PlsC domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9ALJ6_LEIMU

TriTrypDb:

LmxM.08_29.2280

Length:

309

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

E9ALJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046473	phosphatidic acid metabolic process	6	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	30
GO:0016740	transferase activity	2	30
GO:0016746	acyltransferase activity	3	30
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016411	acylglycerol O-acyltransferase activity	6	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0042171	lysophosphatidic acid acyltransferase activity	6	6
GO:0071617	lysophospholipid acyltransferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.525
CLV_NRD_NRD_1	22	24	PF00675	0.308
CLV_PCSK_FUR_1	291	295	PF00082	0.646
CLV_PCSK_KEX2_1	293	295	PF00082	0.594
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.605
CLV_PCSK_SKI1_1	218	222	PF00082	0.489
DEG_Nend_UBRbox_1	1	4	PF02207	0.255
DOC_MAPK_DCC_7	21	30	PF00069	0.544
DOC_MAPK_gen_1	174	182	PF00069	0.291
DOC_MAPK_gen_1	21	29	PF00069	0.508
DOC_MAPK_HePTP_8	28	40	PF00069	0.450
DOC_MAPK_MEF2A_6	176	184	PF00069	0.215
DOC_MAPK_MEF2A_6	21	30	PF00069	0.509
DOC_MAPK_MEF2A_6	31	40	PF00069	0.475
DOC_MAPK_MEF2A_6	83	91	PF00069	0.303
DOC_PP4_FxxP_1	162	165	PF00568	0.168
DOC_USP7_UBL2_3	135	139	PF12436	0.224
DOC_USP7_UBL2_3	282	286	PF12436	0.258
DOC_USP7_UBL2_3	293	297	PF12436	0.303
DOC_WW_Pin1_4	161	166	PF00397	0.245
DOC_WW_Pin1_4	202	207	PF00397	0.262
LIG_14-3-3_CanoR_1	2	7	PF00244	0.323
LIG_14-3-3_CanoR_1	294	300	PF00244	0.378
LIG_14-3-3_CanoR_1	31	37	PF00244	0.488
LIG_14-3-3_CanoR_1	83	88	PF00244	0.423
LIG_APCC_ABBA_1	170	175	PF00400	0.187
LIG_BRCT_BRCA1_1	113	117	PF00533	0.192
LIG_BRCT_BRCA1_1	192	196	PF00533	0.330
LIG_BRCT_BRCA1_1	96	100	PF00533	0.248
LIG_CSL_BTD_1	238	241	PF09270	0.360
LIG_FHA_1	203	209	PF00498	0.313
LIG_FHA_1	33	39	PF00498	0.327
LIG_LIR_Gen_1	114	123	PF02991	0.276
LIG_LIR_Gen_1	252	262	PF02991	0.360
LIG_LIR_Gen_1	97	105	PF02991	0.317
LIG_LIR_Nem_3	114	120	PF02991	0.298
LIG_LIR_Nem_3	168	173	PF02991	0.344
LIG_LIR_Nem_3	216	220	PF02991	0.272
LIG_LIR_Nem_3	252	257	PF02991	0.359
LIG_LIR_Nem_3	5	9	PF02991	0.452
LIG_LIR_Nem_3	97	103	PF02991	0.323
LIG_MLH1_MIPbox_1	113	117	PF16413	0.187
LIG_Pex14_2	158	162	PF04695	0.287
LIG_SH2_CRK	254	258	PF00017	0.301
LIG_SH2_SRC	93	96	PF00017	0.222
LIG_SH2_STAP1	34	38	PF00017	0.386
LIG_SH2_STAT5	130	133	PF00017	0.276
LIG_SH2_STAT5	161	164	PF00017	0.253
LIG_SH2_STAT5	18	21	PF00017	0.295
LIG_SH2_STAT5	229	232	PF00017	0.279
LIG_SH2_STAT5	254	257	PF00017	0.327
LIG_SH2_STAT5	34	37	PF00017	0.396
LIG_SH2_STAT5	93	96	PF00017	0.399
LIG_SH3_1	244	250	PF00018	0.330
