Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ALJ5_LEIMU

TriTrypDb:

LmxM.08_29.2290

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.656
CLV_C14_Caspase3-7	305	309	PF00656	0.552
CLV_NRD_NRD_1	8	10	PF00675	0.542
CLV_PCSK_KEX2_1	8	10	PF00082	0.542
CLV_PCSK_SKI1_1	186	190	PF00082	0.671
CLV_PCSK_SKI1_1	8	12	PF00082	0.566
DEG_APCC_DBOX_1	183	191	PF00400	0.665
DEG_Nend_Nbox_1	1	3	PF02207	0.729
DEG_SCF_FBW7_1	55	62	PF00400	0.670
DEG_SCF_FBW7_1	92	98	PF00400	0.515
DEG_SPOP_SBC_1	14	18	PF00917	0.446
DEG_SPOP_SBC_1	194	198	PF00917	0.513
DEG_SPOP_SBC_1	223	227	PF00917	0.558
DOC_CKS1_1	46	51	PF01111	0.645
DOC_CKS1_1	92	97	PF01111	0.553
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.675
DOC_PP2B_LxvP_1	399	402	PF13499	0.548
DOC_PP2B_LxvP_1	47	50	PF13499	0.606
DOC_PP4_FxxP_1	11	14	PF00568	0.566
DOC_PP4_FxxP_1	376	379	PF00568	0.559
DOC_PP4_MxPP_1	108	111	PF00568	0.608
DOC_USP7_MATH_1	100	104	PF00917	0.775
DOC_USP7_MATH_1	14	18	PF00917	0.656
DOC_USP7_MATH_1	195	199	PF00917	0.625
DOC_USP7_MATH_1	214	218	PF00917	0.684
DOC_USP7_MATH_1	24	28	PF00917	0.561
DOC_USP7_MATH_1	274	278	PF00917	0.518
DOC_USP7_MATH_1	300	304	PF00917	0.642
DOC_USP7_MATH_1	325	329	PF00917	0.634
DOC_USP7_MATH_1	381	385	PF00917	0.562
DOC_USP7_MATH_1	50	54	PF00917	0.641
DOC_USP7_MATH_1	59	63	PF00917	0.601
DOC_USP7_MATH_2	300	306	PF00917	0.545
DOC_WW_Pin1_4	144	149	PF00397	0.675
DOC_WW_Pin1_4	164	169	PF00397	0.478
DOC_WW_Pin1_4	178	183	PF00397	0.520
DOC_WW_Pin1_4	197	202	PF00397	0.457
DOC_WW_Pin1_4	229	234	PF00397	0.716
DOC_WW_Pin1_4	235	240	PF00397	0.618
DOC_WW_Pin1_4	255	260	PF00397	0.441
DOC_WW_Pin1_4	311	316	PF00397	0.544
DOC_WW_Pin1_4	336	341	PF00397	0.633
DOC_WW_Pin1_4	345	350	PF00397	0.782
DOC_WW_Pin1_4	359	364	PF00397	0.527
DOC_WW_Pin1_4	45	50	PF00397	0.647
DOC_WW_Pin1_4	55	60	PF00397	0.572
DOC_WW_Pin1_4	91	96	PF00397	0.632
LIG_14-3-3_CanoR_1	374	379	PF00244	0.614
LIG_BRCT_BRCA1_1	168	172	PF00533	0.654
LIG_BRCT_BRCA1_1	19	23	PF00533	0.623
LIG_CSL_BTD_1	279	282	PF09270	0.597
LIG_FHA_1	205	211	PF00498	0.489
LIG_FHA_1	225	231	PF00498	0.669
LIG_FHA_1	268	274	PF00498	0.479
LIG_IBAR_NPY_1	3	5	PF08397	0.570
LIG_LIR_Nem_3	130	135	PF02991	0.672
LIG_LIR_Nem_3	200	205	PF02991	0.602
LIG_LIR_Nem_3	270	275	PF02991	0.569
LIG_SH2_NCK_1	25	29	PF00017	0.580
LIG_SH2_SRC	119	122	PF00017	0.653
LIG_SH2_STAP1	25	29	PF00017	0.650
LIG_SH2_STAT3	203	206	PF00017	0.648
LIG_SH2_STAT5	252	255	PF00017	0.580
LIG_SH2_STAT5	46	49	PF00017	0.597
LIG_SH3_1	46	52	PF00018	0.646
LIG_SH3_2	49	54	PF14604	0.493
LIG_SH3_3	107	113	PF00018	0.610
LIG_SH3_3	165	171	PF00018	0.618
LIG_SH3_3	198	204	PF00018	0.601
LIG_SH3_3	276	282	PF00018	0.632
LIG_SH3_3	32	38	PF00018	0.637
LIG_SH3_3	385	391	PF00018	0.571
LIG_SH3_3	46	52	PF00018	0.537
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.660
MOD_CDC14_SPxK_1	181	184	PF00782	0.499
MOD_CDC14_SPxK_1	348	351	PF00782	0.658
MOD_CDK_SPxK_1	178	184	PF00069	0.502
MOD_CDK_SPxK_1	345	351	PF00069	0.658
MOD_CK1_1	115	121	PF00069	0.606
MOD_CK1_1	17	23	PF00069	0.674
MOD_CK1_1	217	223	PF00069	0.675
MOD_CK1_1	225	231	PF00069	0.599
MOD_CK1_1	238	244	PF00069	0.543
