DNA replication complex GINS protein SLD5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication complex GINS protein SLD5, putative

Species:

Leishmania mexicana

UniProt:

E9ALJ7_LEIMU

TriTrypDb:

LmxM.08_29.2260

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9ALJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006261	DNA-templated DNA replication	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.553
CLV_NRD_NRD_1	159	161	PF00675	0.378
CLV_PCSK_KEX2_1	123	125	PF00082	0.554
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.531
CLV_PCSK_SKI1_1	129	133	PF00082	0.559
CLV_Separin_Metazoa	153	157	PF03568	0.342
DEG_APCC_DBOX_1	155	163	PF00400	0.351
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DOC_CKS1_1	301	306	PF01111	0.537
DOC_MAPK_MEF2A_6	135	144	PF00069	0.443
DOC_PP1_RVXF_1	144	150	PF00149	0.442
DOC_PP4_FxxP_1	301	304	PF00568	0.451
DOC_USP7_MATH_1	127	131	PF00917	0.557
DOC_USP7_MATH_1	194	198	PF00917	0.637
DOC_USP7_MATH_1	251	255	PF00917	0.608
DOC_USP7_MATH_1	40	44	PF00917	0.668
DOC_USP7_MATH_1	58	62	PF00917	0.522
DOC_WW_Pin1_4	300	305	PF00397	0.537
DOC_WW_Pin1_4	87	92	PF00397	0.484
LIG_14-3-3_CanoR_1	212	218	PF00244	0.419
LIG_14-3-3_CanoR_1	225	235	PF00244	0.455
LIG_Actin_WH2_2	144	162	PF00022	0.374
LIG_APCC_ABBA_1	167	172	PF00400	0.261
LIG_BIR_III_4	18	22	PF00653	0.452
LIG_BRCT_BRCA1_1	45	49	PF00533	0.695
LIG_FHA_1	22	28	PF00498	0.733
LIG_FHA_1	46	52	PF00498	0.738
LIG_FHA_2	82	88	PF00498	0.396
LIG_LIR_Apic_2	299	304	PF02991	0.451
LIG_LIR_Gen_1	10	19	PF02991	0.643
LIG_LIR_Gen_1	303	313	PF02991	0.529
LIG_LIR_Nem_3	10	16	PF02991	0.714
LIG_LIR_Nem_3	168	174	PF02991	0.504
LIG_LIR_Nem_3	303	308	PF02991	0.500
LIG_NRBOX	150	156	PF00104	0.362
LIG_PCNA_yPIPBox_3	106	119	PF02747	0.497
LIG_Rb_LxCxE_1	137	153	PF01857	0.218
LIG_SH2_GRB2like	305	308	PF00017	0.529
LIG_SH2_STAP1	13	17	PF00017	0.647
LIG_SH2_STAT5	270	273	PF00017	0.451
LIG_SH2_STAT5	311	314	PF00017	0.476
LIG_SH3_3	130	136	PF00018	0.475
LIG_SH3_3	20	26	PF00018	0.672
LIG_SH3_3	204	210	PF00018	0.592
LIG_SH3_3	247	253	PF00018	0.399
LIG_SH3_3	52	58	PF00018	0.719
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.512
LIG_TYR_ITIM	11	16	PF00017	0.521
LIG_TYR_ITIM	169	174	PF00017	0.508
LIG_WRPW_2	308	311	PF00400	0.320
MOD_CK1_1	176	182	PF00069	0.431
MOD_CK1_1	197	203	PF00069	0.685
MOD_CK1_1	28	34	PF00069	0.731
MOD_CK1_1	43	49	PF00069	0.722
MOD_CK2_1	213	219	PF00069	0.393
MOD_CK2_1	251	257	PF00069	0.619
MOD_CK2_1	81	87	PF00069	0.391
MOD_GlcNHglycan	175	178	PF01048	0.435
MOD_GlcNHglycan	196	199	PF01048	0.673
MOD_GlcNHglycan	228	231	PF01048	0.484
MOD_GlcNHglycan	236	239	PF01048	0.413
MOD_GlcNHglycan	313	316	PF01048	0.418
MOD_GlcNHglycan	36	39	PF01048	0.683
MOD_GlcNHglycan	42	45	PF01048	0.660
MOD_GlcNHglycan	60	63	PF01048	0.527
MOD_GlcNHglycan	70	73	PF01048	0.433
MOD_GSK3_1	173	180	PF00069	0.487
MOD_GSK3_1	21	28	PF00069	0.539
MOD_GSK3_1	234	241	PF00069	0.525
MOD_GSK3_1	34	41	PF00069	0.668
MOD_GSK3_1	96	103	PF00069	0.507
MOD_N-GLC_1	213	218	PF02516	0.519
MOD_N-GLC_1	7	12	PF02516	0.696
MOD_NEK2_1	165	170	PF00069	0.366
MOD_NEK2_1	181	186	PF00069	0.567
MOD_NEK2_1	226	231	PF00069	0.532
MOD_NEK2_1	234	239	PF00069	0.419
MOD_PIKK_1	108	114	PF00454	0.512
MOD_PIKK_1	179	185	PF00454	0.511
MOD_PIKK_1	25	31	PF00454	0.735
MOD_PKA_2	134	140	PF00069	0.453
MOD_Plk_1	213	219	PF00069	0.462
MOD_Plk_1	7	13	PF00069	0.624
MOD_Plk_2-3	12	18	PF00069	0.432
MOD_Plk_4	100	106	PF00069	0.450
MOD_Plk_4	12	18	PF00069	0.685
MOD_Plk_4	165	171	PF00069	0.398
MOD_ProDKin_1	300	306	PF00069	0.424
MOD_ProDKin_1	87	93	PF00069	0.481
TRG_DiLeu_BaEn_1	12	17	PF01217	0.683
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.235
TRG_ENDOCYTIC_2	13	16	PF00928	0.724
TRG_ENDOCYTIC_2	171	174	PF00928	0.514
TRG_ENDOCYTIC_2	305	308	PF00928	0.304
TRG_ER_diArg_1	155	158	PF00400	0.343
TRG_NES_CRM1_1	266	278	PF08389	0.361
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I580	Leptomonas seymouri	63%	100%
A0A0S4IV76	Bodo saltans	39%	100%
A0A1X0PA08	Trypanosomatidae	40%	100%
A0A3R7MDL7	Trypanosoma rangeli	42%	100%
A0A3S7X2T6	Leishmania donovani	92%	100%
A4HHM6	Leishmania braziliensis	78%	100%
A4I4U0	Leishmania infantum	92%	100%
C9ZLI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AE88	Leishmania major	92%	100%
Q753I0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	100%
V5DTT2	Trypanosoma cruzi	45%	100%