC_2	460	463	PF00928	0.343
TRG_ENDOCYTIC_2	467	470	PF00928	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P658	Leptomonas seymouri	55%	100%
A0A0S4ITH1	Bodo saltans	24%	100%
A0A1X0P970	Trypanosomatidae	39%	100%
A0A3Q8IFB4	Leishmania donovani	90%	100%
A0A422NEK6	Trypanosoma rangeli	33%	100%
A4HHM3	Leishmania braziliensis	79%	100%
A4I4T2	Leishmania infantum	91%	92%
C9ZLH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AE85	Leishmania major	90%	100%