Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALJ8_LEIMU

TriTrypDb:

LmxM.08_29.2250

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.469
CLV_C14_Caspase3-7	528	532	PF00656	0.550
CLV_NRD_NRD_1	67	69	PF00675	0.510
CLV_PCSK_SKI1_1	203	207	PF00082	0.592
CLV_PCSK_SKI1_1	255	259	PF00082	0.434
CLV_PCSK_SKI1_1	268	272	PF00082	0.515
CLV_PCSK_SKI1_1	458	462	PF00082	0.509
CLV_PCSK_SKI1_1	530	534	PF00082	0.432
CLV_PCSK_SKI1_1	677	681	PF00082	0.474
CLV_PCSK_SKI1_1	68	72	PF00082	0.569
DEG_APCC_DBOX_1	366	374	PF00400	0.424
DEG_APCC_DBOX_1	529	537	PF00400	0.427
DOC_CYCLIN_RxL_1	265	275	PF00134	0.511
DOC_MAPK_gen_1	25	31	PF00069	0.485
DOC_MAPK_gen_1	253	260	PF00069	0.431
DOC_MAPK_gen_1	300	307	PF00069	0.427
DOC_MAPK_gen_1	313	320	PF00069	0.436
DOC_MAPK_MEF2A_6	272	281	PF00069	0.446
DOC_MAPK_MEF2A_6	300	307	PF00069	0.447
DOC_MAPK_MEF2A_6	367	374	PF00069	0.544
DOC_MAPK_NFAT4_5	367	375	PF00069	0.548
DOC_PP2B_PxIxI_1	592	598	PF00149	0.467
DOC_USP7_MATH_1	149	153	PF00917	0.537
DOC_USP7_MATH_1	342	346	PF00917	0.550
DOC_USP7_MATH_1	392	396	PF00917	0.731
DOC_USP7_MATH_1	464	468	PF00917	0.683
DOC_USP7_MATH_1	512	516	PF00917	0.465
DOC_USP7_MATH_1	544	548	PF00917	0.601
DOC_USP7_MATH_1	572	576	PF00917	0.641
DOC_USP7_MATH_1	604	608	PF00917	0.578
DOC_USP7_MATH_1	630	634	PF00917	0.654
DOC_USP7_MATH_1	679	683	PF00917	0.583
DOC_USP7_MATH_1	699	703	PF00917	0.404
DOC_WW_Pin1_4	118	123	PF00397	0.614
DOC_WW_Pin1_4	441	446	PF00397	0.605
DOC_WW_Pin1_4	458	463	PF00397	0.734
DOC_WW_Pin1_4	598	603	PF00397	0.643
LIG_14-3-3_CanoR_1	127	135	PF00244	0.527
LIG_14-3-3_CanoR_1	137	143	PF00244	0.566
LIG_14-3-3_CanoR_1	175	179	PF00244	0.645
LIG_14-3-3_CanoR_1	255	261	PF00244	0.445
LIG_14-3-3_CanoR_1	272	277	PF00244	0.439
LIG_14-3-3_CanoR_1	290	294	PF00244	0.572
LIG_14-3-3_CanoR_1	302	306	PF00244	0.378
LIG_14-3-3_CanoR_1	629	635	PF00244	0.658
LIG_14-3-3_CanoR_1	68	74	PF00244	0.595
LIG_Actin_WH2_2	245	263	PF00022	0.464
LIG_APCC_ABBA_1	303	308	PF00400	0.477
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.518
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	344	348	PF00533	0.331
LIG_EH1_1	204	212	PF00400	0.537
LIG_FHA_1	169	175	PF00498	0.610
LIG_FHA_1	389	395	PF00498	0.646
LIG_FHA_1	472	478	PF00498	0.761
LIG_FHA_1	51	57	PF00498	0.584
LIG_FHA_1	687	693	PF00498	0.614
LIG_FHA_2	142	148	PF00498	0.556
LIG_FHA_2	222	228	PF00498	0.724
LIG_FHA_2	290	296	PF00498	0.551
LIG_FHA_2	406	412	PF00498	0.497
LIG_FHA_2	464	470	PF00498	0.781
LIG_FHA_2	614	620	PF00498	0.508
LIG_FHA_2	652	658	PF00498	0.544
LIG_GBD_Chelix_1	277	285	PF00786	0.566