LIG_SH3_3	235	241	PF00018	0.287
LIG_SH3_3	244	250	PF00018	0.305
LIG_SUMO_SIM_par_1	285	292	PF11976	0.270
LIG_SUMO_SIM_par_1	50	56	PF11976	0.299
LIG_TRAF2_1	264	267	PF00917	0.304
LIG_WRC_WIRS_1	134	139	PF05994	0.279
LIG_WRC_WIRS_1	214	219	PF05994	0.280
LIG_WRC_WIRS_1	75	80	PF05994	0.299
MOD_CK1_1	138	144	PF00069	0.198
MOD_CK1_1	216	222	PF00069	0.300
MOD_CK1_1	242	248	PF00069	0.266
MOD_CK1_1	271	277	PF00069	0.401
MOD_CK1_1	53	59	PF00069	0.441
MOD_CK1_1	99	105	PF00069	0.318
MOD_CK2_1	160	166	PF00069	0.194
MOD_CK2_1	99	105	PF00069	0.367
MOD_GlcNHglycan	302	305	PF01048	0.656
MOD_GSK3_1	112	119	PF00069	0.269
MOD_GSK3_1	186	193	PF00069	0.367
MOD_GSK3_1	94	101	PF00069	0.345
MOD_N-GLC_1	202	207	PF02516	0.462
MOD_N-GLC_2	108	110	PF02516	0.406
MOD_NEK2_1	111	116	PF00069	0.251
MOD_NEK2_1	147	152	PF00069	0.289
MOD_NEK2_1	60	65	PF00069	0.310
MOD_NEK2_1	98	103	PF00069	0.394
MOD_NEK2_2	112	117	PF00069	0.275
MOD_NEK2_2	192	197	PF00069	0.215
MOD_PIKK_1	298	304	PF00454	0.298
MOD_PIKK_1	63	69	PF00454	0.355
MOD_Plk_4	112	118	PF00069	0.270
MOD_Plk_4	147	153	PF00069	0.273
MOD_Plk_4	192	198	PF00069	0.180
MOD_Plk_4	2	8	PF00069	0.385
MOD_Plk_4	216	222	PF00069	0.326
MOD_Plk_4	252	258	PF00069	0.193
MOD_Plk_4	295	301	PF00069	0.386
MOD_Plk_4	42	48	PF00069	0.341
MOD_Plk_4	50	56	PF00069	0.360
MOD_Plk_4	65	71	PF00069	0.340
MOD_ProDKin_1	161	167	PF00069	0.245
MOD_ProDKin_1	202	208	PF00069	0.262
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.484
TRG_ENDOCYTIC_2	13	16	PF00928	0.364
TRG_ENDOCYTIC_2	228	231	PF00928	0.270
TRG_ENDOCYTIC_2	254	257	PF00928	0.338
TRG_NES_CRM1_1	278	292	PF08389	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	35%	91%
A0A0N1HTP4	Leptomonas seymouri	34%	100%
A0A0N1I6V1	Leptomonas seymouri	48%	100%
A0A0N1IKX5	Leptomonas seymouri	68%	100%
A0A0S4IQ05	Bodo saltans	45%	91%
A0A0S4IR22	Bodo saltans	38%	100%
A0A0S4JRB2	Bodo saltans	37%	97%
A0A1X0P9F0	Trypanosomatidae	46%	100%
A0A3Q8IFY7	Leishmania donovani	25%	100%
A0A3R7NKA0	Trypanosoma rangeli	46%	100%
A0A3S5H5E4	Leishmania donovani	33%	72%
A0A3S5H7L8	Leishmania donovani	84%	95%
A0A3S7WNW6	Leishmania donovani	33%	87%
A4H418	Leishmania braziliensis	39%	100%
A4H419	Leishmania braziliensis	35%	100%
A4H420	Leishmania braziliensis	32%	100%
A4HHM7	Leishmania braziliensis	74%	100%
A4HSA1	Leishmania infantum	33%	100%
A4HSA2	Leishmania infantum	33%	87%
A4I4U1	Leishmania infantum	54%	95%
A4I4U2	Leishmania infantum	81%	100%
A4I816	Leishmania infantum	25%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AE89	Leishmania major	53%	100%
E9AE90	Leishmania major	80%	100%
Q9NF90	Leishmania major	32%	100%
Q9NF91	Leishmania major	36%	100%
V5C201	Trypanosoma cruzi	43%	100%