MOD_CK1_1	268	274	PF00069	0.620
MOD_CK1_1	290	296	PF00069	0.646
MOD_CK1_1	311	317	PF00069	0.725
MOD_CK1_1	53	59	PF00069	0.655
MOD_CK1_1	62	68	PF00069	0.571
MOD_CK2_1	374	380	PF00069	0.757
MOD_CK2_1	61	67	PF00069	0.817
MOD_GlcNHglycan	125	128	PF01048	0.501
MOD_GlcNHglycan	17	20	PF01048	0.567
MOD_GlcNHglycan	175	178	PF01048	0.604
MOD_GlcNHglycan	190	193	PF01048	0.692
MOD_GlcNHglycan	216	219	PF01048	0.691
MOD_GlcNHglycan	244	247	PF01048	0.592
MOD_GlcNHglycan	255	258	PF01048	0.512
MOD_GlcNHglycan	26	29	PF01048	0.627
MOD_GlcNHglycan	290	293	PF01048	0.815
MOD_GlcNHglycan	30	33	PF01048	0.681
MOD_GlcNHglycan	304	307	PF01048	0.592
MOD_GlcNHglycan	322	325	PF01048	0.634
MOD_GlcNHglycan	376	379	PF01048	0.605
MOD_GlcNHglycan	55	58	PF01048	0.654
MOD_GlcNHglycan	59	62	PF01048	0.651
MOD_GlcNHglycan	77	80	PF01048	0.516
MOD_GSK3_1	123	130	PF00069	0.592
MOD_GSK3_1	13	20	PF00069	0.592
MOD_GSK3_1	140	147	PF00069	0.646
MOD_GSK3_1	166	173	PF00069	0.751
MOD_GSK3_1	193	200	PF00069	0.524
MOD_GSK3_1	225	232	PF00069	0.669
MOD_GSK3_1	234	241	PF00069	0.592
MOD_GSK3_1	24	31	PF00069	0.577
MOD_GSK3_1	263	270	PF00069	0.522
MOD_GSK3_1	290	297	PF00069	0.726
MOD_GSK3_1	332	339	PF00069	0.723
MOD_GSK3_1	53	60	PF00069	0.619
MOD_GSK3_1	62	69	PF00069	0.638
MOD_GSK3_1	80	87	PF00069	0.572
MOD_GSK3_1	91	98	PF00069	0.564
MOD_N-GLC_1	115	120	PF02516	0.660
MOD_N-GLC_1	14	19	PF02516	0.447
MOD_N-GLC_1	374	379	PF02516	0.614
MOD_N-GLC_1	62	67	PF02516	0.590
MOD_NEK2_1	149	154	PF00069	0.647
MOD_NEK2_1	157	162	PF00069	0.687
MOD_NEK2_1	172	177	PF00069	0.577
MOD_NEK2_1	188	193	PF00069	0.566
MOD_NEK2_1	234	239	PF00069	0.592
MOD_NEK2_1	263	268	PF00069	0.633
MOD_NEK2_1	288	293	PF00069	0.769
MOD_NEK2_1	320	325	PF00069	0.717
MOD_NEK2_1	68	73	PF00069	0.665
MOD_PIKK_1	135	141	PF00454	0.628
MOD_PIKK_1	149	155	PF00454	0.579
MOD_PIKK_1	166	172	PF00454	0.595
MOD_PIKK_1	225	231	PF00454	0.669
MOD_PIKK_1	238	244	PF00454	0.543
MOD_PIKK_1	265	271	PF00454	0.587
MOD_PIKK_1	274	280	PF00454	0.607
MOD_PIKK_1	313	319	PF00454	0.740
MOD_PIKK_1	325	331	PF00454	0.632
MOD_PIKK_1	68	74	PF00454	0.730
MOD_PKA_2	300	306	PF00069	0.662
MOD_PKA_2	53	59	PF00069	0.640
MOD_Plk_1	115	121	PF00069	0.660
MOD_Plk_4	100	106	PF00069	0.691
MOD_Plk_4	157	163	PF00069	0.590
MOD_Plk_4	268	274	PF00069	0.601
MOD_Plk_4	332	338	PF00069	0.634
MOD_ProDKin_1	144	150	PF00069	0.674
MOD_ProDKin_1	164	170	PF00069	0.478
MOD_ProDKin_1	178	184	PF00069	0.523
MOD_ProDKin_1	197	203	PF00069	0.461
MOD_ProDKin_1	229	235	PF00069	0.717
MOD_ProDKin_1	255	261	PF00069	0.615
MOD_ProDKin_1	311	317	PF00069	0.546
MOD_ProDKin_1	336	342	PF00069	0.634
MOD_ProDKin_1	345	351	PF00069	0.785
MOD_ProDKin_1	359	365	PF00069	0.525
MOD_ProDKin_1	45	51	PF00069	0.647
MOD_ProDKin_1	55	61	PF00069	0.574
MOD_ProDKin_1	91	97	PF00069	0.629
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.616
TRG_ER_diArg_1	184	187	PF00400	0.668
TRG_ER_diArg_1	7	9	PF00400	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C9	Leptomonas seymouri	33%	98%
A0A3S7X2N6	Leishmania donovani	91%	100%
A4HHM8	Leishmania braziliensis	79%	100%
A4I4U3	Leishmania infantum	92%	100%
E9AE91	Leishmania major	90%	100%