LIG_KLC1_Yacidic_2	640	644	PF13176	0.360
LIG_LIR_Gen_1	485	495	PF02991	0.300
LIG_LIR_Gen_1	615	624	PF02991	0.638
LIG_LIR_Gen_1	633	643	PF02991	0.621
LIG_LIR_Nem_3	361	365	PF02991	0.449
LIG_LIR_Nem_3	446	452	PF02991	0.616
LIG_LIR_Nem_3	485	490	PF02991	0.341
LIG_LIR_Nem_3	615	620	PF02991	0.644
LIG_NRBOX	316	322	PF00104	0.531
LIG_NRBOX	485	491	PF00104	0.603
LIG_Pex14_2	201	205	PF04695	0.462
LIG_SH2_CRK	424	428	PF00017	0.529
LIG_SH2_STAP1	424	428	PF00017	0.529
LIG_SH2_STAP1	617	621	PF00017	0.608
LIG_SH2_STAT3	634	637	PF00017	0.532
LIG_SH2_STAT5	140	143	PF00017	0.587
LIG_SH2_STAT5	192	195	PF00017	0.560
LIG_SH2_STAT5	319	322	PF00017	0.509
LIG_SH2_STAT5	387	390	PF00017	0.576
LIG_SH2_STAT5	535	538	PF00017	0.501
LIG_SH2_STAT5	635	638	PF00017	0.567
LIG_SH2_STAT5	642	645	PF00017	0.529
LIG_SH3_3	225	231	PF00018	0.746
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.397
LIG_SUMO_SIM_anti_2	682	689	PF11976	0.573
LIG_SUMO_SIM_par_1	27	32	PF11976	0.481
LIG_SUMO_SIM_par_1	370	376	PF11976	0.452
LIG_SUMO_SIM_par_1	482	488	PF11976	0.446
LIG_SUMO_SIM_par_1	618	625	PF11976	0.665
LIG_TRAF2_1	213	216	PF00917	0.614
LIG_TRAF2_1	3	6	PF00917	0.571
LIG_TRAF2_1	334	337	PF00917	0.700
LIG_TRAF2_1	546	549	PF00917	0.634
LIG_TRAF2_1	616	619	PF00917	0.487
LIG_WRC_WIRS_1	139	144	PF05994	0.450
MOD_CK1_1	101	107	PF00069	0.696
MOD_CK1_1	236	242	PF00069	0.680
MOD_CK1_1	247	253	PF00069	0.493
MOD_CK1_1	326	332	PF00069	0.553
MOD_CK1_1	376	382	PF00069	0.414
MOD_CK1_1	395	401	PF00069	0.773
MOD_CK1_1	467	473	PF00069	0.588
MOD_CK1_1	50	56	PF00069	0.626
MOD_CK1_1	502	508	PF00069	0.551
MOD_CK1_1	596	602	PF00069	0.662
MOD_CK1_1	633	639	PF00069	0.656
MOD_CK1_1	682	688	PF00069	0.594
MOD_CK1_1	82	88	PF00069	0.572
MOD_CK2_1	127	133	PF00069	0.497
MOD_CK2_1	141	147	PF00069	0.482
MOD_CK2_1	221	227	PF00069	0.746
MOD_CK2_1	405	411	PF00069	0.598
MOD_CK2_1	463	469	PF00069	0.767
MOD_CK2_1	613	619	PF00069	0.504
MOD_CK2_1	651	657	PF00069	0.524
MOD_GlcNHglycan	152	155	PF01048	0.613
MOD_GlcNHglycan	238	241	PF01048	0.745
MOD_GlcNHglycan	261	264	PF01048	0.551
MOD_GlcNHglycan	328	331	PF01048	0.555
MOD_GlcNHglycan	339	342	PF01048	0.656
MOD_GlcNHglycan	394	397	PF01048	0.741
MOD_GlcNHglycan	514	517	PF01048	0.473
MOD_GlcNHglycan	624	627	PF01048	0.568
MOD_GlcNHglycan	82	85	PF01048	0.632
MOD_GSK3_1	174	181	PF00069	0.479
MOD_GSK3_1	259	266	PF00069	0.484
MOD_GSK3_1	337	344	PF00069	0.668
MOD_GSK3_1	388	395	PF00069	0.627
MOD_GSK3_1	458	465	PF00069	0.711
MOD_GSK3_1	467	474	PF00069	0.748
MOD_GSK3_1	498	505	PF00069	0.547
MOD_GSK3_1	593	600	PF00069	0.700
MOD_GSK3_1	604	611	PF00069	0.644
MOD_GSK3_1	682	689	PF00069	0.597
MOD_GSK3_1	94	101	PF00069	0.566
MOD_N-GLC_1	524	529	PF02516	0.534
MOD_N-GLC_1	550	555	PF02516	0.700
MOD_NEK2_1	178	183	PF00069	0.385
MOD_NEK2_1	206	211	PF00069	0.596
MOD_NEK2_1	221	226	PF00069	0.680
MOD_NEK2_1	244	249	PF00069	0.727
MOD_NEK2_1	373	378	PF00069	0.494
MOD_NEK2_1	471	476	PF00069	0.739
MOD_NEK2_1	477	482	PF00069	0.655
MOD_NEK2_1	506	511	PF00069	0.517
MOD_NEK2_1	550	555	PF00069	0.681
MOD_NEK2_1	686	691	PF00069	0.591
MOD_NEK2_2	256	261	PF00069	0.405
MOD_NEK2_2	263	268	PF00069	0.559
MOD_NEK2_2	499	504	PF00069	0.490
MOD_NEK2_2	604	609	PF00069	0.466
MOD_PIKK_1	323	329	PF00454	0.544
MOD_PIKK_1	477	483	PF00454	0.714
MOD_PIKK_1	50	56	PF00454	0.614
MOD_PIKK_1	633	639	PF00454	0.511
MOD_PIKK_1	679	685	PF00454	0.485
MOD_PIKK_1	686	692	PF00454	0.484
MOD_PK_1	272	278	PF00069	0.502
MOD_PKA_1	19	25	PF00069	0.588
MOD_PKA_2	168	174	PF00069	0.569
MOD_PKA_2	216	222	PF00069	0.644
MOD_PKA_2	289	295	PF00069	0.586
MOD_PKA_2	301	307	PF00069	0.374
MOD_PKA_2	506	512	PF00069	0.525
MOD_PKA_2	593	599	PF00069	0.493
MOD_PKA_2	608	614	PF00069	0.580
MOD_PKA_2	80	86	PF00069	0.628
MOD_Plk_2-3	289	295	PF00069	0.660
MOD_Plk_4	206	212	PF00069	0.563
MOD_Plk_4	216	222	PF00069	0.527
MOD_Plk_4	247	253	PF00069	0.366
MOD_Plk_4	266	272	PF00069	0.424
MOD_Plk_4	301	307	PF00069	0.444
MOD_Plk_4	376	382	PF00069	0.496
MOD_Plk_4	630	636	PF00069	0.585
MOD_Plk_4	94	100	PF00069	0.573
MOD_ProDKin_1	118	124	PF00069	0.605
MOD_ProDKin_1	441	447	PF00069	0.611
MOD_ProDKin_1	458	464	PF00069	0.735
MOD_ProDKin_1	598	604	PF00069	0.644
MOD_SUMO_rev_2	13	22	PF00179	0.529
MOD_SUMO_rev_2	669	676	PF00179	0.624
TRG_DiLeu_BaEn_1	216	221	PF01217	0.436
TRG_DiLeu_BaEn_1	361	366	PF01217	0.404
TRG_DiLeu_BaEn_1	6	11	PF01217	0.571
TRG_DiLeu_BaEn_2	410	416	PF01217	0.514
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.638
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.490
TRG_ENDOCYTIC_2	424	427	PF00928	0.532
TRG_ENDOCYTIC_2	617	620	PF00928	0.645
TRG_ENDOCYTIC_2	635	638	PF00928	0.416
TRG_ENDOCYTIC_2	642	645	PF00928	0.529
TRG_ER_diArg_1	591	594	PF00400	0.682
TRG_NES_CRM1_1	295	308	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM6	Leptomonas seymouri	51%	94%
A0A1X0P953	Trypanosomatidae	31%	100%
A0A3R7K9I4	Trypanosoma rangeli	31%	100%
A0A3S7X2P1	Leishmania donovani	89%	100%
A4HHM5	Leishmania braziliensis	76%	100%
A4I4T4	Leishmania infantum	89%	100%
C9ZLI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AE87	Leishmania major	87%	100%
V5BC22	Trypanosoma cruzi	31%	100%